EP1212326A4 - PYRROLO 2,3-d]PYRIMIDINE NUCLEOSIDE ANALOGS - Google Patents

PYRROLO 2,3-d]PYRIMIDINE NUCLEOSIDE ANALOGS

Info

Publication number
EP1212326A4
EP1212326A4 EP00959267A EP00959267A EP1212326A4 EP 1212326 A4 EP1212326 A4 EP 1212326A4 EP 00959267 A EP00959267 A EP 00959267A EP 00959267 A EP00959267 A EP 00959267A EP 1212326 A4 EP1212326 A4 EP 1212326A4
Authority
EP
European Patent Office
Prior art keywords
pyrrolo
nucleoside analogs
pyrimidine nucleoside
pyrimidine
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00959267A
Other languages
German (de)
French (fr)
Other versions
EP1212326A1 (en
Inventor
Guangyi Wang
Robert Tam
Zbigniew Pietrzkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant Pharmaceuticals International Inc USA
Original Assignee
ICN Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc
Publication of EP1212326A1 publication Critical patent/EP1212326A1/en
Publication of EP1212326A4 publication Critical patent/EP1212326A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP00959267A 1999-08-27 2000-08-17 PYRROLO 2,3-d]PYRIMIDINE NUCLEOSIDE ANALOGS Withdrawn EP1212326A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15123399P 1999-08-27 1999-08-27
US151233P 1999-08-27
PCT/US2000/022674 WO2001027114A1 (en) 1999-08-27 2000-08-17 PYRROLO[2,3-d]PYRIMIDINE NUCLEOSIDE ANALOGS

Publications (2)

Publication Number Publication Date
EP1212326A1 EP1212326A1 (en) 2002-06-12
EP1212326A4 true EP1212326A4 (en) 2003-08-20

Family

ID=22537871

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00959267A Withdrawn EP1212326A4 (en) 1999-08-27 2000-08-17 PYRROLO 2,3-d]PYRIMIDINE NUCLEOSIDE ANALOGS

Country Status (18)

Country Link
EP (1) EP1212326A4 (en)
JP (1) JP2003511454A (en)
KR (1) KR20020092904A (en)
CN (1) CN1384834A (en)
AU (1) AU769578B2 (en)
BR (1) BR0013642A (en)
CA (1) CA2381297A1 (en)
HR (1) HRP20020163A2 (en)
HU (1) HUP0301875A2 (en)
IL (1) IL147908A0 (en)
MX (1) MXPA02001753A (en)
NO (1) NO20020931L (en)
PL (1) PL354094A1 (en)
RU (1) RU2002103501A (en)
SI (1) SI20819A (en)
SK (1) SK1772002A3 (en)
WO (1) WO2001027114A1 (en)
ZA (1) ZA200201567B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455508B1 (en) * 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
JP2003183283A (en) * 2001-12-18 2003-07-03 Takeda Chem Ind Ltd Condensed indole compound, method for producing the same and application of the same
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
CN101851241B (en) * 2010-07-02 2012-05-23 西安交通大学 Anti-tumor compound and preparation method and application thereof
JP6012605B2 (en) 2010-09-22 2016-10-25 アリオス バイオファーマ インク． Substituted nucleotide analogs
CN102286048A (en) * 2011-06-24 2011-12-21 吉林大学 4-amino-6-(3-(3-bromophenyl) phenyl-5-cyano-7-(beta-L-xylofuranose) pyrrolo [2,3-d] pyrimidine, like derivatives and application for preparing antitumor drugs
WO2013096679A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2012358804B2 (en) 2011-12-22 2018-04-19 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
CN114404427A (en) 2014-02-13 2022-04-29 配体药物公司 Prodrug compound and use thereof
CN106687118A (en) 2014-07-02 2017-05-17 配体药物公司 Prodrug compounds and uses thereof
AR104326A1 (en) * 2015-05-04 2017-07-12 Lilly Co Eli 5-SUBSTITUTED NUCLEOSID COMPOUNDS
US10953029B2 (en) * 2015-09-23 2021-03-23 Merck Sharp & Dohme Corp. 4′-Substituted nucleoside reverse transcriptase inhibitors and preparations thereof
BR112021019465A8 (en) 2019-04-02 2022-06-07 Aligos Therapeutics Inc Compounds that target prmt5
KR102639275B1 (en) * 2021-06-08 2024-02-21 퓨쳐메디신 주식회사 Nucleoside derivative having kinase multiple target inhibiting activity and pharmaceutical composition for preventing and treating cancer comprising the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4892865A (en) * 1987-12-01 1990-01-09 The Regents Of The University Of Michigan Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents
WO1998016184A2 (en) * 1996-10-16 1998-04-23 Icn Pharmaceuticals, Inc. Purine l-nucleosides, analogs and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988338A (en) * 1974-04-24 1976-10-26 Wisconsin Alumni Research Foundation 4-Substituted amino-2-substituted thio-pyrrolo-[2,3-d]pyrimidine derivatives
US5674998A (en) * 1989-09-15 1997-10-07 Gensia Inc. C-4' modified adenosine kinase inhibitors
JPH08506343A (en) * 1993-02-03 1996-07-09 ジェンシア・インコーポレイテッド Adenosine kinase inhibitors containing lysofuranosyl derivatives
US5665721A (en) * 1995-06-07 1997-09-09 Abbott Laboratories Heterocyclic substituted cyclopentane compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4892865A (en) * 1987-12-01 1990-01-09 The Regents Of The University Of Michigan Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents
WO1998016184A2 (en) * 1996-10-16 1998-04-23 Icn Pharmaceuticals, Inc. Purine l-nucleosides, analogs and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0127114A1 *

Also Published As

Publication number Publication date
KR20020092904A (en) 2002-12-12
AU769578B2 (en) 2004-01-29
AU7061800A (en) 2001-04-23
HUP0301875A2 (en) 2003-09-29
PL354094A1 (en) 2003-12-29
ZA200201567B (en) 2003-07-30
BR0013642A (en) 2002-05-07
JP2003511454A (en) 2003-03-25
RU2002103501A (en) 2003-09-10
SI20819A (en) 2002-08-31
CA2381297A1 (en) 2001-04-19
WO2001027114A1 (en) 2001-04-19
IL147908A0 (en) 2002-08-14
SK1772002A3 (en) 2002-10-08
MXPA02001753A (en) 2002-10-23
NO20020931D0 (en) 2002-02-26
EP1212326A1 (en) 2002-06-12
HRP20020163A2 (en) 2004-02-29
NO20020931L (en) 2002-02-26
CN1384834A (en) 2002-12-11

Similar Documents

Publication Publication Date Title
EG24399A (en) Pyrrolo[2,3-D]pyrimidine compounds
EG23758A (en) Pyrrolo (2,3-d) pyrimidine compounds
SI1220856T1 (en) Pyrazolo(4,3-d)pyrimidine derivatives
AU2002327168A1 (en) Pyrrolo(2,3-d)pyrimidine nucleoside analogs
IL139586A0 (en) PYRROLO [2,3-d] PYRIMIDINE COMPOUNDS
EP1212326A4 (en) PYRROLO 2,3-d]PYRIMIDINE NUCLEOSIDE ANALOGS
PL353366A1 (en) Pyrazolo[4,3-d]pyrimidines
IL131892A0 (en) 6, 7-Disubstituted-4-aminopyrido [2, 3-d] pyrimidine compounds
PL336265A1 (en) 5,6,7-trisubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
SI1087970T1 (en) PYRROLO 2,3-d)PYRIMIDINE COMPOUNDS
SI1210349T1 (en) PYRAZOLO 4,3-d)PYRIMIDINES
ZA994004B (en) Pyrrolo[2,3-d]pyrimidine compounds.
ZA200202763B (en) Pyrazolo [4,3-D] pyrimidine derivatives.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020327

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 31/519 B

Ipc: 7A 61K 31/381 B

Ipc: 7C 07D 487/04 A

Ipc: 7A 61K 31/34 B

Ipc: 7A 61K 31/505 B

A4 Supplementary search report drawn up and despatched

Effective date: 20030704

17Q First examination report despatched

Effective date: 20031008

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RTI1 Title (correction)

Free format text: PYRROLO(2,3-D)PYRIMIDINE NUCLEOSIDE ANALOGA

RTI1 Title (correction)

Free format text: PYRROLO(2,3-D)PYRIMIDINE NUCLEOSIDE ANALOGS

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050719

RTI1 Title (correction)

Free format text: PYRROLO??2,3-D PYRIMIDINE NUCLEOSIDE ANALOGS

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1046410

Country of ref document: HK