IL131651A0 - A pharmaceutical formulation containing benzimidazoles with amino acid/caclodextrin combinations and a process for producing the same - Google Patents

A pharmaceutical formulation containing benzimidazoles with amino acid/caclodextrin combinations and a process for producing the same

Info

Publication number
IL131651A0
IL131651A0 IL13165198A IL13165198A IL131651A0 IL 131651 A0 IL131651 A0 IL 131651A0 IL 13165198 A IL13165198 A IL 13165198A IL 13165198 A IL13165198 A IL 13165198A IL 131651 A0 IL131651 A0 IL 131651A0
Authority
IL
Israel
Prior art keywords
amino acid
pharmaceutical formulation
caclodextrin
combinations
producing
Prior art date
Application number
IL13165198A
Other languages
English (en)
Original Assignee
Hexal Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8226585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL131651(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hexal Ag filed Critical Hexal Ag
Publication of IL131651A0 publication Critical patent/IL131651A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
IL13165198A 1997-03-13 1998-03-13 A pharmaceutical formulation containing benzimidazoles with amino acid/caclodextrin combinations and a process for producing the same IL131651A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97104200 1997-03-13
PCT/EP1998/001478 WO1998040069A2 (fr) 1997-03-13 1998-03-13 Stabilisation de benzimidazoles sensibles aux acides avec des combinaisons amino-cyclodextrine

Publications (1)

Publication Number Publication Date
IL131651A0 true IL131651A0 (en) 2001-01-28

Family

ID=8226585

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13165198A IL131651A0 (en) 1997-03-13 1998-03-13 A pharmaceutical formulation containing benzimidazoles with amino acid/caclodextrin combinations and a process for producing the same

Country Status (24)

Country Link
US (1) US6248758B1 (fr)
JP (1) JP4608031B2 (fr)
KR (1) KR100563764B1 (fr)
CN (1) CN1113649C (fr)
AT (1) ATE209491T1 (fr)
AU (1) AU731186B2 (fr)
BR (1) BR9808581A (fr)
CA (1) CA2282513C (fr)
CZ (1) CZ291842B6 (fr)
DE (1) DE69802688T3 (fr)
DK (1) DK0991407T4 (fr)
ES (1) ES2167891T5 (fr)
HK (1) HK1024182A1 (fr)
HU (1) HU225587B1 (fr)
IL (1) IL131651A0 (fr)
NO (1) NO327212B1 (fr)
NZ (1) NZ337592A (fr)
PL (1) PL191570B1 (fr)
PT (1) PT991407E (fr)
SI (1) SI0991407T2 (fr)
SK (1) SK284811B6 (fr)
TR (1) TR199902233T2 (fr)
WO (1) WO1998040069A2 (fr)
ZA (1) ZA982155B (fr)

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EE03305B1 (et) * 1994-07-08 2000-12-15 Astra Aktiebolag Paljuosaline tableteeritud annusvorm I
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
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HUP0002364A2 (hu) 2000-12-28
CZ291842B6 (cs) 2003-06-18
KR100563764B1 (ko) 2006-03-24
PL335571A1 (en) 2000-05-08
PT991407E (pt) 2002-05-31
AU731186B2 (en) 2001-03-29
US6248758B1 (en) 2001-06-19
NO327212B1 (no) 2009-05-11
ATE209491T1 (de) 2001-12-15
DE69802688T3 (de) 2006-01-26
SI0991407T2 (en) 2005-10-31
WO1998040069A2 (fr) 1998-09-17
TR199902233T2 (xx) 1999-12-21
CZ312899A3 (cs) 2000-02-16
JP2001518083A (ja) 2001-10-09
EP0991407B1 (fr) 2001-11-28
SI0991407T1 (en) 2002-04-30
CN1250372A (zh) 2000-04-12
CA2282513C (fr) 2007-09-18
DK0991407T4 (da) 2005-08-08
SK284811B6 (sk) 2005-12-01
NZ337592A (en) 2001-01-26
DE69802688T2 (de) 2002-08-01
EP0991407A2 (fr) 2000-04-12
AU7207098A (en) 1998-09-29
DE69802688D1 (de) 2002-01-10
KR20000076232A (ko) 2000-12-26
ES2167891T3 (es) 2002-05-16
CN1113649C (zh) 2003-07-09
SK120999A3 (en) 2000-09-12
NO994409D0 (no) 1999-09-10
DK0991407T3 (da) 2002-03-25
ES2167891T5 (es) 2005-11-16
CA2282513A1 (fr) 1998-09-17
PL191570B1 (pl) 2006-06-30
WO1998040069A3 (fr) 1998-12-17
NO994409L (no) 1999-10-21
BR9808581A (pt) 2000-05-30
JP4608031B2 (ja) 2011-01-05
HK1024182A1 (en) 2000-10-05
HU225587B1 (en) 2007-03-28
ZA982155B (en) 1998-12-01
HUP0002364A3 (en) 2001-12-28
EP0991407B9 (fr) 2002-11-13

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