IL130524A - Stable liquid interferon formulations, a kit containing the same and a process for stabilizing the same - Google Patents
Stable liquid interferon formulations, a kit containing the same and a process for stabilizing the sameInfo
- Publication number
- IL130524A IL130524A IL13052497A IL13052497A IL130524A IL 130524 A IL130524 A IL 130524A IL 13052497 A IL13052497 A IL 13052497A IL 13052497 A IL13052497 A IL 13052497A IL 130524 A IL130524 A IL 130524A
- Authority
- IL
- Israel
- Prior art keywords
- same
- liquid
- interferon
- stabilizing
- stable liquid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3435396P | 1996-12-24 | 1996-12-24 | |
PCT/US1997/023817 WO1998028007A1 (en) | 1996-12-24 | 1997-12-23 | Stable liquid interferon formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
IL130524A0 IL130524A0 (en) | 2000-06-01 |
IL130524A true IL130524A (en) | 2005-08-31 |
Family
ID=21875893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13052497A IL130524A (en) | 1996-12-24 | 1997-12-23 | Stable liquid interferon formulations, a kit containing the same and a process for stabilizing the same |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0948358B2 (da) |
JP (5) | JP4878664B2 (da) |
KR (2) | KR20000069664A (da) |
CN (2) | CN1733296B (da) |
AT (1) | ATE270899T1 (da) |
AU (1) | AU738362B2 (da) |
BG (2) | BG65418B1 (da) |
BR (1) | BR9714434A (da) |
CA (1) | CA2275890C (da) |
CZ (1) | CZ300636B6 (da) |
DE (1) | DE69729880T3 (da) |
DK (1) | DK0948358T4 (da) |
EA (1) | EA002754B1 (da) |
EE (2) | EE04266B1 (da) |
ES (1) | ES2224290T5 (da) |
HK (2) | HK1025040A1 (da) |
HU (1) | HU224222B1 (da) |
IL (1) | IL130524A (da) |
IS (1) | IS2070B (da) |
MX (1) | MX337876B (da) |
NO (1) | NO327844B1 (da) |
NZ (2) | NZ336548A (da) |
PL (1) | PL193447B1 (da) |
PT (1) | PT948358E (da) |
SI (1) | SI0948358T2 (da) |
SK (1) | SK284989B6 (da) |
TR (1) | TR199901968T2 (da) |
WO (1) | WO1998028007A1 (da) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20000069664A (ko) * | 1996-12-24 | 2000-11-25 | 아스트루 마이클 제이 | 안정한 액체 인터페론 제제 |
US20030190307A1 (en) | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
DK1017413T4 (da) | 1997-09-23 | 2008-03-25 | Rentschler Biotech Gmbh | Flydende formulering af interferon-beta |
CA2375779A1 (en) * | 1999-05-31 | 2000-12-07 | Mitsubishi Chemical Corporation | Lyophilized hgf preparation |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
UY27373A1 (es) * | 2001-07-09 | 2003-02-28 | Schering Ag | Formulaciones de interferón beta-humano |
AU2002351756A1 (en) | 2001-12-21 | 2003-07-15 | Novo Nordisk Health Care Ag | Liquid composition of factor vii polypeptides |
JP4340540B2 (ja) * | 2002-01-18 | 2009-10-07 | 旭化成ファーマ株式会社 | 可溶性トロンボモジュリン高濃度含有製剤 |
CA2490342C (en) | 2002-06-21 | 2015-06-16 | Novo Nordisk A/S | Stabilised solid compositions of factor vii polypeptides |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
TWI272948B (en) | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
AR044302A1 (es) * | 2003-05-13 | 2005-09-07 | Ares Trading Sa | Formulaciones con proteinas liquidas estabilizadas en recipientes farmaceuticos |
CA2525224A1 (en) | 2003-05-23 | 2004-12-02 | Michael Bech Jensen | Protein stabilization in solution |
CN1318087C (zh) * | 2003-06-06 | 2007-05-30 | 北京三诺佳邑生物技术有限责任公司 | 去白蛋白神经生长因子制剂 |
BRPI0413518A (pt) | 2003-08-14 | 2006-10-10 | Novo Nordisk Healthcare Ag | composição farmacêutica lìquida aquosa, método para preparar e uso da mesma, método para tratar uma sìndrome responsiva ao fator vii, e, recipiente hermético |
KR20070010115A (ko) * | 2003-11-13 | 2007-01-22 | 알자 코포레이션 | 경피전달용 조성물 및 장치 |
EP1532983A1 (en) | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
DK2298287T3 (da) | 2003-12-19 | 2018-07-23 | Novo Nordisk Healthcare Ag | Stabiliserede sammensætninger af faktor VII-polypeptider |
MXPA06014079A (es) * | 2004-06-01 | 2007-02-15 | Ares Trading Sa | Metodo para estabilizar proteinas. |
US20080193997A1 (en) * | 2004-08-24 | 2008-08-14 | Kenji Kangawa | Liquid Preparation of Physiologically Active Peptide |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
CN101056890B (zh) | 2004-11-10 | 2012-05-09 | 诺华疫苗和诊断公司 | 脱酰胺基干扰素-β |
CN101102739B (zh) * | 2005-01-12 | 2017-02-08 | 比奥根Ma公司 | 运输干扰素‑β的方法 |
US20060188555A1 (en) * | 2005-01-21 | 2006-08-24 | Micheal Cormier | Therapeutic peptide formulations with improved stability |
EP1899462B1 (en) | 2005-07-02 | 2011-03-09 | Arecor Limited | Stable aqueous systems comprising proteins |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
CA2810522A1 (en) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Polymorphs |
PL2868315T3 (pl) * | 2007-12-04 | 2018-06-29 | Biogen Chesapeake Llc | Udoskonalone preparaty i sposoby liofilizacji oraz uzyskiwane liofilizaty |
CN101878043A (zh) | 2007-12-20 | 2010-11-03 | 默克雪兰诺有限公司 | PEG-干扰素-β制剂 |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
JP2011519848A (ja) | 2008-05-01 | 2011-07-14 | アレコー リミテッド | タンパク質製剤 |
EP2328607A1 (en) | 2008-07-16 | 2011-06-08 | Arecor Limited | Stable formulation of a therapeutic protein |
KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
US8513264B2 (en) | 2008-09-10 | 2013-08-20 | Boehringer Ingelheim International Gmbh | Combination therapy for the treatment of diabetes and related conditions |
DE102008051574A1 (de) | 2008-10-14 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von Interferon-beta und deren Varianten |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
AU2009331471B2 (en) | 2008-12-23 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Salt forms of organic compound |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
DE102009032179A1 (de) | 2009-07-07 | 2011-01-13 | Biogenerix Ag | Verfahren zur Reinigung von Interferon beta |
KR102668834B1 (ko) | 2009-11-27 | 2024-05-24 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 dpp-iv 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
EP2531218B1 (en) | 2010-02-04 | 2018-12-12 | CSL Behring AG | Immunoglobulin preparation |
EP2361636A1 (en) | 2010-02-26 | 2011-08-31 | CSL Behring AG | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
DE102010011430A1 (de) * | 2010-03-15 | 2011-09-15 | Kurt Koch | Verfahren für den Bau des Nullenergiehauses in Schalenbauweise durch Ausschäumen aller Wände, Decken und Bedachung |
CN102946875A (zh) | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
NZ603319A (en) | 2010-06-24 | 2015-04-24 | Boehringer Ingelheim Int | Diabetes therapy |
AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
JP5538568B2 (ja) * | 2010-12-09 | 2014-07-02 | 丸石製薬株式会社 | アセトアミノフェンの安定化剤 |
SI2686002T1 (en) * | 2011-03-15 | 2018-06-29 | Biogen Ma Inc. | A method for reducing influenza-like symptoms associated with intramuscular delivery of interferon by the rapid titration-enhancing regimen |
US8962636B2 (en) | 2011-07-15 | 2015-02-24 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
CA2864740A1 (en) * | 2012-04-19 | 2013-10-24 | C.R. Bard, Inc. | Infusates with enhanced ph stability under ethylene oxide sterilization |
EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
ITMI20120913A1 (it) | 2012-05-28 | 2013-11-29 | Nicoletta Maxia | Uso della n-acetil-5-metossitriptamina o suoi analoghi per favorire il meccanismo di impianto dell' embrione, e relative composizioni e mezzi di coltura |
CN103143000B (zh) * | 2013-03-07 | 2014-11-05 | 安徽安科生物工程(集团)股份有限公司 | 一种重组人干扰素α2b制剂 |
ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
JP2014208669A (ja) * | 2014-06-17 | 2014-11-06 | 株式会社スリー・ディー・マトリックス | タンパク質の凝集抑制剤 |
MX2018015089A (es) | 2016-06-10 | 2019-05-13 | Boehringer Ingelheim Int | Combinacion de linagliptina y metformina. |
KR101943160B1 (ko) | 2016-10-06 | 2019-01-30 | 에이비온 주식회사 | 인터페론 베타 변이체의 안정화 제제 |
AU2018321335A1 (en) | 2017-08-22 | 2020-02-27 | Biogen Ma Inc. | Pharmaceutical compositions containing anti-beta amyloid antibodies |
KR20210009982A (ko) * | 2019-07-18 | 2021-01-27 | 에이비온 주식회사 | 2당화된 인터페론-베타 단백질의 정제 방법 |
CN110714051B (zh) * | 2019-11-20 | 2023-04-07 | 迈克生物股份有限公司 | 蛋白c活性测定试剂盒 |
MX2022013662A (es) * | 2020-04-29 | 2023-02-01 | Abion Inc | Variante del interferon-beta humano con doble mutacion y metodo para mejorar la estabilidad de la variante del interferon-beta humano. |
CN114177273B (zh) * | 2021-11-29 | 2024-05-28 | 苏州人本药业有限公司 | 一种含有神经毒素的液体制剂及其制备方法 |
WO2023129502A1 (en) * | 2021-12-27 | 2023-07-06 | Enalare Therapeutics Inc. | Respiratory stimulant parenteral formulations |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57175125A (en) * | 1981-04-20 | 1982-10-28 | Wakunaga Yakuhin Kk | Preparation of beta-interferon |
DE3262575D1 (en) * | 1981-12-23 | 1985-04-18 | Schering Corp | Stabilised interferon formulations and their preparation |
JPS60243028A (ja) * | 1984-04-28 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | インタ−フエロンの可溶化方法 |
JPS63196268A (ja) * | 1987-02-10 | 1988-08-15 | Kanegafuchi Chem Ind Co Ltd | 無血清培地で継代増殖可能な形質転換細胞、その育種方法およびその細胞による蛋白質の生産方法 |
EP0284249A1 (en) * | 1987-03-13 | 1988-09-28 | Interferon Sciences, Inc. | Lyophilized lymphokine composition |
DE3729863A1 (de) * | 1987-09-05 | 1989-03-16 | Boehringer Mannheim Gmbh | Stabilisierte erythropoietin-lyophilisate |
US4895716A (en) * | 1987-06-09 | 1990-01-23 | Biogen, Inc. | Stabilized formulations of gamma interferons |
JPH02124832A (ja) * | 1988-07-08 | 1990-05-14 | Toray Ind Inc | インターヘェロンβ組成物 |
DE3939346A1 (de) * | 1989-11-29 | 1991-06-06 | Behringwerke Ag | Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide |
IL109350A (en) * | 1993-05-12 | 2001-01-28 | Genentech Inc | Stable liquid preparations of gamma interferon |
TW249202B (da) * | 1993-08-13 | 1995-06-11 | Ciba Gerigy Corp | |
US5545723A (en) * | 1994-03-15 | 1996-08-13 | Biogen Inc. | Muteins of IFN-β |
CA2185353A1 (en) * | 1994-04-08 | 1995-10-19 | David A. Hafler | Treatment of autoimmune disease using oral tolerization and/or type i interferon |
IT1272252B (it) * | 1994-05-16 | 1997-06-16 | Applied Research Systems | Formulazioni liquide di interferone beta |
TW426523B (en) * | 1995-04-06 | 2001-03-21 | Hoffmann La Roche | Interferon solution |
KR20000069664A (ko) * | 1996-12-24 | 2000-11-25 | 아스트루 마이클 제이 | 안정한 액체 인터페론 제제 |
-
1997
- 1997-12-23 KR KR1019997005701A patent/KR20000069664A/ko not_active Application Discontinuation
- 1997-12-23 JP JP52905698A patent/JP4878664B2/ja not_active Expired - Fee Related
- 1997-12-23 PL PL97334365A patent/PL193447B1/pl unknown
- 1997-12-23 DE DE69729880T patent/DE69729880T3/de not_active Expired - Lifetime
- 1997-12-23 SK SK858-99A patent/SK284989B6/sk not_active IP Right Cessation
- 1997-12-23 EE EEP200300127A patent/EE04266B1/xx unknown
- 1997-12-23 SI SI9730670T patent/SI0948358T2/sl unknown
- 1997-12-23 CZ CZ0228299A patent/CZ300636B6/cs not_active IP Right Cessation
- 1997-12-23 PT PT97952621T patent/PT948358E/pt unknown
- 1997-12-23 WO PCT/US1997/023817 patent/WO1998028007A1/en not_active Application Discontinuation
- 1997-12-23 EA EA199900597A patent/EA002754B1/ru not_active IP Right Cessation
- 1997-12-23 IL IL13052497A patent/IL130524A/xx not_active IP Right Cessation
- 1997-12-23 ES ES97952621T patent/ES2224290T5/es not_active Expired - Lifetime
- 1997-12-23 EE EEP199900313A patent/EE04223B1/xx unknown
- 1997-12-23 AT AT97952621T patent/ATE270899T1/de active
- 1997-12-23 EP EP97952621A patent/EP0948358B2/en not_active Expired - Lifetime
- 1997-12-23 CN CN2005100915177A patent/CN1733296B/zh not_active Expired - Lifetime
- 1997-12-23 CA CA2275890A patent/CA2275890C/en not_active Expired - Lifetime
- 1997-12-23 KR KR1020077010020A patent/KR101042660B1/ko not_active IP Right Cessation
- 1997-12-23 AU AU56191/98A patent/AU738362B2/en not_active Expired
- 1997-12-23 TR TR1999/01968T patent/TR199901968T2/xx unknown
- 1997-12-23 CN CNB971814996A patent/CN1222315C/zh not_active Expired - Lifetime
- 1997-12-23 NZ NZ336548A patent/NZ336548A/en not_active IP Right Cessation
- 1997-12-23 DK DK97952621.7T patent/DK0948358T4/da active
- 1997-12-23 HU HU0000829A patent/HU224222B1/hu active IP Right Grant
- 1997-12-23 BR BR9714434-7A patent/BR9714434A/pt active Search and Examination
-
1999
- 1999-06-21 IS IS5087A patent/IS2070B/xx unknown
- 1999-06-23 NO NO993121A patent/NO327844B1/no not_active IP Right Cessation
- 1999-06-23 MX MX2012000515A patent/MX337876B/es unknown
- 1999-07-19 BG BG109523A patent/BG65418B1/bg unknown
- 1999-07-19 BG BG103594A patent/BG65171B1/bg unknown
-
2000
- 2000-04-12 HK HK00102221A patent/HK1025040A1/xx not_active IP Right Cessation
-
2001
- 2001-07-05 NZ NZ512792A patent/NZ512792A/xx not_active IP Right Cessation
-
2006
- 2006-08-11 HK HK06108948.0A patent/HK1092048A1/xx not_active IP Right Cessation
-
2007
- 2007-05-18 JP JP2007133540A patent/JP2007204501A/ja not_active Withdrawn
-
2011
- 2011-01-07 JP JP2011002557A patent/JP5851695B2/ja not_active Expired - Lifetime
- 2011-10-04 JP JP2011220534A patent/JP2012006979A/ja not_active Withdrawn
-
2014
- 2014-02-25 JP JP2014033581A patent/JP2014098029A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL130524A (en) | Stable liquid interferon formulations, a kit containing the same and a process for stabilizing the same | |
CA2113995A1 (en) | Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins | |
AU6340686A (en) | Pharmaceutical and dietary composition | |
CA2032499A1 (en) | Polypeptide derivatives | |
PL319833A1 (en) | Compounds and composition for carrying active media | |
EP2145897A3 (en) | Therapeutic methods and compositions based on serrate proteins and nucleic acids | |
GR3024632T3 (en) | Sustained-release protein formulations. | |
EP1077070A3 (en) | Oral drug delivery compositions | |
AU4009789A (en) | Recombinant natural killer cell activator | |
LTIP610A (en) | Inhibitors of cells proliferation, pharmaceutical composition and method for preparation of compounds | |
EP0612530A3 (en) | Pharmaceutical preparations which contain the cytotoxic tumor factor. | |
AU3494093A (en) | S-lipophilic aliphatic carbonyl {n-mercaptoacyl-(amino acid or peptide)} compounds as antihypertensive agents | |
EP0063328A3 (en) | Compositions containing secretin and method for preventing the adsorption of secretin | |
JPS57128662A (en) | Amino acid mixture composition | |
Sebald et al. | Cooperation of mitochondrial and cytoplasmic protein synthesis in the formation of cytochrome c oxidase | |
ES8204713A1 (es) | Un procedimiento para aislar un polipeptido purificado | |
ZA837267B (en) | Substituted n-carboxymethyl-(amino acid)-pyrrolidine-alkanoic acids useful as antihypertensive agents | |
MX9709907A (es) | Formulaciones de suspension de peptido/proteina. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |