IL118262A - Isoxazolines, a process for preparing them, use of isoxazolines in the preparation of pharmaceutical compositions, and pharmaceutical compositions containing isoxazolines - Google Patents
Isoxazolines, a process for preparing them, use of isoxazolines in the preparation of pharmaceutical compositions, and pharmaceutical compositions containing isoxazolinesInfo
- Publication number
- IL118262A IL118262A IL11826296A IL11826296A IL118262A IL 118262 A IL118262 A IL 118262A IL 11826296 A IL11826296 A IL 11826296A IL 11826296 A IL11826296 A IL 11826296A IL 118262 A IL118262 A IL 118262A
- Authority
- IL
- Israel
- Prior art keywords
- isoxazolines
- pharmaceutical compositions
- preparing
- compounds
- compositions containing
- Prior art date
Links
- 150000002547 isoxazolines Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 108010012088 Fibrinogen Receptors Proteins 0.000 abstract 1
- 102100022337 Integrin alpha-V Human genes 0.000 abstract 1
- 108010010336 Platelet Membrane Glycoproteins Proteins 0.000 abstract 1
- 102000015795 Platelet Membrane Glycoproteins Human genes 0.000 abstract 1
- 108010048673 Vitronectin Receptors Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000002545 isoxazoles Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000009424 thromboembolic effect Effects 0.000 abstract 1
- 229960000103 thrombolytic agent Drugs 0.000 abstract 1
- 230000002537 thrombolytic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/455,436 US5849736A (en) | 1993-11-24 | 1995-05-31 | Isoxazoline and isoxazole fibrinogen receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
IL118262A0 IL118262A0 (en) | 1996-09-12 |
IL118262A true IL118262A (en) | 2003-02-12 |
Family
ID=23808800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11826296A IL118262A (en) | 1995-05-31 | 1996-05-15 | Isoxazolines, a process for preparing them, use of isoxazolines in the preparation of pharmaceutical compositions, and pharmaceutical compositions containing isoxazolines |
Country Status (26)
Country | Link |
---|---|
US (2) | US5849736A (cs) |
EP (1) | EP0832076B1 (cs) |
JP (1) | JPH11504651A (cs) |
KR (1) | KR19990022198A (cs) |
CN (1) | CN1202893A (cs) |
AT (1) | ATE245150T1 (cs) |
AU (1) | AU723577B2 (cs) |
BR (1) | BR9609151A (cs) |
CA (1) | CA2222147A1 (cs) |
CZ (1) | CZ374397A3 (cs) |
DE (1) | DE69629116T2 (cs) |
EA (1) | EA000924B1 (cs) |
EE (1) | EE9700312A (cs) |
ES (1) | ES2198483T3 (cs) |
HU (1) | HUP9900102A3 (cs) |
IL (1) | IL118262A (cs) |
LT (1) | LT4416B (cs) |
LV (1) | LV12046B (cs) |
NZ (1) | NZ309944A (cs) |
PL (1) | PL323835A1 (cs) |
RO (1) | RO117324B1 (cs) |
SI (1) | SI9620071A (cs) |
SK (1) | SK162097A3 (cs) |
TW (1) | TW454007B (cs) |
WO (1) | WO1996038426A1 (cs) |
ZA (1) | ZA964486B (cs) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1997011940A1 (en) * | 1995-09-29 | 1997-04-03 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
US6004955A (en) * | 1996-08-15 | 1999-12-21 | Dupont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists |
AU6645998A (en) * | 1996-12-23 | 1998-07-17 | Du Pont Pharmaceuticals Company | Oxygen or sulfur containing heteroaromatics as factor xa inhibitors |
US6187797B1 (en) | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
US6022977A (en) * | 1997-03-26 | 2000-02-08 | Dupont Pharmaceuticals Company | Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids |
WO1998043962A1 (en) * | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Heterocyclic integrin inhibitor prodrugs |
AU7958098A (en) * | 1997-06-10 | 1998-12-30 | Regents Of The University Of Minnesota | Inhibitors of microbial adherence or invasion as therapeutic agents and broad-spectrum enhancers of antibiotic therapy |
HRP980291A2 (en) * | 1997-06-16 | 1999-04-30 | Lin-Hua Zhang | Crystalline roxifiban |
US5998424A (en) | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
BR9810151A (pt) * | 1997-06-19 | 2000-08-08 | Du Pont Pharm Co | Composto, composição farmacêutica e método para tratamento ou prevenção de uma desordem tromoboembólica |
ZA988735B (en) * | 1997-10-06 | 2000-03-23 | Du Pont Pharm Co | An efficient method for the conversion of nitriles to amidines. |
CA2315370A1 (en) * | 1997-12-17 | 1999-06-24 | Merck & Co., Inc. | Integrin receptor antagonists |
ZA99168B (en) * | 1998-01-16 | 2000-07-11 | Du Pont Pharm Co | Pharmaceutical formulations and processes for their preparation. |
ES2230841T3 (es) | 1998-03-27 | 2005-05-01 | Bristol-Myers Squibb Pharma Company | Pirazolinas y triazolinas disustituidas como inhibidores del factor xa. |
EP1091945A1 (en) | 1998-06-29 | 2001-04-18 | Du Pont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as iib/iiia antagonists |
AU5467699A (en) | 1998-08-07 | 2000-02-28 | Chiron Corporation | Substituted isoxazole as estrogen receptor modulators |
US6583141B1 (en) | 1998-10-09 | 2003-06-24 | Janssen Pharmaceutica, N.V. | 4,5-dihydro-isoxazole derivatives and their pharmaceutical use |
US6331640B1 (en) | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
US6319937B1 (en) * | 1998-11-18 | 2001-11-20 | Dupont Pharmaceuticals Company | Isoxazoline fibrinogen receptor antagonists |
US6303609B1 (en) * | 1998-11-18 | 2001-10-16 | Dupont Pharmaceuticals Company | Isoxazoline fibrinogen receptor antagonists |
DE60003025T2 (de) | 1999-04-02 | 2004-03-18 | Bristol-Myers Squibb Pharma Co. | Arylsulfonyle als faktor xa inhibitoren |
WO2001007436A2 (en) * | 1999-07-28 | 2001-02-01 | Aventis Pharmaceuticals Inc. | Substituted oxoazaheterocyclyl compounds |
US6849639B2 (en) | 1999-12-14 | 2005-02-01 | Amgen Inc. | Integrin inhibitors and their methods of use |
US7182953B2 (en) | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
TWI288745B (en) * | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
EP1289983A2 (en) * | 2000-06-15 | 2003-03-12 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
UY26780A1 (es) * | 2000-06-15 | 2002-01-31 | Pharmacia Corp | Cicloalquil avb3 antagonistas |
US6906046B2 (en) | 2000-12-22 | 2005-06-14 | Celltech R & D Inc. | Pharmaceutical uses and synthesis of benzobicyclooctanes |
CA2450589C (en) | 2001-06-08 | 2011-12-20 | Cytokine Pharmasciences, Inc. | Isoxazoline compounds having mif antagonist activity |
US20040043988A1 (en) * | 2001-06-15 | 2004-03-04 | Khanna Ish Kurmar | Cycloalkyl alkanoic acids as intergrin receptor antagonists |
WO2003000657A1 (fr) * | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Derives de diamine |
DE10130020A1 (de) * | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
CN100560131C (zh) | 2001-10-22 | 2009-11-18 | 斯克里普斯研究学院 | 抗体靶向化合物 |
BR0215098A (pt) * | 2001-11-26 | 2004-12-14 | Genentech Inc | Composição útil para remoção de coágulos de sangue, método para a remoção de coágulos de sangue, catéter e embalagens de múltiplos compartimentos |
US20070014779A1 (en) * | 2002-11-14 | 2007-01-18 | Genentech, Inc. | Plasminogen activator variant formulations |
WO2004058760A1 (en) * | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Thiazole compounds as integrin receptor antagonists derivatives |
BR0316875A (pt) * | 2002-12-20 | 2005-10-25 | Pharmacia Corp | Compostos de pirazol como derivados antagonistas receptores da integrina, sua composição farmacêutica e respectivo uso |
CA2507699A1 (en) * | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
US7576135B2 (en) * | 2002-12-25 | 2009-08-18 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
US7250415B2 (en) * | 2003-06-04 | 2007-07-31 | Bristol-Myers Squibb Company | 1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors |
HRP20141241T1 (hr) | 2004-03-05 | 2015-02-13 | Nissan Chemical Industries, Ltd. | Spoj benzamida supstituiran izoksazolinom i sredstvo za suzbijanje štetnih organizama |
WO2005094329A2 (en) * | 2004-03-26 | 2005-10-13 | Cytokine Pharmasciences, Inc. | Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor |
ATE548359T1 (de) * | 2004-06-17 | 2012-03-15 | Infinity Discovery Inc | Verbindungen und verfahren zur inhibierung der wechselwirkung von bcl-proteinen mit bindungspartnern |
CN101217953A (zh) * | 2005-03-15 | 2008-07-09 | 加尼亚尔免疫治疗公司 | 具有免疫调节活性的化合物 |
DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
EP1932836B1 (en) | 2005-09-02 | 2013-11-06 | Nissan Chemical Industries, Ltd. | Isoxazoline-substituted benzamide compound and harmful organism-controlling agent |
US20070122408A1 (en) * | 2005-10-20 | 2007-05-31 | The Scripps Research Institute | Fc Labeling for Immunostaining and Immunotargeting |
TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
EA019879B1 (ru) | 2005-12-29 | 2014-07-30 | Лексикон Фармасьютикалз, Инк. | Полициклические производные аминокислот, содержащая их фармацевтическая композиция и способ лечения, использующий эти производные |
TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
US8916148B2 (en) | 2006-11-07 | 2014-12-23 | Genentech, Inc. | Tissue plasminogen activator variant uses |
AU2008261793A1 (en) | 2007-06-13 | 2008-12-18 | E. I. Du Pont De Nemours And Company | Isoxazoline insecticides |
TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
RU2508102C2 (ru) | 2007-06-27 | 2014-02-27 | Е.И.Дюпон Де Немур Энд Компани | Способ борьбы с вредителями животных |
TWI461411B (zh) | 2007-08-17 | 2014-11-21 | Du Pont | 製備5-鹵烷基-4,5-二氫異唑衍生物之方法 |
KR20100075996A (ko) | 2007-10-03 | 2010-07-05 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물 |
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TWI583664B (zh) | 2008-04-09 | 2017-05-21 | 杜邦股份有限公司 | 羰基化合物及其製備方法 |
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UA108881C2 (xx) | 2010-05-27 | 2015-06-25 | Кристалічна форма 4-$5-$3-хлор-5-(трифторметил)феніл]-4,5-дигідро-5-(трифторметил)-3-ізоксазоліл]-n-$2-оксо-2-$(2,2,2-трифторетил)аміно]етил]-1-нафталінкарбоксаміду | |
EP2854805B1 (en) | 2012-04-17 | 2019-06-12 | GeneOne Life Science Inc. | Compounds having immunomodulator activity |
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PT3538525T (pt) | 2016-11-08 | 2022-08-16 | Bristol Myers Squibb Co | Ácidos propiónicos 3-substituídos por inibidores de alfa v integrina |
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-
1995
- 1995-05-31 US US08/455,436 patent/US5849736A/en not_active Expired - Lifetime
-
1996
- 1996-05-15 IL IL11826296A patent/IL118262A/xx not_active IP Right Cessation
- 1996-05-30 PL PL96323835A patent/PL323835A1/xx unknown
- 1996-05-30 DE DE69629116T patent/DE69629116T2/de not_active Expired - Fee Related
- 1996-05-30 ES ES96917833T patent/ES2198483T3/es not_active Expired - Lifetime
- 1996-05-30 WO PCT/US1996/007692 patent/WO1996038426A1/en not_active Application Discontinuation
- 1996-05-30 CZ CZ973743A patent/CZ374397A3/cs unknown
- 1996-05-30 EE EE9700312A patent/EE9700312A/xx unknown
- 1996-05-30 EA EA199700452A patent/EA000924B1/ru not_active IP Right Cessation
- 1996-05-30 CN CN96195931A patent/CN1202893A/zh active Pending
- 1996-05-30 AT AT96917833T patent/ATE245150T1/de not_active IP Right Cessation
- 1996-05-30 JP JP8536579A patent/JPH11504651A/ja active Pending
- 1996-05-30 SK SK1620-97A patent/SK162097A3/sk unknown
- 1996-05-30 KR KR1019970708677A patent/KR19990022198A/ko not_active Ceased
- 1996-05-30 CA CA002222147A patent/CA2222147A1/en not_active Abandoned
- 1996-05-30 EP EP96917833A patent/EP0832076B1/en not_active Expired - Lifetime
- 1996-05-30 HU HU9900102A patent/HUP9900102A3/hu unknown
- 1996-05-30 AU AU60243/96A patent/AU723577B2/en not_active Ceased
- 1996-05-30 NZ NZ309944A patent/NZ309944A/en unknown
- 1996-05-30 RO RO97-02195A patent/RO117324B1/ro unknown
- 1996-05-30 SI SI9620071A patent/SI9620071A/sl unknown
- 1996-05-30 BR BR9609151A patent/BR9609151A/pt unknown
- 1996-05-31 ZA ZA9604486A patent/ZA964486B/xx unknown
- 1996-06-14 TW TW085107183A patent/TW454007B/zh not_active IP Right Cessation
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1997
- 1997-11-24 LT LT97-182A patent/LT4416B/lt not_active IP Right Cessation
- 1997-11-25 US US08/978,295 patent/US6114328A/en not_active Expired - Lifetime
- 1997-12-29 LV LVP-97-239A patent/LV12046B/en unknown
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ZA964486B (en) | 1997-12-01 |
CN1202893A (zh) | 1998-12-23 |
RO117324B1 (ro) | 2002-01-30 |
DE69629116D1 (de) | 2003-08-21 |
HUP9900102A2 (hu) | 1999-05-28 |
LV12046B (en) | 1998-09-20 |
JPH11504651A (ja) | 1999-04-27 |
LT4416B (lt) | 1998-12-28 |
EP0832076B1 (en) | 2003-07-16 |
US6114328A (en) | 2000-09-05 |
BR9609151A (pt) | 1999-06-29 |
HUP9900102A3 (en) | 2001-11-28 |
SK162097A3 (en) | 1999-04-13 |
ATE245150T1 (de) | 2003-08-15 |
EA199700452A1 (ru) | 1998-10-29 |
LV12046A (lv) | 1998-05-20 |
DE69629116T2 (de) | 2004-04-08 |
TW454007B (en) | 2001-09-11 |
IL118262A0 (en) | 1996-09-12 |
SI9620071A (sl) | 1998-12-31 |
KR19990022198A (ko) | 1999-03-25 |
LT97182A (en) | 1998-07-27 |
CZ374397A3 (cs) | 1998-12-16 |
AU6024396A (en) | 1996-12-18 |
AU723577B2 (en) | 2000-08-31 |
NZ309944A (en) | 1999-10-28 |
EE9700312A (et) | 1998-06-15 |
ES2198483T3 (es) | 2004-02-01 |
EA000924B1 (ru) | 2000-06-26 |
CA2222147A1 (en) | 1996-12-05 |
US5849736A (en) | 1998-12-15 |
EP0832076A1 (en) | 1998-04-01 |
PL323835A1 (en) | 1998-04-27 |
WO1996038426A1 (en) | 1996-12-05 |
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