IL117177A - Benzopyran-containing compounds and their use in manufacture of medicaments for treatment of estrogen sensitive diseases such as endometrical cancer - Google Patents
Benzopyran-containing compounds and their use in manufacture of medicaments for treatment of estrogen sensitive diseases such as endometrical cancerInfo
- Publication number
- IL117177A IL117177A IL11717796A IL11717796A IL117177A IL 117177 A IL117177 A IL 117177A IL 11717796 A IL11717796 A IL 11717796A IL 11717796 A IL11717796 A IL 11717796A IL 117177 A IL117177 A IL 117177A
- Authority
- IL
- Israel
- Prior art keywords
- benzopyran
- medicaments
- manufacture
- treatment
- containing compounds
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
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- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0021—Oxiranes at position 14(15)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL15076702A IL150767A0 (en) | 1995-02-21 | 2002-07-16 | Benzopyran-containing compounds and their use in manufacture of medicament for treatment of estrogen sensitive diseases such as endometrial cancer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/388,207 US6060503A (en) | 1991-12-02 | 1995-02-21 | Benzopyran-containing compounds and method for their use |
Publications (2)
Publication Number | Publication Date |
---|---|
IL117177A0 IL117177A0 (en) | 1996-06-18 |
IL117177A true IL117177A (en) | 2003-10-31 |
Family
ID=23533138
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL150767A IL150767A (en) | 1995-02-21 | 1996-02-19 | Benzophyrene compounds and their use in the manufacture of drugs for the treatment of estrogen-sensitive diseases such as endometrial cancer |
IL11717796A IL117177A (en) | 1995-02-21 | 1996-02-19 | Benzopyran-containing compounds and their use in manufacture of medicaments for treatment of estrogen sensitive diseases such as endometrical cancer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL150767A IL150767A (en) | 1995-02-21 | 1996-02-19 | Benzophyrene compounds and their use in the manufacture of drugs for the treatment of estrogen-sensitive diseases such as endometrial cancer |
Country Status (28)
Country | Link |
---|---|
US (1) | US6060503A (de) |
EP (2) | EP0811006B1 (de) |
JP (1) | JPH11500133A (de) |
KR (1) | KR100487647B1 (de) |
CN (1) | CN1158274C (de) |
AR (1) | AR004167A1 (de) |
AT (2) | ATE239007T1 (de) |
AU (1) | AU4660696A (de) |
BR (1) | BR9607259A (de) |
CA (1) | CA2212856C (de) |
DE (2) | DE69627831T2 (de) |
DK (2) | DK1167364T3 (de) |
ES (2) | ES2199912T3 (de) |
FI (1) | FI120940B (de) |
HK (1) | HK1009440A1 (de) |
HU (1) | HU227762B1 (de) |
IL (2) | IL150767A (de) |
MX (1) | MX9706345A (de) |
MY (1) | MY117248A (de) |
NO (2) | NO317055B1 (de) |
NZ (1) | NZ301231A (de) |
PL (1) | PL188076B1 (de) |
PT (2) | PT1167364E (de) |
RU (1) | RU2220143C2 (de) |
TR (1) | TR199600144A2 (de) |
TW (1) | TW434238B (de) |
WO (1) | WO1996026201A1 (de) |
ZA (1) | ZA961316B (de) |
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KR20000001793A (ko) * | 1998-06-13 | 2000-01-15 | 이경하 | 신규한 벤조피란 또는 티오벤조피란 유도체 |
CA2340343C (en) * | 1998-08-14 | 2007-04-24 | Schering Corporation | Enantioselective synthesis |
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DE10013782A1 (de) | 2000-03-15 | 2001-10-18 | Schering Ag | 4-Fluoralkyl-2H-benzopyrane mit antiestrogener Wirksamkeit, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
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WO2002089802A2 (en) | 2001-05-08 | 2002-11-14 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
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WO2005066194A1 (en) * | 2004-01-07 | 2005-07-21 | Endorecherche, Inc. | Helix 12 directed steroidal pharmaceutical products |
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ES2553101T3 (es) | 2004-10-20 | 2015-12-04 | Endorecherche Inc. | Precursor de esteroides sexuales en combinación con un modulador selectivo del receptor de estrógenos para la prevención y tratamiento de atrofia vaginal en mujeres postmenopáusicas |
DE602005010735D1 (de) * | 2004-11-18 | 2008-12-11 | Janssen Pharmaceutica Nv | Neue 2h-chromenderivate als selektive östrogenrezeptor-modulatoren |
GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
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ES2718912T3 (es) | 2007-10-16 | 2019-07-05 | Repros Therapeutics Inc | Trans-clomifeno para el tratamiento de la diabetes en hombres hipogonadales |
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MX2012014431A (es) * | 2010-06-10 | 2013-02-26 | Aragon Pharmaceuticals Inc | Modulares del receptor de estrogenos y usos de los mismos. |
BR112012032189B1 (pt) | 2010-06-16 | 2020-11-03 | Endorecherche, Inc | usos de um agonista ou antagonista de lhrh em associação com um modulador de receptor de estrogênio seletivo e com um precursor de esteróide sexual para a preparação de uma medicamento para o tratamento ou prevenção de doenças relacionadas com estrogênio e kits |
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MD20140054A2 (ro) | 2011-12-16 | 2014-10-31 | Olema Pharmaceuticals, Inc. | Compuşi noi de benzopiran, compoziţii şi utilizări ale acestora |
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WO2014203132A1 (en) | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Substituted benzopyran compounds, compositions and uses thereof |
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KR20160021277A (ko) | 2013-06-19 | 2016-02-24 | 세라곤 파마슈티컬스, 인크. | 에스트로겐 수용체 조절제 및 이의 용도 |
US9744177B2 (en) | 2014-03-10 | 2017-08-29 | Endorecherche, Inc. | Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM |
BR112016020953A2 (pt) * | 2014-03-13 | 2018-01-23 | Hoffmann La Roche | composto, kit, composição farmacêutica, uso de composto, método de tratamento e invenção |
CN107406433A (zh) * | 2014-12-18 | 2017-11-28 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的2,3‑二苯基色烯的衍生物 |
CN107531722B (zh) | 2015-05-26 | 2020-07-17 | 豪夫迈·罗氏有限公司 | 杂环雌激素受体调节剂及其用途 |
EP3368519B1 (de) | 2015-10-27 | 2022-04-06 | Sun Pharma Advanced Research Company Limited | Neuartige heterocyclische antiöstrogene |
US11633382B2 (en) | 2015-11-10 | 2023-04-25 | Paracrine Therapeutics Ab | Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen |
EP3525774B1 (de) | 2016-10-11 | 2021-12-29 | Duke University | Behandlung von er+-brustkrebs mit lasofoxifen |
CN117771239A (zh) | 2018-04-10 | 2024-03-29 | 杜克大学 | 乳腺癌的拉索昔芬治疗 |
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-
1995
- 1995-02-21 US US08/388,207 patent/US6060503A/en not_active Expired - Lifetime
-
1996
- 1996-02-15 TW TW085101901A patent/TW434238B/zh not_active IP Right Cessation
- 1996-02-17 MY MYPI96000645A patent/MY117248A/en unknown
- 1996-02-19 IL IL150767A patent/IL150767A/en not_active IP Right Cessation
- 1996-02-19 IL IL11717796A patent/IL117177A/xx not_active IP Right Cessation
- 1996-02-19 TR TR96/00144A patent/TR199600144A2/xx unknown
- 1996-02-19 AR ARP960101429A patent/AR004167A1/es active IP Right Grant
- 1996-02-20 NZ NZ301231A patent/NZ301231A/xx not_active IP Right Cessation
- 1996-02-20 DK DK01123569T patent/DK1167364T3/da active
- 1996-02-20 HU HU9801230A patent/HU227762B1/hu not_active IP Right Cessation
- 1996-02-20 DK DK96902191T patent/DK0811006T3/da active
- 1996-02-20 DE DE69627831T patent/DE69627831T2/de not_active Expired - Lifetime
- 1996-02-20 MX MX9706345A patent/MX9706345A/es unknown
- 1996-02-20 WO PCT/CA1996/000097 patent/WO1996026201A1/en active IP Right Grant
- 1996-02-20 EP EP96902191A patent/EP0811006B1/de not_active Expired - Lifetime
- 1996-02-20 BR BR9607259A patent/BR9607259A/pt not_active Application Discontinuation
- 1996-02-20 CA CA002212856A patent/CA2212856C/en not_active Expired - Fee Related
- 1996-02-20 PL PL96321892A patent/PL188076B1/pl unknown
- 1996-02-20 PT PT01123569T patent/PT1167364E/pt unknown
- 1996-02-20 ZA ZA9601316A patent/ZA961316B/xx unknown
- 1996-02-20 RU RU97115713/04A patent/RU2220143C2/ru not_active IP Right Cessation
- 1996-02-20 DE DE69628353T patent/DE69628353T2/de not_active Expired - Lifetime
- 1996-02-20 ES ES01123569T patent/ES2199912T3/es not_active Expired - Lifetime
- 1996-02-20 KR KR1019970705813A patent/KR100487647B1/ko not_active IP Right Cessation
- 1996-02-20 AU AU46606/96A patent/AU4660696A/en not_active Abandoned
- 1996-02-20 AT AT96902191T patent/ATE239007T1/de active
- 1996-02-20 PT PT96902191T patent/PT811006E/pt unknown
- 1996-02-20 JP JP8525260A patent/JPH11500133A/ja active Pending
- 1996-02-20 AT AT01123569T patent/ATE240951T1/de active
- 1996-02-20 CN CNB961932392A patent/CN1158274C/zh not_active Expired - Fee Related
- 1996-02-20 EP EP01123569A patent/EP1167364B1/de not_active Expired - Lifetime
- 1996-02-20 ES ES96902191T patent/ES2197232T3/es not_active Expired - Lifetime
-
1997
- 1997-08-20 NO NO19973836A patent/NO317055B1/no not_active IP Right Cessation
- 1997-08-21 FI FI973426A patent/FI120940B/fi not_active IP Right Cessation
-
1998
- 1998-08-25 HK HK98110192A patent/HK1009440A1/xx not_active IP Right Cessation
-
2003
- 2003-12-19 NO NO20035726A patent/NO328598B1/no not_active IP Right Cessation
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