IL114274A - Process for the preparation of 4-acetoxy -2alpha-bezoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en 13alpha-yl (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate - Google Patents

Process for the preparation of 4-acetoxy -2alpha-bezoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en 13alpha-yl (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Info

Publication number
IL114274A
IL114274A IL11427495A IL11427495A IL114274A IL 114274 A IL114274 A IL 114274A IL 11427495 A IL11427495 A IL 11427495A IL 11427495 A IL11427495 A IL 11427495A IL 114274 A IL114274 A IL 114274A
Authority
IL
Israel
Prior art keywords
beta
butoxycarbonylamino
trihydroxy
tax
acetoxy
Prior art date
Application number
IL11427495A
Other languages
English (en)
Other versions
IL114274A0 (en
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL114274(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of IL114274A0 publication Critical patent/IL114274A0/xx
Publication of IL114274A publication Critical patent/IL114274A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
IL11427495A 1994-07-08 1995-06-22 Process for the preparation of 4-acetoxy -2alpha-bezoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en 13alpha-yl (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate IL114274A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (2)

Publication Number Publication Date
IL114274A0 IL114274A0 (en) 1995-10-31
IL114274A true IL114274A (en) 1999-04-11

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11427495A IL114274A (en) 1994-07-08 1995-06-22 Process for the preparation of 4-acetoxy -2alpha-bezoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en 13alpha-yl (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Country Status (38)

Country Link
US (1) US6022985A (forum.php)
EP (1) EP0770070B1 (forum.php)
JP (1) JP3753155B2 (forum.php)
KR (1) KR100391753B1 (forum.php)
CN (1) CN1067996C (forum.php)
AT (1) ATE171702T1 (forum.php)
AU (1) AU706519B2 (forum.php)
BR (1) BR9508789A (forum.php)
CA (1) CA2193531C (forum.php)
CO (1) CO4410189A1 (forum.php)
CZ (1) CZ284695B6 (forum.php)
DE (1) DE69505128T2 (forum.php)
DK (1) DK0770070T3 (forum.php)
DZ (1) DZ1905A1 (forum.php)
ES (1) ES2121404T3 (forum.php)
FI (1) FI119246B (forum.php)
FR (1) FR2722191B1 (forum.php)
GR (1) GR3027558T3 (forum.php)
HU (1) HU220634B1 (forum.php)
IL (1) IL114274A (forum.php)
IN (1) IN183947B (forum.php)
IS (1) IS2032B (forum.php)
MA (1) MA23606A1 (forum.php)
MX (1) MX9700173A (forum.php)
MY (1) MY118481A (forum.php)
NO (1) NO314500B1 (forum.php)
NZ (1) NZ289455A (forum.php)
PE (1) PE8697A1 (forum.php)
PL (1) PL179876B1 (forum.php)
RU (1) RU2126397C1 (forum.php)
SI (1) SI0770070T1 (forum.php)
SK (1) SK280520B6 (forum.php)
TN (1) TNSN95071A1 (forum.php)
TW (1) TW419473B (forum.php)
UA (1) UA51624C2 (forum.php)
UY (1) UY23991A1 (forum.php)
WO (1) WO1996001815A1 (forum.php)
ZA (1) ZA955646B (forum.php)

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US6638502B1 (en) 1997-04-28 2003-10-28 Gencell Sas Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors
SE510650C2 (sv) 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
EP1694660B1 (en) 2003-12-12 2009-04-08 Quiral Quimica Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
US8034765B2 (en) 2005-08-31 2011-10-11 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
BRPI0615265A8 (pt) * 2005-08-31 2018-03-06 Abraxis Bioscience Llc composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos
TW200730518A (en) * 2005-10-12 2007-08-16 Sicor Inc Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
BRPI0706580A2 (pt) * 2006-01-20 2011-03-29 Landmark Graphics Corp gerenciamento dinámico de sistema de produção
AU2007226937A1 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
JP2010506932A (ja) * 2006-10-20 2010-03-04 シノファーム シンガポール ピーティーイー，リミテッド 結晶性の無水ドセタキセルの製造方法
KR100868116B1 (ko) 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
JP5824511B2 (ja) 2010-05-03 2015-11-25 テイコク ファーマ ユーエスエー インコーポレーテッド 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
HRP20182194T1 (hr) 2011-09-08 2019-02-22 New York University Onkolitički herpes simpleks virus i njegova terapeutska uporaba
US9745631B2 (en) 2011-12-20 2017-08-29 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
NZ700073A (en) 2012-04-04 2016-08-26 Halozyme Inc Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
AU2013266243A1 (en) 2012-05-24 2014-12-18 Beth Israel Deaconess Medical Center, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer
US20150285802A1 (en) 2012-07-18 2015-10-08 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
WO2014149871A1 (en) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
US10130590B2 (en) 2013-10-01 2018-11-20 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
US10350264B2 (en) 2014-03-27 2019-07-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
US10967015B2 (en) 2015-06-15 2021-04-06 New York University Method of treatment using oncolytic viruses
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
IS4411A (is) 1997-01-07
AU706519B2 (en) 1999-06-17
PE8697A1 (es) 1997-03-26
GR3027558T3 (en) 1998-11-30
DE69505128D1 (de) 1998-11-05
HU9700041D0 (en) 1997-02-28
KR100391753B1 (ko) 2004-02-11
EP0770070A1 (fr) 1997-05-02
TNSN95071A1 (fr) 1996-02-06
DZ1905A1 (fr) 2002-02-17
CZ3597A3 (en) 1997-04-16
MX9700173A (es) 1997-04-30
CO4410189A1 (es) 1997-01-09
UY23991A1 (es) 1995-09-20
JP3753155B2 (ja) 2006-03-08
FI119246B (fi) 2008-09-15
FR2722191A1 (fr) 1996-01-12
FR2722191B1 (fr) 1996-08-23
SK280520B6 (sk) 2000-03-13
CN1151741A (zh) 1997-06-11
CZ284695B6 (cs) 1999-02-17
ZA955646B (en) 1996-02-21
NO970007L (no) 1997-01-02
CA2193531A1 (fr) 1996-01-25
HU220634B1 (hu) 2002-03-28
AU2930595A (en) 1996-02-09
RU2126397C1 (ru) 1999-02-20
DE69505128T2 (de) 1999-04-01
MY118481A (en) 2004-11-30
FI970069L (fi) 1997-01-07
NZ289455A (en) 1997-12-19
IL114274A0 (en) 1995-10-31
WO1996001815A1 (fr) 1996-01-25
ATE171702T1 (de) 1998-10-15
PL179876B1 (pl) 2000-11-30
SI0770070T1 (en) 1998-12-31
CA2193531C (fr) 2006-12-05
FI970069A0 (fi) 1997-01-07
HUT76833A (en) 1997-11-28
BR9508789A (pt) 1997-10-21
IN183947B (forum.php) 2000-05-20
JPH10502627A (ja) 1998-03-10
SK697A3 (en) 1997-06-04
PL318195A1 (en) 1997-05-26
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
US6022985A (en) 2000-02-08
UA51624C2 (uk) 2002-12-16
IS2032B (is) 2005-08-15
CN1067996C (zh) 2001-07-04
NO970007D0 (no) 1997-01-02
EP0770070B1 (fr) 1998-09-30
ES2121404T3 (es) 1998-11-16
DK0770070T3 (da) 1999-03-01
KR970704721A (ko) 1997-09-06
TW419473B (en) 2001-01-21

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