IL109316A - History 1, 5 - Benzodiazepines, their preparation and pharmaceutical preparations containing them - Google Patents

History 1, 5 - Benzodiazepines, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL109316A
IL109316A IL10931694A IL10931694A IL109316A IL 109316 A IL109316 A IL 109316A IL 10931694 A IL10931694 A IL 10931694A IL 10931694 A IL10931694 A IL 10931694A IL 109316 A IL109316 A IL 109316A
Authority
IL
Israel
Prior art keywords
phenyl
4alkyl
group
formula
hydroxy
Prior art date
Application number
IL10931694A
Other languages
English (en)
Hebrew (he)
Other versions
IL109316A0 (en
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of IL109316A0 publication Critical patent/IL109316A0/xx
Publication of IL109316A publication Critical patent/IL109316A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0827Tripeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IL10931694A 1993-04-15 1994-04-13 History 1, 5 - Benzodiazepines, their preparation and pharmaceutical preparations containing them IL109316A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin

Publications (2)

Publication Number Publication Date
IL109316A0 IL109316A0 (en) 1994-07-31
IL109316A true IL109316A (en) 1999-03-12

Family

ID=10733915

Family Applications (2)

Application Number Title Priority Date Filing Date
IL10931694A IL109316A (en) 1993-04-15 1994-04-13 History 1, 5 - Benzodiazepines, their preparation and pharmaceutical preparations containing them
IL10931594A IL109315A0 (en) 1993-04-15 1994-04-13 1, 5-benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL10931594A IL109315A0 (en) 1993-04-15 1994-04-13 1, 5-benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them

Country Status (34)

Country Link
US (2) US5646140A (no)
EP (1) EP0694039B1 (no)
JP (1) JP3406317B2 (no)
KR (1) KR100364948B1 (no)
CN (1) CN1058487C (no)
AP (2) AP512A (no)
AT (1) ATE198894T1 (no)
AU (1) AU681139B2 (no)
CA (1) CA2158973C (no)
CZ (1) CZ286695B6 (no)
DE (1) DE69426624T2 (no)
DK (1) DK0694039T3 (no)
EC (1) ECSP941066A (no)
ES (1) ES2154674T3 (no)
FI (1) FI954853A0 (no)
GB (1) GB9307833D0 (no)
GR (1) GR3035641T3 (no)
HK (1) HK1003943A1 (no)
HU (1) HU223467B1 (no)
IL (2) IL109316A (no)
IS (2) IS4148A (no)
MY (2) MY131569A (no)
NO (1) NO311133B1 (no)
NZ (1) NZ265272A (no)
OA (1) OA10355A (no)
PE (2) PE50994A1 (no)
PH (1) PH30897A (no)
PL (1) PL178790B1 (no)
PT (1) PT694039E (no)
RU (1) RU2135486C1 (no)
SK (1) SK281211B6 (no)
TW (1) TW487703B (no)
WO (1) WO1994024149A1 (no)
ZA (2) ZA942570B (no)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3621416B2 (ja) * 1993-12-28 2005-02-16 塩野義製薬株式会社 新規なベンゾジアゼピン誘導体
US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
PL180026B1 (pl) * 1994-04-14 2000-12-29 Glaxo Wellcome Inc Pochodne 5-heterocyklo-1,5-benzodiazepiny, sposób ich wytwarzania oraz kompozycja zawierajaca te zwiazki PL PL PL PL PL PL PL PL
JPH09511998A (ja) * 1994-04-15 1997-12-02 グラクソ、ウェルカム、インコーポレーテッド 1,4 − ベンゾジアゼピン化合物を用いたコレシストキニンアゴニスト活性の誘導方法
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
GB9420747D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
GB9420748D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
US5910495A (en) * 1994-10-14 1999-06-08 Glaxo Wellcome Inc. Use of 1,5-benzo b!1,4-diazepines to control gastric emptying
US5780464A (en) * 1994-10-14 1998-07-14 Glaxo Wellcome Inc. Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
WO1997021731A1 (en) 1995-12-11 1997-06-19 New England Medical Center Hospitals, Inc. Assay for and uses of peptide hormone receptor ligands
AU721081B2 (en) * 1996-12-10 2000-06-22 Zeria Pharmaceutical Co., Ltd. 1,5-benzodiazepine derivatives
HUP0000838A3 (en) 1997-04-15 2001-04-28 Csir Extract containing steroid-glucosid, process for its isolation and synthesis, pharmaceutical composition containing it having appetite suppressant activity
AR022044A1 (es) * 1999-05-06 2002-09-04 Glaxo Group Ltd Derivados de 1,5-benzodiazepina
GB2355657B (en) 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
US20020180095A1 (en) * 2001-05-29 2002-12-05 Berard Steven O. Thermally conductive carbon fiber extrusion compounder and method of using same
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
DE60325834D1 (de) * 2002-02-20 2009-03-05 Abbott Lab Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1)
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) * 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
AP2006003768A0 (en) * 2004-05-25 2006-10-31 Pfizer Prod Inc TetraazabenzoÄeÜazulene derivatives and analogs tehereof
CN1333077C (zh) * 2005-04-15 2007-08-22 华南农业大学 缩胆囊素活性片段的串联表达及其应用
US7767705B2 (en) * 2006-08-25 2010-08-03 Abbott Laboratories Compounds that inhibit TRPV1 and uses thereof
EP2450346A1 (en) 2006-12-20 2012-05-09 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
JP2011515414A (ja) * 2008-03-20 2011-05-19 アボット・ラボラトリーズ Trpv1アンタゴニストである中枢神経系薬剤を作製する方法
CN103102285B (zh) * 2013-01-30 2015-07-29 淮阴师范学院 对氨基苯乙腈的制备方法
CN106029076B (zh) 2013-11-18 2019-06-07 福马疗法公司 作为bet溴域抑制剂的苯并哌嗪组合物
MX370535B (es) 2013-11-18 2019-12-17 Forma Therapeutics Inc Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer.
WO2017015449A1 (en) 2015-07-22 2017-01-26 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as rsv inhibitors
MA44007A (fr) 2016-02-05 2018-12-19 Denali Therapeutics Inc Inhibiteurs du récepteur interagissant avec protéine kinase 1
LT3552017T (lt) 2016-12-09 2022-05-10 Denali Therapeutics Inc. Junginiai, naudotini kaip ripk1 inhibitoriai
KR102573499B1 (ko) 2017-02-16 2023-08-31 이난타 파마슈티칼스, 인코포레이티드 벤조디아제핀 유도체의 제조 방법
US10752598B2 (en) * 2017-06-07 2020-08-25 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as RSV inhibitors
WO2019006291A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
US10881666B2 (en) 2017-09-29 2021-01-05 Enanta Pharmaceuticals, Inc. Combination pharmaceutical agents as RSV inhibitors
WO2019094920A1 (en) 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as rsv inhibitors
WO2019199908A1 (en) 2018-04-11 2019-10-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
KR20210138684A (ko) 2019-03-18 2021-11-19 이난타 파마슈티칼스, 인코포레이티드 Rsv 억제제로서의 벤조디아제핀 유도체
US11179400B2 (en) 2019-04-09 2021-11-23 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
WO2022010882A1 (en) 2020-07-07 2022-01-13 Enanta Pharmaceuticals, Inc, Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
WO2023137035A1 (en) 2022-01-12 2023-07-20 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
JP2904941B2 (ja) * 1991-01-28 1999-06-14 出光興産株式会社 スチレン系重合体の精製方法
GB9201180D0 (en) * 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds
PL180026B1 (pl) * 1994-04-14 2000-12-29 Glaxo Wellcome Inc Pochodne 5-heterocyklo-1,5-benzodiazepiny, sposób ich wytwarzania oraz kompozycja zawierajaca te zwiazki PL PL PL PL PL PL PL PL

Also Published As

Publication number Publication date
GB9307833D0 (en) 1993-06-02
NO311133B1 (no) 2001-10-15
NZ265272A (en) 1997-07-27
PE50594A1 (es) 1995-01-06
MY131569A (en) 2007-08-30
IL109316A0 (en) 1994-07-31
TW487703B (en) 2002-05-21
CN1058487C (zh) 2000-11-15
PH30897A (en) 1997-12-23
SK281211B6 (sk) 2001-01-18
RU2135486C1 (ru) 1999-08-27
PT694039E (pt) 2001-06-29
ECSP941066A (es) 1994-11-16
PE50994A1 (es) 1995-01-06
CZ286695B6 (en) 2000-06-14
OA10355A (en) 2001-10-19
JPH08508744A (ja) 1996-09-17
NO954090D0 (no) 1995-10-13
DE69426624T2 (de) 2001-06-21
EP0694039A1 (en) 1996-01-31
DE69426624D1 (de) 2001-03-01
CA2158973C (en) 2006-06-06
KR100364948B1 (ko) 2003-03-29
CN1120843A (zh) 1996-04-17
AU6567694A (en) 1994-11-08
SK125395A3 (en) 1996-06-05
ES2154674T3 (es) 2001-04-16
FI954853A (fi) 1995-10-12
US5585376A (en) 1996-12-17
ZA942571B (en) 1994-11-11
DK0694039T3 (da) 2001-05-21
CA2158973A1 (en) 1994-10-27
CZ267595A3 (en) 1996-04-17
ZA942570B (en) 1994-11-11
WO1994024149A1 (en) 1994-10-27
GR3035641T3 (en) 2001-06-29
US5646140A (en) 1997-07-08
IL109315A0 (en) 1994-07-31
JP3406317B2 (ja) 2003-05-12
MY112237A (en) 2001-05-31
HU223467B1 (hu) 2004-07-28
AU681139B2 (en) 1997-08-21
FI954853A0 (fi) 1995-10-12
NO954090L (no) 1995-12-13
EP0694039B1 (en) 2001-01-24
HUT74102A (en) 1996-11-28
IS4147A (is) 1994-10-16
HU9502978D0 (en) 1995-12-28
HK1003943A1 (en) 1998-11-13
AP9400634A0 (en) 1994-04-30
ATE198894T1 (de) 2001-02-15
AP462A (en) 1996-02-19
PL311084A1 (en) 1996-02-05
AP9400635A0 (en) 1994-04-30
AP512A (en) 1996-07-29
IS4148A (is) 1994-10-16
PL178790B1 (pl) 2000-06-30

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