IL102520A - 8-vinyl-, 8-propenyl and 8-ethinyl-quinolone- carboxylic acids, their preparation, intermediates therefor and pharmaceutical compositions containing them - Google Patents

8-vinyl-, 8-propenyl and 8-ethinyl-quinolone- carboxylic acids, their preparation, intermediates therefor and pharmaceutical compositions containing them

Info

Publication number
IL102520A
IL102520A IL102520A IL10252092A IL102520A IL 102520 A IL102520 A IL 102520A IL 102520 A IL102520 A IL 102520A IL 10252092 A IL10252092 A IL 10252092A IL 102520 A IL102520 A IL 102520A
Authority
IL
Israel
Prior art keywords
methyl
alkyl
atoms
represents hydrogen
halogen
Prior art date
Application number
IL102520A
Other languages
English (en)
Other versions
IL102520A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL102520A0 publication Critical patent/IL102520A0/xx
Publication of IL102520A publication Critical patent/IL102520A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
IL102520A 1991-07-19 1992-07-16 8-vinyl-, 8-propenyl and 8-ethinyl-quinolone- carboxylic acids, their preparation, intermediates therefor and pharmaceutical compositions containing them IL102520A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4123918A DE4123918A1 (de) 1991-07-19 1991-07-19 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren

Publications (2)

Publication Number Publication Date
IL102520A0 IL102520A0 (en) 1993-01-14
IL102520A true IL102520A (en) 1997-07-13

Family

ID=6436512

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102520A IL102520A (en) 1991-07-19 1992-07-16 8-vinyl-, 8-propenyl and 8-ethinyl-quinolone- carboxylic acids, their preparation, intermediates therefor and pharmaceutical compositions containing them

Country Status (22)

Country Link
EP (1) EP0523512B1 (index.php)
JP (1) JP3174405B2 (index.php)
KR (1) KR100240608B1 (index.php)
AT (1) ATE147733T1 (index.php)
AU (1) AU658901B2 (index.php)
CA (1) CA2073993A1 (index.php)
CZ (1) CZ282037B6 (index.php)
DE (2) DE4123918A1 (index.php)
DK (1) DK0523512T3 (index.php)
ES (1) ES2097835T3 (index.php)
FI (1) FI103043B1 (index.php)
GR (1) GR3022305T3 (index.php)
HU (1) HU219910B (index.php)
IE (1) IE80557B1 (index.php)
IL (1) IL102520A (index.php)
MX (1) MX9204110A (index.php)
NO (1) NO302886B1 (index.php)
PL (1) PL171910B1 (index.php)
RU (1) RU2077533C1 (index.php)
SK (1) SK279221B6 (index.php)
TW (1) TW201309B (index.php)
ZA (1) ZA925351B (index.php)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE4230804A1 (de) * 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4418510A1 (de) * 1994-05-27 1995-11-30 Bayer Ag 1,9-überbrückte Thiazolol[3,4-a]chinolinderivate
DE4425659A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue N1-diverse 6-Fluor-8-difluormethoxy substituierte Chinoloncarbonsäuren
DE4427530A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
CZ291251B6 (cs) * 1996-02-23 2003-01-15 Bayer Aktiengesellschaft Popřípadě substituované 8-kyan-1-cyklopropyl-7-(2,8-diazabicyklo-[4,3,0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolinkarboxylové kyseliny a jejich deriváty, způsob jejich výroby, léčiva tyto látka obsahující a jejich pouľití
EP0897919B1 (en) * 1996-04-19 2004-06-16 Wakunaga Pharmaceutical Co., Ltd. Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient
AU1040597A (en) * 1996-12-04 1998-06-29 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
AR013493A1 (es) 1997-09-15 2000-12-27 Procter & Gamble COMPUESTO DE QUINOLONA, SU USO PARA LA FABRICACIoN DE UN MEDICAMENTO Y COMPOSICIoN FARMACEUTICA QUE LO COMPRENDE
ES2424676T3 (es) 2003-09-10 2013-10-07 Kyorin Pharmaceutical Co., Ltd. Derivado de ácido 7-(3-ciclopropilaminometil-1-pirrolidinil 4-sustituido)quinoloncarboxílico
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
JP5073497B2 (ja) * 2005-09-28 2012-11-14 第一三共株式会社 テトラ置換−５−アザスピロ［２．４］へプタン誘導体の製法およびその光学活性中間体
WO2007110835A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
HRP20110558T1 (hr) 2006-03-28 2011-09-30 Warner Chilcott Company Malatne soli i polimorfi od (3s, 5s)-7-[3-amino-5-metil-piperidinil]-1-ciklopropil-1, 4-dihidro-8-metoksi-4-okso-3-kinolinkarboksilne kiseline
JP5322927B2 (ja) 2007-05-24 2013-10-23 杏林製薬株式会社 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
ES2945559T3 (es) * 2018-05-09 2023-07-04 Bayer Animal Health Gmbh Derivados de quinolina antihelmínticos
RU2757741C1 (ru) * 2021-03-01 2021-10-21 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Производное ципрофлоксацина, обладающее антибактериальной активностью в отношении антибиотикоустойчивых штаммов микроорганизмов

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123536A (en) * 1977-12-14 1978-10-31 Warner-Lambert Company Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)propanedioates
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US5047538A (en) * 1990-04-12 1991-09-10 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents

Also Published As

Publication number Publication date
NO922639D0 (no) 1992-07-03
IE922348A1 (en) 1993-01-27
JP3174405B2 (ja) 2001-06-11
CZ219192A3 (en) 1993-02-17
CZ282037B6 (cs) 1997-04-16
DE59207880D1 (de) 1997-02-27
FI923268A0 (fi) 1992-07-16
MX9204110A (es) 1993-08-01
SK219192A3 (en) 1998-08-05
KR930002320A (ko) 1993-02-22
ZA925351B (en) 1993-04-28
FI103043B (fi) 1999-04-15
IE80557B1 (en) 1998-09-23
NO302886B1 (no) 1998-05-04
PL295331A1 (en) 1993-07-12
DE4123918A1 (de) 1993-01-21
FI103043B1 (fi) 1999-04-15
HUT61741A (en) 1993-03-01
AU1966392A (en) 1993-01-21
RU2077533C1 (ru) 1997-04-20
GR3022305T3 (en) 1997-04-30
EP0523512B1 (de) 1997-01-15
AU658901B2 (en) 1995-05-04
TW201309B (index.php) 1993-03-01
NO922639L (no) 1993-01-20
IL102520A0 (en) 1993-01-14
FI923268L (fi) 1993-01-20
KR100240608B1 (ko) 2000-03-02
PL171910B1 (pl) 1997-06-30
DK0523512T3 (da) 1997-06-30
CA2073993A1 (en) 1993-01-20
ATE147733T1 (de) 1997-02-15
ES2097835T3 (es) 1997-04-16
HU9202349D0 (en) 1992-10-28
SK279221B6 (sk) 1998-08-05
JPH05262738A (ja) 1993-10-12
EP0523512A1 (de) 1993-01-20
HU219910B (hu) 2001-09-28

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees