ES8507513A1 - Un procedimiento para preparar derivados bis-dioxopiperazinicos - Google Patents

Un procedimiento para preparar derivados bis-dioxopiperazinicos

Info

Publication number
ES8507513A1
ES8507513A1 ES537206A ES537206A ES8507513A1 ES 8507513 A1 ES8507513 A1 ES 8507513A1 ES 537206 A ES537206 A ES 537206A ES 537206 A ES537206 A ES 537206A ES 8507513 A1 ES8507513 A1 ES 8507513A1
Authority
ES
Spain
Prior art keywords
radical
carbon atoms
substituted
alkoxy
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537206A
Other languages
English (en)
Other versions
ES537206A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Publication of ES537206A0 publication Critical patent/ES537206A0/es
Publication of ES8507513A1 publication Critical patent/ES8507513A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS BIS-DIOXOPIPERAZINICOS.CONSISTE EN TRATAR UN COMPUESTO DE FORMULA (II) CON UN DERIVADO REACTIVO DE UN COMPUESTO DE FORMULA (III), COMO UN CLORURO O ANHIDRIDO ORGANICO, EN UN DISOLVENTE POLAR ATROPICO, COMO ACETONITRILO, O CLOROFORMO, A UNA TEMPERATURA ENTRE C10JC A 120JC, EN PRESENCIA DE AGENTES DE CONDENSACION COMO YODURO DE 1-METIL-2-CLOROPIRIDINILO, DURANTE 1 A 24 HORAS, PARA OBTENER UN COMPUESTO DERIVADO DE BIS-DIOXOPIPERAZINICOS DE FORMULA (I) Y SUS SALES NO TOXICAS. SIENDO: R UN ALQUILO DE C 1 A 27, UN RADICAL CICLOALQUILO DE C 3 A 7 Y OTROS.SE UTILIZAN EN FARMACOLOGIA COMO ANTITUMORAL Y ANTIMETASTATICO POR SU BAJA TOXICIDAD.
ES537206A 1983-10-31 1984-10-30 Un procedimiento para preparar derivados bis-dioxopiperazinicos Expired ES8507513A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58204448A JPS6097963A (ja) 1983-10-31 1983-10-31 ビス−ジオキソピペラジン誘導体，その製造方法及びそれからなる抗腫瘍剤

Publications (2)

Publication Number Publication Date
ES537206A0 ES537206A0 (es) 1985-09-01
ES8507513A1 true ES8507513A1 (es) 1985-09-01

Family

ID=16490690

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537206A Expired ES8507513A1 (es) 1983-10-31 1984-10-30 Un procedimiento para preparar derivados bis-dioxopiperazinicos

Country Status (9)

Country Link
US (1) US4650799A (es)
EP (1) EP0140327B1 (es)
JP (1) JPS6097963A (es)
AU (1) AU571273B2 (es)
CA (1) CA1244430A (es)
DE (1) DE3482322D1 (es)
DK (1) DK162639C (es)
ES (1) ES8507513A1 (es)
NO (1) NO170682C (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0674251B2 (ja) * 1986-02-07 1994-09-21 全薬工業株式▲会▼社 ビス−ジオキソピペラジン誘導体
WO1992000971A1 (en) * 1990-07-04 1992-01-23 Zenyaku Kogyo Kabushiki Kaisha Water-soluble bis-dioxopiperazine derivative
JP5732453B2 (ja) * 2009-06-25 2015-06-10 アルカーメス ファーマ アイルランド リミテッド Ｎｈ酸性化合物のプロドラッグ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL273692A (es) * 1961-01-19 1900-01-01
GB1234935A (en) * 1967-07-03 1971-06-09 Nat Res Dev Piperazine derivatives
GB1236947A (en) * 1968-08-15 1971-06-23 Ici Ltd Process for the preparation of piperazine derivatives
DE2511891A1 (de) * 1975-03-19 1976-10-07 Gruenenthal Chemie Neue derivate des 2,6-dioxopiperazins, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel sowie verfahren zu deren herstellung
CH635828A5 (de) * 1978-08-30 1983-04-29 Ciba Geigy Ag N-substituierte imide und bisimide.
US4404381A (en) * 1981-06-19 1983-09-13 The Dow Chemical Company Novel 3,5-diketo-piperazinyl compounds containing epoxide substituted imides
US4536564A (en) * 1983-12-09 1985-08-20 The Dow Chemical Company Polyamide from bis-carboxy containing 3,5,3',5'-tetraoxo-1,2-dipiperazine compound and diamine

Also Published As

Publication number Publication date
EP0140327A3 (en) 1986-07-23
CA1244430A (en) 1988-11-08
AU571273B2 (en) 1988-04-14
NO170682B (no) 1992-08-10
ES537206A0 (es) 1985-09-01
EP0140327B1 (en) 1990-05-23
JPS6097963A (ja) 1985-05-31
DE3482322D1 (de) 1990-06-28
NO170682C (no) 1992-11-18
US4650799A (en) 1987-03-17
DK162639C (da) 1992-04-13
DK162639B (da) 1991-11-25
EP0140327A2 (en) 1985-05-08
NO844183L (no) 1985-05-02
AU3441684A (en) 1985-05-09
JPS6334153B2 (es) 1988-07-08
DK493384A (da) 1985-05-01
DK493384D0 (da) 1984-10-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102