ES8301220A1 - Procedimiento para la preparacion de derivados de imidazol - Google Patents
Procedimiento para la preparacion de derivados de imidazolInfo
- Publication number
- ES8301220A1 ES8301220A1 ES503678A ES503678A ES8301220A1 ES 8301220 A1 ES8301220 A1 ES 8301220A1 ES 503678 A ES503678 A ES 503678A ES 503678 A ES503678 A ES 503678A ES 8301220 A1 ES8301220 A1 ES 8301220A1
- Authority
- ES
- Spain
- Prior art keywords
- groups
- optionally substituted
- residues
- alkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE IMIDAZOL, DE FORMULA GENERAL (I), EN DONDE AR Y AR SIGNIFICAN UN RADICAL FENILO EVENTUALMENTE SUSTITUIDO CON ATOMOS DE HALOGENO, CON RADICALES ALCOHILO O CON RADICALES ALCOXI, O UN RADICAL FURILO O UN RADICAL TIENILO; R SIGNIFICA HIDROGENO O UN RADICAL ALCOHILO; N PUEDE SER 0, 1 O 2; Y Z SIGNIFICA UN RADICAL FENILO EVENTUALMENTE SUSTITUIDO CON ATOMOS DE HALOGENO, CON GRUPOS ALCOHILO, CON GRUPOS ALCOXI O CON GRUPOS NITRO; Y SUS SALES DE ACIDO FISIOLOGICAMENTE INOCUAS. CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA GENERAL (II), EN DONDE AR , AR Y R TIENEN LOS SIGNIFICADOS YA INDICADOS, CON UN COMPUEST DE FORMULA GENERAL (III), EN DONDE Z TIENE EL SIGNIFICADO YA INDICADO >DE APLICACION EN FARMACIA POR SU ACTIVIDAD ANTIINFLAMATORIA Y ANTIALERGICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803025484 DE3025484A1 (de) | 1980-07-03 | 1980-07-03 | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8301220A1 true ES8301220A1 (es) | 1982-12-01 |
| ES503678A0 ES503678A0 (es) | 1982-12-01 |
Family
ID=6106465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES503678A Granted ES503678A0 (es) | 1980-07-03 | 1981-07-03 | Procedimiento para la preparacion de derivados de imidazol |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4402960A (es) |
| EP (1) | EP0043788B1 (es) |
| JP (1) | JPS5775973A (es) |
| AT (1) | ATE16281T1 (es) |
| AU (1) | AU7249481A (es) |
| CA (1) | CA1169063A (es) |
| DD (1) | DD206152A5 (es) |
| DE (2) | DE3025484A1 (es) |
| DK (1) | DK293381A (es) |
| ES (1) | ES503678A0 (es) |
| FI (1) | FI812106L (es) |
| GR (1) | GR78231B (es) |
| IE (1) | IE52822B1 (es) |
| IL (1) | IL63190A0 (es) |
| NO (1) | NO812265L (es) |
| PT (1) | PT73280B (es) |
| ZA (1) | ZA814540B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3025484A1 (de) * | 1980-07-03 | 1982-02-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3141063A1 (de) * | 1981-10-13 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US5300519A (en) * | 1988-07-06 | 1994-04-05 | The University Of Sheffield | Immunosuppressive agents |
| JP2614756B2 (ja) * | 1988-08-10 | 1997-05-28 | 日本ケミファ株式会社 | イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
| CA2003283A1 (en) * | 1988-12-05 | 1990-06-05 | C. Anne Higley | Imidazoles for the treatment of atherosclerosis |
| GB8907656D0 (en) * | 1989-04-05 | 1989-05-17 | May & Baker Ltd | New compositions of matter |
| US5011851A (en) * | 1990-02-13 | 1991-04-30 | Bristol-Myers Squibb Co. | Imidazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith |
| GB9005966D0 (en) * | 1990-03-16 | 1990-05-09 | May & Baker Ltd | New compositions of matter |
| US5441515A (en) * | 1993-04-23 | 1995-08-15 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
| US6040320A (en) * | 1997-06-30 | 2000-03-21 | Ortho-Mcneil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
| DE19842833B4 (de) | 1998-09-18 | 2005-04-14 | Merckle Gmbh | 2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung |
| DE10107683A1 (de) * | 2001-02-19 | 2002-08-29 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| DE10238045A1 (de) * | 2002-08-20 | 2004-03-04 | Merckle Gmbh Chem.-Pharm. Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| EP1894925A1 (en) * | 2006-08-24 | 2008-03-05 | Merckle Gmbh | Imidazole compounds having an antiinflammatory effect |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6614808A (es) * | 1965-10-21 | 1967-04-24 | ||
| US3651080A (en) * | 1969-11-07 | 1972-03-21 | Ciba Geigy Corp | Certain substituted 2-alkylmercaptoimidazole derivatives |
| US4190666A (en) * | 1975-08-11 | 1980-02-26 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones |
| US4215217A (en) * | 1975-10-29 | 1980-07-29 | Sk&F Lab Co. | Process for preparing 4-substituted imidazole compounds |
| US4182769A (en) * | 1977-02-09 | 1980-01-08 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones |
| DE2963572D1 (en) * | 1978-04-11 | 1982-10-21 | Ciba Geigy Ag | Mercapto-imidazole derivatives, their preparation, mercapto-imidazole derivatives for the treatment of inflammatory diseases and their pharmaceutical compositions |
| DE2960506D1 (en) * | 1978-04-24 | 1981-10-29 | Dumex Ltd As | Arylimidazoles, their synthesis and pharmaceutical or veterinary preparations containing them |
| DE2823197A1 (de) * | 1978-05-24 | 1979-11-29 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE2856909A1 (de) * | 1978-12-28 | 1980-07-17 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3025484A1 (de) * | 1980-07-03 | 1982-02-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US4330552A (en) * | 1980-11-06 | 1982-05-18 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-arylthioimidazoles |
-
1980
- 1980-07-03 DE DE19803025484 patent/DE3025484A1/de not_active Withdrawn
-
1981
- 1981-06-26 IL IL63190A patent/IL63190A0/xx unknown
- 1981-06-29 PT PT73280A patent/PT73280B/pt unknown
- 1981-06-30 EP EP81730061A patent/EP0043788B1/de not_active Expired
- 1981-06-30 AT AT81730061T patent/ATE16281T1/de active
- 1981-06-30 DE DE8181730061T patent/DE3172757D1/de not_active Expired
- 1981-07-01 GR GR65403A patent/GR78231B/el unknown
- 1981-07-02 DD DD81231398A patent/DD206152A5/de unknown
- 1981-07-02 CA CA000380977A patent/CA1169063A/en not_active Expired
- 1981-07-02 DK DK293381A patent/DK293381A/da not_active Application Discontinuation
- 1981-07-02 JP JP56102324A patent/JPS5775973A/ja active Granted
- 1981-07-02 IE IE1484/81A patent/IE52822B1/en unknown
- 1981-07-02 NO NO812265A patent/NO812265L/no unknown
- 1981-07-02 US US06/280,163 patent/US4402960A/en not_active Expired - Fee Related
- 1981-07-02 AU AU72494/81A patent/AU7249481A/en not_active Abandoned
- 1981-07-03 ES ES503678A patent/ES503678A0/es active Granted
- 1981-07-03 FI FI812106A patent/FI812106L/fi not_active Application Discontinuation
- 1981-07-03 ZA ZA814540A patent/ZA814540B/xx unknown
-
1983
- 1983-07-22 US US06/516,395 patent/US4528298A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0043788A1 (de) | 1982-01-13 |
| DD206152A5 (de) | 1984-01-18 |
| DE3172757D1 (en) | 1985-12-05 |
| IE811484L (en) | 1982-01-03 |
| GR78231B (es) | 1984-09-26 |
| PT73280A (de) | 1981-07-01 |
| JPH0254343B2 (es) | 1990-11-21 |
| US4402960A (en) | 1983-09-06 |
| ES503678A0 (es) | 1982-12-01 |
| JPS5775973A (en) | 1982-05-12 |
| AU7249481A (en) | 1982-01-07 |
| PT73280B (de) | 1982-07-22 |
| DE3025484A1 (de) | 1982-02-04 |
| EP0043788B1 (de) | 1985-10-30 |
| IE52822B1 (en) | 1988-03-16 |
| IL63190A0 (en) | 1981-09-13 |
| US4528298A (en) | 1985-07-09 |
| CA1169063A (en) | 1984-06-12 |
| NO812265L (no) | 1982-01-04 |
| DK293381A (da) | 1982-01-04 |
| ATE16281T1 (de) | 1985-11-15 |
| ZA814540B (en) | 1982-07-28 |
| FI812106L (fi) | 1982-01-04 |
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