ES8503343A1 - "un procedimiento para preparar derivados de carboximida" - Google Patents

"un procedimiento para preparar derivados de carboximida"

Info

Publication number
ES8503343A1
ES8503343A1 ES523205A ES523205A ES8503343A1 ES 8503343 A1 ES8503343 A1 ES 8503343A1 ES 523205 A ES523205 A ES 523205A ES 523205 A ES523205 A ES 523205A ES 8503343 A1 ES8503343 A1 ES 8503343A1
Authority
ES
Spain
Prior art keywords
image
group
formula
substituted
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523205A
Other languages
English (en)
Other versions
ES523205A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES8503343A1 publication Critical patent/ES8503343A1/es
Publication of ES523205A0 publication Critical patent/ES523205A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C07D209/76—4,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE CARBOXIMIDA, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN ACIDO CARBOXILICO DE FORMULA GENERAL (III) O CON UN DERIVADO REACTIVO DEL MISMO.DE APLICACION EN MEDICINA Y FARMACIA COMO AGENTES CON ACTIVIDAD HIPOGLUCEMICA Y COMO AGENTES UTILES EN EL TRATAMIENTO DE LA DIABETES.
ES523205A 1981-05-29 1983-06-13 "un procedimiento para preparar derivados de carboximida" Granted ES523205A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56080866A JPS57197265A (en) 1981-05-29 1981-05-29 Carboxylic acid imide derivative, its preparation and medicament containing the same

Publications (2)

Publication Number Publication Date
ES8503343A1 true ES8503343A1 (es) 1985-02-16
ES523205A0 ES523205A0 (es) 1985-02-16

Family

ID=13730258

Family Applications (3)

Application Number Title Priority Date Filing Date
ES512642A Granted ES512642A0 (es) 1981-05-29 1982-05-28 "un procedimiento para preparar derivados de carboximida".
ES523205A Granted ES523205A0 (es) 1981-05-29 1983-06-13 "un procedimiento para preparar derivados de carboximida"
ES537721A Expired ES8601156A1 (es) 1981-05-29 1984-11-16 Un procedimiento para preparar derivados de carboximida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES512642A Granted ES512642A0 (es) 1981-05-29 1982-05-28 "un procedimiento para preparar derivados de carboximida".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES537721A Expired ES8601156A1 (es) 1981-05-29 1984-11-16 Un procedimiento para preparar derivados de carboximida

Country Status (15)

Country Link
US (1) US4479954A (es)
JP (1) JPS57197265A (es)
KR (1) KR870001027B1 (es)
BE (1) BE893378A (es)
CA (1) CA1211436A (es)
CH (1) CH649287A5 (es)
DE (1) DE3220262A1 (es)
DK (1) DK241982A (es)
ES (3) ES512642A0 (es)
FR (1) FR2506771A1 (es)
GB (1) GB2101590B (es)
IT (1) IT1151781B (es)
NL (1) NL8202173A (es)
PH (3) PH19837A (es)
SE (1) SE450894B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US4641251A (en) * 1982-02-16 1987-02-03 Inoue-Japax Research Incorporated Robot
JPS5976059A (ja) * 1982-10-21 1984-04-28 Sumitomo Chem Co Ltd 環状イミド誘導体及びその酸付加塩
JPS5995267A (ja) * 1982-11-25 1984-06-01 Eisai Co Ltd カルボン酸イミド誘導体およびその製造方法
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
JPS61238784A (ja) * 1985-04-17 1986-10-24 Sumitomo Seiyaku Kk コハク酸イミド誘導体及びその酸付加塩
JP2660407B2 (ja) * 1986-09-26 1997-10-08 住友製薬株式会社 新規なイミド誘導体
DE8630918U1 (de) * 1986-11-18 1987-11-05 Fritz Bauer + Söhne oHG, 8503 Altdorf Längenverstellbare Gasfeder für höhenverstellbare Stühle, Tische od.dgl.
US4804751A (en) * 1987-06-30 1989-02-14 American Home Products Corporation Polycyclic hydrocarbon succinimides with psychotropic activity
US5053508A (en) * 1990-03-09 1991-10-01 American Home Products Corporation Fused heterotricyclic imides with psychotropic activity and intermedrates thereof
US6083950A (en) * 1997-11-13 2000-07-04 Ranbaxy Laboratories Limited 1-(4-arylpiperazin-1-yl)-ω-[n-(α,ω-dicarboximido)]-alka nes useful as uro-selective α1-adrenoceptor blockers
SK932001A3 (en) * 1998-07-21 2001-08-06 Ranbaxy Lab Ltd ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVEì (54) ALPHA1-ADRENOCEPTOR BLOCKERS
WO2000005206A1 (en) * 1998-07-21 2000-02-03 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as uro-selective alpha-1-adrenoceptor blockers
HUP0400545A3 (en) 2000-11-30 2007-05-02 Ranbaxy Lab Ltd 1,4-disubstituted piperazine derivatives useful as uro-selectives alpha1-adrenoceptor blockers, and pharmaceutical compositions containing them
JP2005527578A (ja) * 2002-04-08 2005-09-15 ランバクシー ラボラトリーズ リミテッド 有用な尿選択的α１Ａアドレナリン受容体遮断薬としてのα，ω−ジカルボキシイミド誘導体
US7605260B2 (en) 2003-07-29 2009-10-20 Dainippon Sumitomo Pharma Co., Ltd. Process for producing imide compound
EP1758583A2 (en) * 2004-05-31 2007-03-07 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as adrenergic receptor antagonists
US20060247249A1 (en) * 2005-11-16 2006-11-02 Mohammad Salman Carboximide derivatives as useful uro-selective alpha-1a adrenoceptor blockers

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126395A (en) * 1964-03-24 Chj czhs
US3126396A (en) * 1964-03-24 Chiih
US2343198A (en) * 1940-04-03 1944-02-29 Abbott Lab Nu-alkamine substituted derivatives of phthalimide
US3198798A (en) * 1962-11-02 1965-08-03 Sterling Drug Inc Phthalimido- and isoindolinyl-alkylpiperazines and their preparation
US3563986A (en) * 1965-10-12 1971-02-16 Ernst Frankus 4 - phthalimido - n - heterocyclic amino methyl or piperidino hydrazino piperidine diones 2,6
US3579524A (en) * 1968-06-05 1971-05-18 Miles Lab 2-aminoalkyl derivatives of phthalimidines
US3850921A (en) * 1972-09-20 1974-11-26 I Matuo Derivatives of 2,3-norbornanedicarboxamide
US3936449A (en) * 1974-04-11 1976-02-03 Sadao Ohki Anti-arrhythmic agents
US3980667A (en) * 1975-03-05 1976-09-14 Bristol-Myers Company Anti-arrhythmic 5-endo-substituted oxy-N-(aminoloweralkyl)bicycle [2.2.2.]oc
US4018767A (en) * 1975-05-22 1977-04-19 Bristol-Myers Company Anti-arrhythmic agents
US4070465A (en) * 1976-06-24 1978-01-24 E. R. Squibb & Sons, Inc. Various 2-(substituted piperazinyl)-1H-benz [de]isoquinoline-1,3 (2H) -diones
US4139533A (en) * 1976-08-19 1979-02-13 Bristol-Myers Company Bicyclo[2,2,1]heptane-2,3-diendo carboxylic acid imide esters of quinoline carboxylic acid

Also Published As

Publication number Publication date
US4479954A (en) 1984-10-30
CH649287A5 (de) 1985-05-15
JPS57197265A (en) 1982-12-03
ES8308548A1 (es) 1983-09-01
GB2101590B (en) 1985-06-19
GB2101590A (en) 1983-01-19
PH19291A (en) 1986-03-04
JPH0229671B2 (es) 1990-07-02
ES537721A0 (es) 1985-10-16
ES8601156A1 (es) 1985-10-16
PH19272A (en) 1986-02-21
KR830010103A (ko) 1983-12-26
IT8221563A0 (it) 1982-05-28
IT1151781B (it) 1986-12-24
DK241982A (da) 1982-11-30
NL8202173A (nl) 1982-12-16
SE8203272L (sv) 1982-11-30
FR2506771A1 (fr) 1982-12-03
DE3220262A1 (de) 1982-12-16
CA1211436A (en) 1986-09-16
FR2506771B1 (es) 1985-03-01
ES512642A0 (es) 1983-09-01
KR870001027B1 (ko) 1987-05-25
BE893378A (fr) 1982-12-01
SE450894B (sv) 1987-08-10
ES523205A0 (es) 1985-02-16
PH19837A (en) 1986-07-22

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