IL102520A - 8-vinyl-, 8-propenyl and 8-ethinyl-quinolone- carboxylic acids, their preparation, intermediates therefor and pharmaceutical compositions containing them - Google Patents
8-vinyl-, 8-propenyl and 8-ethinyl-quinolone- carboxylic acids, their preparation, intermediates therefor and pharmaceutical compositions containing themInfo
- Publication number
- IL102520A IL102520A IL102520A IL10252092A IL102520A IL 102520 A IL102520 A IL 102520A IL 102520 A IL102520 A IL 102520A IL 10252092 A IL10252092 A IL 10252092A IL 102520 A IL102520 A IL 102520A
- Authority
- IL
- Israel
- Prior art keywords
- methyl
- alkyl
- atoms
- represents hydrogen
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4123918A DE4123918A1 (de) | 1991-07-19 | 1991-07-19 | 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL102520A0 IL102520A0 (en) | 1993-01-14 |
| IL102520A true IL102520A (en) | 1997-07-13 |
Family
ID=6436512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL102520A IL102520A (en) | 1991-07-19 | 1992-07-16 | 8-vinyl-, 8-propenyl and 8-ethinyl-quinolone- carboxylic acids, their preparation, intermediates therefor and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0523512B1 (fi) |
| JP (1) | JP3174405B2 (fi) |
| KR (1) | KR100240608B1 (fi) |
| AT (1) | ATE147733T1 (fi) |
| AU (1) | AU658901B2 (fi) |
| CA (1) | CA2073993A1 (fi) |
| CZ (1) | CZ282037B6 (fi) |
| DE (2) | DE4123918A1 (fi) |
| DK (1) | DK0523512T3 (fi) |
| ES (1) | ES2097835T3 (fi) |
| FI (1) | FI103043B1 (fi) |
| GR (1) | GR3022305T3 (fi) |
| HU (1) | HU219910B (fi) |
| IE (1) | IE80557B1 (fi) |
| IL (1) | IL102520A (fi) |
| MX (1) | MX9204110A (fi) |
| NO (1) | NO302886B1 (fi) |
| PL (1) | PL171910B1 (fi) |
| RU (1) | RU2077533C1 (fi) |
| SK (1) | SK219192A3 (fi) |
| TW (1) | TW201309B (fi) |
| ZA (1) | ZA925351B (fi) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4121214A1 (de) * | 1991-06-27 | 1993-01-14 | Bayer Ag | 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate |
| DE4230804A1 (de) * | 1992-09-15 | 1994-03-17 | Bayer Ag | 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate |
| DE4303657A1 (de) * | 1993-02-09 | 1994-08-11 | Bayer Ag | Neue Chinolon- und Naphthyridoncarbonsäurederivate |
| KR950018003A (ko) * | 1993-12-09 | 1995-07-22 | 스미스클라인 비참 피엘씨 | 신규한 퀴놀론 유도체 및 그의 제조 방법 |
| DE4418510A1 (de) * | 1994-05-27 | 1995-11-30 | Bayer Ag | 1,9-überbrückte Thiazolol[3,4-a]chinolinderivate |
| DE4425659A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Neue N1-diverse 6-Fluor-8-difluormethoxy substituierte Chinoloncarbonsäuren |
| DE4427530A1 (de) * | 1994-08-04 | 1996-02-08 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäure-Derivate |
| DE69729565T2 (de) * | 1996-04-19 | 2005-06-09 | Wakunaga Pharmaceutical Co., Ltd. | Neue Pyridoncarbonsäure-Derivate oder Salze dieser Derivate und antibakterielle Mittel, die diese aktiven Wirkstoffe enthalten |
| WO1998024781A1 (fr) * | 1996-12-04 | 1998-06-11 | Daiichi Pharmaceutical Co., Ltd. | Derives d'aminomethylpyrrolidine substitue |
| CN1264837C (zh) | 1997-09-15 | 2006-07-19 | 普罗克特和甘保尔公司 | 喹诺酮抗微生物剂、其组合物和应用 |
| AU2004272414B2 (en) | 2003-09-10 | 2009-05-28 | Kyorin Pharmaceutical Co., Ltd. | 7-(4-substituted 3- cyclopropylaminomethyl-1- pyrrolidinyl) quinolonecarboxylic acid derivative |
| US7563805B2 (en) | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
| JP5073497B2 (ja) * | 2005-09-28 | 2012-11-14 | 第一三共株式会社 | テトラ置換−５−アザスピロ［２．４］へプタン誘導体の製法およびその光学活性中間体 |
| AU2007230630B2 (en) | 2006-03-28 | 2012-12-20 | Taigen Biotechnology Co., Ltd | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid |
| WO2007110835A2 (en) | 2006-03-28 | 2007-10-04 | The Procter & Gamble Company | A coupling process for preparing quinolone intermediates |
| EP2149571A4 (en) | 2007-05-24 | 2010-09-01 | Kyorin Seiyaku Kk | MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14 |
| SG11202010024UA (en) * | 2018-05-09 | 2020-11-27 | Bayer Animal Health Gmbh | New quinoline derivatives |
| RU2757741C1 (ru) * | 2021-03-01 | 2021-10-21 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Производное ципрофлоксацина, обладающее антибактериальной активностью в отношении антибиотикоустойчивых штаммов микроорганизмов |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4123536A (en) * | 1977-12-14 | 1978-10-31 | Warner-Lambert Company | Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)propanedioates |
| DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
| JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
| US5047538A (en) * | 1990-04-12 | 1991-09-10 | Warner-Lambert Company | Quinolinecarboxylic acid antibacterial agents |
-
1991
- 1991-07-19 DE DE4123918A patent/DE4123918A1/de not_active Withdrawn
-
1992
- 1992-06-26 TW TW081105031A patent/TW201309B/zh active
- 1992-07-03 NO NO922639A patent/NO302886B1/no not_active IP Right Cessation
- 1992-07-06 EP EP92111454A patent/EP0523512B1/de not_active Expired - Lifetime
- 1992-07-06 ES ES92111454T patent/ES2097835T3/es not_active Expired - Lifetime
- 1992-07-06 DE DE59207880T patent/DE59207880D1/de not_active Expired - Fee Related
- 1992-07-06 DK DK92111454.2T patent/DK0523512T3/da active
- 1992-07-06 AT AT92111454T patent/ATE147733T1/de not_active IP Right Cessation
- 1992-07-13 SK SK2191-92A patent/SK219192A3/sk unknown
- 1992-07-13 CZ CS922191A patent/CZ282037B6/cs not_active IP Right Cessation
- 1992-07-14 AU AU19663/92A patent/AU658901B2/en not_active Ceased
- 1992-07-14 MX MX9204110A patent/MX9204110A/es not_active IP Right Cessation
- 1992-07-16 CA CA002073993A patent/CA2073993A1/en not_active Abandoned
- 1992-07-16 IL IL102520A patent/IL102520A/xx not_active IP Right Cessation
- 1992-07-16 FI FI923268A patent/FI103043B1/fi active IP Right Grant
- 1992-07-17 ZA ZA925351A patent/ZA925351B/xx unknown
- 1992-07-17 PL PL92295331A patent/PL171910B1/pl unknown
- 1992-07-17 JP JP21245092A patent/JP3174405B2/ja not_active Expired - Fee Related
- 1992-07-17 RU SU925052410A patent/RU2077533C1/ru active
- 1992-07-17 HU HU9202349A patent/HU219910B/hu not_active IP Right Cessation
- 1992-07-17 IE IE922348A patent/IE80557B1/en not_active IP Right Cessation
- 1992-07-18 KR KR1019920012826A patent/KR100240608B1/ko not_active IP Right Cessation
-
1997
- 1997-01-16 GR GR970400065T patent/GR3022305T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |