FI923268A - 8-vinyl- och 8-etynylkinolonkarboxylsyror - Google Patents

8-vinyl- och 8-etynylkinolonkarboxylsyror Download PDF

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Publication number
FI923268A
FI923268A FI923268A FI923268A FI923268A FI 923268 A FI923268 A FI 923268A FI 923268 A FI923268 A FI 923268A FI 923268 A FI923268 A FI 923268A FI 923268 A FI923268 A FI 923268A
Authority
FI
Finland
Prior art keywords
vinyl
ethynylkinolonkarboxylsyror
och
ethynyl
novel
Prior art date
Application number
FI923268A
Other languages
English (en)
Other versions
FI103043B1 (fi
FI103043B (fi
FI923268A0 (fi
Inventor
Uwe Petersen
Thomas Himmler
Thomas Schenke
Andreas Krebs
Klaus Grohe
Klaus-Dieter Bremm
Karl Georg Metzger
Rainer Endermann
Hans-Joachim Zeiler
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI923268A0 publication Critical patent/FI923268A0/fi
Publication of FI923268A publication Critical patent/FI923268A/fi
Priority to FI970312A priority Critical patent/FI970312A/fi
Application granted granted Critical
Publication of FI103043B1 publication Critical patent/FI103043B1/fi
Publication of FI103043B publication Critical patent/FI103043B/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI923268A 1991-07-19 1992-07-16 Menetelmä uusien, terapeuttisesti käyttökelpoisten 8-vinyyli- ja 8-ety nyylikinolonikarboksyylihappojohdannaisten valmistamiseksi sekä menete lmässä käyttökelpoiset välituotteet FI103043B (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI970312A FI970312A (fi) 1991-07-19 1997-01-24 8-halogeenikinoliinikarboksyylihappojohdannaiset

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4123918A DE4123918A1 (de) 1991-07-19 1991-07-19 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
DE4123918 1991-07-19

Publications (4)

Publication Number Publication Date
FI923268A0 FI923268A0 (fi) 1992-07-16
FI923268A true FI923268A (fi) 1993-01-20
FI103043B1 FI103043B1 (fi) 1999-04-15
FI103043B FI103043B (fi) 1999-04-15

Family

ID=6436512

Family Applications (1)

Application Number Title Priority Date Filing Date
FI923268A FI103043B (fi) 1991-07-19 1992-07-16 Menetelmä uusien, terapeuttisesti käyttökelpoisten 8-vinyyli- ja 8-ety nyylikinolonikarboksyylihappojohdannaisten valmistamiseksi sekä menete lmässä käyttökelpoiset välituotteet

Country Status (22)

Country Link
EP (1) EP0523512B1 (fi)
JP (1) JP3174405B2 (fi)
KR (1) KR100240608B1 (fi)
AT (1) ATE147733T1 (fi)
AU (1) AU658901B2 (fi)
CA (1) CA2073993A1 (fi)
CZ (1) CZ282037B6 (fi)
DE (2) DE4123918A1 (fi)
DK (1) DK0523512T3 (fi)
ES (1) ES2097835T3 (fi)
FI (1) FI103043B (fi)
GR (1) GR3022305T3 (fi)
HU (1) HU219910B (fi)
IE (1) IE80557B1 (fi)
IL (1) IL102520A (fi)
MX (1) MX9204110A (fi)
NO (1) NO302886B1 (fi)
PL (1) PL171910B1 (fi)
RU (1) RU2077533C1 (fi)
SK (1) SK219192A3 (fi)
TW (1) TW201309B (fi)
ZA (1) ZA925351B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE4230804A1 (de) * 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4418510A1 (de) * 1994-05-27 1995-11-30 Bayer Ag 1,9-überbrückte Thiazolol[3,4-a]chinolinderivate
DE4425659A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue N1-diverse 6-Fluor-8-difluormethoxy substituierte Chinoloncarbonsäuren
DE4427530A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
EP0897919B1 (en) 1996-04-19 2004-06-16 Wakunaga Pharmaceutical Co., Ltd. Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient
WO1998024781A1 (fr) * 1996-12-04 1998-06-11 Daiichi Pharmaceutical Co., Ltd. Derives d'aminomethylpyrrolidine substitue
CN1264837C (zh) 1997-09-15 2006-07-19 普罗克特和甘保尔公司 喹诺酮抗微生物剂、其组合物和应用
PT1666477E (pt) 2003-09-10 2013-08-28 Kyorin Seiyaku Kk Derivado de 7-(4-substituído-3-ciclopropilaminometil-1- pirrolidinil) quinolonecarboxílico
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
US7842818B2 (en) 2005-09-28 2010-11-30 Daiichi Sankyo Company, Limited Process for preparation of tetrasubstituted 5-azaspiro[2.4]- heptane derivatives and optically active intermediates thereof
BRPI0709772B8 (pt) 2006-03-28 2021-05-25 The Protecter & Gamble Company sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico
BRPI0709220A2 (pt) 2006-03-28 2011-07-12 Procter & Gamble processo de acoplamento para preparo de intermediários de quinolona
WO2008143343A1 (ja) 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. 14位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
ES2945559T3 (es) * 2018-05-09 2023-07-04 Bayer Animal Health Gmbh Derivados de quinolina antihelmínticos
RU2757741C1 (ru) * 2021-03-01 2021-10-21 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Производное ципрофлоксацина, обладающее антибактериальной активностью в отношении антибиотикоустойчивых штаммов микроорганизмов

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123536A (en) * 1977-12-14 1978-10-31 Warner-Lambert Company Dialkyl ({[3-(alkoxycarbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)propanedioates
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US5047538A (en) * 1990-04-12 1991-09-10 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents

Also Published As

Publication number Publication date
SK279221B6 (sk) 1998-08-05
HU219910B (hu) 2001-09-28
RU2077533C1 (ru) 1997-04-20
PL171910B1 (pl) 1997-06-30
JPH05262738A (ja) 1993-10-12
DE59207880D1 (de) 1997-02-27
FI103043B1 (fi) 1999-04-15
FI103043B (fi) 1999-04-15
IE80557B1 (en) 1998-09-23
AU658901B2 (en) 1995-05-04
EP0523512A1 (de) 1993-01-20
TW201309B (fi) 1993-03-01
DK0523512T3 (da) 1997-06-30
PL295331A1 (en) 1993-07-12
KR100240608B1 (ko) 2000-03-02
ZA925351B (en) 1993-04-28
SK219192A3 (en) 1998-08-05
IL102520A (en) 1997-07-13
NO302886B1 (no) 1998-05-04
EP0523512B1 (de) 1997-01-15
HU9202349D0 (en) 1992-10-28
IL102520A0 (en) 1993-01-14
IE922348A1 (en) 1993-01-27
HUT61741A (en) 1993-03-01
ATE147733T1 (de) 1997-02-15
JP3174405B2 (ja) 2001-06-11
FI923268A0 (fi) 1992-07-16
MX9204110A (es) 1993-08-01
KR930002320A (ko) 1993-02-22
CZ219192A3 (en) 1993-02-17
CZ282037B6 (cs) 1997-04-16
ES2097835T3 (es) 1997-04-16
CA2073993A1 (en) 1993-01-20
DE4123918A1 (de) 1993-01-21
NO922639D0 (no) 1992-07-03
AU1966392A (en) 1993-01-21
NO922639L (no) 1993-01-20
GR3022305T3 (en) 1997-04-30

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FG Patent granted

Owner name: BAYER AKTIENGESELLSCHAFT