IE60514B1 - (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives - Google Patents

(1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives

Info

Publication number
IE60514B1
IE60514B1 IE248787A IE248787A IE60514B1 IE 60514 B1 IE60514 B1 IE 60514B1 IE 248787 A IE248787 A IE 248787A IE 248787 A IE248787 A IE 248787A IE 60514 B1 IE60514 B1 IE 60514B1
Authority
IE
Ireland
Prior art keywords
formula
parts
compound
alkyl
reaction
Prior art date
Application number
IE248787A
Other languages
English (en)
Other versions
IE872487L (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IE872487L publication Critical patent/IE872487L/xx
Publication of IE60514B1 publication Critical patent/IE60514B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IE248787A 1986-09-15 1987-09-14 (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives IE60514B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90790386A 1986-09-15 1986-09-15

Publications (2)

Publication Number Publication Date
IE872487L IE872487L (en) 1988-03-15
IE60514B1 true IE60514B1 (en) 1994-07-27

Family

ID=25424835

Family Applications (1)

Application Number Title Priority Date Filing Date
IE248787A IE60514B1 (en) 1986-09-15 1987-09-14 (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives

Country Status (23)

Country Link
EP (1) EP0260744B1 (forum.php)
JP (1) JPS6485975A (forum.php)
KR (1) KR960014353B1 (forum.php)
CN (1) CN1020903C (forum.php)
AU (1) AU595064B2 (forum.php)
BG (1) BG61321B2 (forum.php)
CA (1) CA1323366C (forum.php)
CY (1) CY1803A (forum.php)
DE (1) DE3783107T2 (forum.php)
DK (1) DK174728B1 (forum.php)
ES (1) ES2053524T3 (forum.php)
FI (1) FI87781C (forum.php)
GR (1) GR3006841T3 (forum.php)
HK (1) HK123694A (forum.php)
HU (1) HU198039B (forum.php)
IE (1) IE60514B1 (forum.php)
IL (1) IL83892A (forum.php)
NO (1) NO167202C (forum.php)
NZ (1) NZ221729A (forum.php)
PH (1) PH25022A (forum.php)
PT (1) PT85692B (forum.php)
SU (1) SU1662350A3 (forum.php)
ZA (1) ZA876881B (forum.php)

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US4826862A (en) * 1988-02-12 1989-05-02 Janssen Pharmaceutica, N.V. Anthelminthic [(5(6) (1H-azole-1-ylmethyl)benzimidazole]carbamates
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
PT95899A (pt) * 1989-11-17 1991-09-13 Glaxo Group Ltd Processo para a preparacao de derivados indole
US5021448A (en) * 1990-02-22 1991-06-04 Ciba-Geigy Corporation Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist
FR2663028B1 (fr) * 1990-06-08 1994-10-14 Roussel Uclaf Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5216003A (en) * 1992-01-02 1993-06-01 G. D. Searle & Co. Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
WO1995004723A1 (fr) * 1993-08-04 1995-02-16 Yamanouchi Pharmaceutical Co., Ltd. Derive d'imidazolylalkylamine et composition pharmaceutique contenant ledit derive
FI961418L (fi) * 1993-09-30 1996-03-29 Yamanouchi Pharma Co Ltd Atsolijohdannainen ja sen farmaseuttinen seos
WO1995022541A1 (en) * 1994-02-18 1995-08-24 Janssen Pharmaceutica N.V. Enantiomerically pure(-)-liarozole
SG52325A1 (en) * 1994-02-18 1998-09-28 Janssen Pharmaceutica Nv Enantiomerically pure(+)-liarozole
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US5688808A (en) * 1994-12-22 1997-11-18 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
US6696459B1 (en) 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
ATE252560T1 (de) * 1994-12-22 2003-11-15 Ligand Pharm Inc Steroidrezeptor-modulator verbindungen und methoden
TW316902B (forum.php) * 1994-12-28 1997-10-01 Janssen Pharmaceutica Nv
WO1996026927A1 (fr) * 1995-03-01 1996-09-06 Yamanouchi Pharmaceutical Co., Ltd. Derives d'imidazole et composition medicinale a base desdits derives
US6288100B1 (en) * 1995-06-06 2001-09-11 American Home Products Corporation Benzimidazole derivatives
DE19535500A1 (de) * 1995-09-25 1997-03-27 Bayer Ag Verfahren zur Herstellung von 3-Chlor-3'-nitro-4'-methoxybenzophenon
BR9612434A (pt) * 1995-12-28 1999-12-28 Fujiwasa Pharmaceutical Co Ltd Derivados de benzimidazol
SK282769B6 (sk) 1996-06-27 2002-12-03 Janssen Pharmaceutica N. V. N-[4-(Heteroarylmetyl)fenyl]heteroarylamín, spôsob jeho výroby a použitia, kompozícia na jeho báze
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
CN1104422C (zh) * 1996-11-25 2003-04-02 普罗克特和甘保尔公司 用作α－2肾上腺素能受体兴奋剂的胍基杂环化合物
WO1998037070A1 (fr) * 1997-02-21 1998-08-27 Takeda Chemical Industries, Ltd. Composes a anneaux condenses, leur procede de production et leur utilisation
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
EP1037880B1 (en) * 1997-12-11 2004-06-30 Janssen Pharmaceutica N.V. Retinoic acid mimetic anilides
DE19831985A1 (de) 1998-07-16 2000-01-20 Bayer Ag Substituierte Benzimidazole, ihre Herstellung und ihre Verwendung als Mittel gegen parasitäre Protozoen
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
DE60007310D1 (de) * 1999-06-04 2004-01-29 Elan Pharma Int Ltd Zusammensetzungen und methoden zur verhinderung des zelltods
CZ20023422A3 (cs) 2000-03-16 2003-01-15 F. Hoffmann-La Roche Ag Deriváty karboxylových kyselin jako antagonisté IP
NZ526387A (en) 2000-11-17 2004-02-27 Takeda Chemical Industries Ltd Imidazole derivatives having a steroid C17,20-lyase- inhibitory activity, their production process and use thereof
DE60144246D1 (de) 2000-11-20 2011-04-28 Takeda Pharmaceutical Imidazolderivate, verfahren zu deren herstellung und deren verwendung
US7067537B2 (en) 2000-12-08 2006-06-27 Takeda Pharmaceutical Company Limited Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
US6492517B1 (en) * 2001-07-19 2002-12-10 Air Products And Chemicals, Inc. Method for preparing halomethyl heterocyclic compounds
DE60228316D1 (en) * 2001-11-16 2008-09-25 Nippon Chemiphar Co Xanthinoxidaseinhibitoren
JP2006513162A (ja) * 2002-11-01 2006-04-20 パラテック ファーマシューティカルズ インコーポレイテッド 転写因子調節化合物およびその使用方法
EP1654221A2 (en) * 2003-06-10 2006-05-10 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
FR2860235A1 (fr) * 2003-09-29 2005-04-01 Yang Ji Chemical Company Ltd Utilisation d'un compose de formule (i) inhibiteur de l'aromatase a des fins therapeutiques et composes de formule (i) en tant que tels
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US7348438B2 (en) 2004-09-30 2008-03-25 Janssen Pharmaceutica N.V. Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS)
MY149459A (en) * 2006-01-24 2013-08-30 Janssen Pharmaceutica Nv Novel 2-substituted benzimidazoles as selective androgen receptor modulator (sarms)
US7820821B2 (en) 2006-02-10 2010-10-26 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
KR101307497B1 (ko) * 2006-04-19 2013-09-11 주식회사 동진쎄미켐 디이미다졸계 화합물 및 이를 이용한 유기발광소자
CN100496308C (zh) * 2006-06-02 2009-06-10 上海烟草（集团）公司 造纸法再造烟叶半逆流多级萃取工艺
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JP5492075B2 (ja) * 2007-05-23 2014-05-14 アラーガン インコーポレイテッド アドレナリンレセプター作用薬としての（（二環式ヘテロアリール）イミダゾリル）メチルヘテロアリール化合物
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US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
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KR101884447B1 (ko) * 2015-07-06 2018-08-01 삼성에스디아이 주식회사 모노머, 유기막 조성물, 유기막, 및 패턴형성방법
EP4412660A1 (en) * 2021-10-04 2024-08-14 Bolt Biotherapeutics, Inc. Asymmetric bis-benzimidazole sting agonist immunoconjugates and uses thereof

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GR75101B (forum.php) * 1980-10-23 1984-07-13 Pfizer
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles

Also Published As

Publication number Publication date
BG61321B2 (bg) 1997-05-30
FI87781C (fi) 1993-02-25
GR3006841T3 (forum.php) 1993-06-30
EP0260744B1 (en) 1992-12-16
IL83892A0 (en) 1988-02-29
IL83892A (en) 1991-11-21
SU1662350A3 (ru) 1991-07-07
CY1803A (en) 1987-09-09
JPH0587071B2 (forum.php) 1993-12-15
IE872487L (en) 1988-03-15
CA1323366C (en) 1993-10-19
DK174728B1 (da) 2003-10-06
HUT45051A (en) 1988-05-30
KR880003935A (ko) 1988-06-01
FI873977A7 (fi) 1988-03-16
EP0260744A2 (en) 1988-03-23
NO873840D0 (no) 1987-09-14
ZA876881B (en) 1989-04-26
NZ221729A (en) 1989-07-27
PH25022A (en) 1991-01-28
DK479487D0 (da) 1987-09-14
JPS6485975A (en) 1989-03-30
CN87106423A (zh) 1988-04-20
HK123694A (en) 1994-11-18
DK479487A (da) 1988-03-16
FI87781B (fi) 1992-11-13
NO167202C (no) 1991-10-16
PT85692A (en) 1987-10-01
NO873840L (no) 1988-03-16
HU198039B (en) 1989-07-28
CN1020903C (zh) 1993-05-26
AU595064B2 (en) 1990-03-22
DE3783107T2 (de) 1993-04-22
DE3783107D1 (de) 1993-01-28
AU7838587A (en) 1988-04-14
NO167202B (no) 1991-07-08
FI873977A0 (fi) 1987-09-14
KR960014353B1 (ko) 1996-10-15
ES2053524T3 (es) 1994-08-01
PT85692B (pt) 1990-06-29
EP0260744A3 (en) 1989-01-18

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