IL83892A - (1h-imidazol-1-ylmethyl)substituted benzimidazole derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

(1h-imidazol-1-ylmethyl)substituted benzimidazole derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL83892A
IL83892A IL83892A IL8389287A IL83892A IL 83892 A IL83892 A IL 83892A IL 83892 A IL83892 A IL 83892A IL 8389287 A IL8389287 A IL 8389287A IL 83892 A IL83892 A IL 83892A
Authority
IL
Israel
Prior art keywords
imidazol
ylmethyl
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL83892A
Other languages
English (en)
Other versions
IL83892A0 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL83892A0 publication Critical patent/IL83892A0/xx
Publication of IL83892A publication Critical patent/IL83892A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL83892A 1986-09-15 1987-09-14 (1h-imidazol-1-ylmethyl)substituted benzimidazole derivatives,their preparation and pharmaceutical compositions containing them IL83892A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90790386A 1986-09-15 1986-09-15

Publications (2)

Publication Number Publication Date
IL83892A0 IL83892A0 (en) 1988-02-29
IL83892A true IL83892A (en) 1991-11-21

Family

ID=25424835

Family Applications (1)

Application Number Title Priority Date Filing Date
IL83892A IL83892A (en) 1986-09-15 1987-09-14 (1h-imidazol-1-ylmethyl)substituted benzimidazole derivatives,their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
EP (1) EP0260744B1 (forum.php)
JP (1) JPS6485975A (forum.php)
KR (1) KR960014353B1 (forum.php)
CN (1) CN1020903C (forum.php)
AU (1) AU595064B2 (forum.php)
BG (1) BG61321B2 (forum.php)
CA (1) CA1323366C (forum.php)
CY (1) CY1803A (forum.php)
DE (1) DE3783107T2 (forum.php)
DK (1) DK174728B1 (forum.php)
ES (1) ES2053524T3 (forum.php)
FI (1) FI87781C (forum.php)
GR (1) GR3006841T3 (forum.php)
HK (1) HK123694A (forum.php)
HU (1) HU198039B (forum.php)
IE (1) IE60514B1 (forum.php)
IL (1) IL83892A (forum.php)
NO (1) NO167202C (forum.php)
NZ (1) NZ221729A (forum.php)
PH (1) PH25022A (forum.php)
PT (1) PT85692B (forum.php)
SU (1) SU1662350A3 (forum.php)
ZA (1) ZA876881B (forum.php)

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US4826862A (en) * 1988-02-12 1989-05-02 Janssen Pharmaceutica, N.V. Anthelminthic [(5(6) (1H-azole-1-ylmethyl)benzimidazole]carbamates
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
FR2643903A1 (fr) * 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
PT95899A (pt) * 1989-11-17 1991-09-13 Glaxo Group Ltd Processo para a preparacao de derivados indole
US5021448A (en) * 1990-02-22 1991-06-04 Ciba-Geigy Corporation Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist
FR2663028B1 (fr) * 1990-06-08 1994-10-14 Roussel Uclaf Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5216003A (en) * 1992-01-02 1993-06-01 G. D. Searle & Co. Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
WO1995004723A1 (fr) * 1993-08-04 1995-02-16 Yamanouchi Pharmaceutical Co., Ltd. Derive d'imidazolylalkylamine et composition pharmaceutique contenant ledit derive
US5807880A (en) * 1993-09-30 1998-09-15 Yamanouchi Pharmaceutical Co., Ltd. Azole derivative and pharmaceutical composition thereof
SG47122A1 (en) * 1994-02-18 1998-03-20 Janssen Pharmaceutica Nv Enantiomerically pure(-)-liarozole
AU689206B2 (en) * 1994-02-18 1998-03-26 Janssen Pharmaceutica N.V. Enantiomerically pure (+)-liarozole
GB9418443D0 (en) * 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
US6696459B1 (en) 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
US5688810A (en) * 1994-12-22 1997-11-18 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
ATE269336T1 (de) * 1994-12-22 2004-07-15 Ligand Pharm Inc Steroidrezeptor-modulator verbindungen und methoden
TW316902B (forum.php) * 1994-12-28 1997-10-01 Janssen Pharmaceutica Nv
EP0820989A4 (en) * 1995-03-01 1998-05-06 Yamanouchi Pharma Co Ltd IMIDAZOLE DERIVATIVES AND MEDICINAL COMPOSITION BASED ON SAID DERIVATIVES
US6288100B1 (en) * 1995-06-06 2001-09-11 American Home Products Corporation Benzimidazole derivatives
DE19535500A1 (de) * 1995-09-25 1997-03-27 Bayer Ag Verfahren zur Herstellung von 3-Chlor-3'-nitro-4'-methoxybenzophenon
US6166219A (en) 1995-12-28 2000-12-26 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
WO1997049704A1 (en) * 1996-06-27 1997-12-31 Janssen Pharmaceutica N.V. N-[4-(heteroarylmethyl)phenyl]-heteroarylamines
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
DE69732244T2 (de) * 1996-11-25 2006-06-29 The Board Of Regents Of The University Of Nebraska, Lincoln Guanidyl-heterocyclische verbindungen als alpha-2 adrenoceptor agonisten
ATE231128T1 (de) 1997-02-21 2003-02-15 Takeda Chemical Industries Ltd Verbindungen mit kondensierten ringen, verfahren zu ihrer herstellung und ihre anwendung
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
AU2160899A (en) 1997-12-11 1999-06-28 Janssen Pharmaceutica N.V. Retinoic acid mimetic anilides
DE19831985A1 (de) 1998-07-16 2000-01-20 Bayer Ag Substituierte Benzimidazole, ihre Herstellung und ihre Verwendung als Mittel gegen parasitäre Protozoen
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP1189889B1 (en) * 1999-06-04 2003-12-17 Elan Pharma International Limited Compositions and methods for inhibiting cell death
PL207869B1 (pl) 2000-03-16 2011-02-28 Hoffmann La Roche Pochodne kwasu karboksylowego, środek farmaceutyczny i sposób wytwarzania pochodnych kwasu karboksylowego
AR034854A1 (es) 2000-11-17 2004-03-24 Takeda Chemical Industries Ltd Compuesto de imidazol condensado, prodroga del mismo, composición farmaceutica y agente para reducir androgenos que lo contienen ,metodo para producirlo, sal diastereomerica de dicho compuesto y metodo para producir un compuesto opticamente activo del compuesto
DE60144246D1 (de) 2000-11-20 2011-04-28 Takeda Pharmaceutical Imidazolderivate, verfahren zu deren herstellung und deren verwendung
ATE440096T1 (de) 2000-12-08 2009-09-15 Takeda Pharmaceutical Substituierte thiazolderivate mit 3- pyridylgruppen, verfahren zu deren herstellung und deren verwendung
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
US6492517B1 (en) * 2001-07-19 2002-12-10 Air Products And Chemicals, Inc. Method for preparing halomethyl heterocyclic compounds
CN100338040C (zh) * 2001-11-16 2007-09-19 日本化学医药株式会社 黄嘌呤氧化酶抑制化合物
WO2004041209A2 (en) * 2002-11-01 2004-05-21 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
JP2007500245A (ja) * 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション 化合物
FR2860235A1 (fr) * 2003-09-29 2005-04-01 Yang Ji Chemical Company Ltd Utilisation d'un compose de formule (i) inhibiteur de l'aromatase a des fins therapeutiques et composes de formule (i) en tant que tels
JP2008504233A (ja) 2004-04-23 2008-02-14 パラテック ファーマシューティカルズ インコーポレイテッド 転写因子調節化合物およびその使用法
CA2582356A1 (en) * 2004-09-30 2006-04-13 Janssen Pharmaceutica N.V. Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
CA2582347C (en) 2004-09-30 2014-09-23 Janssen Pharmaceutica N.V. Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
WO2007087518A2 (en) * 2006-01-24 2007-08-02 Janssen Pharmaceutica N.V. 2-substituted benzimidazoles as selective androgen receptor modulators (sarms)
AU2007215247B2 (en) 2006-02-10 2012-12-13 Transtech Pharma, Llc Benzazole derivatives, compositions, and methods of use as Aurora kinase inhibitors
KR101307497B1 (ko) * 2006-04-19 2013-09-11 주식회사 동진쎄미켐 디이미다졸계 화합물 및 이를 이용한 유기발광소자
CN100496308C (zh) * 2006-06-02 2009-06-10 上海烟草（集团）公司 造纸法再造烟叶半逆流多级萃取工艺
EP1992228A1 (en) * 2007-05-14 2008-11-19 Bayer CropScience AG Insecticidal substituted thiourea derivatives
BRPI0811783A2 (pt) * 2007-05-23 2014-11-11 Allergan Inc Compostos de ((heteroarila bicíclica)imidazolil)metil-heteroarila como agonistas dos receptores adrenérgicos.
DE102009038950A1 (de) 2009-08-26 2011-03-03 Bayer Animal Health Gmbh Neue antiparasitäre Kombination von Wirkstoffen
WO2012052540A1 (en) * 2010-10-21 2012-04-26 Universitaet Des Saarlandes Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
EP2760854B1 (en) * 2011-09-30 2017-08-30 Asana BioSciences, LLC Imidazole derivatives as cyp17 inhibitors for the treatment of cancer
KR101884447B1 (ko) * 2015-07-06 2018-08-01 삼성에스디아이 주식회사 모노머, 유기막 조성물, 유기막, 및 패턴형성방법
JP2024536342A (ja) * 2021-10-04 2024-10-04 ボルト バイオセラピューティクス、インコーポレーテッド 非対称ビス－ベンゾイミダゾールｓｔｉｎｇアゴニスト免疫複合体及びその使用

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* Cited by examiner, † Cited by third party
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GR75101B (forum.php) * 1980-10-23 1984-07-13 Pfizer
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles

Also Published As

Publication number Publication date
ZA876881B (en) 1989-04-26
FI873977A0 (fi) 1987-09-14
FI87781C (fi) 1993-02-25
NO873840L (no) 1988-03-16
AU595064B2 (en) 1990-03-22
NO167202B (no) 1991-07-08
JPH0587071B2 (forum.php) 1993-12-15
CN1020903C (zh) 1993-05-26
SU1662350A3 (ru) 1991-07-07
GR3006841T3 (forum.php) 1993-06-30
HU198039B (en) 1989-07-28
JPS6485975A (en) 1989-03-30
EP0260744B1 (en) 1992-12-16
CY1803A (en) 1987-09-09
HUT45051A (en) 1988-05-30
PT85692B (pt) 1990-06-29
AU7838587A (en) 1988-04-14
CN87106423A (zh) 1988-04-20
PT85692A (en) 1987-10-01
IL83892A0 (en) 1988-02-29
NO167202C (no) 1991-10-16
FI873977A7 (fi) 1988-03-16
PH25022A (en) 1991-01-28
DE3783107D1 (de) 1993-01-28
FI87781B (fi) 1992-11-13
DK174728B1 (da) 2003-10-06
IE60514B1 (en) 1994-07-27
EP0260744A3 (en) 1989-01-18
IE872487L (en) 1988-03-15
ES2053524T3 (es) 1994-08-01
EP0260744A2 (en) 1988-03-23
HK123694A (en) 1994-11-18
CA1323366C (en) 1993-10-19
DK479487D0 (da) 1987-09-14
BG61321B2 (bg) 1997-05-30
KR880003935A (ko) 1988-06-01
DE3783107T2 (de) 1993-04-22
KR960014353B1 (ko) 1996-10-15
DK479487A (da) 1988-03-16
NZ221729A (en) 1989-07-27
NO873840D0 (no) 1987-09-14

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