IE59406B1 - Solubilization of proteins for pharmaceutical compositions using polymer conjugation - Google Patents
Solubilization of proteins for pharmaceutical compositions using polymer conjugationInfo
- Publication number
- IE59406B1 IE59406B1 IE170686A IE170686A IE59406B1 IE 59406 B1 IE59406 B1 IE 59406B1 IE 170686 A IE170686 A IE 170686A IE 170686 A IE170686 A IE 170686A IE 59406 B1 IE59406 B1 IE 59406B1
- Authority
- IE
- Ireland
- Prior art keywords
- protein
- polymer
- peg
- conjugated
- ifn
- Prior art date
Links
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
- A61K47/6827—Ricin A
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- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
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- Botany (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74995585A | 1985-06-26 | 1985-06-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE861706L IE861706L (en) | 1986-12-26 |
| IE59406B1 true IE59406B1 (en) | 1994-02-23 |
Family
ID=25015921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE170686A IE59406B1 (en) | 1985-06-26 | 1986-06-25 | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0229108B1 (Direct) |
| JP (1) | JP2524586B2 (Direct) |
| KR (1) | KR900004801B1 (Direct) |
| CA (1) | CA1291708C (Direct) |
| DE (1) | DE3676670D1 (Direct) |
| DK (1) | DK169874B1 (Direct) |
| FI (1) | FI93424C (Direct) |
| GR (1) | GR861641B (Direct) |
| IE (1) | IE59406B1 (Direct) |
| IL (1) | IL79235A (Direct) |
| IN (1) | IN163200B (Direct) |
| MX (1) | MX174442B (Direct) |
| NZ (1) | NZ216618A (Direct) |
| PH (1) | PH25004A (Direct) |
| PT (1) | PT82834B (Direct) |
| WO (1) | WO1987000056A1 (Direct) |
| ZA (1) | ZA864766B (Direct) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS54157816A (en) * | 1978-05-27 | 1979-12-13 | Unitika Ltd | Fixing of bioactive substance to solid surface |
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| EP0098110B1 (en) * | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
| WO1985003934A1 (fr) * | 1984-03-06 | 1985-09-12 | Takeda Chemical Industries, Ltd. | Proteine modifiee chimiquement et son procede de preparation |
| EP0154316B1 (en) * | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
-
1986
- 1986-06-06 EP EP86903990A patent/EP0229108B1/en not_active Expired - Lifetime
- 1986-06-06 WO PCT/US1986/001252 patent/WO1987000056A1/en not_active Ceased
- 1986-06-06 DE DE8686903990T patent/DE3676670D1/de not_active Expired - Lifetime
- 1986-06-06 JP JP61503399A patent/JP2524586B2/ja not_active Expired - Lifetime
- 1986-06-12 CA CA000511466A patent/CA1291708C/en not_active Expired - Lifetime
- 1986-06-20 NZ NZ216618A patent/NZ216618A/xx unknown
- 1986-06-23 IN IN464/CAL/86A patent/IN163200B/en unknown
- 1986-06-24 PH PH33934A patent/PH25004A/en unknown
- 1986-06-24 PT PT82834A patent/PT82834B/pt unknown
- 1986-06-25 GR GR861641A patent/GR861641B/el unknown
- 1986-06-25 IE IE170686A patent/IE59406B1/en not_active IP Right Cessation
- 1986-06-25 IL IL79235A patent/IL79235A/xx not_active IP Right Cessation
- 1986-06-26 ZA ZA864766A patent/ZA864766B/xx unknown
- 1986-06-26 KR KR1019860005125A patent/KR900004801B1/ko not_active Expired
- 1986-06-26 MX MX002938A patent/MX174442B/es unknown
-
1987
- 1987-02-25 DK DK097987A patent/DK169874B1/da not_active IP Right Cessation
- 1987-02-25 FI FI870809A patent/FI93424C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI93424B (fi) | 1994-12-30 |
| ZA864766B (en) | 1988-02-24 |
| DK169874B1 (da) | 1995-03-20 |
| KR900004801B1 (ko) | 1990-07-06 |
| DK97987A (da) | 1987-02-25 |
| PT82834B (pt) | 1988-12-15 |
| EP0229108A1 (en) | 1987-07-22 |
| NZ216618A (en) | 1989-05-29 |
| FI93424C (fi) | 1995-04-10 |
| FI870809L (fi) | 1987-02-25 |
| DE3676670D1 (de) | 1991-02-07 |
| DK97987D0 (da) | 1987-02-25 |
| PT82834A (en) | 1986-07-01 |
| PH25004A (en) | 1991-01-28 |
| WO1987000056A1 (en) | 1987-01-15 |
| KR870000423A (ko) | 1987-02-18 |
| IL79235A0 (en) | 1986-09-30 |
| FI870809A0 (fi) | 1987-02-25 |
| IN163200B (Direct) | 1988-08-20 |
| MX174442B (es) | 1994-05-17 |
| CA1291708C (en) | 1991-11-05 |
| GR861641B (en) | 1986-09-12 |
| JPS62503171A (ja) | 1987-12-17 |
| JP2524586B2 (ja) | 1996-08-14 |
| EP0229108B1 (en) | 1990-12-27 |
| IL79235A (en) | 1991-01-31 |
| IE861706L (en) | 1986-12-26 |
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