ID29829A - Epotilon termodifikasi pada c-21 - Google Patents
Epotilon termodifikasi pada c-21Info
- Publication number
- ID29829A ID29829A IDW00200101797A ID20011797A ID29829A ID 29829 A ID29829 A ID 29829A ID W00200101797 A IDW00200101797 A ID W00200101797A ID 20011797 A ID20011797 A ID 20011797A ID 29829 A ID29829 A ID 29829A
- Authority
- ID
- Indonesia
- Prior art keywords
- epothylons
- modificated
- modificated epothylons
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1999107588 DE19907588A1 (de) | 1999-02-22 | 1999-02-22 | C-21 Modifizierte Epothilone |
DE1999130111 DE19930111A1 (de) | 1999-07-01 | 1999-07-01 | C-21 Modifizierte Epothilone |
Publications (1)
Publication Number | Publication Date |
---|---|
ID29829A true ID29829A (id) | 2001-10-11 |
Family
ID=26051995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW00200101797A ID29829A (id) | 1999-02-22 | 2000-02-17 | Epotilon termodifikasi pada c-21 |
Country Status (37)
Country | Link |
---|---|
US (1) | US6262094B1 (ja) |
EP (1) | EP1157023B1 (ja) |
JP (1) | JP4598957B2 (ja) |
KR (1) | KR100685336B1 (ja) |
CN (1) | CN1205208C (ja) |
AR (1) | AR028815A1 (ja) |
AT (1) | ATE254615T1 (ja) |
AU (1) | AU771089B2 (ja) |
BG (1) | BG64987B1 (ja) |
BR (1) | BR0008379A (ja) |
CA (1) | CA2360452C (ja) |
CO (1) | CO5140093A1 (ja) |
CZ (1) | CZ301498B6 (ja) |
DE (1) | DE60006649T2 (ja) |
DK (1) | DK1157023T3 (ja) |
EE (1) | EE04852B1 (ja) |
ES (1) | ES2209831T3 (ja) |
GE (1) | GEP20033067B (ja) |
HK (1) | HK1038923B (ja) |
HU (1) | HUP0200076A3 (ja) |
ID (1) | ID29829A (ja) |
IL (1) | IL144501A0 (ja) |
LT (1) | LT4944B (ja) |
LV (1) | LV12755B (ja) |
MX (1) | MXPA01008374A (ja) |
MY (1) | MY120601A (ja) |
NO (1) | NO320806B1 (ja) |
NZ (1) | NZ513629A (ja) |
PE (1) | PE20001546A1 (ja) |
PL (1) | PL212545B1 (ja) |
PT (1) | PT1157023E (ja) |
RU (1) | RU2253652C2 (ja) |
SK (1) | SK287200B6 (ja) |
TR (1) | TR200102401T2 (ja) |
TW (1) | TWI270546B (ja) |
UY (1) | UY26024A1 (ja) |
WO (1) | WO2000050423A1 (ja) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT941227E (pt) * | 1996-11-18 | 2004-08-31 | Biotechnolog Forschung Mbh Gbf | Epothilona d sua preparacao e sua utilizacao como agente citostatico ou como agente de proteccao fitossanitaria |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
JP4579351B2 (ja) | 1996-12-03 | 2010-11-10 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロンの合成とその中間体及びその類似物並びにその使用 |
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
GB9810659D0 (en) * | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
US6589968B2 (en) * | 2001-02-13 | 2003-07-08 | Kosan Biosciences, Inc. | Epothilone compounds and methods for making and using the same |
EP1319011B1 (de) | 2000-09-22 | 2012-12-05 | Helmholtz-Zentrum für Infektionsforschung GmbH | Triazolo-epothilone |
AU2002213248A1 (en) * | 2000-10-13 | 2002-04-22 | The University Of Mississipi | Synthesis of epothilones and relates analogs |
JP2004521122A (ja) | 2001-01-25 | 2004-07-15 | ブリストル−マイヤーズ スクイブ カンパニー | エポチロン類似体の非経口製剤 |
US6893859B2 (en) | 2001-02-13 | 2005-05-17 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
EE200300396A (et) | 2001-02-20 | 2003-12-15 | Bristol-Myers Squibb Company | Epotilooni derivaatide kasutamine refraktaarsete kasvajate raviks |
CA2438598A1 (en) * | 2001-02-20 | 2002-08-29 | Francis Y. F. Lee | Epothilone derivatives for the treatment of refractory tumors |
CZ305799B6 (cs) | 2001-03-14 | 2016-03-23 | Bristol-Myers Squibb Company | Kombinace analogů epothilonu a chemoterapeutických činidel pro léčení proliferačních nemocí |
CA2471509A1 (en) * | 2002-01-14 | 2003-07-17 | Novartis Ag | Combinations comprising epothilones and anti-metabolites |
TW200303202A (en) | 2002-02-15 | 2003-09-01 | Bristol Myers Squibb Co | Method of preparation of 21-amino epothilone derivatives |
US6900331B2 (en) * | 2002-03-01 | 2005-05-31 | University Of Notre Dame | Derivatives of epothilone B and D and synthesis thereof |
CN100402029C (zh) * | 2002-03-08 | 2008-07-16 | 诺瓦提斯公司 | 包含埃坡霉素衍生物和烷化剂的组合 |
SI1485090T1 (sl) * | 2002-03-08 | 2008-06-30 | Novartis Ag | Kombinacija vključujoča derivat epotilona in imidazotetrazinon |
DE60330651D1 (en) | 2002-03-12 | 2010-02-04 | Bristol Myers Squibb Co | C3-cyanoepothilonderivate |
AU2003218107A1 (en) * | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
TW200403994A (en) * | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
MXPA04010853A (es) * | 2002-05-01 | 2005-02-14 | Novartis Ag | Derivado de epotilona para el tratamiento de hepatoma y otras enfermedades de cancer. |
TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
EP1506203B1 (en) | 2002-08-23 | 2007-01-03 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
KR101406635B1 (ko) | 2002-09-23 | 2014-06-11 | 브리스톨-마이어스 스큅 컴퍼니 | 에포틸론 b의 제조, 분리 및 정제 방법, 및 에포틸론 b의 x-선 결정 구조 |
KR20050051688A (ko) * | 2002-10-09 | 2005-06-01 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론(Еpo) D + 5-플루오로우라실(FU)/겜시타빈 |
US7169771B2 (en) | 2003-02-06 | 2007-01-30 | Bristol-Myers Squibb Company | Thiazolyl-based compounds useful as kinase inhibitors |
US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
EP1559447A1 (en) | 2004-01-30 | 2005-08-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism |
GB0405898D0 (en) | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
US20090004277A1 (en) * | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US20060134214A1 (en) * | 2004-11-18 | 2006-06-22 | Ismat Ullah | Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof |
ATE397442T1 (de) * | 2004-11-18 | 2008-06-15 | Bristol Myers Squibb Co | Magensaftresistent beschichtetes pellet mit ixabepilon |
JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Birドメイン結合化合物 |
US8003801B2 (en) * | 2005-11-22 | 2011-08-23 | The Scripps Research Institute | Chemical synthesis of a highly potent epothilone |
US7348325B2 (en) | 2005-11-30 | 2008-03-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
WO2007131366A1 (en) | 2006-05-16 | 2007-11-22 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
WO2008109075A2 (en) * | 2007-03-05 | 2008-09-12 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to ctla-4 antagonists |
WO2008147941A1 (en) | 2007-05-25 | 2008-12-04 | Bristol-Myers Squibb Company | Processes for making epothilone compounds and analogs |
CN101909693A (zh) | 2008-01-08 | 2010-12-08 | 百时美施贵宝公司 | 用于治疗增殖性疾病的抗-ctla4抗体与微管蛋白调节剂的组合 |
PT2276485E (pt) * | 2008-04-24 | 2014-10-20 | Bristol Myers Squibb Co | Utilização de epotilona d no tratamento de doenças tauassociadas que compreendem a doença de alzheimer |
US20090311187A1 (en) * | 2008-05-29 | 2009-12-17 | Bristol-Myers Squibb Company | Methods for predicting patient response to modulation of the Co-stimulatory pathway |
US8119129B2 (en) | 2008-08-01 | 2012-02-21 | Bristol-Myers Squibb Company | Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases |
SI2769737T1 (sl) | 2009-07-20 | 2017-06-30 | Bristol-Myers Squibb Company | Kombinacija anti-ctla4 protitelesa z etoposidom za sinergistično zdravljenje proliferativnih bolezni |
WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
AP2012006294A0 (en) | 2009-11-05 | 2012-06-30 | Rhizen Pharmaceuticals Sa | Novel kinase modulators. |
AU2011214057B2 (en) | 2010-02-12 | 2016-11-17 | Pharmascience Inc. | IAP BIR domain binding compounds |
WO2011146382A1 (en) | 2010-05-17 | 2011-11-24 | Bristol-Myers Squibb Company | Improved immunotherapeutic dosing regimens and combinations thereof |
CA2798080C (en) | 2010-05-17 | 2020-08-25 | Incozen Therapeutics Pvt. Ltd. | 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases |
EP2571525A4 (en) | 2010-05-18 | 2016-04-27 | Cerulean Pharma Inc | Compositions and methods for treating autoimmune and other diseases |
EP2705029B1 (en) | 2011-05-04 | 2018-10-24 | Rhizen Pharmaceuticals S.A. | Novel compounds as modulators of protein kinases |
CN102863474A (zh) | 2011-07-09 | 2013-01-09 | 陈小平 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
CN102993239A (zh) | 2011-09-19 | 2013-03-27 | 陈小平 | 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物 |
EA026412B1 (ru) | 2012-03-30 | 2017-04-28 | Ризен Фармасьютикалз Са | НОВЫЕ СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ c-MET ПРОТЕИНКИНАЗ |
WO2014075391A1 (zh) | 2012-11-17 | 2014-05-22 | 北京市丰硕维康技术开发有限责任公司 | 离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物 |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
US20160264670A1 (en) | 2013-11-06 | 2016-09-15 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
EP3227335A1 (en) | 2014-12-04 | 2017-10-11 | Bristol-Myers Squibb Company | Combination of anti-cs1 and anti-pd1 antibodies to treat cancer (myeloma) |
MX2017015765A (es) | 2015-06-29 | 2018-04-13 | Squibb Bristol Myers Co | Regimenes de dosificacion inmunoterapeutica que comprenden pomalidomida y un anticuerpo anti-cs1 para el tratamiento de cancer. |
CN105153177B (zh) * | 2015-09-28 | 2017-08-08 | 湖南大学 | 呋喃并色满肟烯/炔丙基醚及其制备方法与应用 |
US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE301115C (ja) | ||||
DE75883C (de) | W. schulte in Siegen und F. A. SAPP in Hillnhütten, Kreis Siegen | Ofen zur Erzeugung von Cyanammonium | ||
DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
ES2178093T5 (es) | 1995-11-17 | 2009-02-16 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Derivados de epotilon y su preparacion. |
DE19639456A1 (de) | 1996-09-25 | 1998-03-26 | Biotechnolog Forschung Gmbh | Epothilon-Derivate, Herstellung und Mittel |
DE19542986A1 (de) | 1995-11-17 | 1997-05-22 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Verwendung |
DE19645362A1 (de) | 1996-10-28 | 1998-04-30 | Ciba Geigy Ag | Verfahren zur Herstellung von Epothilon A und B und Derivaten |
DE19636343C1 (de) | 1996-08-30 | 1997-10-23 | Schering Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B |
DE19645361A1 (de) | 1996-08-30 | 1998-04-30 | Ciba Geigy Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II |
AU716610B2 (en) | 1996-08-30 | 2000-03-02 | Novartis Ag | Method for producing epothilones, and intermediate products obtained during the production process |
PT941227E (pt) * | 1996-11-18 | 2004-08-31 | Biotechnolog Forschung Mbh Gbf | Epothilona d sua preparacao e sua utilizacao como agente citostatico ou como agente de proteccao fitossanitaria |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
JP4579351B2 (ja) | 1996-12-03 | 2010-11-10 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロンの合成とその中間体及びその類似物並びにその使用 |
US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
DE19707303B4 (de) | 1997-02-11 | 2006-05-11 | Mitteldeutsches Bitumenwerk Gmbh | Verfahren zur Gewinnung von Mikrowachsen, Paraffinen und Ölen aus Altkunststoffen oder Altkunststoffgemischen |
CN1128803C (zh) | 1997-02-25 | 2003-11-26 | 生物技术研究有限公司(Gbf) | 环氧噻嗪酮b-n-氧化物及其制备方法 |
DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
ATE225783T1 (de) | 1997-04-18 | 2002-10-15 | Studiengesellschaft Kohle Mbh | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
DE19821954A1 (de) | 1997-05-15 | 1998-11-19 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung eines Epothilon-Derivats |
DE19720312A1 (de) | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
DE19726627A1 (de) | 1997-06-17 | 1998-12-24 | Schering Ag | Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon |
JP2001510189A (ja) | 1997-07-16 | 2001-07-31 | シエーリング アクチエンゲゼルシヤフト | チアゾール誘導体、その製造法および使用 |
JP2001512723A (ja) | 1997-08-09 | 2001-08-28 | シエーリング アクチエンゲゼルシヤフト | 新規エポチロン誘導体、その製法およびその薬学的使用 |
US6498257B1 (en) | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
HUP0200296A2 (en) * | 1998-12-23 | 2002-05-29 | Bristol Myers Squibb Co | Microbial transformation method for the preparation of an epothilone |
-
2000
- 2000-02-17 US US09/506,481 patent/US6262094B1/en not_active Expired - Lifetime
- 2000-02-17 CZ CZ20012991A patent/CZ301498B6/cs not_active IP Right Cessation
- 2000-02-17 CN CNB008039461A patent/CN1205208C/zh not_active Expired - Fee Related
- 2000-02-17 BR BR0008379-8A patent/BR0008379A/pt not_active IP Right Cessation
- 2000-02-17 PL PL350179A patent/PL212545B1/pl unknown
- 2000-02-17 DE DE60006649T patent/DE60006649T2/de not_active Expired - Lifetime
- 2000-02-17 TW TW089102732A patent/TWI270546B/zh not_active IP Right Cessation
- 2000-02-17 AT AT00910219T patent/ATE254615T1/de active
- 2000-02-17 DK DK00910219T patent/DK1157023T3/da active
- 2000-02-17 WO PCT/US2000/004068 patent/WO2000050423A1/en active IP Right Grant
- 2000-02-17 TR TR2001/02401T patent/TR200102401T2/xx unknown
- 2000-02-17 EP EP00910219A patent/EP1157023B1/en not_active Expired - Lifetime
- 2000-02-17 NZ NZ513629A patent/NZ513629A/xx unknown
- 2000-02-17 GE GEAP20006055A patent/GEP20033067B/en unknown
- 2000-02-17 JP JP2000601003A patent/JP4598957B2/ja not_active Expired - Fee Related
- 2000-02-17 RU RU2001125435/04A patent/RU2253652C2/ru not_active IP Right Cessation
- 2000-02-17 PT PT00910219T patent/PT1157023E/pt unknown
- 2000-02-17 HU HU0200076A patent/HUP0200076A3/hu unknown
- 2000-02-17 IL IL14450100A patent/IL144501A0/xx not_active IP Right Cessation
- 2000-02-17 CA CA2360452A patent/CA2360452C/en not_active Expired - Fee Related
- 2000-02-17 ES ES00910219T patent/ES2209831T3/es not_active Expired - Lifetime
- 2000-02-17 MX MXPA01008374A patent/MXPA01008374A/es active IP Right Grant
- 2000-02-17 KR KR1020017010421A patent/KR100685336B1/ko not_active IP Right Cessation
- 2000-02-17 ID IDW00200101797A patent/ID29829A/id unknown
- 2000-02-17 AU AU32348/00A patent/AU771089B2/en not_active Ceased
- 2000-02-17 EE EEP200100437A patent/EE04852B1/xx unknown
- 2000-02-17 SK SK1078-2001A patent/SK287200B6/sk not_active IP Right Cessation
- 2000-02-21 MY MYPI20000629A patent/MY120601A/en unknown
- 2000-02-22 PE PE2000000140A patent/PE20001546A1/es not_active Application Discontinuation
- 2000-02-22 CO CO00012008A patent/CO5140093A1/es unknown
- 2000-02-22 UY UY26024A patent/UY26024A1/es not_active Application Discontinuation
- 2000-02-22 AR ARP000100744A patent/AR028815A1/es unknown
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2001
- 2001-08-17 BG BG105830A patent/BG64987B1/bg unknown
- 2001-08-17 NO NO20014017A patent/NO320806B1/no not_active IP Right Cessation
- 2001-08-23 LV LV010126A patent/LV12755B/xx unknown
- 2001-08-24 LT LT2001086A patent/LT4944B/lt not_active IP Right Cessation
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2002
- 2002-01-22 HK HK02100498.5A patent/HK1038923B/zh not_active IP Right Cessation
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