ID25469A - Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya - Google Patents

Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya

Info

Publication number
ID25469A
ID25469A IDW20001303A ID20001303A ID25469A ID 25469 A ID25469 A ID 25469A ID W20001303 A IDW20001303 A ID W20001303A ID 20001303 A ID20001303 A ID 20001303A ID 25469 A ID25469 A ID 25469A
Authority
ID
Indonesia
Prior art keywords
sefalosporine
christalography
amorf
stories
making
Prior art date
Application number
IDW20001303A
Other languages
English (en)
Indonesian (id)
Inventor
Masahiro Onodera
Masamichi Sukegawa
Kiyoshi Yasui
Tatsuo Watanabe
Toyomi Sato
Yasushi Muria
Katsuharu Iinuma
Original Assignee
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha filed Critical Meiji Seika Kaisha
Publication of ID25469A publication Critical patent/ID25469A/id

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IDW20001303A 1998-01-07 1999-01-07 Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya ID25469A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP192098 1998-01-07

Publications (1)

Publication Number Publication Date
ID25469A true ID25469A (id) 2000-10-05

Family

ID=11515039

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20001303A ID25469A (id) 1998-01-07 1999-01-07 Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya

Country Status (22)

Country Link
US (2) US6342493B1 (cs)
EP (1) EP1051978B1 (cs)
JP (1) JP3413406B2 (cs)
KR (1) KR100435315B1 (cs)
CN (1) CN1151845C (cs)
AU (1) AU736555B2 (cs)
BR (1) BRPI9907084B8 (cs)
CA (1) CA2316841C (cs)
CZ (1) CZ302082B6 (cs)
EA (1) EA002881B1 (cs)
ES (1) ES2393972T3 (cs)
HU (1) HU230295B1 (cs)
ID (1) ID25469A (cs)
IL (2) IL137004A0 (cs)
NZ (1) NZ505871A (cs)
PL (1) PL194097B1 (cs)
PT (1) PT1051978E (cs)
SK (1) SK286631B6 (cs)
TR (1) TR200001903T2 (cs)
TW (1) TW587946B (cs)
UA (1) UA70311C2 (cs)
WO (1) WO1999034832A1 (cs)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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JP3413406B2 (ja) * 1998-01-07 2003-06-03 明治製菓株式会社 結晶学的に安定な非晶質セファロスポリンの組成物とその製造方法
DE60017180T2 (de) 1999-10-08 2005-12-08 Affinium Pharmaceuticals, Inc., Toronto Fab i inhibitoren
CA2444597A1 (en) 2001-04-06 2002-10-06 Affinium Pharmaceuticals, Inc. Fab i inhibitors
US7527808B2 (en) 2001-04-26 2009-05-05 Meiji Seika Kaisha, Ltd. Amorphous cefditoren pivoxil composition and process for producing the same
US8648065B2 (en) * 2002-10-02 2014-02-11 Meiji Seika Pharma Co., Ltd. Antibacterial medicinal composition of enhanced oral absorptivity
ES2518316T3 (es) 2002-12-06 2014-11-05 Debiopharm International Sa Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia
EP1608377B1 (en) * 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
WO2004113424A1 (ja) * 2003-06-20 2004-12-29 Meiji Seika Kaisha, Ltd. 難水溶性物質と水溶性高分子との共沈物の製造方法
WO2005034957A1 (ja) 2003-10-08 2005-04-21 Meiji Seika Kaisha, Ltd. セフジトレン ピボキシルを含有する非晶性抗菌組成物
EP1689755A2 (en) * 2003-11-07 2006-08-16 Ranbaxy Laboratories Limited Processes for the preparation of highly pure 3-(2-substituted vinyl) cephalosporin
JP2005162696A (ja) * 2003-12-04 2005-06-23 Nichiko Pharmaceutical Co Ltd 溶出性に優れたセフジトレンピボキシル製剤
WO2005082330A2 (en) * 2004-02-19 2005-09-09 Ranbaxy Laboratories Limited Co-precipitated amorphous cefditoren pivoxil and dosage forms comprising the same
SI1828167T1 (sl) 2004-06-04 2014-12-31 Debiopharm International Sa Forum "Apres-Demain" Akrilamidni derivati kot anitibiotična sredstva
US20080069879A1 (en) * 2006-05-02 2008-03-20 Ravishekhar Bhiwgade Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof
CA2658506C (en) 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab 1 inhibitors
WO2008057058A1 (en) * 2006-11-10 2008-05-15 Nobel Ilac Sanayii Ve Ticaret As Oral pharmaceutical compositions
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
CN101560216B (zh) * 2009-05-27 2011-06-15 上海交通大学 头孢妥仑酯的制备方法
WO2012010938A2 (en) * 2010-07-23 2012-01-26 Lupin Limited Pharmaceutical compositions of cefditoren pivoxil
EP2623498B1 (en) 2010-09-30 2015-11-18 Toyama Chemical Co., Ltd. Sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
SI2623497T1 (sl) 2010-09-30 2016-04-29 Toyama Chemical Co., Ltd. Megluminska sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida
TR201909016T4 (tr) 2012-06-19 2019-07-22 Debiopharm Int Sa (E)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamidin ön ilaç türevleri.
WO2015029066A1 (en) * 2013-08-29 2015-03-05 Cadila Healthcare Limited Polymorphic form of pyrrole derivative and intermediate thereof
EP3244879A1 (en) 2015-01-16 2017-11-22 Ögün, Yusuf Toktamis Cefditoren pivoxil compositions with improved stability and production methods thereof
HUE052140T2 (hu) 2016-02-26 2021-04-28 Debiopharm Int Sa Diabéteszes lábfertõzések kezelésére szolgáló gyógyszer
CN109053768A (zh) * 2018-08-07 2018-12-21 中国医药集团总公司四川抗菌素工业研究所 一种无定型头孢妥仑酯的制备方法
CN113423390B (zh) 2019-02-14 2023-05-23 德彪药业国际股份公司 阿法比星制剂及其制备方法
EA202290048A1 (ru) 2019-06-14 2022-03-10 Дебиофарм Интернэшнл C.A. Лекарственное средство и его применение для лечения бактериальных инфекций, связанных с биопленкой
CN110251467A (zh) * 2019-06-26 2019-09-20 北京济美堂医药研究有限公司 一种无定形态头孢妥仑匹酯组合物的制备方法
CN112190539B (zh) * 2020-11-10 2021-11-02 深圳立健药业有限公司 一种头孢妥仑匹酯组合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0678234B2 (ja) * 1988-04-19 1994-10-05 明治製菓株式会社 経口投与用抗菌組成物
JPH05306227A (ja) * 1992-04-27 1993-11-19 Lion Corp 徐放性口腔内疾患治療剤
JP2576927B2 (ja) * 1992-05-15 1997-01-29 ファイザー製薬株式会社 細粒核
JPH06316517A (ja) * 1993-02-22 1994-11-15 Grelan Pharmaceut Co Ltd 放出制御製剤
JPH0717866A (ja) * 1993-06-16 1995-01-20 Meiji Seika Kaisha Ltd 医薬組成物
WO1996019239A1 (fr) 1994-12-21 1996-06-27 Yamanouchi Pharmaceutical Co., Ltd. Composition solide a solubilite et absorbabilite ameliorees
AR004014A1 (es) * 1995-10-13 1998-09-30 Meiji Seika Kaisha Una composicion antibacteriana de cefditoren pivoxilo para administracion oral y metodo para obtener dicha composicion
ATE255883T1 (de) 1996-05-20 2003-12-15 Janssen Pharmaceutica Nv Fungizide mittel mit verbesserter bioverfügbarkeit
RO120196B1 (ro) * 1996-09-20 2005-10-28 Meiji Seika Kaisha Ltd. Pivoxil cefditoren, sub formă cristalină, şi procedeu de preparare a acestuia
JP3413406B2 (ja) * 1998-01-07 2003-06-03 明治製菓株式会社 結晶学的に安定な非晶質セファロスポリンの組成物とその製造方法

Also Published As

Publication number Publication date
EP1051978A4 (en) 2007-05-02
KR100435315B1 (ko) 2004-06-10
HK1035148A1 (en) 2001-11-16
PL341589A1 (en) 2001-04-23
PL194097B1 (pl) 2007-04-30
WO1999034832A8 (fr) 1999-10-28
CA2316841A1 (en) 1999-07-15
CZ20002542A3 (cs) 2000-12-13
IL137004A0 (en) 2001-06-14
BRPI9907084B8 (pt) 2021-05-25
BRPI9907084B1 (pt) 2017-04-25
EP1051978A1 (en) 2000-11-15
AU1784599A (en) 1999-07-26
TW587946B (en) 2004-05-21
HUP0101272A3 (en) 2002-07-29
HUP0101272A2 (hu) 2001-12-28
IL137004A (en) 2008-11-03
AU736555B2 (en) 2001-08-02
CN1151845C (zh) 2004-06-02
NZ505871A (en) 2002-10-25
CZ302082B6 (cs) 2010-09-29
TR200001903T2 (tr) 2000-11-21
US6342493B1 (en) 2002-01-29
EA002881B1 (ru) 2002-10-31
BR9907084A (pt) 2000-10-17
CA2316841C (en) 2007-11-20
US6486149B2 (en) 2002-11-26
ES2393972T8 (es) 2013-02-25
CN1290177A (zh) 2001-04-04
JP3413406B2 (ja) 2003-06-03
UA70311C2 (uk) 2004-10-15
WO1999034832A1 (fr) 1999-07-15
SK10262000A3 (sk) 2001-01-18
EP1051978B1 (en) 2012-08-22
US20020037322A1 (en) 2002-03-28
ES2393972T3 (es) 2013-01-03
PT1051978E (pt) 2012-11-20
EA200000742A1 (ru) 2001-02-26
HU230295B1 (hu) 2015-12-28
KR20010033961A (ko) 2001-04-25
SK286631B6 (sk) 2009-02-05

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