ID30238A - Komposisi-komposisi amifostin amorf yang stabil dan metode-metode untuk pembuatan dan penggunaannya - Google Patents

Komposisi-komposisi amifostin amorf yang stabil dan metode-metode untuk pembuatan dan penggunaannya

Info

Publication number
ID30238A
ID30238A IDW00200101302A ID20011302A ID30238A ID 30238 A ID30238 A ID 30238A ID W00200101302 A IDW00200101302 A ID W00200101302A ID 20011302 A ID20011302 A ID 20011302A ID 30238 A ID30238 A ID 30238A
Authority
ID
Indonesia
Prior art keywords
amorf
amifostin
compositions
stable
making
Prior art date
Application number
IDW00200101302A
Other languages
English (en)
Inventor
Stogniew Martin
Javad M Zadel
Original Assignee
Us Bioscience
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Bioscience filed Critical Us Bioscience
Publication of ID30238A publication Critical patent/ID30238A/id

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IDW00200101302A 1998-11-16 1999-11-15 Komposisi-komposisi amifostin amorf yang stabil dan metode-metode untuk pembuatan dan penggunaannya ID30238A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/192,933 US6407278B2 (en) 1998-11-16 1998-11-16 Stable amorphous amifostine compositions and methods for the preparation and use of the same

Publications (1)

Publication Number Publication Date
ID30238A true ID30238A (id) 2001-11-15

Family

ID=22711626

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW00200101302A ID30238A (id) 1998-11-16 1999-11-15 Komposisi-komposisi amifostin amorf yang stabil dan metode-metode untuk pembuatan dan penggunaannya

Country Status (16)

Country Link
US (1) US6407278B2 (id)
EP (1) EP1131103A1 (id)
JP (1) JP4703854B2 (id)
KR (1) KR20010101015A (id)
CN (1) CN1195549C (id)
AU (1) AU1725500A (id)
BR (1) BR9915379A (id)
CA (1) CA2350815C (id)
CZ (1) CZ20011722A3 (id)
HK (1) HK1041639B (id)
HU (1) HUP0104372A2 (id)
ID (1) ID30238A (id)
MX (1) MXPA01004867A (id)
PL (1) PL347691A1 (id)
SK (1) SK6672001A3 (id)
WO (1) WO2000029025A1 (id)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
US6384259B1 (en) * 1998-11-16 2002-05-07 Medimmune Oncology, Inc. Stable amorphous amifostine compositions and dosage form
DE10043170C2 (de) * 2000-09-01 2002-10-24 Klinge Co Chem Pharm Fab Amifostin-Monohydrat und Verfahren zu seiner Herstellung
MXPA04007328A (es) * 2002-02-01 2005-07-05 Shimoda Biotech Pty Ltd Composicion farmaceutica.
US7629333B2 (en) * 2002-03-29 2009-12-08 Medimmune, Llc Stable amorphous amifostine compositions and methods for the preparation and use of same
US20030215394A1 (en) * 2002-05-17 2003-11-20 Short Robert E. Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
SI21302A (sl) * 2002-10-11 2004-04-30 LEK farmacevtska dru�ba d.d. Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino
US20050049209A1 (en) * 2003-08-06 2005-03-03 Chen Andrew Xian Pharmaceutical compositions for delivering macrolides
CN100563658C (zh) 2003-11-14 2009-12-02 味之素株式会社 苯丙氨酸衍生物的固体分散体或固体分散体医药制剂
JP4526838B2 (ja) * 2004-03-04 2010-08-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 配合適性試験用試料の調製方法及びそれに用いるキット
WO2006044738A2 (en) * 2004-10-18 2006-04-27 Maroon Biotech Corporation Methods and compositions for treatment of free radical injury
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
JPWO2007108463A1 (ja) * 2006-03-23 2009-08-06 塩野義製薬株式会社 溶解性が改善された固形製剤
US8815833B2 (en) * 2006-11-09 2014-08-26 Seidose, LLC Stable amifostine liquid concentrate
WO2008119032A1 (en) 2007-03-27 2008-10-02 Perscitus Biosciences, Llc Compositions and methods for protecting cells from toxic exposures
JPWO2009038112A1 (ja) 2007-09-21 2011-01-06 塩野義製薬株式会社 Ｎｐｙｙ５受容体拮抗剤を含有する固形製剤
CN101347412B (zh) * 2008-09-02 2011-07-27 大连美罗药业股份有限公司 三水合氨磷汀结晶冻干制剂及其制备方法
JP5563528B2 (ja) * 2010-06-29 2014-07-30 高田製薬株式会社 ニコチン酸アミドを含有するゲムシタビン凍結乾燥製剤
CN102286019B (zh) * 2011-07-11 2014-02-05 大连美罗大药厂 二水合3-氨基丙基胺乙基硫代磷酸的制备方法
CN104744478B (zh) * 2015-03-20 2016-08-24 中国人民解放军第二军医大学 一种防治辐射损伤的化合物、单晶及其制备方法和应用
EP3330251A1 (en) * 2016-11-30 2018-06-06 Clevexel Pharma Process for the preparation of freeze-dried 2-[(3-aminopropyl)amino]ethanethiol
CN113164420A (zh) * 2018-10-01 2021-07-23 温特穆特生物医学公司 治疗组合物
CN110755373B (zh) * 2019-11-18 2020-09-08 扬子江药业集团广州海瑞药业有限公司 一种盐酸法舒地尔注射液药物组合物及制备方法
CN116283682B (zh) * 2023-02-21 2024-08-02 梯尔希（南京）药物研发有限公司 一种同位素标记的氨磷汀代谢物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892824A (en) 1968-12-16 1975-07-01 Southern Res Inst S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates
JPS6041676B2 (ja) 1977-09-21 1985-09-18 山之内製薬株式会社 Ｓ−２−（３−アミノプロピルアミノ）エチルジハイドロジエンホスホロチオエ−ト１水和結晶の新規製法
US4424216A (en) 1979-07-31 1984-01-03 The Rockefeller University Method for the reduction of mucin viscosity
SG47101A1 (en) 1992-07-31 1998-03-20 Us Bioscience Crystalline amifostine compositions and methods for the preparation and use of same
US5424471A (en) * 1992-07-31 1995-06-13 U.S. Bioscience, Inc. Crystalline amifostine compositions and methods of the preparation and use of same
US5665760A (en) * 1995-09-18 1997-09-09 Sanofi Winthrop, Inc. Lyophilized thioxanthenone antitumor agents
CA2250570A1 (en) * 1996-03-26 1997-10-02 Eli Lilly And Company Formulations of ob protein
US6051563A (en) 1997-02-12 2000-04-18 U.S. Bioscience, Inc. Methods for the administration of amifostine and related compounds
US6537561B1 (en) * 1997-02-27 2003-03-25 Nippon Shinyaku Co., Ltd. Fat emulsion for oral administration

Also Published As

Publication number Publication date
WO2000029025A1 (en) 2000-05-25
AU1725500A (en) 2000-06-05
JP4703854B2 (ja) 2011-06-15
HK1041639A1 (en) 2002-07-19
CZ20011722A3 (cs) 2001-10-17
JP2002529519A (ja) 2002-09-10
US20020010357A1 (en) 2002-01-24
MXPA01004867A (es) 2003-07-21
KR20010101015A (ko) 2001-11-14
EP1131103A1 (en) 2001-09-12
HK1041639B (zh) 2005-09-30
SK6672001A3 (en) 2001-11-06
BR9915379A (pt) 2002-01-15
CN1333694A (zh) 2002-01-30
PL347691A1 (en) 2002-04-22
CA2350815A1 (en) 2000-05-25
HUP0104372A2 (hu) 2002-04-29
CN1195549C (zh) 2005-04-06
US6407278B2 (en) 2002-06-18
CA2350815C (en) 2008-10-07

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