HUT74170A - Bicyclic tetrahydro pyrazolopyridines - Google Patents

Bicyclic tetrahydro pyrazolopyridines Download PDF

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Publication number
HUT74170A
HUT74170A HU9503934A HU9503934A HUT74170A HU T74170 A HUT74170 A HU T74170A HU 9503934 A HU9503934 A HU 9503934A HU 9503934 A HU9503934 A HU 9503934A HU T74170 A HUT74170 A HU T74170A
Authority
HU
Hungary
Prior art keywords
ethyl
oxo
tetrahydro
pyridine
phenyl
Prior art date
Application number
HU9503934A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9503934D0 (en
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HU9503934D0 publication Critical patent/HU9503934D0/hu
Publication of HUT74170A publication Critical patent/HUT74170A/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU9503934A 1993-07-06 1994-06-16 Bicyclic tetrahydro pyrazolopyridines HUT74170A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8829293A 1993-07-06 1993-07-06

Publications (2)

Publication Number Publication Date
HU9503934D0 HU9503934D0 (en) 1996-03-28
HUT74170A true HUT74170A (en) 1996-11-28

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9503934A HUT74170A (en) 1993-07-06 1994-06-16 Bicyclic tetrahydro pyrazolopyridines

Country Status (20)

Country Link
EP (1) EP0707585A1 (enrdf_load_stackoverflow)
JP (1) JP2944048B2 (enrdf_load_stackoverflow)
KR (1) KR100228949B1 (enrdf_load_stackoverflow)
CN (1) CN1048015C (enrdf_load_stackoverflow)
AU (1) AU695301B2 (enrdf_load_stackoverflow)
BR (1) BR9406946A (enrdf_load_stackoverflow)
CA (1) CA2166721C (enrdf_load_stackoverflow)
CZ (1) CZ3696A3 (enrdf_load_stackoverflow)
EG (1) EG20513A (enrdf_load_stackoverflow)
FI (1) FI943208A7 (enrdf_load_stackoverflow)
HU (1) HUT74170A (enrdf_load_stackoverflow)
IL (1) IL110175A (enrdf_load_stackoverflow)
MX (1) MX9405132A (enrdf_load_stackoverflow)
NO (1) NO305029B1 (enrdf_load_stackoverflow)
NZ (1) NZ266525A (enrdf_load_stackoverflow)
PL (1) PL312426A1 (enrdf_load_stackoverflow)
RU (1) RU2131876C1 (enrdf_load_stackoverflow)
TW (1) TW316904B (enrdf_load_stackoverflow)
WO (1) WO1995001980A1 (enrdf_load_stackoverflow)
ZA (1) ZA944844B (enrdf_load_stackoverflow)

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DK0837860T3 (da) * 1995-06-06 2002-05-27 Pfizer Tricykliske 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4-triazolo-[4,3-alfa]pyridiner
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
JP3554337B2 (ja) * 1996-09-04 2004-08-18 ファイザー・インク インダゾール誘導体、およびホスホジエステラーゼ（ｐｄｅ）タイプ４と腫瘍壊死因子（ｔｎｆ）産生の阻害剤としてのインダゾール誘導体の使用
CN1167420C (zh) * 1997-09-26 2004-09-22 赞塔里斯有限公司 用于调制丝氨酸/苏氨酸蛋白激酶功能的氮杂苯并咪唑类化合物
AU759711B2 (en) 1998-12-23 2003-04-17 Bristol-Myers Squibb Holdings Ireland Unlimited Company Nitrogen containing heterobicycles as factor XA inhibitors
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
JP5038568B2 (ja) 1999-08-21 2012-10-03 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 協力剤の組合せ物
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
CN102060857A (zh) * 2000-08-10 2011-05-18 辉瑞意大利有限公司 具有激酶抑制剂活性的二环吡唑类、其制备方法和包含它们的药物组合物
HU230538B1 (hu) * 2000-08-14 2016-11-28 Ortho Mcneil Pharmaceutical, Inc. Szubsztituált pirazolok és ezeket tartalmazó gyógyszerkészítmények
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
US6750225B2 (en) 2001-04-18 2004-06-15 Bristol-Myers Squibb Pharms Company 1,4,5,6-tetrahydropyrazolo-[3,4,-c]-pyridin-7-ones useful as factor Xa inhibitors
EP1379244A4 (en) 2001-04-18 2006-03-15 Bristol Myers Squibb Co 1,4,5,6-TETRAHYDROPYRAZOLO-3,4-C] -PYRIDINE-7-ONE AS FACTOR XA HEMMER
JP4196678B2 (ja) * 2001-04-26 2008-12-17 味の素株式会社 複素環化合物
PL204653B1 (pl) * 2001-09-21 2010-01-29 Bristol Myers Squibb Co Pochodna pirazolo [3, 4-c] pirydyny, jej zastosowanie i kompozycja farmaceutyczna
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2515197C (en) 2003-02-27 2011-10-18 J. Uriach Y Compania S.A. Pyrazolopyridine derivates
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
DE102005031580A1 (de) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituierte Sulfolanylpyrazole und ihre Verwendung
AR065804A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (8)

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US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
HU183325B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
EP0068378B1 (en) * 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Also Published As

Publication number Publication date
MX9405132A (es) 1995-01-31
FI943208L (fi) 1995-01-07
JP2944048B2 (ja) 1999-08-30
TW316904B (enrdf_load_stackoverflow) 1997-10-01
CN1048015C (zh) 2000-01-05
FI943208A7 (fi) 1995-01-07
CA2166721C (en) 1999-07-27
HU9503934D0 (en) 1996-03-28
CA2166721A1 (en) 1995-01-19
ZA944844B (en) 1996-01-05
WO1995001980A1 (en) 1995-01-19
NZ266525A (en) 1997-10-24
KR960703852A (ko) 1996-08-31
EP0707585A1 (en) 1996-04-24
JPH08507084A (ja) 1996-07-30
EG20513A (en) 1999-06-30
CZ3696A3 (en) 1997-06-11
CN1129940A (zh) 1996-08-28
BR9406946A (pt) 1996-08-06
NO960056D0 (no) 1996-01-05
KR100228949B1 (ko) 1999-11-01
AU695301B2 (en) 1998-08-13
PL312426A1 (en) 1996-04-29
IL110175A (en) 2000-01-31
NO305029B1 (no) 1999-03-22
IL110175A0 (en) 1994-10-07
NO960056L (no) 1996-01-05
RU2131876C1 (ru) 1999-06-20
FI943208A0 (fi) 1994-07-05
AU6805794A (en) 1995-02-06

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Legal Events

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DFD9 Temporary protection cancelled due to non-payment of fee