FI943208A7 - Bisyklisiä tetrahydropyratsolopyridiinejä - Google Patents

Bisyklisiä tetrahydropyratsolopyridiinejä Download PDF

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Publication number
FI943208A7
FI943208A7 FI943208A FI943208A FI943208A7 FI 943208 A7 FI943208 A7 FI 943208A7 FI 943208 A FI943208 A FI 943208A FI 943208 A FI943208 A FI 943208A FI 943208 A7 FI943208 A7 FI 943208A7
Authority
FI
Finland
Prior art keywords
tetrahydropyrazolopyridines
bicyclic
bicyclic tetrahydropyrazolopyridines
Prior art date
Application number
FI943208A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943208A0 (fi
FI943208L (fi
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI943208A0 publication Critical patent/FI943208A0/fi
Publication of FI943208A7 publication Critical patent/FI943208A7/fi
Publication of FI943208L publication Critical patent/FI943208L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI943208A 1993-07-06 1994-07-05 Bisyklisiä tetrahydropyratsolopyridiinejä FI943208L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8829293A 1993-07-06 1993-07-06

Publications (3)

Publication Number Publication Date
FI943208A0 FI943208A0 (fi) 1994-07-05
FI943208A7 true FI943208A7 (fi) 1995-01-07
FI943208L FI943208L (fi) 1995-01-07

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943208A FI943208L (fi) 1993-07-06 1994-07-05 Bisyklisiä tetrahydropyratsolopyridiinejä

Country Status (20)

Country Link
EP (1) EP0707585A1 (enrdf_load_stackoverflow)
JP (1) JP2944048B2 (enrdf_load_stackoverflow)
KR (1) KR100228949B1 (enrdf_load_stackoverflow)
CN (1) CN1048015C (enrdf_load_stackoverflow)
AU (1) AU695301B2 (enrdf_load_stackoverflow)
BR (1) BR9406946A (enrdf_load_stackoverflow)
CA (1) CA2166721C (enrdf_load_stackoverflow)
CZ (1) CZ3696A3 (enrdf_load_stackoverflow)
EG (1) EG20513A (enrdf_load_stackoverflow)
FI (1) FI943208L (enrdf_load_stackoverflow)
HU (1) HUT74170A (enrdf_load_stackoverflow)
IL (1) IL110175A (enrdf_load_stackoverflow)
MX (1) MX9405132A (enrdf_load_stackoverflow)
NO (1) NO305029B1 (enrdf_load_stackoverflow)
NZ (1) NZ266525A (enrdf_load_stackoverflow)
PL (1) PL312426A1 (enrdf_load_stackoverflow)
RU (1) RU2131876C1 (enrdf_load_stackoverflow)
TW (1) TW316904B (enrdf_load_stackoverflow)
WO (1) WO1995001980A1 (enrdf_load_stackoverflow)
ZA (1) ZA944844B (enrdf_load_stackoverflow)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT77517A (hu) * 1994-10-20 1998-05-28 Pfizer Inc. Biciklusos tetrahidro-pirazolo-piridin-származékok, alkalmazásuk és ilyen vegyületeket tartalmazó gyógyászati készítmények
US6004974A (en) * 1995-06-06 1999-12-21 Pfizer Inc Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-α]pyridines
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
HUP9903248A3 (en) * 1996-09-04 2000-07-28 Pfizer Indazole derivatives and pharmaceutical compositions containing them with the effect of inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)
SK285357B6 (sk) * 1997-09-26 2006-11-03 Zentaris Gmbh Zlúčeniny na báze azabenzimidazolu modulujúce funkciu serínovej/treonínovej proteínkinázy
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
DE69921358T2 (de) * 1998-12-23 2006-03-09 Bristol-Myers Squibb Pharma Co. Stickstoffhaltige heterobicyclen als faktor-xa-hemmer
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
ATE320800T1 (de) 1999-08-21 2006-04-15 Altana Pharma Ag Synergistische kombination von roflumilast und salmeterol
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
DK1320531T3 (da) * 2000-08-10 2011-01-03 Pfizer Italia Srl Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
CA2419552C (en) * 2000-08-14 2010-10-12 Ortho-Mcneil Pharmaceutical, Inc. Substituted pyrazoles
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
EP1379245A4 (en) 2001-04-18 2006-07-26 Bristol Myers Squibb Co 1, 4, 5, 6-TETRAHYDROPYRAZOLO- 3, 4-C-PYRIDINE-7-ONE AS FACTOR XA HEMMER
US6706730B2 (en) 2001-04-18 2004-03-16 Bristol-Myers Squibb Pharma Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors
US7902179B2 (en) 2001-04-26 2011-03-08 Ajinomoto Co., Inc. Heterocyclic compounds
ATE439360T1 (de) * 2001-09-21 2009-08-15 Bristol Myers Squibb Co Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
MXPA05009069A (es) 2003-02-27 2005-10-19 Uriach Y Compania S A J Derivados de pirazolopiridina.
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
TW200618800A (en) * 2004-08-03 2006-06-16 Uriach Y Compania S A J Heterocyclic compounds
DE102005031580A1 (de) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituierte Sulfolanylpyrazole und ihre Verwendung
PE20081889A1 (es) * 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
EP2998314B1 (en) 2007-06-04 2020-01-22 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP3366698A1 (en) 2011-03-01 2018-08-29 Synergy Pharmaceuticals Inc. Guanylate cyclase c agonists
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
HK1220611A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 用於治療胃腸道病症的組成物
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2913737A1 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
EP3884935B1 (en) 2013-08-09 2023-06-14 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
US3365459A (en) 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
HU183325B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
EP0068378B1 (en) * 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Also Published As

Publication number Publication date
JP2944048B2 (ja) 1999-08-30
CZ3696A3 (en) 1997-06-11
AU695301B2 (en) 1998-08-13
EP0707585A1 (en) 1996-04-24
CN1048015C (zh) 2000-01-05
IL110175A0 (en) 1994-10-07
NO960056L (no) 1996-01-05
ZA944844B (en) 1996-01-05
BR9406946A (pt) 1996-08-06
CA2166721C (en) 1999-07-27
CA2166721A1 (en) 1995-01-19
WO1995001980A1 (en) 1995-01-19
JPH08507084A (ja) 1996-07-30
NO305029B1 (no) 1999-03-22
EG20513A (en) 1999-06-30
FI943208A0 (fi) 1994-07-05
HU9503934D0 (en) 1996-03-28
AU6805794A (en) 1995-02-06
NO960056D0 (no) 1996-01-05
HUT74170A (en) 1996-11-28
MX9405132A (es) 1995-01-31
RU2131876C1 (ru) 1999-06-20
PL312426A1 (en) 1996-04-29
CN1129940A (zh) 1996-08-28
KR960703852A (ko) 1996-08-31
KR100228949B1 (ko) 1999-11-01
FI943208L (fi) 1995-01-07
TW316904B (enrdf_load_stackoverflow) 1997-10-01
IL110175A (en) 2000-01-31
NZ266525A (en) 1997-10-24

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