HUT61543A - Process for producing serotonin antagonist indole derivatives and pharmaceutical compositions comprising same as active ingredient - Google Patents

Process for producing serotonin antagonist indole derivatives and pharmaceutical compositions comprising same as active ingredient

Info

Publication number
HUT61543A
HUT61543A HU913792A HU379291A HUT61543A HU T61543 A HUT61543 A HU T61543A HU 913792 A HU913792 A HU 913792A HU 379291 A HU379291 A HU 379291A HU T61543 A HUT61543 A HU T61543A
Authority
HU
Hungary
Prior art keywords
active ingredient
pharmaceutical compositions
same
indole derivatives
serotonin antagonist
Prior art date
Application number
HU913792A
Other languages
English (en)
Other versions
HU211081B (en
HU913792D0 (en
Inventor
Arnold Keith Dixon
Rudolf Karl Andreas Giger
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909027425A external-priority patent/GB9027425D0/en
Priority claimed from GB909027424A external-priority patent/GB9027424D0/en
Priority claimed from GB919113596A external-priority patent/GB9113596D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of HU913792D0 publication Critical patent/HU913792D0/hu
Publication of HUT61543A publication Critical patent/HUT61543A/hu
Publication of HU211081B publication Critical patent/HU211081B/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU913792A 1990-12-18 1991-12-04 Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same HU211081B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909027425A GB9027425D0 (en) 1990-12-18 1990-12-18 Improvements in or relating to organic compounds
GB909027424A GB9027424D0 (en) 1990-12-18 1990-12-18 Improvements in or relating to organic compounds
GB919113596A GB9113596D0 (en) 1991-06-24 1991-06-24 Improvements in or relating to organic compounds

Publications (3)

Publication Number Publication Date
HU913792D0 HU913792D0 (en) 1992-02-28
HUT61543A true HUT61543A (en) 1993-01-28
HU211081B HU211081B (en) 1995-10-30

Family

ID=27265408

Family Applications (1)

Application Number Title Priority Date Filing Date
HU913792A HU211081B (en) 1990-12-18 1991-12-04 Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same

Country Status (22)

Country Link
US (2) US5272154A (hu)
EP (1) EP0491664B1 (hu)
JP (1) JP2740777B2 (hu)
KR (1) KR920011489A (hu)
AT (1) ATE163648T1 (hu)
AU (1) AU651640B2 (hu)
CA (1) CA2057391A1 (hu)
CZ (1) CZ280647B6 (hu)
DE (1) DE69129009T2 (hu)
DK (1) DK0491664T3 (hu)
ES (1) ES2113368T3 (hu)
FI (1) FI102069B1 (hu)
GR (1) GR3026506T3 (hu)
HU (1) HU211081B (hu)
IE (1) IE914387A1 (hu)
IL (1) IL100384A (hu)
MX (1) MX9102582A (hu)
MY (1) MY109983A (hu)
NZ (1) NZ240993A (hu)
PT (1) PT99829B (hu)
SG (1) SG47026A1 (hu)
SK (1) SK278597B6 (hu)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69111816D1 (de) * 1990-08-31 1995-09-07 Nippon Shinyaku Co Ltd Indolederivate und ihre verwendung als serotonin-antagoniste.
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
AR036040A1 (es) 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
ATE355293T1 (de) * 2001-09-12 2006-03-15 Pharmacia & Upjohn Co Llc Substituierte 7-aza-(2.2.1)bicycloheptane für die behandlung von krankheiten
BR0213612A (pt) 2001-10-02 2004-08-24 Upjohn Co Composto, composição farmacêutica, uso do composto e método para tratamento de doença ou condição
US6849620B2 (en) 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
JP2005510492A (ja) * 2001-10-26 2005-04-21 ユニバーシティ オブ コネチカット 新規な種類の効力のあるカンナビミメティックリガンド
EP1442037A1 (en) 2001-11-09 2004-08-04 PHARMACIA &amp; UPJOHN COMPANY Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands
BR0307735A (pt) * 2002-02-19 2005-01-25 Upjohn Co Carboxamidas heteroaromáticas com ligação-n em ponte biciclìcas fundidas para o tratamento de doença
WO2003070731A2 (en) * 2002-02-19 2003-08-28 Pharmacia & Upjohn Company Azabicyclic compounds for the treatment of disease
CA2499128C (en) * 2002-09-25 2012-07-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
WO2004039815A2 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
US7396833B2 (en) * 2003-12-22 2008-07-08 Memory Pharmaceuticals Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
RU2417225C2 (ru) * 2004-03-25 2011-04-27 Мемори Фармасьютиклз Корпорейшн Индазолы, бензотиазолы, бензоизотиазолы, бензизоксазолы и их получение и применение
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ATE487716T1 (de) * 2004-04-22 2010-11-15 Memory Pharm Corp Indole, 1h-indazole, 1,2-benzisoxazole, 1,2- benzoisothiazole, deren herstellung und verwendungen
AU2005243147A1 (en) * 2004-05-07 2005-11-24 Memory Pharmaceuticals Corporation 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
JP5086091B2 (ja) * 2004-11-05 2012-11-28 セラヴァンス， インコーポレーテッド ５−ｈｔ４受容体アゴニスト化合物
JP5042028B2 (ja) * 2004-11-05 2012-10-03 セラヴァンス， インコーポレーテッド キノリノン−カルボキサミド化合物
JP2008525464A (ja) 2004-12-22 2008-07-17 メモリー・ファーマシューティカルズ・コーポレイション α−７ニコチン性受容体リガンド並びにその製造及び使用
JP5159317B2 (ja) * 2004-12-22 2013-03-06 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物
WO2006094063A1 (en) * 2005-03-02 2006-09-08 Theravance, Inc. Quinolinone compounds as 5-ht4 receptor agonists
US8106066B2 (en) * 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
KR101565469B1 (ko) * 2007-10-01 2015-11-03 코멘티스, 인코포레이티드 알츠하이머병의 치료를 위한 알파 7 니코틴 아세틸콜린 수용체 리간드로서 퀴누클리딘-4-일메틸 1ｈ-인돌-3-카르복실레이트 유도체
JOP20130213B1 (ar) 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
TW201617342A (zh) 2014-07-11 2016-05-16 阿法馬根公司 調節α７活性之啶類
PL3201203T3 (pl) 2014-09-29 2021-11-22 Takeda Pharmaceutical Company Limited Krystaliczna postać 1-(1-metylo-1h-pirazol-4-ilo)-n-((1r,5s,7s)-9-metylo-3-oksa-9-azabicyklo[3.3.1]nonan-7-ylo)-1h-indolo-3-karboksyamidu

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936675A (ja) * 1982-07-13 1984-02-28 サンド・アクチエンゲゼルシヤフト 二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
ATE86110T1 (de) * 1984-12-20 1993-03-15 Sandoz Ag Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
EP0200444B1 (en) * 1985-04-27 1992-11-11 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-ht antagonist activity
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
US4859662A (en) * 1986-11-28 1989-08-22 Glaxo Group Limited Tetrahydro-imidazolylmethylcarbazolones and analogs thereof for treating 5-HT function disturbances
DE3751404T2 (de) * 1986-12-17 1995-12-21 Glaxo Group Ltd Verwendung von heterocyclischen Verbindungen zur Behandlung von Bewusstseinsstörungen.
JPS63277622A (ja) * 1986-12-17 1988-11-15 グラクソ、グループ、リミテッド 医薬
GB8701022D0 (en) * 1987-01-19 1987-02-18 Beecham Group Plc Treatment
GB8720693D0 (en) * 1987-09-03 1987-10-07 Glaxo Group Ltd Chemical compounds
JPH01258673A (ja) * 1987-10-22 1989-10-16 Glaxo Group Ltd ケトン誘導体
EP0340270B1 (en) * 1987-11-14 1992-07-15 Beecham Group Plc 5-ht 3? receptor antagonists for treatment of cough and bronchoconstriction
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
EP0339959A3 (en) * 1988-04-27 1991-03-20 Glaxo Group Limited Lactam derivatives
GB8814277D0 (en) * 1988-06-16 1988-07-20 Glaxo Group Ltd Chemical compounds
DE68926553T2 (de) * 1988-08-02 1996-10-17 Glaxo Group Ltd., London Lactamderivate
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1228293B (it) * 1989-02-06 1991-06-07 Angeli Inst Spa Benzoderivati di composti eterociclici contenenti azoto.
GB8904551D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical compounds
NZ233285A (en) * 1989-04-18 1992-06-25 Duphar Int Res Imidazole-substituted carbamoyl-indoles and condensed analogues thereof and pharmaceutical compositions
GB8916682D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Pharmaceutical compounds

Also Published As

Publication number Publication date
KR920011489A (ko) 1992-07-24
PT99829B (pt) 2000-08-31
DE69129009T2 (de) 1998-07-23
MY109983A (en) 1997-10-31
DK0491664T3 (da) 1998-09-28
IL100384A0 (en) 1992-09-06
US5543426A (en) 1996-08-06
EP0491664B1 (en) 1998-03-04
HU211081B (en) 1995-10-30
CZ280647B6 (cs) 1996-03-13
AU8979191A (en) 1992-06-25
GR3026506T3 (en) 1998-07-31
JPH04308590A (ja) 1992-10-30
IE914387A1 (en) 1992-07-01
FI102069B (fi) 1998-10-15
IL100384A (en) 1996-05-14
US5272154A (en) 1993-12-21
CA2057391A1 (en) 1992-06-19
MX9102582A (es) 1993-01-01
AU651640B2 (en) 1994-07-28
FI102069B1 (fi) 1998-10-15
EP0491664A1 (en) 1992-06-24
HU913792D0 (en) 1992-02-28
FI915920A (fi) 1992-06-19
CS381591A3 (en) 1992-07-15
DE69129009D1 (de) 1998-04-09
PT99829A (pt) 1992-12-31
SK278597B6 (en) 1997-11-05
FI915920A0 (fi) 1991-12-16
SG47026A1 (en) 1998-03-20
JP2740777B2 (ja) 1998-04-15
ATE163648T1 (de) 1998-03-15
NZ240993A (en) 1994-08-26
ES2113368T3 (es) 1998-05-01

Similar Documents

Publication Publication Date Title
HUT61543A (en) Process for producing serotonin antagonist indole derivatives and pharmaceutical compositions comprising same as active ingredient
HUT59109A (en) Process for producing hydroxymethyl-(methylenecyclopentyl)-purines and -pyrimidines, their pharmaceutically acceptable salts and pharmaceutical compositions comprising same
MY107157A (en) Quinuclidine derivatives.
NZ225820A (en) Piperidyl substituted indole derivatives and pharmaceutical compositions
CA2123403A1 (en) Acyclic ethylenediamine derivatives as substance p receptor antagonists
UA27749C2 (uk) Заміщені циклопропіламіно-1,3,5-триазини, їх оптичні ізомери, рацемічні суміші чи їх солі приєднання нетоксичних фармацевтично прийнятних кислот, що мають фармакологічну активність, спосіб їх одержання (варіанти) та фармацевтична композиція на їх основі
OA09521A (en) Heterocyclic N-oxide derivatives of substituted benzo 5,6 cycloheptapyridines compositions and methods of use
CA2258548A1 (en) Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
SG46641A1 (en) 1,3-Substituted cycloalkenes and cycloalkanes as central nervous system agents
FI920023A0 (fi) Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
HUT61004A (en) Process for producing quinoxaline derivatives and pharmaceutical compositions comprising such compounds as active ingredient
DE69008142D1 (de) 4-Substituierten Imidazolen zur Senkung des intraokularen Druckes.
FR2669029B1 (fr) Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
HUT46664A (en) Process for producing new dihydropyridineamide derivatives and pharmaceutical compositions comprising these compounds
NO176097C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte cykloheksener
HUT68190A (en) Process for producing ergoline derivatives of serotoninergic activity
YU140491A (sh) 6-supstituisani-tetrahidrobenz(c,d) indoli
HUT57227A (en) 2&#39;-dezamino-4&#39;-desoxy-4&#39;-amino-8-fluoro-anthracycline derivatives, process for producing them as well as pharmaceutical preparatives containing said compounds as active substance
HUT45059A (en) Process for producing abeoergoline derivatives
HUT54682A (en) Process for producing 13-bromine- and 13,14-dibromine-ergoline derivatives and pharmaceutical preparatives containing these compounds
ZA924888B (en) Process for the synthesis of enantiomers of 3-aminochroman compounds
HUT60495A (en) Process for producing ergoline derivatives and pharmaceutical compositions comprising such compounds
HUT58721A (en) Process for producing indolyl derivatives and pharmaceutical compositions containing them as active components
HU893309D0 (en) Process for producing antagonists of alpha-adrenergic receptor and pharmaceutical preparatives containing these compounds
GR3020922T3 (en) Amide derivatives of 1-amino-octahydropyrido[2,1-c][1,4]oxazine, processes for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
HPC4 Succession in title of patentee

Owner name: NOVARTIS AG, CH

HMM4 Cancellation of final prot. due to non-payment of fee