DE69008142D1 - 4-Substituierten Imidazolen zur Senkung des intraokularen Druckes. - Google Patents

4-Substituierten Imidazolen zur Senkung des intraokularen Druckes.

Info

Publication number
DE69008142D1
DE69008142D1 DE69008142T DE69008142T DE69008142D1 DE 69008142 D1 DE69008142 D1 DE 69008142D1 DE 69008142 T DE69008142 T DE 69008142T DE 69008142 T DE69008142 T DE 69008142T DE 69008142 D1 DE69008142 D1 DE 69008142D1
Authority
DE
Germany
Prior art keywords
intraocular pressure
lowering intraocular
substituted imidazoles
lowering
chr3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69008142T
Other languages
English (en)
Other versions
DE69008142T2 (de
Inventor
Risto Lammintausta
Arto Karjalainen
Ewen Macdonald
Arto Urtti
Raimo Virtanen
Thomas Yorio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898925618A external-priority patent/GB8925618D0/en
Priority claimed from GB898928288A external-priority patent/GB8928288D0/en
Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy
Publication of DE69008142D1 publication Critical patent/DE69008142D1/de
Application granted granted Critical
Publication of DE69008142T2 publication Critical patent/DE69008142T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69008142T 1989-11-13 1990-11-12 4-Substituierten Imidazolen zur Senkung des intraokularen Druckes. Expired - Fee Related DE69008142T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898925618A GB8925618D0 (en) 1989-11-13 1989-11-13 Compositions and their use in lowering intraocular pressur
GB898928288A GB8928288D0 (en) 1989-12-14 1989-12-14 Compositions and their use in lowering intraocular pressure

Publications (2)

Publication Number Publication Date
DE69008142D1 true DE69008142D1 (de) 1994-05-19
DE69008142T2 DE69008142T2 (de) 1994-07-21

Family

ID=26296200

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69008142T Expired - Fee Related DE69008142T2 (de) 1989-11-13 1990-11-12 4-Substituierten Imidazolen zur Senkung des intraokularen Druckes.

Country Status (12)

Country Link
US (1) US5304569A (de)
EP (1) EP0437030B1 (de)
JP (1) JP3005035B2 (de)
AT (1) ATE104145T1 (de)
AU (1) AU624031B2 (de)
CA (1) CA2029657C (de)
DE (1) DE69008142T2 (de)
DK (1) DK0437030T3 (de)
ES (1) ES2051479T3 (de)
HU (1) HU207443B (de)
IE (1) IE64064B1 (de)
NZ (1) NZ236034A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
GB9111732D0 (en) * 1991-05-31 1991-07-24 Orion Yhtymae Oy The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US20100203165A1 (en) 2008-08-01 2010-08-12 Gerald Horn Compositions and methods for treatment of disorders or conditions of the eye
US8283350B2 (en) 2008-08-01 2012-10-09 Alpha Synergy Development, Inc. Compositions and methods for reducing capillary permeability
US8952011B2 (en) 2008-08-01 2015-02-10 Eye Therapies Llc Compositions and methods for the treatment of nasal conditions
US8987270B2 (en) 2009-07-27 2015-03-24 Eye Therapies Llc Formulations of selective alpha-2 agonists and methods of use thereof
US20110152271A1 (en) * 2009-12-17 2011-06-23 Gerald Horn Compositions and methods for ophthalmic delivery of nasal decongestants
US8445526B2 (en) 2011-02-03 2013-05-21 Glaucoma & Nasal Therapies Llc Compositions and methods for treatment of glaucoma
US20120202863A1 (en) * 2011-02-03 2012-08-09 Gerald Horn Compositions and methods for treatment of glaucoma
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
WO2013115844A1 (en) 2012-02-02 2013-08-08 Alpha Synergy Development, Inc. Compositions and methods for treatment of glaucoma
US8999938B2 (en) 2013-06-21 2015-04-07 Gnt Llc Ophthalmic lipophilic drug delivery vehicle formulations
US10772871B2 (en) 2013-10-07 2020-09-15 Teikoku Pharma Usa, Inc. Dexmedetomidine transdermal delivery devices and methods for using the same
TWI709417B (zh) 2013-10-07 2020-11-11 美商帝國製藥美國股份有限公司 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物
EP3054930B1 (de) 2013-10-07 2020-12-02 Teikoku Pharma USA, Inc. Verfahren und zusammensetzungen zur transdermalen verabreichung einer nicht-sedierenden menge an descmedetomidin
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
CA1201066A (en) * 1981-11-20 1986-02-25 Alcon Laboratories, Inc. N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure
FR2549049B1 (fr) * 1983-07-13 1986-06-20 Chauvin Blache Lab Nouvelles amidines, leur procede de preparation et leur application therapeutique

Also Published As

Publication number Publication date
ATE104145T1 (de) 1994-04-15
AU6652390A (en) 1991-05-16
DK0437030T3 (da) 1994-05-16
HUT56351A (en) 1991-08-28
AU624031B2 (en) 1992-05-28
JPH03170423A (ja) 1991-07-24
HU207443B (en) 1993-04-28
DE69008142T2 (de) 1994-07-21
ES2051479T3 (es) 1994-06-16
CA2029657A1 (en) 1991-05-14
NZ236034A (en) 1993-03-26
EP0437030B1 (de) 1994-04-13
CA2029657C (en) 2002-06-18
IE64064B1 (en) 1995-07-12
EP0437030A3 (en) 1991-10-30
IE904069A1 (en) 1991-05-22
US5304569A (en) 1994-04-19
JP3005035B2 (ja) 2000-01-31
HU907099D0 (en) 1991-05-28
EP0437030A2 (de) 1991-07-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN

8339 Ceased/non-payment of the annual fee
8327 Change in the person/name/address of the patent owner

Owner name: ORION CORP., ESPOO, FI