HUP9900459A2 - Eljárások és készítmények ligandumpár kötődésének nem fluoreszcens jelölőanyag alkalmazásával történő kimutatására - Google Patents

Eljárások és készítmények ligandumpár kötődésének nem fluoreszcens jelölőanyag alkalmazásával történő kimutatására

Info

Publication number
HUP9900459A2
HUP9900459A2 HU9900459A HUP9900459A HUP9900459A2 HU P9900459 A2 HUP9900459 A2 HU P9900459A2 HU 9900459 A HU9900459 A HU 9900459A HU P9900459 A HUP9900459 A HU P9900459A HU P9900459 A2 HUP9900459 A2 HU P9900459A2
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HU
Hungary
Prior art keywords
procedures
methods
increase
well
compositions
Prior art date
Application number
HU9900459A
Other languages
English (en)
Inventor
Jeffry Howbert
John T. Mulligan
John C. Tabone
Jeffrey Van Ness
Original Assignee
Rapigene, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rapigene, Inc. filed Critical Rapigene, Inc.
Publication of HUP9900459A2 publication Critical patent/HUP9900459A2/hu
Publication of HUP9900459A3 publication Critical patent/HUP9900459A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/167—Mass label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/627—Detection means characterised by use of a special device being a mass spectrometer

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A találmány tárgyát specifikűs jelzőtőldalékők és kapcsőlókőmpőnensekalkalmazási eljárásai képezik, azaz ligandűmpárők tagjainak egymáshőzkötődésének detektálására alkalmas eljárásők; génexpresszió biőlógiaimintában történő vizsgálatára alkalmas eljárásők; valamint az ilyeneljárásőkban alkalmazható vegyületek, készítmények és reagenskészletekképezik. A megőldás előnyösen alkalmazható vizsgálati eljárásőkspecifitásának és érzékenységének főkőzására, valamint az eljárásbanegyidejűleg vizsgálható minták számának növelésére. A megőldássegítségével javítható ilyen eljárásők jellemző példái közé tartőznak,példáűl, a standard nűkleinsav-hibridizációs reakciók, a diagnősztikaireakciók, vagy az őligőnűkleőtid-ligálási vizsgálati eljárásők, melyekgéntérképezésre, klónők karakterizálására, gyógyászati genetikaivizsgálatőkra, DNS-szekvencia-analízisre, valamint a szekvenálásellenőrzésére alkalmazhatók. ŕ
HU9900459A 1996-01-23 1997-01-23 Methods and compositions for detecting binding of ligand pair using non-fluorescent label HUP9900459A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1043696P 1996-01-23 1996-01-23
US1540296P 1996-03-21 1996-03-21

Publications (2)

Publication Number Publication Date
HUP9900459A2 true HUP9900459A2 (hu) 1999-06-28
HUP9900459A3 HUP9900459A3 (en) 1999-11-29

Family

ID=26681173

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900459A HUP9900459A3 (en) 1996-01-23 1997-01-23 Methods and compositions for detecting binding of ligand pair using non-fluorescent label

Country Status (17)

Country Link
EP (1) EP0850320B1 (hu)
JP (2) JP2000507091A (hu)
KR (2) KR100538669B1 (hu)
CN (2) CN1515541A (hu)
AT (1) ATE187501T1 (hu)
AU (1) AU717330B2 (hu)
BR (1) BR9707060A (hu)
CA (1) CA2243989A1 (hu)
CZ (1) CZ218398A3 (hu)
DE (1) DE69700902T2 (hu)
ES (1) ES2143848T3 (hu)
GR (1) GR3032843T3 (hu)
HU (1) HUP9900459A3 (hu)
NZ (1) NZ331042A (hu)
PL (1) PL328272A1 (hu)
PT (1) PT850320E (hu)
WO (1) WO1997027327A2 (hu)

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Also Published As

Publication number Publication date
DE69700902D1 (de) 2000-01-13
GR3032843T3 (en) 2000-07-31
ATE187501T1 (de) 1999-12-15
PT850320E (pt) 2000-05-31
PL328272A1 (en) 1999-01-18
AU1707997A (en) 1997-08-20
JP2000507091A (ja) 2000-06-13
EP0850320A2 (en) 1998-07-01
KR19990081923A (ko) 1999-11-15
JP2008220370A (ja) 2008-09-25
KR100538669B1 (ko) 2005-12-26
CN1212019A (zh) 1999-03-24
WO1997027327A3 (en) 1997-11-20
WO1997027327A2 (en) 1997-07-31
DE69700902T2 (de) 2000-07-20
CA2243989A1 (en) 1997-07-31
CN1159452C (zh) 2004-07-28
KR20040081811A (ko) 2004-09-22
AU717330B2 (en) 2000-03-23
KR100473903B1 (ko) 2005-09-30
ES2143848T3 (es) 2000-05-16
EP0850320B1 (en) 1999-12-08
NZ331042A (en) 1999-10-28
HUP9900459A3 (en) 1999-11-29
CN1515541A (zh) 2004-07-28
CZ218398A3 (cs) 1998-12-16
BR9707060A (pt) 1999-12-28

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