DK220890D0 - Fremgangsmaade til fremstilling af c-terminalt amiderede peptider - Google Patents

Fremgangsmaade til fremstilling af c-terminalt amiderede peptider

Info

Publication number
DK220890D0
DK220890D0 DK220890A DK220890A DK220890D0 DK 220890 D0 DK220890 D0 DK 220890D0 DK 220890 A DK220890 A DK 220890A DK 220890 A DK220890 A DK 220890A DK 220890 D0 DK220890 D0 DK 220890D0
Authority
DK
Denmark
Prior art keywords
peptides
terminally
preparation
aralkyl
cleavage
Prior art date
Application number
DK220890A
Other languages
English (en)
Inventor
Ole Buchardt
Klaus Breddam
Dennis Henriksen
Original Assignee
Ole Buchardt
Klaus Breddam
Dennis Henriksen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ole Buchardt, Klaus Breddam, Dennis Henriksen filed Critical Ole Buchardt
Priority to DK220890A priority Critical patent/DK220890D0/da
Publication of DK220890D0 publication Critical patent/DK220890D0/da
Priority to ES91916824T priority patent/ES2102405T3/es
Priority to CA002092721A priority patent/CA2092721C/en
Priority to EP91916824A priority patent/EP0548217B1/en
Priority to JP51522091A priority patent/JP3329810B2/ja
Priority to PCT/DK1991/000268 priority patent/WO1992005271A1/en
Priority to DE69125614T priority patent/DE69125614T2/de
Priority to AT91916824T priority patent/ATE151463T1/de
Priority to AU86131/91A priority patent/AU660944B2/en
Priority to DK91916824.5T priority patent/DK0548217T3/da
Priority to IE325591A priority patent/IE913255A1/en
Priority to US08/431,539 priority patent/US5580751A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
DK220890A 1990-09-14 1990-09-14 Fremgangsmaade til fremstilling af c-terminalt amiderede peptider DK220890D0 (da)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DK220890A DK220890D0 (da) 1990-09-14 1990-09-14 Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
DK91916824.5T DK0548217T3 (da) 1990-09-14 1991-09-13 Fremgangsmåde til fremstilling af C-terminalt amiderede peptider
JP51522091A JP3329810B2 (ja) 1990-09-14 1991-09-13 Ｃ−末端アミド化ペプチド化合物の製造方法
CA002092721A CA2092721C (en) 1990-09-14 1991-09-13 Process for the preparation of c-terminally amidated peptides
EP91916824A EP0548217B1 (en) 1990-09-14 1991-09-13 Process for the preparation of c-terminally amidated peptides
ES91916824T ES2102405T3 (es) 1990-09-14 1991-09-13 Procedimiento para la preparacion de peptidos amidados en el extremo c terminal.
PCT/DK1991/000268 WO1992005271A1 (en) 1990-09-14 1991-09-13 Process for the preparation of c-terminally amidated peptides
DE69125614T DE69125614T2 (de) 1990-09-14 1991-09-13 Verfahren zur herstellung c-terminal amidierter peptide
AT91916824T ATE151463T1 (de) 1990-09-14 1991-09-13 Verfahren zur herstellung c-terminal amidierter peptide
AU86131/91A AU660944B2 (en) 1990-09-14 1991-09-13 Process for the preparation of C-terminally amidated peptides
IE325591A IE913255A1 (en) 1990-09-14 1991-09-16 Process for the preparation of c-terminally amidated¹peptides
US08/431,539 US5580751A (en) 1990-09-14 1995-04-21 Process for the preparation of C-terminally amidated peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK220890A DK220890D0 (da) 1990-09-14 1990-09-14 Fremgangsmaade til fremstilling af c-terminalt amiderede peptider

Publications (1)

Publication Number Publication Date
DK220890D0 true DK220890D0 (da) 1990-09-14

Family

ID=8110810

Family Applications (2)

Application Number Title Priority Date Filing Date
DK220890A DK220890D0 (da) 1990-09-14 1990-09-14 Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
DK91916824.5T DK0548217T3 (da) 1990-09-14 1991-09-13 Fremgangsmåde til fremstilling af C-terminalt amiderede peptider

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK91916824.5T DK0548217T3 (da) 1990-09-14 1991-09-13 Fremgangsmåde til fremstilling af C-terminalt amiderede peptider

Country Status (10)

Country Link
EP (1) EP0548217B1 (da)
JP (1) JP3329810B2 (da)
AT (1) ATE151463T1 (da)
AU (1) AU660944B2 (da)
CA (1) CA2092721C (da)
DE (1) DE69125614T2 (da)
DK (2) DK220890D0 (da)
ES (1) ES2102405T3 (da)
IE (1) IE913255A1 (da)
WO (1) WO1992005271A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9407933A (pt) * 1993-11-01 1996-11-26 Japat Ltd Antagonistas de receptores de endotelina
US5801195A (en) 1994-12-30 1998-09-01 Celgene Corporation Immunotherapeutic aryl amides
NZ331042A (en) * 1996-01-23 1999-10-28 Rapigene Inc Methods and compositions for detecting binding of ligand pair using non-fluorescent label
KR100482915B1 (ko) * 1996-01-23 2005-09-12 퀴아진 지노믹스, 인코포레이티드 크기기술을사용하여핵산분자를분석하기위한방법및조성물
CN100580087C (zh) * 2003-10-10 2010-01-13 诺和诺德医疗保健公司 肽的缀合
US7524813B2 (en) 2003-10-10 2009-04-28 Novo Nordisk Health Care Ag Selectively conjugated peptides and methods of making the same
WO2006084888A2 (en) 2005-02-10 2006-08-17 Novo Nordisk A/S C-terminally pegylated growth hormones
CN101228129A (zh) 2005-04-20 2008-07-23 詹森药业有限公司 氟代吡啶n-氧化物凝血酶调节剂和含氮杂芳基化合物的n-氧化方法
DE102005046113A1 (de) * 2005-09-27 2007-03-29 Sanofi-Aventis Deutschland Gmbh Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen
KR20110039348A (ko) 2008-08-06 2011-04-15 노보 노르디스크 헬스 케어 악티엔게젤샤프트 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질
KR20110122100A (ko) 2009-01-22 2011-11-09 노보 노르디스크 헬스 케어 악티엔게젤샤프트 안정한 성장 호르몬 화합물
EP2461831B1 (en) 2009-08-06 2018-11-21 Novo Nordisk Health Care AG Growth hormones with prolonged in-vivo efficacy
CN102834109B (zh) 2010-01-22 2016-01-20 诺沃—诺迪斯克保健股份有限公司 稳定的生长激素化合物
JP5980689B2 (ja) 2010-01-22 2016-08-31 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
JP6464145B2 (ja) 2013-04-05 2019-02-06 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 成長ホルモン化合物製剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU545416B2 (en) * 1979-04-06 1985-07-11 Carlsberg Biotechnology Ltd. A/S A process for enzymatic production of peptides
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
US4708934A (en) * 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
JPS6229997A (ja) * 1985-04-08 1987-02-07 Sankyo Co Ltd Ｃ末端にプロリンアミドを有するペプチドの製法

Also Published As

Publication number Publication date
JP3329810B2 (ja) 2002-09-30
IE913255A1 (en) 1992-02-25
DE69125614D1 (de) 1997-05-15
DE69125614T2 (de) 1997-09-11
EP0548217B1 (en) 1997-04-09
ATE151463T1 (de) 1997-04-15
AU660944B2 (en) 1995-07-13
AU8613191A (en) 1992-04-15
CA2092721A1 (en) 1992-03-15
JPH06503471A (ja) 1994-04-21
EP0548217A1 (en) 1993-06-30
DK0548217T3 (da) 1997-07-28
ES2102405T3 (es) 1997-08-01
WO1992005271A1 (en) 1992-04-02
CA2092721C (en) 2002-08-13

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