HUP0401434A2 - Szulfonált mezo-tetrafenil-klorint tartalmazó fényérzékenyítő szer, eljárás az előállítására és ezt tartalmazó gyógyszerkészítmények - Google Patents
Szulfonált mezo-tetrafenil-klorint tartalmazó fényérzékenyítő szer, eljárás az előállítására és ezt tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0401434A2 HUP0401434A2 HU0401434A HUP0401434A HUP0401434A2 HU P0401434 A2 HUP0401434 A2 HU P0401434A2 HU 0401434 A HU0401434 A HU 0401434A HU P0401434 A HUP0401434 A HU P0401434A HU P0401434 A2 HUP0401434 A2 HU P0401434A2
- Authority
- HU
- Hungary
- Prior art keywords
- meso
- phenylporphyrin
- tetra
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 239000003504 photosensitizing agent Substances 0.000 title abstract 3
- YNHJECZULSZAQK-UHFFFAOYSA-N tetraphenylporphyrin Chemical class C1=CC(C(=C2C=CC(N2)=C(C=2C=CC=CC=2)C=2C=CC(N=2)=C(C=2C=CC=CC=2)C2=CC=C3N2)C=2C=CC=CC=2)=NC1=C3C1=CC=CC=C1 YNHJECZULSZAQK-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002428 photodynamic therapy Methods 0.000 abstract 1
- -1 porphyrin macrocycle Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/008—Two-Photon or Multi-Photon PDT, e.g. with upconverting dyes or photosensitisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Detergent Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
Abstract
%-5> A találmány egy szulfonált mezo-tetrafenilporfirin, előnyösendiszulfonált mezo-tetrafenilporfirin, például TPPS2a porfirin-makrociklusában lévő egyetlen kettőskötés redukálásával előállítottfényérzékenyítő anyagokra vonatkozik. A képződő szulfonált mezo-tetrafenilklorinok például olyan (I) általános képletű vegyületek,amelyek képletében X jelentése -SO3H képletű csoport; n, p, q és rértéke 0 vagy l; és n, p, q és r értékének összege 1 és 4 közöttiegész szám, előnyösen legalább 2, például 2 vagy 4, vagy ezek izomereivagy izomereinek keverékei. A találmány szerinti vegyületek és ezekgyógyászatilag elfogadható sói különösen jól alkalmazhatók molekulákfotokémiai bevitelére és fotodinamikus terápiában fényérzékenyítőanyagként. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0121023.6A GB0121023D0 (en) | 2001-08-30 | 2001-08-30 | Compound |
PCT/GB2002/003973 WO2003020309A2 (en) | 2001-08-30 | 2002-08-30 | Compound |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0401434A2 true HUP0401434A2 (hu) | 2004-12-28 |
HUP0401434A3 HUP0401434A3 (en) | 2008-05-28 |
HU229623B1 HU229623B1 (en) | 2014-03-28 |
Family
ID=9921225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0401434A HU229623B1 (en) | 2001-08-30 | 2002-08-30 | Photosensitizing agent containing sulphonated meso-tetra-phenylporphyrin |
Country Status (20)
Country | Link |
---|---|
US (2) | US7662807B2 (hu) |
EP (1) | EP1420824B1 (hu) |
JP (1) | JP5068920B2 (hu) |
KR (1) | KR100883927B1 (hu) |
CN (1) | CN100438909C (hu) |
AT (1) | ATE327768T1 (hu) |
BR (1) | BRPI0212172B8 (hu) |
CA (1) | CA2457856C (hu) |
DE (1) | DE60211918T2 (hu) |
ES (1) | ES2265047T3 (hu) |
GB (1) | GB0121023D0 (hu) |
HK (1) | HK1060974A1 (hu) |
HU (1) | HU229623B1 (hu) |
MX (1) | MXPA04001813A (hu) |
NO (1) | NO332191B1 (hu) |
NZ (1) | NZ531598A (hu) |
PL (1) | PL206900B1 (hu) |
PT (1) | PT1420824E (hu) |
RU (1) | RU2323940C2 (hu) |
WO (1) | WO2003020309A2 (hu) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0415263D0 (en) * | 2004-07-07 | 2004-08-11 | Norwegian Radium Hospital Res | Method |
FR2877943B1 (fr) * | 2004-11-16 | 2008-09-05 | Univ De Coimbra | Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique |
CN100361994C (zh) * | 2004-12-10 | 2008-01-16 | 吉林大学 | 四苯基卟啉衍生物及其在有机电致发光器件中的应用 |
GB0613753D0 (en) | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
CN101153085B (zh) * | 2006-09-25 | 2010-05-12 | 中国科学院化学研究所 | 具有可逆手性的超分子手性膜及其制备方法 |
WO2008102669A1 (ja) * | 2007-02-19 | 2008-08-28 | Rei Medical Co., Ltd. | 新規な糖連結クロリン誘導体及びその製造方法 |
GB0811955D0 (en) | 2008-06-30 | 2008-07-30 | Pci Biotech As | Method |
KR100972504B1 (ko) * | 2008-07-14 | 2010-07-26 | 김현종 | 휴대가 가능한 접철식 노트북 받침대 |
CN102159569B (zh) * | 2008-09-18 | 2016-02-03 | 拜莱泰克制药市场有限公司 | 用于pdt的不对称内消旋取代的卟啉和二氢卟酚及其应用 |
GB0819594D0 (en) | 2008-10-24 | 2008-12-03 | Univ Coimbrra | Process |
GB0914286D0 (en) * | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
GB0914287D0 (en) * | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
CN102260269B (zh) * | 2010-05-25 | 2013-11-06 | 苏州和健医药科技有限公司 | 一种含有卟啉或二氢卟吩的树状化合物及其应用 |
CN102653541B (zh) * | 2011-03-04 | 2014-01-15 | 国家纳米科学中心 | 一种卟啉化合物及其制备方法和应用 |
CN102786526B (zh) * | 2011-05-20 | 2014-07-16 | 国家纳米科学中心 | 一种卟啉-酞菁二连体及其制备方法和应用 |
US8907081B2 (en) | 2011-05-27 | 2014-12-09 | Sharp Laboratories Of America, Inc. | Long wavelength absorbing porphyrin photosensitizers for dye-sensitized solar cells |
GB201208548D0 (en) | 2012-05-15 | 2012-06-27 | Pci Biotech As | Compound and method |
CN102952143B (zh) * | 2012-11-08 | 2015-12-02 | 唐江涛 | 一种四苯基卟吩的制备方法 |
CA2906279A1 (en) * | 2013-03-15 | 2014-09-18 | Pci Biotech As | A method of generating antigen presenting cells using photochemical internalisation |
EP3038619B1 (en) | 2013-08-28 | 2023-10-04 | PCI Biotech AS | Compound and method for vaccination and immunisation |
WO2015028575A1 (en) * | 2013-08-28 | 2015-03-05 | Pci Biotech As | Immunisation method by photochemical internalisation |
AU2015308345B9 (en) | 2014-08-28 | 2020-12-24 | Pci Biotech As | Compound and method |
CN104459099B (zh) * | 2014-12-18 | 2016-04-13 | 东南大学 | 卟啉衍生物在制备检测炎症相关疾病试剂中的应用 |
GB201503776D0 (en) | 2015-03-05 | 2015-04-22 | Pci Biotech As | Compound and method |
RU2019109682A (ru) | 2016-10-14 | 2020-11-16 | ПиСиАй БИОТЕК АС | Лечение холангиокарциномы с применением tpcs-2-индуцированной фотохимической интернализации гемцитабина |
GB201718631D0 (en) | 2017-11-10 | 2017-12-27 | Pci Biotech As | Method |
EP3823668A1 (en) | 2018-07-16 | 2021-05-26 | DCPrime B.V. | A combination product for use in tumor vaccination |
WO2020217226A1 (en) | 2019-04-25 | 2020-10-29 | Dcprime B.V. | Methods of tumor vaccination |
CN112898310A (zh) * | 2019-12-03 | 2021-06-04 | 中国石油天然气股份有限公司 | 地质卟啉加氢衍生化方法、所得加氢产物及同位素分析法 |
CN115916963A (zh) | 2020-03-27 | 2023-04-04 | 门德斯有限公司 | 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途 |
EP4125943A1 (en) | 2020-03-27 | 2023-02-08 | Mendus B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
JP2023547520A (ja) | 2020-11-05 | 2023-11-10 | メンドゥス・ベスローテン・フェンノートシャップ | 免疫療法における腫瘍非依存性抗原の使用 |
AU2022235341A1 (en) | 2021-03-12 | 2023-09-21 | Mendus B.V. | Methods of vaccination and use of cd47 blockade |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU204856B (en) | 1987-08-12 | 1992-02-28 | Orszagos Mueszaki Fejlesztesi | Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates |
JPH05253466A (ja) * | 1992-03-12 | 1993-10-05 | Res Dev Corp Of Japan | 磁気異方性薄膜の製造方法 |
NO180167C (no) | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
GB9700396D0 (en) | 1997-01-10 | 1997-02-26 | Photocure As | Photochemotherapeutic compositions |
JP2000007693A (ja) * | 1998-06-26 | 2000-01-11 | Lederle Japan Ltd | クロリン誘導体 |
GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
AU4139600A (en) * | 1999-04-14 | 2000-11-14 | University Of British Columbia, The | 1,3-dipolar cycloadditions to polypyrrolic macrocycles |
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2001
- 2001-08-30 GB GBGB0121023.6A patent/GB0121023D0/en not_active Ceased
-
2002
- 2002-08-30 AT AT02753157T patent/ATE327768T1/de active
- 2002-08-30 CA CA2457856A patent/CA2457856C/en not_active Expired - Lifetime
- 2002-08-30 US US10/489,559 patent/US7662807B2/en active Active
- 2002-08-30 ES ES02753157T patent/ES2265047T3/es not_active Expired - Lifetime
- 2002-08-30 RU RU2004109228/15A patent/RU2323940C2/ru active
- 2002-08-30 PT PT02753157T patent/PT1420824E/pt unknown
- 2002-08-30 JP JP2003524616A patent/JP5068920B2/ja not_active Expired - Lifetime
- 2002-08-30 DE DE60211918T patent/DE60211918T2/de not_active Expired - Lifetime
- 2002-08-30 PL PL369289A patent/PL206900B1/pl unknown
- 2002-08-30 WO PCT/GB2002/003973 patent/WO2003020309A2/en active IP Right Grant
- 2002-08-30 CN CNB028169093A patent/CN100438909C/zh not_active Expired - Lifetime
- 2002-08-30 MX MXPA04001813A patent/MXPA04001813A/es active IP Right Grant
- 2002-08-30 HU HU0401434A patent/HU229623B1/hu unknown
- 2002-08-30 NZ NZ531598A patent/NZ531598A/en not_active IP Right Cessation
- 2002-08-30 EP EP02753157A patent/EP1420824B1/en not_active Expired - Lifetime
- 2002-08-30 BR BR0212172-7 patent/BRPI0212172B8/pt not_active IP Right Cessation
- 2002-08-30 KR KR1020047002977A patent/KR100883927B1/ko active IP Right Grant
-
2004
- 2004-02-25 NO NO20040822A patent/NO332191B1/no not_active IP Right Cessation
- 2004-06-02 HK HK04103959A patent/HK1060974A1/xx not_active IP Right Cessation
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2010
- 2010-01-19 US US12/689,327 patent/US8096419B2/en not_active Expired - Fee Related
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