HUP0400519A2 - Katalizátor aszimmetrikus (transzfer) hidrogénezéshez - Google Patents

Katalizátor aszimmetrikus (transzfer) hidrogénezéshez

Info

Publication number
HUP0400519A2
HUP0400519A2 HU0400519A HUP0400519A HUP0400519A2 HU P0400519 A2 HUP0400519 A2 HU P0400519A2 HU 0400519 A HU0400519 A HU 0400519A HU P0400519 A HUP0400519 A HU P0400519A HU P0400519 A2 HUP0400519 A2 HU P0400519A2
Authority
HU
Hungary
Prior art keywords
catalyst
hydrogenation
asymmetric
transfer
general formula
Prior art date
Application number
HU0400519A
Other languages
English (en)
Inventor
Michel Berg
Ben Feringa
Adriaan Jacobus Minnaard
Johannes Gerardus Vries
Original Assignee
Dsm Ip Assets B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B.V. filed Critical Dsm Ip Assets B.V.
Publication of HUP0400519A2 publication Critical patent/HUP0400519A2/hu
Publication of HUP0400519A3 publication Critical patent/HUP0400519A3/hu
Publication of HU229665B1 publication Critical patent/HU229665B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1845—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing phosphorus
    • B01J31/185—Phosphites ((RO)3P), their isomeric phosphonates (R(RO)2P=O) and RO-substitution derivatives thereof
    • B01J31/1855—Triamide derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657154—Cyclic esteramides of oxyacids of phosphorus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/827—Iridium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya MLaXbSc általános képletű katalizátor aszimmetrikus(transzfer) hidrogénezéshez, mely képletben M jelentése egy átmenetifém, amelyet a ródium és ruténium közül választunk ki, X jelentéseellenion és S jelentése ligandum, a jelentése 0,5-3, b és c jelentéseegymástól függetlenül 0-2, és L jelentése (I) általános képletűkirális ligandum, mely képletben Cn a két O-atommal és a P-atommalegyütt szubsztituált vagy szubsztituálatlan 2-4 szénatomos gyűrűtképez, R1 és R2 jelentése egymástól függetlenül H, adott esetbenszubsztituált alkil-, aril-, aralkil- vagy alkarilcsoport, vagy akapcsolódó N-atommal együtt egy heterociklusos gyűrűt képezhetnek. Atalálmány tárgyát képezi továbbá egy eljárás olefinesen telítetlenvegyület, keton, imin- vagy oximszármazék aszimmetrikus (transzfer)hidrogénezésére egy MLaXbSc általános képletű katalizátorral, melyképletben M jelentése átmeneti fém, melyet a ródium, irídium ésruténium közül választanak ki, X, S és L jelentése pedig a fentiekbenmegadott. A találmány szerinti katalizátorral és eljárással magasenantioszelektivitás érhető el. Ó
HU0400519A 2000-07-07 2001-07-06 Katalizátor aszimmetrikus (transzfer) hidrogénezéshez HU229665B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1015655A NL1015655C2 (nl) 2000-07-07 2000-07-07 Katalysator voor de asymmetrische hydrogenering.
PCT/NL2001/000517 WO2002004466A2 (en) 2000-07-07 2001-07-06 Catalyst for asymmetric (transfer) hydrogenation

Publications (3)

Publication Number Publication Date
HUP0400519A2 true HUP0400519A2 (hu) 2004-06-28
HUP0400519A3 HUP0400519A3 (en) 2005-10-28
HU229665B1 HU229665B1 (hu) 2014-04-28

Family

ID=19771696

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400519A HU229665B1 (hu) 2000-07-07 2001-07-06 Katalizátor aszimmetrikus (transzfer) hidrogénezéshez

Country Status (16)

Country Link
US (1) US6989461B2 (hu)
EP (1) EP1325013B1 (hu)
JP (1) JP4958374B2 (hu)
CN (3) CN1827214A (hu)
AT (1) ATE339430T1 (hu)
AU (1) AU2001271145A1 (hu)
CA (1) CA2414202C (hu)
CY (1) CY1106288T1 (hu)
CZ (1) CZ304071B6 (hu)
DE (1) DE60123093T2 (hu)
DK (1) DK1325013T3 (hu)
ES (1) ES2271043T3 (hu)
HU (1) HU229665B1 (hu)
NL (1) NL1015655C2 (hu)
PT (1) PT1325013E (hu)
WO (1) WO2002004466A2 (hu)

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KR20040024564A (ko) 2001-07-12 2004-03-20 아베시아 리미티드 마이크로캡슐화된 촉매, 이의 제조 방법 및 이의 사용 방법
EP1364932A1 (en) * 2002-05-23 2003-11-26 DSM IP Assets B.V. Process for the preparation of enantiomerically enriched compounds
WO2004024684A2 (en) * 2002-09-13 2004-03-25 Yale University Enantioselective amination and etherification
DE10247633A1 (de) * 2002-10-11 2004-04-29 Studiengesellschaft Kohle Mbh Mischungen von chiralen Monophosphor-Verbindungen als Ligandensysteme für die asymmetrische Übergangsmetallkatalyse
JP2004150960A (ja) * 2002-10-30 2004-05-27 Nichirei Corp 物性測定用プローブ
JP2006508161A (ja) * 2002-12-02 2006-03-09 ソルヴィーアス　アクチェンゲゼルシャフト 炭素−ヘテロ原子二重結合の接触水素化
WO2004078766A1 (en) * 2003-02-27 2004-09-16 Mitsubishi Chemical Corporation Optically active phosphites and phosphoramides bearing biphenol skeletons with axial chirality, and their use in catalytic asymmetric reactions
CN1309728C (zh) * 2004-07-30 2007-04-11 中国科学院上海有机化学研究所 一类手性有机－无机高分子组装体催化剂、合成方法及用途
CN100482671C (zh) * 2004-09-29 2009-04-29 中国科学院上海有机化学研究所 手性单磷配体、合成方法及其用途
JP5704786B2 (ja) * 2004-11-16 2015-04-22 ヴェロシス，インク． マイクロチャネル技術を用いる多相反応プロセス
AT501193B1 (de) * 2004-12-27 2007-03-15 Dsm Fine Chem Austria Gmbh Verfahen zur übergangsmetall - katalysierten asymmetrischen hydrierung von acrylsäurederivaten
EP1846350A2 (en) * 2005-01-27 2007-10-24 University of Nottingham Improved method for the preparation of enantiomerically enriched secondary alcohols by the addition of organoaluminium reagents to carbonyl compounds
DE102005044355A1 (de) * 2005-09-16 2007-03-22 Studiengesellschaft Kohle Mbh Chirale Phosphoramidite
US20070213540A1 (en) * 2006-03-09 2007-09-13 Degussa Ag Process for the hydrogenation of imines
JP2009046452A (ja) * 2007-08-22 2009-03-05 Erick M Carreira ホスホルアミダイト配位子およびそれを用いたアリルアミンの製造方法
CN101508702B (zh) * 2009-03-27 2012-07-04 中国科学院上海有机化学研究所 四氢喹啉和吲哚啉衍生的磷氮配体、合成方法和应用
WO2013026773A1 (en) 2011-08-19 2013-02-28 Dsm Ip Assets B.V. Synthesis of r-biphenylalaninol
GB201307049D0 (en) 2013-04-18 2013-05-29 Isis Innovation Catalysts and use thereof
DE102013107421A1 (de) * 2013-07-12 2015-01-15 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Verfahren zum asymmetrischen Hydrieren von Enolestern
EP2829546A3 (de) * 2013-07-23 2015-05-06 Evonik Industries AG Isomerisierungsarme Hydroformylierung von Ölsäureester-haltigen Gemischen
SG11201600441QA (en) * 2013-07-23 2016-02-26 Evonik Degussa Gmbh Phosphoramidite derivatives in the hydroformylation of unsaturated compounds
DE102013214378A1 (de) * 2013-07-23 2015-01-29 Evonik Industries Ag Phosphoramiditderivate in der Hydroformylierung von olefinhaltigen Gemischen
WO2015063790A1 (en) 2013-11-01 2015-05-07 Council Of Scientific And Industrial Research Catalyst for asymmetric transfer hydrogenation of ketones and imines
CN105524111B (zh) * 2016-01-25 2017-10-27 西北农林科技大学 手性亚磷酰胺单齿配体及其合成方法与应用
EP3301087A1 (en) 2016-09-30 2018-04-04 DPx Fine Chemicals Austria GmbH & Co KG Process for preparing chiral amines
CN108101785A (zh) * 2016-11-24 2018-06-01 中国科学院大连化学物理研究所 一种铱催化不对称氢化制备手性β-羟基酯的方法
JP7138106B2 (ja) 2016-12-23 2022-09-15 ノバルティス アーゲー 初期サクビトリル中間体のための新規な方法
KR20200038182A (ko) * 2018-10-02 2020-04-10 주식회사 글라세움 탄소 이중결합 함유 화합물의 비대칭 수소첨가 반응용 촉매
CN111454136A (zh) * 2019-01-22 2020-07-28 中国科学院上海高等研究院 用于催化偕二取代芳香烯烃的氢甲酰化反应的催化剂及其制备方法和用途
US20230001399A1 (en) * 2019-11-07 2023-01-05 Dsm Ip Assets B.V. New transition metal catalyst
CN111333573B (zh) * 2020-04-10 2021-09-28 浙江工业大学 一种右美沙芬中间体的制备工艺
CN111548329B (zh) * 2020-05-27 2022-06-17 浙江乐普药业股份有限公司 一种布瓦西坦的制备方法

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Also Published As

Publication number Publication date
ATE339430T1 (de) 2006-10-15
CN1440416A (zh) 2003-09-03
NL1015655C2 (nl) 2002-01-08
AU2001271145A1 (en) 2002-01-21
ES2271043T3 (es) 2007-04-16
EP1325013B1 (en) 2006-09-13
CZ304071B6 (cs) 2013-09-25
WO2002004466A3 (en) 2002-03-28
PT1325013E (pt) 2006-12-29
CN1974010A (zh) 2007-06-06
CZ200341A3 (cs) 2003-04-16
JP4958374B2 (ja) 2012-06-20
HUP0400519A3 (en) 2005-10-28
EP1325013A2 (en) 2003-07-09
WO2002004466A2 (en) 2002-01-17
CN100584460C (zh) 2010-01-27
CA2414202C (en) 2010-03-23
HU229665B1 (hu) 2014-04-28
DK1325013T3 (da) 2006-12-04
DE60123093T2 (de) 2007-03-15
US20030199713A1 (en) 2003-10-23
JP2004502543A (ja) 2004-01-29
CN1289515C (zh) 2006-12-13
CA2414202A1 (en) 2002-01-17
US6989461B2 (en) 2006-01-24
CY1106288T1 (el) 2011-10-12
DE60123093D1 (de) 2006-10-26
CN1827214A (zh) 2006-09-06

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