DE60123093D1 - Katalysator für asymmetrische hydrogenierung - Google Patents

Katalysator für asymmetrische hydrogenierung

Info

Publication number
DE60123093D1
DE60123093D1 DE60123093T DE60123093T DE60123093D1 DE 60123093 D1 DE60123093 D1 DE 60123093D1 DE 60123093 T DE60123093 T DE 60123093T DE 60123093 T DE60123093 T DE 60123093T DE 60123093 D1 DE60123093 D1 DE 60123093D1
Authority
DE
Germany
Prior art keywords
sub
sup
catalyst
atoms
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60123093T
Other languages
English (en)
Other versions
DE60123093T2 (de
Inventor
Van Den Michel Berg
Jacobus Minnaard
Ben Feringa
De Gerardus Vries
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of DE60123093D1 publication Critical patent/DE60123093D1/de
Application granted granted Critical
Publication of DE60123093T2 publication Critical patent/DE60123093T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1845—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing phosphorus
    • B01J31/185—Phosphites ((RO)3P), their isomeric phosphonates (R(RO)2P=O) and RO-substitution derivatives thereof
    • B01J31/1855—Triamide derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657154—Cyclic esteramides of oxyacids of phosphorus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/827—Iridium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60123093T 2000-07-07 2001-07-06 Katalysator für asymmetrische hydrogenierung Expired - Lifetime DE60123093T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL1015655A NL1015655C2 (nl) 2000-07-07 2000-07-07 Katalysator voor de asymmetrische hydrogenering.
NL1015655 2000-07-07
PCT/NL2001/000517 WO2002004466A2 (en) 2000-07-07 2001-07-06 Catalyst for asymmetric (transfer) hydrogenation

Publications (2)

Publication Number Publication Date
DE60123093D1 true DE60123093D1 (de) 2006-10-26
DE60123093T2 DE60123093T2 (de) 2007-03-15

Family

ID=19771696

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60123093T Expired - Lifetime DE60123093T2 (de) 2000-07-07 2001-07-06 Katalysator für asymmetrische hydrogenierung

Country Status (16)

Country Link
US (1) US6989461B2 (de)
EP (1) EP1325013B1 (de)
JP (1) JP4958374B2 (de)
CN (3) CN1827214A (de)
AT (1) ATE339430T1 (de)
AU (1) AU2001271145A1 (de)
CA (1) CA2414202C (de)
CY (1) CY1106288T1 (de)
CZ (1) CZ304071B6 (de)
DE (1) DE60123093T2 (de)
DK (1) DK1325013T3 (de)
ES (1) ES2271043T3 (de)
HU (1) HU229665B1 (de)
NL (1) NL1015655C2 (de)
PT (1) PT1325013E (de)
WO (1) WO2002004466A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0400164A2 (hu) 2001-07-12 2004-07-28 Avecia Ltd. Mikrokapszulázott katalizátor, eljárás előállítására és alkalmazása
EP1364932A1 (de) * 2002-05-23 2003-11-26 DSM IP Assets B.V. Verfahren zur Herstelling von enatiomeren angereicherten Verbindungen
US7732365B2 (en) 2002-09-13 2010-06-08 Yale University Enantioselective amination and etherification
DE10247633A1 (de) * 2002-10-11 2004-04-29 Studiengesellschaft Kohle Mbh Mischungen von chiralen Monophosphor-Verbindungen als Ligandensysteme für die asymmetrische Übergangsmetallkatalyse
JP2004150960A (ja) * 2002-10-30 2004-05-27 Nichirei Corp 物性測定用プローブ
WO2004050585A1 (en) * 2002-12-02 2004-06-17 Solvias Ag Catalytic hydrogeneration of carbon-heteroatom double bonds
WO2004078766A1 (en) * 2003-02-27 2004-09-16 Mitsubishi Chemical Corporation Optically active phosphites and phosphoramides bearing biphenol skeletons with axial chirality, and their use in catalytic asymmetric reactions
CN1309728C (zh) * 2004-07-30 2007-04-11 中国科学院上海有机化学研究所 一类手性有机－无机高分子组装体催化剂、合成方法及用途
CN100482671C (zh) * 2004-09-29 2009-04-29 中国科学院上海有机化学研究所 手性单磷配体、合成方法及其用途
CN102258968A (zh) * 2004-11-16 2011-11-30 万罗赛斯公司 使用微通道技术的多相反应方法
AT501193B1 (de) 2004-12-27 2007-03-15 Dsm Fine Chem Austria Gmbh Verfahen zur übergangsmetall - katalysierten asymmetrischen hydrierung von acrylsäurederivaten
EP1846350A2 (de) * 2005-01-27 2007-10-24 University of Nottingham Verbessertes verfahren zur herstellung von enantiomeren angereichteren sekundären alkoholen durch addition von aluminiumorganischen reagenzien an carbonylverbindungen
DE102005044355A1 (de) * 2005-09-16 2007-03-22 Studiengesellschaft Kohle Mbh Chirale Phosphoramidite
US20070213540A1 (en) * 2006-03-09 2007-09-13 Degussa Ag Process for the hydrogenation of imines
JP2009046452A (ja) * 2007-08-22 2009-03-05 Erick M Carreira ホスホルアミダイト配位子およびそれを用いたアリルアミンの製造方法
CN101508702B (zh) * 2009-03-27 2012-07-04 中国科学院上海有机化学研究所 四氢喹啉和吲哚啉衍生的磷氮配体、合成方法和应用
US9139515B2 (en) 2011-08-19 2015-09-22 Dpx Holdings B.V. Synthesis of R-biphenylalaninol
GB201307049D0 (en) 2013-04-18 2013-05-29 Isis Innovation Catalysts and use thereof
DE102013107421A1 (de) * 2013-07-12 2015-01-15 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Verfahren zum asymmetrischen Hydrieren von Enolestern
SG11201600441QA (en) * 2013-07-23 2016-02-26 Evonik Degussa Gmbh Phosphoramidite derivatives in the hydroformylation of unsaturated compounds
EP2829546A3 (de) * 2013-07-23 2015-05-06 Evonik Industries AG Isomerisierungsarme Hydroformylierung von Ölsäureester-haltigen Gemischen
DE102013214378A1 (de) * 2013-07-23 2015-01-29 Evonik Industries Ag Phosphoramiditderivate in der Hydroformylierung von olefinhaltigen Gemischen
WO2015063790A1 (en) 2013-11-01 2015-05-07 Council Of Scientific And Industrial Research Catalyst for asymmetric transfer hydrogenation of ketones and imines
CN105524111B (zh) * 2016-01-25 2017-10-27 西北农林科技大学 手性亚磷酰胺单齿配体及其合成方法与应用
EP3301087A1 (de) 2016-09-30 2018-04-04 DPx Fine Chemicals Austria GmbH & Co KG Verfahren zur herstellung von chiralen aminen
CN108101785A (zh) * 2016-11-24 2018-06-01 中国科学院大连化学物理研究所 一种铱催化不对称氢化制备手性β-羟基酯的方法
JP7138106B2 (ja) 2016-12-23 2022-09-15 ノバルティス アーゲー 初期サクビトリル中間体のための新規な方法
KR20200038182A (ko) * 2018-10-02 2020-04-10 주식회사 글라세움 탄소 이중결합 함유 화합물의 비대칭 수소첨가 반응용 촉매
CN111454136A (zh) * 2019-01-22 2020-07-28 中国科学院上海高等研究院 用于催化偕二取代芳香烯烃的氢甲酰化反应的催化剂及其制备方法和用途
BR112022008568A2 (pt) * 2019-11-07 2022-08-09 Dsm Ip Assets Bv Catalisador de metal de transição
CN111333573B (zh) * 2020-04-10 2021-09-28 浙江工业大学 一种右美沙芬中间体的制备工艺
CN111548329B (zh) * 2020-05-27 2022-06-17 浙江乐普药业股份有限公司 一种布瓦西坦的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2116905A5 (fr) * 1970-12-10 1972-07-21 Inst Francais Du Petrole Nouveaux coordinats bidentes,leur fabrication et leurs applications
EP0005500B1 (de) * 1978-05-18 1981-10-07 Ciba-Geigy Ag Dioxaphosphepine, ihre Herstellung und Verwendung als Stabilisatoren für organisches Material
US4981995A (en) * 1987-03-20 1991-01-01 Varadaraj Elango Method for producing ibuprofen
AU5777300A (en) * 1999-06-30 2001-01-31 Penn State Research Foundation, The Ligands based on chiral 2-amino-2'-hydroxy-1,1'-binaphthyl and related frameworks for asymmetric catalysis
DE19936473A1 (de) * 1999-08-03 2001-02-08 Studiengesellschaft Kohle Mbh Neue chirale Phosphorliganden und ihre Verwendung in der Herstellung optisch aktiver Produkte

Also Published As

Publication number Publication date
JP4958374B2 (ja) 2012-06-20
CN1827214A (zh) 2006-09-06
CN1289515C (zh) 2006-12-13
CA2414202A1 (en) 2002-01-17
US20030199713A1 (en) 2003-10-23
WO2002004466A2 (en) 2002-01-17
EP1325013B1 (de) 2006-09-13
CN1440416A (zh) 2003-09-03
AU2001271145A1 (en) 2002-01-21
CN100584460C (zh) 2010-01-27
US6989461B2 (en) 2006-01-24
ES2271043T3 (es) 2007-04-16
EP1325013A2 (de) 2003-07-09
NL1015655C2 (nl) 2002-01-08
JP2004502543A (ja) 2004-01-29
HUP0400519A2 (hu) 2004-06-28
CY1106288T1 (el) 2011-10-12
ATE339430T1 (de) 2006-10-15
DK1325013T3 (da) 2006-12-04
CA2414202C (en) 2010-03-23
WO2002004466A3 (en) 2002-03-28
HU229665B1 (hu) 2014-04-28
CN1974010A (zh) 2007-06-06
CZ304071B6 (cs) 2013-09-25
PT1325013E (pt) 2006-12-29
DE60123093T2 (de) 2007-03-15
HUP0400519A3 (en) 2005-10-28
CZ200341A3 (cs) 2003-04-16

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