HUP0400280A2 - Peroxiszóma proliferátorral aktivált receptorokat módosító hatóanyagok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Peroxiszóma proliferátorral aktivált receptorokat módosító hatóanyagok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0400280A2
HUP0400280A2 HU0400280A HUP0400280A HUP0400280A2 HU P0400280 A2 HUP0400280 A2 HU P0400280A2 HU 0400280 A HU0400280 A HU 0400280A HU P0400280 A HUP0400280 A HU P0400280A HU P0400280 A2 HUP0400280 A2 HU P0400280A2
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HU
Hungary
Prior art keywords
group
substituted
aromatic
aliphatic
formula
Prior art date
Application number
HU0400280A
Other languages
English (en)
Inventor
Dawn Alisa Brooks
Alan M. Warshawsky
Chahrzad Montrose-Rafezadeh
Anne Reifel-Miller
Lourdes Prieto
Isabel Rojo
Jose Alfredo Martin
Maria Rosario Gonzales Garcia
Alicia Torrado
Rafael Ferritto Crespo
Carlos Lamas-Peteira
Maria Martin-Ortega Finger
Robert J. Ardecky
Original Assignee
Eli Lilly And Co.
Ligand Pharmaceuticals, Inc.
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Application filed by Eli Lilly And Co., Ligand Pharmaceuticals, Inc. filed Critical Eli Lilly And Co.
Publication of HUP0400280A2 publication Critical patent/HUP0400280A2/hu
Publication of HUP0400280A3 publication Critical patent/HUP0400280A3/hu

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    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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Abstract

A jelen találmány tárgya (I) általános képletű vegyületek, amelyképletben Ar jelentése helyettesített vagy helyettesítetlen aromáscsoport; Q jelentése kovalens kötés, -CH2-, -CH2CH2-, -CH2CH2CH2-,vagy -CH2CH2CH2CH2- képletű csoport; W jelentése helyettesített vagyhelyettesítetlen, 2-10 atomos alkilén csoport, vagy helyettesítettvagy helyettesítetlen heteroalkilén csoport, ahol a heteroalkiléncsoport 2-10 atom hosszúságú, előnyösen 2 és 7 közötti számú atomhosszúságú. Az A jelű fenilgyűrű az R1 csoport mellett, adott esetbenlegfeljebb 4 további csoporttal lehet helyettesített. R1 jelentése -(CH2)n-CH(OR2)-(CH2)mE, -(CH)=C(OR2)-(CH2)mE, -(CH2)n-CH(Y)-(CH2)mEvagy -(CH)=C(Y)-(CH2)mE képletű csoport, amelyben E jelentése COOR3képletű csoport, 1-3 szénatomos alkilcsoporttal helyettesítettnitrilcsoport, karboxamid, szulfonamid, acilszulfonamid vagy tetrazolcsoport, ahol a szulfonamid, acilszulfonamid vagy tetrazol csoportokadott esetben, egymástól függetlenül, egy vagy több alábbiak közülválasztott csoporttal helyettesítettek: 1-6 szénatomos alkilcsoport,halogénezett alkilcsoport, és arilcsoporttal helyettesített 0-4szénatomos alkilcsoport; R2 jelentése hidrogénatom, alifás csoport,helyettesített alifás csoport, halogénezett alkilcsoport,arilalkilcsoport, helyettesített arilalkil-csoport, aromás csoport,helyettesített aromás csoport, -COR4, -COOR4, -CONR5R6, -C(S)R4, -C(S)OR4 vagy -C(S)NR5R6 képletű csoport. R3 jelentése hidrogénatom,alifás csoport, helyettesített alifás csoport, aromás csoport vagyhelyettesített aromás csoport. Y jelentése oxigénatom, -CH2-, -CH2CH2-vagy -CH=CH- képletű csoport, amely az A jelű fenilgyűrű R1-hez képestorto helyzetű szénatomjához kapcsolódik; R4-R6 jelentése egymástólfüggetlenül hidrogénatom, alifás csoport, helyettesített alifáscsoport, aromás csoport vagy helyettesített aromás csoport. n és mértéke egymástól függetlenül 0, 1 vagy 2. A találmány kiterjed avegyületek előállítására és ezeket tartalmazó gyógyszerkészítményekreis. Ó
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