AU2001284660A1 - Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists - Google Patents

Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists

Info

Publication number
AU2001284660A1
AU2001284660A1 AU2001284660A AU8466001A AU2001284660A1 AU 2001284660 A1 AU2001284660 A1 AU 2001284660A1 AU 2001284660 A AU2001284660 A AU 2001284660A AU 8466001 A AU8466001 A AU 8466001A AU 2001284660 A1 AU2001284660 A1 AU 2001284660A1
Authority
AU
Australia
Prior art keywords
oxazolyl
acid derivatives
ppar agonists
arylpropionic acid
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001284660A
Inventor
Robert J Ardecky
Dawn Alisa Brooks
Alexander Glenn Godfrey
Sarah Beth Jones
Nathan Bryan Mantlo
James Ray Mccarthy
Pierre-Yves Michellys
Christopher John Rito
John. S. Tyhonas
Leonard Larry Winneroski Jr.
Yanping Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand Pharmaceuticals Inc
Eli Lilly and Co
Original Assignee
Ligand Pharmaceuticals Inc
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharmaceuticals Inc, Eli Lilly and Co filed Critical Ligand Pharmaceuticals Inc
Publication of AU2001284660A1 publication Critical patent/AU2001284660A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel compounds that are modulators of PPAR receptors, and pharmaceutically acceptable salts, solvates and hydrates thereof, processes for making the compounds, pharmaceutical compositions containing the compounds, or pharmaceutically acceptable salts, solvates and hydrates thereof
AU2001284660A 2000-08-23 2001-08-23 Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists Abandoned AU2001284660A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22745600P 2000-08-23 2000-08-23
US60227456 2000-08-23
PCT/US2001/022617 WO2002016332A1 (en) 2000-08-23 2001-08-23 Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists

Publications (1)

Publication Number Publication Date
AU2001284660A1 true AU2001284660A1 (en) 2002-03-04

Family

ID=22853183

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001284660A Abandoned AU2001284660A1 (en) 2000-08-23 2001-08-23 Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists

Country Status (10)

Country Link
US (1) US7176224B2 (en)
EP (1) EP1313717B1 (en)
JP (1) JP2004506722A (en)
AT (1) ATE375985T1 (en)
AU (1) AU2001284660A1 (en)
CA (1) CA2418134A1 (en)
DE (1) DE60131001T2 (en)
ES (1) ES2295200T3 (en)
MX (1) MXPA03001610A (en)
WO (1) WO2002016332A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE361283T1 (en) 2000-08-23 2007-05-15 Lilly Co Eli OXAZOLYLARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS
US6982278B2 (en) 2000-08-23 2006-01-03 Eli Lilly And Company Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists
BR0210190A (en) * 2001-06-07 2004-04-06 Lilly Co Eli Peroxisome Proliferator Activated Receptor Modulators
JP2005502600A (en) 2001-06-07 2005-01-27 イーライ・リリー・アンド・カンパニー Modulator of peroxisome proliferator activated receptor (PPAR)
AU2002335231B2 (en) * 2001-10-12 2008-05-08 Nippon Chemiphar Co., Ltd. Activator for peroxisome proliferator-activated receptor delta
US20050080115A1 (en) * 2002-10-28 2005-04-14 Lone Jeppesen Novel compounds, their preparation and use
CN1711084B (en) * 2002-11-08 2010-04-28 霍夫曼-拉罗奇有限公司 Substituted 4-alkoxyoxazol derivatives as PPAR agonists
US7192970B2 (en) * 2002-11-26 2007-03-20 Chipscreen Biosciences, Ltd. Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity
EP1597248B1 (en) 2003-02-14 2007-12-26 Eli Lilly And Company Sulfonamide derivatives as ppar modulators
DE102004060227B3 (en) * 2004-12-15 2006-07-20 Sanofi-Aventis Deutschland Gmbh Process for the preparation of oxazoles by condensation of aromatic aldehydes with α-ketoximes to N-oxides and subsequent reaction with activated acid derivatives
JPWO2007013694A1 (en) * 2005-07-29 2009-02-12 武田薬品工業株式会社 Phenoxyalkanoic acid compound
KR20120051670A (en) 2009-08-05 2012-05-22 다이이찌 산쿄 가부시키가이샤 Amide derivative
RU2585765C2 (en) * 2010-10-14 2016-06-10 Дайити Санкио Компани, Лимитед Acylbenzene derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
US5232945A (en) * 1992-07-20 1993-08-03 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives
US5902726A (en) * 1994-12-23 1999-05-11 Glaxo Wellcome Inc. Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
ES2202582T3 (en) 1996-02-02 2004-04-01 MERCK & CO., INC. ANTIDIABETIC AGENTS.
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
KR20000068151A (en) * 1996-08-19 2000-11-25 미즈노 마사루 Propionic acid derivatives and use thereof
EP1067109B1 (en) 1998-03-10 2009-12-09 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
DE60005973T2 (en) 1999-08-27 2004-05-13 Eli Lilly And Co., Indianapolis BIARYL-OXA (THIA) ZOL DERIVATIVES AND THEIR USE AS PPARS MODULATORS
JP4316787B2 (en) 2000-01-11 2009-08-19 壽製薬株式会社 An ether or amide derivative, a process for producing the same, and a therapeutic agent for diabetes containing the same,
ATE361283T1 (en) * 2000-08-23 2007-05-15 Lilly Co Eli OXAZOLYLARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS
US6982278B2 (en) 2000-08-23 2006-01-03 Eli Lilly And Company Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists

Also Published As

Publication number Publication date
EP1313717B1 (en) 2007-10-17
US20040138277A1 (en) 2004-07-15
WO2002016332A1 (en) 2002-02-28
US7176224B2 (en) 2007-02-13
EP1313717A1 (en) 2003-05-28
DE60131001T2 (en) 2008-07-17
ATE375985T1 (en) 2007-11-15
JP2004506722A (en) 2004-03-04
DE60131001D1 (en) 2007-11-29
MXPA03001610A (en) 2003-09-10
ES2295200T3 (en) 2008-04-16
CA2418134A1 (en) 2002-02-28

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