YU804A - Sinteza novih 4'-c-hidroksimetil nukleozida - Google Patents

Abstract

Novi derivati formule I gde je Y šestočlani ili petočlani prsten, a A je N; B, C, E i F su izabrani od CH, CO, N, NR1, C, C-R2, pri čemu je R1: H, alkil od C1 do C4 atoma, COCH3, R2 je: H, OH, halogeni, CN, NH2, COOCH3, CONH2, alkil od C1 do C4 atoma, aril ili supstituisani heterocikl; D je izabrano od: CH, CO, N, C-R2, gde je R2: H, OH, halogeni, CN, NH2, alkil od C1 do C4 atoma, aril ili supstituisani heterocikl, a R je H ili Bz. Kada je Y supstituisani heterocikl X je O, S, a R3 je H, NH2 ili CN. Nova jedinjenja su potencijalni biološki aktivni agensi.[Novel derivatives of formula 1 Where Y is hexagonal or pentagonal ring and A is N B, C, E and F are chosen from CH, CO, N, NR1, C, C-R2, where it is R1: H, alkyl from C1 to C4 atoms, COCH3, R2 is: H, OH, halogens, CN, NH2, COOCH3, CONH2, alkyl from C1 to C4 atoms, aryl or substituted heretocyclile; D is chosen from: CH, CO, N, C-R2, where R2:H, OH, halogens, CN, NH2, alkyl from C1 to C4 atoms, aryl or substituted hererocyclile, while R is H or Bz. When Y is substituted heterocyclile X is O, S, and R3 is H, NH2 or CN. Novel compounds are potential biologically active agents.