HUP0303443A2 - Eljárás imidazolszármazékok előállítására - Google Patents

Eljárás imidazolszármazékok előállítására

Info

Publication number
HUP0303443A2
HUP0303443A2 HU0303443A HUP0303443A HUP0303443A2 HU P0303443 A2 HUP0303443 A2 HU P0303443A2 HU 0303443 A HU0303443 A HU 0303443A HU P0303443 A HUP0303443 A HU P0303443A HU P0303443 A2 HUP0303443 A2 HU P0303443A2
Authority
HU
Hungary
Prior art keywords
methyl
preparation
chlorophenyl
imidazole derivatives
quinolinone
Prior art date
Application number
HU0303443A
Other languages
English (en)
Inventor
Rudy Laurent Maria Broeckx
Walter Ferdinand Maria Filliers
Stefan Marcel Herman Leurs
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HUP0303443A2 publication Critical patent/HUP0303443A2/hu
Publication of HUP0303443A3 publication Critical patent/HUP0303443A3/hu
Publication of HU230282B1 publication Critical patent/HU230282B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)

Abstract

A találmány olyan 5-szubsztituált-imidazol-származékok előállításáravonatkozik, amelyeknek farnezil-transzferázt gátló aktivitásuk van,továbbá amelyek felhasználhatók ilyen aktivitást mutató másimdazolszármazékok előállításánál mint köztitermékek. Közelebbről atalálmány tárgya eljárás a (III) képletű 4-(3-klórfenil)-6-[(4-klórfenil)hidroxi(1-metil-lH-imidazol-5-il)metil]-1-metil-2(1H)-kinolinon és gyógyászatilag elfogadható sói előállítására. A találmányértelmében úgy járnak el, hogy a (II) képletű 6-(4-klórbenzoil)-4-(3-klórfenil)-1-metil-2(H)-kinolinont egy, az alkilrészben 6-8 szénatomottartalmazó alkillítiumszármazékkal, 1-metilimidazollal és egy tri(4-6szénatomot tartalmazó)alkilszililhalogeniddel reagáltatják. Atalálmány szerinti eljárás főbb előnyei a magasabb hozamban, nagyobbtisztaságban és az ipari alkalmazhatóság szempontjából kedvezőbbreakcióparaméterekben rejlenek. Ó
HU0303443A 2001-03-12 2002-03-05 Eljárás imidazol-származékok előállítására HU230282B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01200928.8 2001-03-12
EP01200928 2001-03-12
PCT/EP2002/002459 WO2002072574A1 (en) 2001-03-12 2002-03-05 Process for the preparation of imidazole compounds

Publications (3)

Publication Number Publication Date
HUP0303443A2 true HUP0303443A2 (hu) 2004-01-28
HUP0303443A3 HUP0303443A3 (en) 2012-09-28
HU230282B1 HU230282B1 (hu) 2015-12-28

Family

ID=8180004

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303443A HU230282B1 (hu) 2001-03-12 2002-03-05 Eljárás imidazol-származékok előállítására

Country Status (32)

Country Link
US (1) US6844439B2 (hu)
EP (1) EP1373255B1 (hu)
JP (1) JP4257698B2 (hu)
KR (1) KR100849042B1 (hu)
CN (1) CN1246318C (hu)
AR (1) AR035944A1 (hu)
AT (1) ATE287882T1 (hu)
AU (1) AU2002253101B2 (hu)
BR (1) BRPI0208075B8 (hu)
CA (1) CA2438421C (hu)
CZ (1) CZ300622B6 (hu)
DE (1) DE60202755T2 (hu)
DK (1) DK1373255T3 (hu)
EA (1) EA006770B1 (hu)
EE (1) EE05247B1 (hu)
ES (1) ES2236505T3 (hu)
HK (1) HK1063315A1 (hu)
HR (1) HRP20030695B1 (hu)
HU (1) HU230282B1 (hu)
IL (2) IL157839A0 (hu)
MX (1) MXPA03008205A (hu)
MY (1) MY124838A (hu)
NO (1) NO324954B1 (hu)
NZ (1) NZ528620A (hu)
PL (1) PL208238B1 (hu)
PT (1) PT1373255E (hu)
SI (1) SI1373255T1 (hu)
SK (1) SK287807B6 (hu)
TW (1) TWI249532B (hu)
UA (1) UA74871C2 (hu)
WO (1) WO2002072574A1 (hu)
ZA (1) ZA200307117B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2291455T3 (es) 2001-03-12 2008-03-01 Avanir Pharmaceuticals Compuestos de bencimidazol para modular ige e inhibir la proliferacion celular.
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
AU2003270426A1 (en) 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
JP2007538004A (ja) * 2004-03-18 2007-12-27 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド シヌクレイノパチーを治療する方法
US7524961B2 (en) 2004-05-03 2009-04-28 Janssen Pharmaceutica, N.V. Diastereoselective addition of lithiated N-methylimidazole on sulfinimines
JP4917022B2 (ja) * 2004-05-03 2012-04-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ６−ブロモ−４−（３−クロロフェニル）−２−メトキシ−キノリンを用いるジアステレオ選択的合成方法
ATE397600T1 (de) 2004-05-03 2008-06-15 Janssen Pharmaceutica Nv Diastereoselektives syntheseverfahren zur herstellung vn imidazolverbindungen
EP1968591A4 (en) 2005-12-23 2010-02-17 Link Medicine Corp TREATMENT OF SYNUCLEINOPATHIES
US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
KR101044430B1 (ko) * 2009-09-25 2011-06-27 듀오백코리아 주식회사 요추받이를 포함하는 의자의 등 지지 장치
KR101107900B1 (ko) * 2009-10-21 2012-01-25 성용기업 주식회사 의자용 허리지지장치
PT3277842T (pt) 2015-08-17 2019-09-05 Kura Oncology Inc Métodos de tratamento de doentes com cancro usando inibidores da farnesiltransferase
EP3838275A1 (en) 2016-11-03 2021-06-23 Kura Oncology, Inc. Farnesyltransferase inhibitors for use in methods of treating cancer
US10954210B2 (en) 2016-12-08 2021-03-23 Hangzhou Solipharma Co., Ltd. Crystal form of tipifarnib and preparation method and pharmaceutical composition thereof
AU2019270163A1 (en) * 2018-05-18 2020-12-03 Kura Oncology, Inc. Synthesis of tipifarnib

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349948B (en) 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
SI1162201T1 (sl) * 1995-12-08 2006-08-31 Janssen Pharmaceutica Nv (Imidazol-5-il)metil-2-kinolinonski derivati kot inhibitorji farnezil protein transferaze
TW591030B (en) 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
CA2288140C (en) 1997-04-25 2007-04-03 Janssen Pharmaceutica N.V. Farnesyltransferase inhibiting quinazolinones
JP3495706B2 (ja) * 1998-08-27 2004-02-09 ファイザー・プロダクツ・インク 抗癌薬として有用なアルキニル置換キノリン−２−オン誘導体
ES2237125T3 (es) 1998-08-27 2005-07-16 Pfizer Products Inc. Derivados de quinolin-2-ona utiles como agentes anticancerigenos.

Also Published As

Publication number Publication date
CN1496363A (zh) 2004-05-12
CZ300622B6 (cs) 2009-07-01
NO20034003L (no) 2003-10-22
WO2002072574A1 (en) 2002-09-19
EA200300998A1 (ru) 2004-02-26
MY124838A (en) 2006-07-31
US20040138256A1 (en) 2004-07-15
SK12462003A3 (sk) 2004-06-08
MXPA03008205A (es) 2004-01-29
BRPI0208075B8 (pt) 2021-05-25
KR20030079971A (ko) 2003-10-10
HK1063315A1 (en) 2004-12-24
ZA200307117B (en) 2004-09-13
CA2438421A1 (en) 2002-09-19
PT1373255E (pt) 2005-05-31
HRP20030695B1 (en) 2011-07-31
NO20034003D0 (no) 2003-09-10
HRP20030695A2 (en) 2005-02-28
SI1373255T1 (hu) 2005-08-31
SK287807B6 (sk) 2011-10-04
HUP0303443A3 (en) 2012-09-28
TWI249532B (en) 2006-02-21
NO324954B1 (no) 2008-01-14
CZ20032704A3 (en) 2004-03-17
AR035944A1 (es) 2004-07-28
AU2002253101B2 (en) 2007-08-09
CA2438421C (en) 2010-05-18
IL157839A (en) 2008-07-08
PL363263A1 (en) 2004-11-15
IL157839A0 (en) 2004-03-28
EE200300442A (et) 2003-12-15
EP1373255A1 (en) 2004-01-02
JP2004523575A (ja) 2004-08-05
DE60202755D1 (de) 2005-03-03
EP1373255B1 (en) 2005-01-26
BR0208075A (pt) 2004-03-02
CN1246318C (zh) 2006-03-22
PL208238B1 (pl) 2011-04-29
DK1373255T3 (da) 2005-05-23
EE05247B1 (et) 2009-12-15
KR100849042B1 (ko) 2008-07-29
ES2236505T3 (es) 2005-07-16
ATE287882T1 (de) 2005-02-15
BRPI0208075B1 (pt) 2018-02-14
US6844439B2 (en) 2005-01-18
DE60202755T2 (de) 2006-03-30
JP4257698B2 (ja) 2009-04-22
NZ528620A (en) 2005-01-28
UA74871C2 (en) 2006-02-15
EA006770B1 (ru) 2006-04-28
HU230282B1 (hu) 2015-12-28

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