MA38080A1 - Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1 - Google Patents
Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1Info
- Publication number
- MA38080A1 MA38080A1 MA38080A MA38080A MA38080A1 MA 38080 A1 MA38080 A1 MA 38080A1 MA 38080 A MA38080 A MA 38080A MA 38080 A MA38080 A MA 38080A MA 38080 A1 MA38080 A1 MA 38080A1
- Authority
- MA
- Morocco
- Prior art keywords
- pharmaceutically acceptable
- adp
- ribose
- polymerase
- poly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La présente invention concerne des nouveaux composés de formule générale (i), leurs stéréoisomères, leurs régioisomères, leurs formes tautomères et des nouveaux intermédiaires impliqués dans leur synthèse, leurs sels pharmaceutiquement acceptables, leurs solvates pharmaceutiquement acceptables et des compositions pharmaceutiques les contenant. La présente invention concerne également un procédé de préparation des nouveaux composés de formule générale (i), de leurs stéréoisomères, de leurs régioisomères, de leurs formes tautomères, de leurs sels pharmaceutiquement acceptables, de leurs solvates pharmaceutiquement acceptables, de compositions pharmaceutiques les contenant et de nouveaux intermédiaires impliqués dans leur synthèse. Les composés de formule (i) sont utiles comme inhibiteurs de parp-1 pour le traitement, par exemple, du cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3742MU2012 | 2012-12-31 | ||
| PCT/IN2013/000794 WO2014102817A1 (fr) | 2012-12-31 | 2013-12-23 | Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA38080A1 true MA38080A1 (fr) | 2018-02-28 |
Family
ID=54198806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38080A MA38080A1 (fr) | 2012-12-31 | 2013-12-23 | Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9598418B2 (fr) |
| EP (1) | EP2938598B1 (fr) |
| JP (1) | JP5930452B2 (fr) |
| KR (1) | KR101652654B1 (fr) |
| CN (1) | CN104918917A (fr) |
| AP (1) | AP2015008439A0 (fr) |
| AR (1) | AR094299A1 (fr) |
| AU (1) | AU2013368842B2 (fr) |
| BR (1) | BR112015012425A2 (fr) |
| CA (1) | CA2890309A1 (fr) |
| CL (1) | CL2015001655A1 (fr) |
| CO (1) | CO7400872A2 (fr) |
| DK (1) | DK2938598T3 (fr) |
| EA (1) | EA201591239A1 (fr) |
| ES (1) | ES2614885T3 (fr) |
| GE (1) | GEP201706691B (fr) |
| HK (1) | HK1210466A1 (fr) |
| HR (1) | HRP20170219T1 (fr) |
| HU (1) | HUE030613T2 (fr) |
| IL (1) | IL238714A0 (fr) |
| MA (1) | MA38080A1 (fr) |
| MX (1) | MX2015006780A (fr) |
| NZ (1) | NZ708255A (fr) |
| PH (1) | PH12015501199A1 (fr) |
| PL (1) | PL2938598T3 (fr) |
| PT (1) | PT2938598T (fr) |
| SG (1) | SG11201503670YA (fr) |
| TW (1) | TWI553005B (fr) |
| WO (1) | WO2014102817A1 (fr) |
| ZA (1) | ZA201503218B (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| PT3074400T (pt) | 2013-11-26 | 2018-01-22 | Hoffmann La Roche | Novo octahidro-ciclobuta [1,2-c;3,4-c']dipirrol-2-il |
| EP3590939A1 (fr) | 2014-03-26 | 2020-01-08 | F. Hoffmann-La Roche AG | Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique |
| WO2016187620A2 (fr) | 2015-05-21 | 2016-11-24 | The Regents Of The University Of California | Composés anti-cancereux |
| AU2016316717B2 (en) | 2015-09-04 | 2021-02-18 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| JP6845230B2 (ja) | 2015-09-24 | 2021-03-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 |
| KR20180054635A (ko) * | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서 이환형 화합물 |
| CN107922415B (zh) * | 2015-09-24 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 新的作为双重atx/ca抑制剂的二环化合物 |
| MX2018002217A (es) | 2015-09-24 | 2018-03-23 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de autotaxina (atx). |
| CN107428762B (zh) * | 2015-10-30 | 2020-03-10 | 四川科伦博泰生物医药股份有限公司 | 酞嗪酮衍生物、其制备方法及用途 |
| WO2017101796A1 (fr) * | 2015-12-16 | 2017-06-22 | 四川科伦博泰生物医药股份有限公司 | Dérivé de phtalazinone, et procédé de préparation et utilisation associés |
| SG11201811393WA (en) | 2016-06-24 | 2019-01-30 | Univ California | Phthalazine derivatives as inhibitors of parp1, parp2 and/or tubulin useful for the treatment of cancer |
| CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
| BR112019019017A2 (pt) | 2017-03-16 | 2020-04-14 | Hoffmann La Roche | compostos heterocíclicos de utilidade como inibidores duplos de atx/ca |
| PT3448859T (pt) | 2017-03-20 | 2019-10-25 | Forma Therapeutics Inc | Composições de pirrolopirrole como ativadores de piruvato quinase (pkr). |
| CN109251204A (zh) * | 2017-07-13 | 2019-01-22 | 中国药科大学 | 含有酞嗪-1(2h)-酮结构的parp抑制剂、其制法及医药用途 |
| CN108164468B (zh) * | 2018-02-09 | 2021-02-02 | 上海卫岑医药科技有限公司 | 一种parp抑制剂、其药物组合物、制备方法及应用 |
| CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
| EP3853206B1 (fr) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Traitement de la drépanocytose avec un composé activant la pyruvate kinase r |
| US20230159469A1 (en) * | 2020-05-08 | 2023-05-25 | Txinno Bioscience Inc. | Novel phthalazine derivative having ectonucloeotide pyrophosphatase/phosphodieste rase inhibitory activity, and use thereof |
| EP4304720A1 (fr) * | 2021-03-11 | 2024-01-17 | Mirati Therapeutics, Inc. | Inhibiteurs de prmt5 coopératif à base de mta |
| EP4370125A1 (fr) * | 2021-07-16 | 2024-05-22 | Oregon Health and Science University | Inhibiteurs de parp-1 à base de phtalazinone |
| WO2023174250A1 (fr) * | 2022-03-15 | 2023-09-21 | Beigene , Ltd. | Dérivés de 4-(aminométhyl)-6-(1-méthyl-1h-pyrazol-4-yl) isoquinolin-1(2h)-one utilisés comme inhibiteurs de la prmt5 coopérant avec la mta |
| WO2024046420A1 (fr) * | 2022-08-31 | 2024-03-07 | 江苏恒瑞医药股份有限公司 | Composé bicyclique fusionné, son procédé de préparation et son utilisation en médecine |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6531464B1 (en) | 1999-12-07 | 2003-03-11 | Inotek Pharmaceutical Corporation | Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives |
| MXPA03003218A (es) | 2000-10-30 | 2004-12-03 | Kudos Pharm Ltd | Derivados de ftalazinona. |
| US7449464B2 (en) * | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| EP1633724B1 (fr) | 2003-03-12 | 2011-05-04 | Kudos Pharmaceuticals Limited | Derives de phtalazinone |
| AU2004312193B2 (en) | 2004-01-05 | 2008-09-25 | Astrazeneca Ab | Thiophene derivatives as CHK 1 inihibitors |
| BRPI0514632A (pt) | 2004-08-26 | 2008-06-17 | Kudos Pharm Ltd | derivados de ftalazinona 4-heteroarilmetila substituìdos |
| US20060079510A1 (en) | 2004-09-30 | 2006-04-13 | Kristoffer Hellstrand | Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis |
| MX2007012448A (es) | 2005-04-06 | 2007-10-19 | Astrazeneca Ab | Heterociclos sustituidos y su uso como inhibidores de chk1, pdk1 y pak. |
| CA2630900A1 (fr) | 2005-11-25 | 2007-05-31 | University Of Medicine And Dentistry Of New Jersey | Utilisation d'inhibiteurs du parp-1 |
| GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| TWI404716B (zh) | 2006-10-17 | 2013-08-11 | Kudos Pharm Ltd | 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物 |
| NZ598352A (en) * | 2006-12-28 | 2013-08-30 | Abbott Lab | Inhibitors of poly(adp-ribose)polymerase |
| US8466150B2 (en) * | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| BRPI0811059A2 (pt) | 2007-05-25 | 2017-05-09 | Astrazeneca Ab | combinação, composição farmacêutica, método para tratar câncer em um animal de sangue quente, e, uso de uma combinação |
| US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
| MX2010005070A (es) * | 2007-11-15 | 2010-05-24 | Angeletti P Ist Richerche Bio | Derivados de piridazinona como inhibidores de parp. |
| AR070221A1 (es) | 2008-01-23 | 2010-03-25 | Astrazeneca Ab | Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas. |
| HUE030800T2 (en) | 2008-10-07 | 2017-05-29 | Astrazeneca Uk Ltd | Pharmaceutical Form No. 514 |
| JP2013532683A (ja) | 2010-07-27 | 2013-08-19 | カディラ ヘルスケア リミティド | ポリ（ａｄｐリボース）ポリメラーゼ−１阻害剤としての、置換４−（４−フルオロ−３−（ピペラジン−１−カルボニル）ベンジル）フタラジン−１（２ｈ）−オン誘導体 |
| CN102372716A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| CN102372706A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| CN102372698A (zh) * | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| JP5699223B2 (ja) * | 2010-12-02 | 2015-04-08 | シャンハイ デュァ ノボ ファルマテック カンパニー リミテッド | 複素環誘導体、その合成法および医療用途 |
| CN102485721B (zh) | 2010-12-03 | 2015-12-09 | 曹亚 | 取代的2,3-二氮杂萘酮化合物及其用途 |
| US20140221314A1 (en) | 2011-05-31 | 2014-08-07 | Newgen Therapeutics, Inc. | Tricyclic inhibitors of poly(adp-ribose)polymerase |
| KR20140036312A (ko) | 2011-07-13 | 2014-03-25 | 산텐 세이야꾸 가부시키가이샤 | Ｐａｒｐ 저해 활성을 갖는 신규 화합물 |
| US20130053365A1 (en) | 2011-08-30 | 2013-02-28 | Biomarin Pharmaceutical, Inc. | Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp) |
| AU2011384859B2 (en) | 2011-12-31 | 2016-03-17 | Beigene, Ltd. | Fused tetra or penta-cyclic pyridophthalazinones as PARP inhibitors |
| CN103242273B (zh) | 2012-02-09 | 2015-06-03 | 中国科学院上海药物研究所 | 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途 |
| HUE029717T2 (en) | 2012-02-09 | 2017-03-28 | Merck Patent Gmbh | Tetrahydroquinazoline derivatives such as TANK (Tankirase) and PARP inhibitors |
-
2013
- 2013-12-23 PT PT138289962T patent/PT2938598T/pt unknown
- 2013-12-23 GE GEAP201313901A patent/GEP201706691B/en unknown
- 2013-12-23 MA MA38080A patent/MA38080A1/fr unknown
- 2013-12-23 AP AP2015008439A patent/AP2015008439A0/xx unknown
- 2013-12-23 CA CA2890309A patent/CA2890309A1/fr not_active Abandoned
- 2013-12-23 ES ES13828996.2T patent/ES2614885T3/es active Active
- 2013-12-23 JP JP2015550210A patent/JP5930452B2/ja not_active Expired - Fee Related
- 2013-12-23 HU HUE13828996A patent/HUE030613T2/en unknown
- 2013-12-23 PL PL13828996T patent/PL2938598T3/pl unknown
- 2013-12-23 WO PCT/IN2013/000794 patent/WO2014102817A1/fr active Application Filing
- 2013-12-23 BR BR112015012425A patent/BR112015012425A2/pt not_active IP Right Cessation
- 2013-12-23 DK DK13828996.2T patent/DK2938598T3/en active
- 2013-12-23 EP EP13828996.2A patent/EP2938598B1/fr not_active Not-in-force
- 2013-12-23 KR KR1020157017355A patent/KR101652654B1/ko active IP Right Grant
- 2013-12-23 MX MX2015006780A patent/MX2015006780A/es unknown
- 2013-12-23 US US14/647,088 patent/US9598418B2/en not_active Expired - Fee Related
- 2013-12-23 EA EA201591239A patent/EA201591239A1/ru unknown
- 2013-12-23 SG SG11201503670YA patent/SG11201503670YA/en unknown
- 2013-12-23 NZ NZ708255A patent/NZ708255A/en not_active IP Right Cessation
- 2013-12-23 AU AU2013368842A patent/AU2013368842B2/en not_active Ceased
- 2013-12-23 CN CN201380069025.0A patent/CN104918917A/zh active Pending
- 2013-12-26 TW TW102148473A patent/TWI553005B/zh not_active IP Right Cessation
- 2013-12-27 AR ARP130105054A patent/AR094299A1/es unknown
-
2015
- 2015-05-08 ZA ZA2015/03218A patent/ZA201503218B/en unknown
- 2015-05-10 IL IL238714A patent/IL238714A0/en not_active IP Right Cessation
- 2015-05-28 PH PH12015501199A patent/PH12015501199A1/en unknown
- 2015-06-03 CO CO15127891A patent/CO7400872A2/es unknown
- 2015-06-12 CL CL2015001655A patent/CL2015001655A1/es unknown
- 2015-11-13 HK HK15111208.8A patent/HK1210466A1/xx not_active IP Right Cessation
-
2017
- 2017-02-09 HR HRP20170219TT patent/HRP20170219T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA38080A1 (fr) | Dérivés substitués de phtalazin-1(2h)-one comme inhibiteurs sélectifs de la poly(adp-ribose) polymérase-1 | |
| MA32135B1 (fr) | Inhibiteurs de pim kinase et leurs procedes d'utilisation | |
| TN2009000450A1 (fr) | Derives de pyridine | |
| MA38138A1 (fr) | Dérivés inédits de quinolone | |
| MA41134B1 (fr) | Composés substitués de 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione pour le traitement et la prophylaxie des infections virales | |
| MY155653A (en) | Triazine compounds as p13 kinase and mtor inhibitors | |
| MA37712B1 (fr) | Inhibiteurs macrocycliques de virus flaviviridae | |
| MA31574B1 (fr) | Dérivés de pyrazole et leur utilisation comme inhibiteurs de raf | |
| TN2016000188A1 (fr) | Derives de purines 2,6-substitues et leur utilisation dans le traitement de troubles proliferatifs. | |
| TN2011000316A1 (fr) | Derives de sulfonamides | |
| MA32351B1 (fr) | Derives d'aminodihydrothiazine a titre d'inhibiteurs de bace pour le traitement de la maladie d'alzheimer | |
| MA38323A1 (fr) | Dérivés pyrimidone et leur utilisation dans le traitement, l'amélioration ou la prévention d'une maladie virale | |
| MA31170B1 (fr) | Dérivés de 2-amino-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine servant d'inhibiteurs de la hsp-90 pour le traitement du cancer | |
| MA33745B1 (fr) | Piperidines substituees qui accroissent l'activite de p53, et utilisation de ces composes | |
| MA27801A1 (fr) | Nouveaux composes heterocycliques pour le traitement des affections inflammatoires et allergiques, leur procede de preparation et compositions pharmaceutiques les contenant | |
| MA40225B1 (fr) | Composés dihydroisoquinolinone substitués | |
| MA37405A1 (fr) | Composés hétérocyclyle | |
| TNSN07022A1 (fr) | Derives de pyridine | |
| MA29926B1 (fr) | Derives de pyrazine | |
| MX2008013583A (es) | Compuestos del inhibidor de fosfoinositido 3-cinasa y composiciones farmaceuticas que los contienen. | |
| TN2015000547A1 (fr) | Composes heteroaromatiques et leur utilisation comme ligands de dopamine d1 | |
| MA31710B1 (fr) | (carboxylalkylenephenyl)phényloxamides, procédés pour la production de ceux-ci et utilisation de ceux-ci en tant que medicament | |
| MX2011012337A (es) | Nuevos derivados de pirimidina y su uso en el tratamiento de cancer y de otras enfermedades. | |
| NZ612909A (en) | Processes for preparing isoquinolinones and solid forms of isoquinolinones | |
| CR20200286A (es) | DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA (Divisional 2014-0294) |