HUP0303103A2 - Kondenzált pirrolokarbazolok, ezeket tartalmazó gyógyszerkészítmények és a vegyületek alkalmazása - Google Patents

Kondenzált pirrolokarbazolok, ezeket tartalmazó gyógyszerkészítmények és a vegyületek alkalmazása

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Publication number
HUP0303103A2
HUP0303103A2 HU0303103A HUP0303103A HUP0303103A2 HU P0303103 A2 HUP0303103 A2 HU P0303103A2 HU 0303103 A HU0303103 A HU 0303103A HU P0303103 A HUP0303103 A HU P0303103A HU P0303103 A2 HUP0303103 A2 HU P0303103A2
Authority
HU
Hungary
Prior art keywords
group
alkyl group
general formula
compounds
hydrogen atom
Prior art date
Application number
HU0303103A
Other languages
English (en)
Inventor
Diane E. Gingrich
Robert L. Hudkins
Original Assignee
Cephalon, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon, Inc. filed Critical Cephalon, Inc.
Publication of HUP0303103A2 publication Critical patent/HUP0303103A2/hu
Publication of HUP0303103A3 publication Critical patent/HUP0303103A3/hu
Publication of HU230128B1 publication Critical patent/HU230128B1/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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Abstract

A találmány (I) általános képletű kondenzált pirrolokarbazolokra,ezeket tartalmazó gyógyászati készítményekre és a vegyületekalkalmazására vonatkozik gyógyászati készítmények előállítására. Az (I) általános képletben R1 és R2 egymással azonos vagy egymástólkülönböző és jelentésük hidrogénatom vagy hidroxilcsoporttal vagy -OR4általános képletű csoporttal szubsztituált 1-8 szénatomosalkilcsoport, ahol R4 jelentése 1-4 szénatomos alkilcsoport,arilcsoport vagy a karboxilcsoport hidroxilcsoportjánakeltávolításával képzett aminosavmaradék; és R3 jelentése -CH2OH, -CH2OR7, -(CH2)nSR5, -(CH2)nS(O)yR5, -CH2SR5 általános képletű csoportvagy -OH, -OR5, -OR8, -CH2OR7, -S(O)yR6 vagy SR6 általános képletűcsoporttal szubsztituált 1-8 szénatomos alkílcsoport; és ahol R5jelentése 1-4 szénatomos alkilcsoport vagy arilcsoport, R6 jelentésehidrogénatom, 1-4 szénatomos alkilcsoport, 6-10 szénatomosarilcsoport; R7 jelentése hidrogénatom vagy 1-4 szénatomosalkilcsoport, R8 jelentése a karboxilcsoport hidroxilcsoportjánakeltávolításával képzett aminosavmaradék; n értéke 1-4-ig terjedő egészszám; és y értéke 1 vagy 2. Ó
HU0303103A 2000-08-25 2001-08-23 Kiválasztott kondenzált pirrolokarbazolok HU230128B1 (hu)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22780300P 2000-08-25 2000-08-25
US60/227,803 2000-08-25
US27845501P 2001-03-23 2001-03-23
US60/278,455 2001-03-23
US09/935,285 US6630500B2 (en) 2000-08-25 2001-08-22 Selected fused pyrrolocarbazoles
US09/935,285 2001-08-22
PCT/US2001/026266 WO2002017914A2 (en) 2000-08-25 2001-08-23 Fused pyrrolocarbazoles against inflammation

Publications (3)

Publication Number Publication Date
HUP0303103A2 true HUP0303103A2 (hu) 2003-12-29
HUP0303103A3 HUP0303103A3 (en) 2004-11-29
HU230128B1 HU230128B1 (hu) 2015-08-28

Family

ID=27397767

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303103A HU230128B1 (hu) 2000-08-25 2001-08-23 Kiválasztott kondenzált pirrolokarbazolok

Country Status (26)

Country Link
US (3) US6630500B2 (hu)
EP (1) EP1311263B1 (hu)
JP (1) JP5399598B2 (hu)
KR (1) KR100810190B1 (hu)
CN (1) CN1298323C (hu)
AR (1) AR034143A1 (hu)
AT (1) ATE306920T1 (hu)
AU (1) AU8520501A (hu)
BG (1) BG66103B1 (hu)
BR (1) BR0113776A (hu)
CA (1) CA2420592C (hu)
CZ (1) CZ303707B6 (hu)
DE (1) DE60114215T2 (hu)
DK (1) DK1311263T3 (hu)
EA (1) EA006371B1 (hu)
ES (1) ES2250463T3 (hu)
HK (1) HK1053989A1 (hu)
HU (1) HU230128B1 (hu)
IL (2) IL154590A0 (hu)
MX (1) MXPA03001562A (hu)
NO (1) NO325689B1 (hu)
NZ (1) NZ524288A (hu)
PL (1) PL212956B1 (hu)
SK (1) SK287498B6 (hu)
TW (1) TWI299731B (hu)
WO (1) WO2002017914A2 (hu)

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