HUP0100144A2 - Eljárás dioxo-tiazolidin-származékok előállítására - Google Patents

Eljárás dioxo-tiazolidin-származékok előállítására

Info

Publication number
HUP0100144A2
HUP0100144A2 HU0100144A HUP0100144A HUP0100144A2 HU P0100144 A2 HUP0100144 A2 HU P0100144A2 HU 0100144 A HU0100144 A HU 0100144A HU P0100144 A HUP0100144 A HU P0100144A HU P0100144 A2 HUP0100144 A2 HU P0100144A2
Authority
HU
Hungary
Prior art keywords
pharmaceutically acceptable
general formula
group
compound
optionally substituted
Prior art date
Application number
HU0100144A
Other languages
English (en)
Inventor
Robert Gordon Giles
Norman John Lewis
John Kirby Quick
Original Assignee
Smithkline Beecham Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10821570&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0100144(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc. filed Critical Smithkline Beecham Plc.
Publication of HUP0100144A2 publication Critical patent/HUP0100144A2/hu
Publication of HUP0100144A3 publication Critical patent/HUP0100144A3/hu
Publication of HU224547B1 publication Critical patent/HU224547B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány egy (I) általános képletű vegyület - amelynek képletébenA1 jelentése adott esetben szubsztituált aromás heterociklusoscsoport; R1 jelentése hidrogénatom, alkilcsoport, acilcsoport,aralkilcsoport, amelyben az arilcsoport adott esetben szubsztituált,vagy adott esetben szubsztituált arilcsoport; A2 jelentése adottesetben legfeljebb ötszörösen szubsztituált benzolgyűrű; és n értéke2, 3, 4, 5 vagy 6 -, tautomer formái, gyógyászatilag elfogadható sóiés gyógyászatilag elfogadható szolvátjai előállítási eljárásáravonatkozik, amelynek során egy (II) általános képletű vegyületet -amelynek képletében A1, R1 és A2 jelentése, valamint n értéke az (I)általános képletnél meghatározott - katalitikusan redukálnak, és amelyeljárásra az jellemző, hogy a redukciós reakciót 138 kPa (20 psi)feletti hidrogénnyomás alkalmazásával hajtják végre, és ezt követőenkívánt esetben előállítják az (I), általános képletű vegyületnek egygyógyászatilag elfogadható sóját és/vagy gyógyászatilag elfogadhatószolvátját. Ó
HU0100144A 1997-11-04 1998-10-27 Eljárás dioxo-tiazolidin-származékok előállítására HU224547B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9723295.3A GB9723295D0 (en) 1997-11-04 1997-11-04 Novel process
PCT/EP1998/006997 WO1999023095A1 (en) 1997-11-04 1998-10-27 Process for the preparation of thiazolidinedione derivatives

Publications (3)

Publication Number Publication Date
HUP0100144A2 true HUP0100144A2 (hu) 2001-08-28
HUP0100144A3 HUP0100144A3 (en) 2002-04-29
HU224547B1 HU224547B1 (hu) 2005-10-28

Family

ID=10821570

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100144A HU224547B1 (hu) 1997-11-04 1998-10-27 Eljárás dioxo-tiazolidin-származékok előállítására

Country Status (44)

Country Link
US (2) US20060106221A1 (hu)
EP (2) EP1219620A1 (hu)
JP (2) JP3723448B2 (hu)
KR (1) KR100602551B1 (hu)
CN (1) CN1160351C (hu)
AP (1) AP1519A (hu)
AR (1) AR016660A1 (hu)
AT (1) ATE238302T1 (hu)
AU (2) AU1559599A (hu)
BG (1) BG64559B1 (hu)
BR (1) BR9814622A (hu)
CA (1) CA2309461A1 (hu)
CO (1) CO5011075A1 (hu)
CZ (1) CZ297209B6 (hu)
DE (1) DE69813869T2 (hu)
DK (1) DK1028960T3 (hu)
DZ (1) DZ2637A1 (hu)
EA (1) EA002722B1 (hu)
EC (1) ECSP082712A (hu)
ES (1) ES2197519T3 (hu)
GB (1) GB9723295D0 (hu)
HK (2) HK1048804A1 (hu)
HR (1) HRP20000263B1 (hu)
HU (1) HU224547B1 (hu)
ID (1) ID24644A (hu)
IL (1) IL135898A (hu)
IN (1) IN192870B (hu)
MA (1) MA26560A1 (hu)
MY (1) MY118605A (hu)
NO (1) NO315557B1 (hu)
OA (1) OA11521A (hu)
PE (1) PE129399A1 (hu)
PL (1) PL192503B1 (hu)
PT (1) PT1028960E (hu)
RS (1) RS49793B (hu)
SA (1) SA98190820B1 (hu)
SI (1) SI1028960T1 (hu)
SK (1) SK285233B6 (hu)
TR (1) TR200001239T2 (hu)
TW (1) TW538037B (hu)
UA (1) UA56269C2 (hu)
UY (1) UY25227A1 (hu)
WO (1) WO1999023095A1 (hu)
ZA (1) ZA9810033B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091359B2 (en) 1997-11-04 2006-08-15 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives
GB9723295D0 (en) 1997-11-04 1998-01-07 Smithkline Beecham Plc Novel process
HU225919B1 (en) * 1999-12-18 2007-12-28 Richter Gedeon Nyrt Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates
GB0023971D0 (en) * 2000-09-29 2000-11-15 Smithkline Beecham Plc Novel pharmaceutical
GB0023970D0 (en) * 2000-09-29 2000-11-15 Smithkline Beecham Plc Novel pharmaceutical
AU2002366812A1 (en) * 2001-12-20 2003-07-09 Teva Pharmaceutical Industries Ltd. Hydrogenation of precursors to thiazolidinedione antihyperglycemics
GB0307259D0 (en) * 2003-03-28 2003-05-07 Glaxo Group Ltd Process
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
AR047541A1 (es) * 2004-02-13 2006-01-25 Sandoz Ag Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas
EP1745043A1 (en) * 2004-05-12 2007-01-24 Medichem S.A. Process for the preparation of rosiglitazone
CZ297266B6 (cs) * 2004-09-10 2006-10-11 Zentiva, A. S. Zpusob prípravy rosiglitazonu
CZ297347B6 (cs) * 2004-09-21 2006-11-15 Zentiva, A. S. Zpusob prípravy rosiglitazonu
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
CN102727489A (zh) * 2012-07-18 2012-10-17 西南大学 5-芳(杂环)亚甲基噻唑烷-2，4-二酮在制备ppar激动剂中的应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
US4812570A (en) 1986-07-24 1989-03-14 Takeda Chemical Industries, Ltd. Method for producing thiazolidinedione derivatives
US5260445A (en) * 1987-09-04 1993-11-09 Beecham Group P.L.C. 2,4-thiazolidinediones
US6288095B1 (en) * 1987-09-04 2001-09-11 Beecham Group P.L.C. Compounds
US5646169A (en) * 1987-09-04 1997-07-08 Beecham Group P.L.C. Compounds for treating eating disorders in which blood glucose levels are raised
US5232925A (en) * 1987-09-04 1993-08-03 Beecham Group P.L.C. Compounds
US5194443A (en) * 1987-09-04 1993-03-16 Beecham Group P.L.C. Compounds
SG59988A1 (en) * 1987-09-04 1999-02-22 Beecham Group Plc Substituted thiazolidinedione derivatives
US20020049240A1 (en) * 1994-12-19 2002-04-25 Beecham Group P.1.C. Novel compounds
GB9023583D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023585D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9124513D0 (en) * 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
US6462337B1 (en) * 2000-04-20 2002-10-08 Agilent Technologies, Inc. Mass spectrometer electrospray ionization
US5585495A (en) 1991-12-20 1996-12-17 The Upjohn Company Reduction method for substituted 5-methylene-thiazolidinediones
GB9218830D0 (en) 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
US5741803A (en) * 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
US6632947B2 (en) * 1997-02-18 2003-10-14 Smithkline Beecham Plc Process for the preparation of substituted thiazolidinedione
UY24886A1 (es) 1997-02-18 2001-08-27 Smithkline Beecham Plc Tiazolidindiona
US7091359B2 (en) * 1997-11-04 2006-08-15 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives
GB9723295D0 (en) 1997-11-04 1998-01-07 Smithkline Beecham Plc Novel process

Also Published As

Publication number Publication date
RS49793B (sr) 2008-06-05
HUP0100144A3 (en) 2002-04-29
JP2004339235A (ja) 2004-12-02
KR20010031720A (ko) 2001-04-16
HRP20000263A2 (en) 2000-12-31
US20070066662A1 (en) 2007-03-22
AP1519A (en) 2005-12-20
EP1028960B1 (en) 2003-04-23
EP1028960A1 (en) 2000-08-23
ES2197519T3 (es) 2004-01-01
SA98190820B1 (ar) 2006-10-29
OA11521A (en) 2004-02-09
CO5011075A1 (es) 2001-02-28
EA200000484A1 (ru) 2000-10-30
TW538037B (en) 2003-06-21
UA56269C2 (uk) 2003-05-15
UY25227A1 (es) 1999-05-14
YU33800A (sh) 2002-10-18
PE129399A1 (es) 2000-02-24
NO20002174D0 (no) 2000-04-27
ATE238302T1 (de) 2003-05-15
HK1048804A1 (zh) 2003-04-17
DZ2637A1 (fr) 2003-03-08
PL192503B1 (pl) 2006-10-31
ECSP082712A (es) 2008-08-29
BG64559B1 (bg) 2005-07-29
DE69813869D1 (de) 2003-05-28
BR9814622A (pt) 2000-10-03
US7351832B2 (en) 2008-04-01
TR200001239T2 (tr) 2001-07-23
CN1160351C (zh) 2004-08-04
IL135898A0 (en) 2001-05-20
MY118605A (en) 2004-12-31
AU2002300593B2 (en) 2006-03-23
HU224547B1 (hu) 2005-10-28
AU2002300593B8 (en) 2006-05-04
KR100602551B1 (ko) 2006-07-19
PL340366A1 (en) 2001-01-29
BG104505A (en) 2001-01-31
GB9723295D0 (en) 1998-01-07
AP2000001808A0 (en) 2000-06-30
NO315557B1 (no) 2003-09-22
CZ297209B6 (cs) 2006-10-11
CZ20001633A3 (cs) 2000-10-11
MA26560A1 (fr) 2004-12-20
AU1559599A (en) 1999-05-24
DK1028960T3 (da) 2003-08-11
HRP20000263B1 (en) 2009-01-31
WO1999023095A1 (en) 1999-05-14
HK1032046A1 (en) 2001-07-06
ID24644A (id) 2000-07-27
PT1028960E (pt) 2003-09-30
JP2001521937A (ja) 2001-11-13
EP1219620A1 (en) 2002-07-03
DE69813869T2 (de) 2004-01-29
CN1278818A (zh) 2001-01-03
IN192870B (hu) 2004-05-22
CA2309461A1 (en) 1999-05-14
JP3723448B2 (ja) 2005-12-07
IL135898A (en) 2005-08-31
SK6502000A3 (en) 2000-09-12
AR016660A1 (es) 2001-07-25
EA002722B1 (ru) 2002-08-29
US20060106221A1 (en) 2006-05-18
SI1028960T1 (en) 2003-10-31
NO20002174L (no) 2000-05-30
ZA9810033B (en) 2000-05-03
SK285233B6 (sk) 2006-09-07

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20050913

MM4A Lapse of definitive patent protection due to non-payment of fees