BR9814622A - Processo para a preparação de derivados de tiazolidinadiona - Google Patents
Processo para a preparação de derivados de tiazolidinadionaInfo
- Publication number
- BR9814622A BR9814622A BR9814622-0A BR9814622A BR9814622A BR 9814622 A BR9814622 A BR 9814622A BR 9814622 A BR9814622 A BR 9814622A BR 9814622 A BR9814622 A BR 9814622A
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- pharmaceutically acceptable
- group
- compound
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE TIAZOLIDINADIONA" Um processo para preparação de um composto de fórmula (I) ou uma sua forma tautomérica ou seu sal farmaceuticamente aceitável, ou um seu solvato farmaceuticamente aceítável, onde: A¹ representa um grupo hetero ciclila aromático substituído ou não-substituído; R¹ representa um átomo de hidrogênio, um grupo alquila, um grupo acila, um grupo aralquila, onde a metade arila pode estar substituída ou não-substituída, ou um grupo arila substituído ou não-substituído; A² representa um anel benzeno tendo no total até cinco substituintes; e n representa um inteiro na faixa de 2 a 6, cujo processo compreende redução catalítica de um composto de fórmula (II): onde A¹, R¹, A² e n são como definidos em relação a fórmula (I), caracterizado em que a reação de redução é realizada usando-se uma pressão de hidrogênio acima de 1,4 kgf/cm²; e a seguir, se requerido formando um sal farmaceuticamente aceitável e/ou um solvato farmaceuticamente aceitável do composto de fórmula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9723295.3A GB9723295D0 (en) | 1997-11-04 | 1997-11-04 | Novel process |
PCT/EP1998/006997 WO1999023095A1 (en) | 1997-11-04 | 1998-10-27 | Process for the preparation of thiazolidinedione derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9814622A true BR9814622A (pt) | 2000-10-03 |
Family
ID=10821570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9814622-0A BR9814622A (pt) | 1997-11-04 | 1998-10-27 | Processo para a preparação de derivados de tiazolidinadiona |
Country Status (44)
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7091359B2 (en) | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
GB9723295D0 (en) | 1997-11-04 | 1998-01-07 | Smithkline Beecham Plc | Novel process |
HU225919B1 (en) * | 1999-12-18 | 2007-12-28 | Richter Gedeon Nyrt | Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates |
GB0023971D0 (en) * | 2000-09-29 | 2000-11-15 | Smithkline Beecham Plc | Novel pharmaceutical |
GB0023970D0 (en) * | 2000-09-29 | 2000-11-15 | Smithkline Beecham Plc | Novel pharmaceutical |
EP1465881A4 (en) * | 2001-12-20 | 2005-04-13 | Teva Pharma | HYDROGENATION OF PRECURSORS OF ANTI-HYPERGLYCEMIATING THIAZOLIDINEDIONE SUBSTANCES |
GB0307259D0 (en) * | 2003-03-28 | 2003-05-07 | Glaxo Group Ltd | Process |
GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
AR047541A1 (es) * | 2004-02-13 | 2006-01-25 | Sandoz Ag | Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas |
CA2566352A1 (en) * | 2004-05-12 | 2005-11-17 | Medichem S.A. | Process for the preparation of rosiglitazone |
CZ297266B6 (cs) * | 2004-09-10 | 2006-10-11 | Zentiva, A. S. | Zpusob prípravy rosiglitazonu |
CZ297347B6 (cs) * | 2004-09-21 | 2006-11-15 | Zentiva, A. S. | Zpusob prípravy rosiglitazonu |
CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
CN102727489A (zh) * | 2012-07-18 | 2012-10-17 | 西南大学 | 5-芳(杂环)亚甲基噻唑烷-2,4-二酮在制备ppar激动剂中的应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522636A (en) | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
US4812570A (en) | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
EP0842925A1 (en) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
US5232925A (en) * | 1987-09-04 | 1993-08-03 | Beecham Group P.L.C. | Compounds |
US6288095B1 (en) * | 1987-09-04 | 2001-09-11 | Beecham Group P.L.C. | Compounds |
US5260445A (en) * | 1987-09-04 | 1993-11-09 | Beecham Group P.L.C. | 2,4-thiazolidinediones |
US5194443A (en) * | 1987-09-04 | 1993-03-16 | Beecham Group P.L.C. | Compounds |
US5646169A (en) * | 1987-09-04 | 1997-07-08 | Beecham Group P.L.C. | Compounds for treating eating disorders in which blood glucose levels are raised |
US20020049240A1 (en) * | 1994-12-19 | 2002-04-25 | Beecham Group P.1.C. | Novel compounds |
GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
GB9023583D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
US6462337B1 (en) * | 2000-04-20 | 2002-10-08 | Agilent Technologies, Inc. | Mass spectrometer electrospray ionization |
GB9124513D0 (en) * | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
EP0618915A1 (en) | 1991-12-20 | 1994-10-12 | The Upjohn Company | A reduction method for substituted 5-methylene-thiazolidinediones |
GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
US5741803A (en) * | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
UY24886A1 (es) | 1997-02-18 | 2001-08-27 | Smithkline Beecham Plc | Tiazolidindiona |
US6632947B2 (en) * | 1997-02-18 | 2003-10-14 | Smithkline Beecham Plc | Process for the preparation of substituted thiazolidinedione |
GB9723295D0 (en) | 1997-11-04 | 1998-01-07 | Smithkline Beecham Plc | Novel process |
US7091359B2 (en) * | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
-
1997
- 1997-11-04 GB GBGB9723295.3A patent/GB9723295D0/en not_active Ceased
-
1998
- 1998-10-27 PL PL340366A patent/PL192503B1/pl not_active IP Right Cessation
- 1998-10-27 DK DK98959834T patent/DK1028960T3/da active
- 1998-10-27 BR BR9814622-0A patent/BR9814622A/pt not_active Application Discontinuation
- 1998-10-27 AU AU15595/99A patent/AU1559599A/en not_active Abandoned
- 1998-10-27 OA OA1200000131A patent/OA11521A/en unknown
- 1998-10-27 SI SI9830468T patent/SI1028960T1/xx unknown
- 1998-10-27 EP EP02075969A patent/EP1219620A1/en not_active Withdrawn
- 1998-10-27 CZ CZ20001633A patent/CZ297209B6/cs not_active IP Right Cessation
- 1998-10-27 TR TR2000/01239T patent/TR200001239T2/xx unknown
- 1998-10-27 EA EA200000484A patent/EA002722B1/ru not_active IP Right Cessation
- 1998-10-27 SK SK650-2000A patent/SK285233B6/sk not_active IP Right Cessation
- 1998-10-27 JP JP2000518965A patent/JP3723448B2/ja not_active Expired - Fee Related
- 1998-10-27 HU HU0100144A patent/HU224547B1/hu not_active IP Right Cessation
- 1998-10-27 RS YUP-338/00A patent/RS49793B/sr unknown
- 1998-10-27 AP APAP/P/2000/001808A patent/AP1519A/en active
- 1998-10-27 PT PT98959834T patent/PT1028960E/pt unknown
- 1998-10-27 IL IL13589898A patent/IL135898A/xx unknown
- 1998-10-27 WO PCT/EP1998/006997 patent/WO1999023095A1/en active IP Right Grant
- 1998-10-27 KR KR1020007004783A patent/KR100602551B1/ko not_active IP Right Cessation
- 1998-10-27 UA UA2000042451A patent/UA56269C2/uk unknown
- 1998-10-27 ES ES98959834T patent/ES2197519T3/es not_active Expired - Lifetime
- 1998-10-27 CN CNB98810959XA patent/CN1160351C/zh not_active Expired - Fee Related
- 1998-10-27 AT AT98959834T patent/ATE238302T1/de active
- 1998-10-27 CA CA002309461A patent/CA2309461A1/en not_active Abandoned
- 1998-10-27 ID IDW20000822A patent/ID24644A/id unknown
- 1998-10-27 EP EP98959834A patent/EP1028960B1/en not_active Expired - Lifetime
- 1998-10-27 DE DE69813869T patent/DE69813869T2/de not_active Expired - Lifetime
- 1998-10-28 UY UY25227A patent/UY25227A1/es not_active IP Right Cessation
- 1998-11-02 MY MYPI98004975A patent/MY118605A/en unknown
- 1998-11-02 MA MA25328A patent/MA26560A1/fr unknown
- 1998-11-02 AR ARP980105505A patent/AR016660A1/es active IP Right Grant
- 1998-11-03 CO CO98064433A patent/CO5011075A1/es unknown
- 1998-11-03 IN IN3258DE1998 patent/IN192870B/en unknown
- 1998-11-03 PE PE1998001038A patent/PE129399A1/es not_active Application Discontinuation
- 1998-11-03 TW TW087118222A patent/TW538037B/zh not_active IP Right Cessation
- 1998-11-03 DZ DZ980247A patent/DZ2637A1/xx active
- 1998-11-03 ZA ZA9810033A patent/ZA9810033B/xx unknown
- 1998-11-25 SA SA98190820A patent/SA98190820B1/ar unknown
-
2000
- 2000-04-27 NO NO20002174A patent/NO315557B1/no not_active IP Right Cessation
- 2000-05-04 HR HR20000263A patent/HRP20000263B1/xx not_active IP Right Cessation
- 2000-06-05 BG BG104505A patent/BG64559B1/bg unknown
-
2001
- 2001-02-02 HK HK02108713.7A patent/HK1048804A1/zh unknown
- 2001-02-02 HK HK01100772A patent/HK1032046A1/xx not_active IP Right Cessation
-
2002
- 2002-07-09 AU AU2002300593A patent/AU2002300593B8/en not_active Ceased
-
2004
- 2004-08-04 JP JP2004228226A patent/JP2004339235A/ja active Pending
-
2006
- 2006-01-05 US US11/326,003 patent/US20060106221A1/en not_active Abandoned
- 2006-10-18 US US11/550,506 patent/US7351832B2/en not_active Expired - Fee Related
-
2008
- 2008-07-08 EC EC2008002712A patent/ECSP082712A/es unknown
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Legal Events
Date | Code | Title | Description |
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTARADA DA INT. CL.: C07D 417/12; C07C 5/02; A61K 31/395; A61P 3/10. Ipc: C07D 417/12 (2008.04), C07C 5/02 (2008.04), A61K 3 |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE A MATERIA PLEITEADA NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA ( ARTIGOS 8O E 13 DA LPI ) O RELATORIO NAO DESCREVE CLARA E SUFICIENTEMENTE O OBJETO, DE MODO A POSSIBILITAR SUA REALIZACAO POR UM TECNICO NO ASSUNTO ( ARTIGO 24 DA LPI ) AS REIVNIDICACOES NAO ESTAO FUNDAMENTADAS NO RELATORIO DESCRITIVO ( ARTIGO 25 DA LPI ) |
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B12B | Appeal against refusal [chapter 12.2 patent gazette] |