HUP0001459A2 - Eljárás szubsztituált dioxo-tiazolidin-származékok előállítására - Google Patents

Eljárás szubsztituált dioxo-tiazolidin-származékok előállítására

Info

Publication number
HUP0001459A2
HUP0001459A2 HU0001459A HUP0001459A HUP0001459A2 HU P0001459 A2 HUP0001459 A2 HU P0001459A2 HU 0001459 A HU0001459 A HU 0001459A HU P0001459 A HUP0001459 A HU P0001459A HU P0001459 A2 HUP0001459 A2 HU P0001459A2
Authority
HU
Hungary
Prior art keywords
general formula
medicinally acceptable
preparation
compound
reducing agent
Prior art date
Application number
HU0001459A
Other languages
English (en)
Inventor
Robert Gordon Giles
Norman John Lewis
Stephen Moore
Colin Ripley Pool
John Kirby Quick
Michael Urquhart
Original Assignee
Smithkline Beecham Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268725&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0001459(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9703310.4A external-priority patent/GB9703310D0/en
Priority claimed from GBGB9703334.4A external-priority patent/GB9703334D0/en
Priority claimed from GBGB9703338.5A external-priority patent/GB9703338D0/en
Application filed by Smithkline Beecham Plc. filed Critical Smithkline Beecham Plc.
Publication of HUP0001459A2 publication Critical patent/HUP0001459A2/hu
Publication of HUP0001459A3 publication Critical patent/HUP0001459A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány (I) általános képletű vegyületek - amelyek képletében J oxo- vagy tioxocsoport; T adott esetben szubsztituált arilcsoport: és T1 oxi- vagy tiocsoport - vagy tautomer formáik, gyógyászatilagelfogadható sóik vagy gyógyászatilag elfogadható szolvátjaikelőállítási eljárására vonatkozik, amelynek során egy (II) általánosképletű vegyületet - amelynek képletében J, T és T1 jelentése az (I)általános képletnél meghatározott - vagy tautomer formáját,gyógyászatilag elfogadható sóját vagy gyógyászatilag elfogadhatószolvátját egy komplex hidrid redukáló- szerrel vagy egy komplexhidrid redukálószernek egy forrásával redukálják, és ezt követőenkívánt esetben előállítják az (I) általános képletű vegyületnek vagytautomer formájának egy gyógyászatilag elfogadható sóját vagygyógyászatilag elfogadható szolvátját. Ó
HU0001459A 1997-02-18 1998-02-13 Process for the preparation of substituted thiazolidinedione derivatives HUP0001459A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9703310.4A GB9703310D0 (en) 1997-02-18 1997-02-18 Novel process
GBGB9703334.4A GB9703334D0 (en) 1997-02-18 1997-02-18 Novel compounds
GBGB9703338.5A GB9703338D0 (en) 1997-02-18 1997-02-18 Novel process
PCT/EP1998/000818 WO1998037073A1 (en) 1997-02-18 1998-02-13 Process for the preparation of substituted thiazolidinedione

Publications (2)

Publication Number Publication Date
HUP0001459A2 true HUP0001459A2 (hu) 2000-10-28
HUP0001459A3 HUP0001459A3 (en) 2002-11-28

Family

ID=27268725

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001459A HUP0001459A3 (en) 1997-02-18 1998-02-13 Process for the preparation of substituted thiazolidinedione derivatives

Country Status (29)

Country Link
EP (2) EP0970063A1 (hu)
JP (2) JP2001514619A (hu)
KR (1) KR20000071138A (hu)
CN (1) CN1252065A (hu)
AP (1) AP1359A (hu)
AR (1) AR011447A1 (hu)
AU (1) AU6622398A (hu)
BG (1) BG64311B1 (hu)
BR (1) BR9807395A (hu)
CA (1) CA2281695C (hu)
CZ (1) CZ296272B6 (hu)
DZ (1) DZ2430A1 (hu)
EA (1) EA199900754A1 (hu)
HU (1) HUP0001459A3 (hu)
ID (1) ID22222A (hu)
IL (1) IL131392A (hu)
IN (1) IN188379B (hu)
MA (1) MA24475A1 (hu)
MY (1) MY129475A (hu)
NO (2) NO313290B1 (hu)
NZ (1) NZ337179A (hu)
OA (1) OA11148A (hu)
PE (1) PE71899A1 (hu)
PL (1) PL195482B1 (hu)
SK (2) SK287512B6 (hu)
TR (1) TR199902019T2 (hu)
TW (1) TWI222446B (hu)
UY (1) UY24886A1 (hu)
WO (1) WO1998037073A1 (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9723295D0 (en) 1997-11-04 1998-01-07 Smithkline Beecham Plc Novel process
US7091359B2 (en) 1997-11-04 2006-08-15 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives
ATE246191T1 (de) * 1999-04-23 2003-08-15 Smithkline Beecham Plc Polymorph von 5-(4-(2-(n-methyl-n-(2- pyrdyl)amino)äthoxy)benzyl)thiazolidin-2,4-dion maleinsäuresalz
FR2820741A1 (fr) * 2001-02-14 2002-08-16 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
FR2820742B1 (fr) * 2001-02-14 2005-03-11 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
EP1567112B1 (en) 2002-11-22 2008-10-15 Smithkline Beecham Corporation THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS
AR047541A1 (es) * 2004-02-13 2006-01-25 Sandoz Ag Fosfato de 5-[[4-[2-metil-2-piridinil-amino-etoxi]fenil]metil]-2,4 tiazolidinadiona (rosiglitazona) y sus formas polimorficas
WO2005108394A1 (en) * 2004-05-12 2005-11-17 Medichem S.A. Process for the preparation of rosiglitazone
CZ297266B6 (cs) * 2004-09-10 2006-10-11 Zentiva, A. S. Zpusob prípravy rosiglitazonu
CZ297347B6 (cs) * 2004-09-21 2006-11-15 Zentiva, A. S. Zpusob prípravy rosiglitazonu
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
DE10199003I1 (de) * 1987-09-04 2003-06-12 Beecham Group Plc Substituierte Thiazolidinionderivate
JPH0377875A (ja) * 1989-08-18 1991-04-03 Kaken Pharmaceut Co Ltd チアゾリジン‐２，４‐ジオン誘導体およびその製造法
EP0839812A1 (en) * 1990-04-27 1998-05-06 Sankyo Company Limited Preparation of benzylthiazolidine derivatives
US5585495A (en) * 1991-12-20 1996-12-17 The Upjohn Company Reduction method for substituted 5-methylene-thiazolidinediones
JPH08157473A (ja) * 1994-10-06 1996-06-18 Nissan Chem Ind Ltd ピラゾール系チアゾリジン類
JPH08217717A (ja) * 1995-02-10 1996-08-27 Sumitomo Chem Co Ltd 環状ケトン系化合物、その製造法およびそれを有効成分とするゴキブリ誘引剤
DE69633059T2 (de) * 1995-05-31 2005-08-18 Sumitomo Pharmaceuticals Co., Ltd. Neue naphthyridinderivate.

Also Published As

Publication number Publication date
SK285979B6 (sk) 2007-12-06
EP0970063A1 (en) 2000-01-12
TR199902019T2 (xx) 1999-12-21
CA2281695A1 (en) 1998-08-27
UY24886A1 (es) 2001-08-27
BR9807395A (pt) 2000-03-14
AU6622398A (en) 1998-09-09
TWI222446B (en) 2004-10-21
NZ337179A (en) 2001-07-27
JP2001514619A (ja) 2001-09-11
EP1770092A1 (en) 2007-04-04
NO20023937D0 (no) 2002-08-19
PL195482B1 (pl) 2007-09-28
SK112099A3 (en) 2000-05-16
CZ296272B6 (cs) 2006-02-15
AP1359A (en) 2004-12-02
MY129475A (en) 2007-04-30
AR011447A1 (es) 2000-08-16
CN1252065A (zh) 2000-05-03
JP2009149616A (ja) 2009-07-09
IL131392A (en) 2005-07-25
BG64311B1 (bg) 2004-09-30
CA2281695C (en) 2006-12-12
NO313290B1 (no) 2002-09-09
OA11148A (en) 2003-04-16
CZ292499A3 (cs) 2000-02-16
NO993949L (no) 1999-09-07
BG103735A (en) 2000-06-30
NO20023937L (no) 1999-09-07
PL335163A1 (en) 2000-04-10
HUP0001459A3 (en) 2002-11-28
WO1998037073A1 (en) 1998-08-27
EA199900754A1 (ru) 2000-04-24
NO993949D0 (no) 1999-08-17
IN188379B (hu) 2002-09-14
DZ2430A1 (fr) 2003-01-11
AP9901626A0 (en) 1999-09-30
KR20000071138A (ko) 2000-11-25
SK287512B6 (sk) 2010-12-07
IL131392A0 (en) 2001-01-28
MA24475A1 (fr) 1998-10-01
PE71899A1 (es) 1999-09-15
ID22222A (id) 1999-09-16

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished