HUP0003629A2 - Szinergista gyógyszerkészítmény diabetes kezelésére amely dioxo-tiazolidint, inzulin secretagogot és diguanidint tartalmaz - Google Patents
Szinergista gyógyszerkészítmény diabetes kezelésére amely dioxo-tiazolidint, inzulin secretagogot és diguanidint tartalmazInfo
- Publication number
- HUP0003629A2 HUP0003629A2 HU0003629A HUP0003629A HUP0003629A2 HU P0003629 A2 HUP0003629 A2 HU P0003629A2 HU 0003629 A HU0003629 A HU 0003629A HU P0003629 A HUP0003629 A HU P0003629A HU P0003629 A2 HUP0003629 A2 HU P0003629A2
- Authority
- HU
- Hungary
- Prior art keywords
- treatment
- diguanide
- pharmaceutical composition
- insulin secretagogue
- diabetes containing
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 3
- 229940122199 Insulin secretagogue Drugs 0.000 title abstract 2
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 title 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 title 1
- 229940123464 Thiazolidinedione Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- ZILVNHNSYBNLSZ-UHFFFAOYSA-N 2-(diaminomethylideneamino)guanidine Chemical compound NC(N)=NNC(N)=N ZILVNHNSYBNLSZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940122355 Insulin sensitizer Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
A találmány diabetes mellitus, különösen II. típusú diabetes, valamintdiabetes mellitusszal kapcsolatos állapotok emlősökben végzettkezelési eljárására vonatkozik, amelynek során egy ilyen kezeléstigénylő emlősnek beadják egy inzulin szenzibilizátor, egy inzulinsecretagogum és egy biguanidin anti-hyperglykaemiás hatóanyag hatásos,nemtoxikus és gyógyászatilag elfogadható mennyiségét. A találmánykiterjed az említett hatóanyagokat tartalmazó gyógyszerkészítményekreis. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9715295A GB9715295D0 (en) | 1997-07-18 | 1997-07-18 | Novel method of treatment |
PCT/GB1998/002110 WO1999003477A1 (en) | 1997-07-18 | 1998-07-16 | Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0003629A2 true HUP0003629A2 (hu) | 2001-07-30 |
HUP0003629A3 HUP0003629A3 (en) | 2003-04-28 |
Family
ID=10816167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0003629A HUP0003629A3 (en) | 1997-07-18 | 1998-07-16 | Synergic pharmaceutical composition for the treatment of diabetes containing thiazolidinedione, insulin secretagogue and diguanide |
Country Status (40)
Country | Link |
---|---|
EP (1) | EP1001783B1 (hu) |
JP (2) | JP2001510159A (hu) |
KR (1) | KR100671918B1 (hu) |
CN (1) | CN1264303A (hu) |
AP (1) | AP1352A (hu) |
AR (1) | AR016349A1 (hu) |
AT (1) | ATE305790T1 (hu) |
AU (1) | AU8448898A (hu) |
BG (1) | BG64785B1 (hu) |
BR (1) | BR9810445A (hu) |
CA (1) | CA2296653C (hu) |
CO (1) | CO4940420A1 (hu) |
CY (1) | CY1105254T1 (hu) |
DE (1) | DE69831808T2 (hu) |
DK (1) | DK1001783T3 (hu) |
DZ (1) | DZ2562A1 (hu) |
EA (1) | EA003021B1 (hu) |
ES (1) | ES2251093T3 (hu) |
GB (1) | GB9715295D0 (hu) |
HK (1) | HK1028550A1 (hu) |
HU (1) | HUP0003629A3 (hu) |
ID (1) | ID24211A (hu) |
IL (1) | IL134046A0 (hu) |
IN (1) | IN189275B (hu) |
MA (1) | MA24607A1 (hu) |
MY (1) | MY155219A (hu) |
NO (1) | NO325727B1 (hu) |
NZ (2) | NZ501164A (hu) |
OA (1) | OA11279A (hu) |
PE (1) | PE99599A1 (hu) |
PL (2) | PL198017B1 (hu) |
SA (1) | SA98190468B1 (hu) |
SI (1) | SI1001783T1 (hu) |
SK (1) | SK285484B6 (hu) |
TR (1) | TR200000134T2 (hu) |
TW (1) | TW505516B (hu) |
UA (1) | UA70303C2 (hu) |
UY (1) | UY25102A1 (hu) |
WO (1) | WO1999003477A1 (hu) |
ZA (1) | ZA986363B (hu) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6011049A (en) * | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
US6099862A (en) * | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
SK287038B6 (sk) * | 1998-11-12 | 2009-10-07 | Smithkline Beecham Plc | Farmaceutický prostriedok na postupné uvoľňovanie 5-[4-[2-(N- metyl-N-(2-pyridyl)amino)etoxy]benzyl]tiazolidín-2,4-diónu a metformínu a spôsob jeho výroby |
SE9902918D0 (sv) * | 1999-08-13 | 1999-08-13 | Pharmacia & Upjohn Ab | Methods for identification of compounds stimulating insulin secretion |
JP2003514011A (ja) * | 1999-11-16 | 2003-04-15 | スミスクライン ビーチャム パブリック リミテッド カンパニー | チアゾリジンジオン−塩酸メトホルミンを含む医薬組成物 |
MY125516A (en) * | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
FR2812547B1 (fr) * | 2000-08-04 | 2002-10-31 | Lipha | Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete |
US7964216B2 (en) | 2001-01-12 | 2011-06-21 | Sun Pharma Advanced Research Company Limited | Spaced drug delivery system |
ITFI20010126A1 (it) * | 2001-07-09 | 2003-01-09 | Molteni & C | Composizioni farmaceutiche per uso orale,contenenti,in combinazione,metformina e gliclazide |
MXPA04000180A (es) * | 2001-07-10 | 2004-11-22 | Kos Life Sciences Inc | Formulacion de nucleo que comprende hidrocloruro de pioglitazona y una biguanida. |
WO2003105809A1 (en) | 2002-06-17 | 2003-12-24 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
UA80991C2 (en) | 2002-10-07 | 2007-11-26 | Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes | |
NZ546337A (en) | 2003-10-31 | 2009-03-31 | Takeda Pharmaceutical | Solid preparation comprising an insulin sensitizer such as pioglitazone hydrochloride, an insulin secretagogue such as glimepiride and a polyoxyethylene sorbitan fatty acid ester such as Polysorbate 80 |
MXPA05010977A (es) * | 2005-10-12 | 2007-04-11 | Abdala Leopoldo Espinosa | Composiciones farmaceuticas que comprenden sustancias antidiabeticas combinadas para su uso en diabetes mellitus. |
KR100812538B1 (ko) * | 2006-10-23 | 2008-03-11 | 한올제약주식회사 | 약물 제어방출형 메트포르민-글리메피리드 복합제제 |
CN101417130B (zh) * | 2007-10-22 | 2010-10-06 | 鲁南制药集团股份有限公司 | 一种治疗ⅱ型糖尿病及其并发症的药物组合物 |
JP7005050B2 (ja) | 2017-10-20 | 2022-01-21 | ノブメタファーマ カンパニー リミテッド | 亜鉛塩、シクロ-ヒスプロおよび抗糖尿薬物を有効成分として含有する糖尿病の予防または治療用薬学的組成物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS5697277A (en) * | 1980-01-07 | 1981-08-05 | Takeda Chem Ind Ltd | Thiazolidine derivative |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
US4582839A (en) * | 1984-03-21 | 1986-04-15 | Takeda Chemical Industries, Ltd. | 2,4-thiazolidinediones |
CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
US4812570A (en) * | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
US4791125A (en) * | 1987-12-02 | 1988-12-13 | Pfizer Inc. | Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents |
US5061717A (en) * | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
WO1989008651A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
JPH04210683A (ja) * | 1990-12-06 | 1992-07-31 | Terumo Corp | チアゾリジン−2,4−ジオン誘導体およびこれを含有する糖尿病合併症治療薬 |
DK0601001T3 (da) * | 1991-08-26 | 1997-10-20 | Upjohn Co | Flydende næringsmiddelprodukt indeholdende 3-guanidinopropionsyre. |
US5917052A (en) * | 1994-09-28 | 1999-06-29 | Shaman Pharmaceuticals, Inc. | Hypoglycemic agent from cryptolepis |
TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
EA003025B1 (ru) * | 1997-06-18 | 2002-12-26 | Смитклайн Бичам Плс | Лечение диабета тиазолидиндионом и сульфонилмочевиной |
-
1997
- 1997-07-18 GB GB9715295A patent/GB9715295D0/en active Pending
-
1998
- 1998-07-15 DZ DZ980172A patent/DZ2562A1/xx active
- 1998-07-16 PL PL378474A patent/PL198017B1/pl not_active IP Right Cessation
- 1998-07-16 EP EP98935127A patent/EP1001783B1/en not_active Expired - Lifetime
- 1998-07-16 AU AU84488/98A patent/AU8448898A/en not_active Abandoned
- 1998-07-16 UA UA2000010261A patent/UA70303C2/uk unknown
- 1998-07-16 SK SK59-2000A patent/SK285484B6/sk not_active IP Right Cessation
- 1998-07-16 HU HU0003629A patent/HUP0003629A3/hu unknown
- 1998-07-16 PL PL338126A patent/PL197844B1/pl not_active IP Right Cessation
- 1998-07-16 CA CA002296653A patent/CA2296653C/en not_active Expired - Fee Related
- 1998-07-16 ES ES98935127T patent/ES2251093T3/es not_active Expired - Lifetime
- 1998-07-16 NZ NZ501164A patent/NZ501164A/en unknown
- 1998-07-16 SI SI9830804T patent/SI1001783T1/sl unknown
- 1998-07-16 EA EA200000139A patent/EA003021B1/ru not_active IP Right Cessation
- 1998-07-16 BR BR9810445-4A patent/BR9810445A/pt not_active Application Discontinuation
- 1998-07-16 TR TR2000/00134T patent/TR200000134T2/xx unknown
- 1998-07-16 PE PE1998000629A patent/PE99599A1/es not_active Application Discontinuation
- 1998-07-16 JP JP2000502776A patent/JP2001510159A/ja not_active Withdrawn
- 1998-07-16 CN CN98807319A patent/CN1264303A/zh active Pending
- 1998-07-16 ID IDW20000075A patent/ID24211A/id unknown
- 1998-07-16 MA MA25171A patent/MA24607A1/fr unknown
- 1998-07-16 WO PCT/GB1998/002110 patent/WO1999003477A1/en active IP Right Grant
- 1998-07-16 AP APAP/P/2000/001733A patent/AP1352A/en active
- 1998-07-16 AR ARP980103481A patent/AR016349A1/es unknown
- 1998-07-16 DE DE69831808T patent/DE69831808T2/de not_active Expired - Fee Related
- 1998-07-16 AT AT98935127T patent/ATE305790T1/de not_active IP Right Cessation
- 1998-07-16 NZ NZ511608A patent/NZ511608A/xx unknown
- 1998-07-16 KR KR1020007000512A patent/KR100671918B1/ko not_active IP Right Cessation
- 1998-07-16 DK DK98935127T patent/DK1001783T3/da active
- 1998-07-16 IL IL13404698A patent/IL134046A0/xx unknown
- 1998-07-17 ZA ZA9806363A patent/ZA986363B/xx unknown
- 1998-07-17 TW TW087111770A patent/TW505516B/zh active
- 1998-07-17 UY UY25102A patent/UY25102A1/es not_active IP Right Cessation
- 1998-07-17 CO CO98040747A patent/CO4940420A1/es unknown
- 1998-07-17 MY MYPI98003288A patent/MY155219A/en unknown
- 1998-07-20 IN IN2087DE1998 patent/IN189275B/en unknown
- 1998-08-29 SA SA98190468A patent/SA98190468B1/ar unknown
-
2000
- 2000-01-17 NO NO20000228A patent/NO325727B1/no not_active IP Right Cessation
- 2000-01-18 OA OA1200000012A patent/OA11279A/en unknown
- 2000-02-07 BG BG104135A patent/BG64785B1/bg unknown
- 2000-11-08 HK HK00107103A patent/HK1028550A1/xx not_active IP Right Cessation
-
2005
- 2005-04-21 JP JP2005123562A patent/JP2005213273A/ja active Pending
- 2005-12-07 CY CY20051101486T patent/CY1105254T1/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |