HU226294B1 - Peg-urate oxidase conjugates and use thereof - Google Patents
Peg-urate oxidase conjugates and use thereof Download PDFInfo
- Publication number
- HU226294B1 HU226294B1 HU0103003A HUP0103003A HU226294B1 HU 226294 B1 HU226294 B1 HU 226294B1 HU 0103003 A HU0103003 A HU 0103003A HU P0103003 A HUP0103003 A HU P0103003A HU 226294 B1 HU226294 B1 HU 226294B1
- Authority
- HU
- Hungary
- Prior art keywords
- uricase
- peg
- conjugate
- tetrameric
- porcine
- Prior art date
Links
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
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- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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Landscapes
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- Enzymes And Modification Thereof (AREA)
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- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
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Applications Claiming Priority (2)
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| US13039298A | 1998-08-06 | 1998-08-06 | |
| PCT/US1999/017514 WO2000007629A2 (en) | 1998-08-06 | 1999-08-02 | Peg-urate oxidase conjugates and use thereof |
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| HUP0103003A2 HUP0103003A2 (hu) | 2001-11-28 |
| HUP0103003A3 HUP0103003A3 (en) | 2006-04-28 |
| HU226294B1 true HU226294B1 (en) | 2008-08-28 |
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| HU0103003A HU226294B1 (en) | 1998-08-06 | 1999-08-02 | Peg-urate oxidase conjugates and use thereof |
| HU0800112A HU228916B1 (en) | 1998-08-06 | 1999-08-02 | Polyethylen-glycol/carbamate oxydase conjugates and pharmaceutical compositions containing thereof |
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| HU0800112A HU228916B1 (en) | 1998-08-06 | 1999-08-02 | Polyethylen-glycol/carbamate oxydase conjugates and pharmaceutical compositions containing thereof |
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| EP (1) | EP1100542B1 (cg-RX-API-DMAC10.html) |
| JP (3) | JP5183836B2 (cg-RX-API-DMAC10.html) |
| KR (2) | KR100488848B1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU770014B2 (cg-RX-API-DMAC10.html) |
| BR (2) | BRPI9917760B8 (cg-RX-API-DMAC10.html) |
| CZ (1) | CZ303751B6 (cg-RX-API-DMAC10.html) |
| HU (2) | HU226294B1 (cg-RX-API-DMAC10.html) |
| IL (3) | IL141220A0 (cg-RX-API-DMAC10.html) |
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| PL (2) | PL220873B1 (cg-RX-API-DMAC10.html) |
| RU (3) | RU2278680C2 (cg-RX-API-DMAC10.html) |
| TW (1) | TW570981B (cg-RX-API-DMAC10.html) |
| WO (1) | WO2000007629A2 (cg-RX-API-DMAC10.html) |
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| CA2728907C (en) | 1998-08-06 | 2015-11-24 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
| RU2290439C2 (ru) | 1998-08-06 | 2006-12-27 | Дьюк Юниверсити | Рекомбинантный белок уриказы млекопитающего для конъюгирования с пэг, молекула нуклеиновой кислоты, кодирующая его, вектор для его экспрессии, способ его получения и применение |
| HU226294B1 (en) * | 1998-08-06 | 2008-08-28 | Mountain View Pharmaceuticals | Peg-urate oxidase conjugates and use thereof |
| US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| AU2006203252B8 (en) * | 2000-02-10 | 2009-06-18 | Duke University | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| KR100777195B1 (ko) | 2000-04-03 | 2007-11-19 | 산텐 세이야꾸 가부시키가이샤 | 송달성 물질 및 이를 이용한 약물 송달 시스템 |
| AU2001268734A1 (en) * | 2000-06-28 | 2002-01-08 | Merck & Co., Inc. | Use of agents capable of reducing uric acid levels for the treatment of cardiovascular disease |
| EP1421175B1 (en) | 2001-06-28 | 2008-11-19 | Mountain View Pharmaceuticals, Inc. | Polymer stabilized proteinases |
| US6913915B2 (en) * | 2001-08-02 | 2005-07-05 | Phoenix Pharmacologics, Inc. | PEG-modified uricase |
| US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| NZ543934A (en) | 2003-05-12 | 2008-06-30 | Affymax Inc | Novel spacer moiety for poly (ethylene glycol)-modified peptide-based compounds |
| PL1625156T3 (pl) | 2003-05-12 | 2013-03-29 | Affymax Inc | Peptydy wiążące się do receptora erytropoetyny |
| KR101100059B1 (ko) * | 2004-06-30 | 2011-12-29 | 넥타르 테라퓨틱스 | 중합체인자 ｉｘ 부분의 접합체 |
| US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
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