BRPI9912974B8 - conjugados de peg-urato oxidase e seu uso - Google Patents
conjugados de peg-urato oxidase e seu usoInfo
- Publication number
- BRPI9912974B8 BRPI9912974B8 BRPI9912974A BR9912974A BRPI9912974B8 BR PI9912974 B8 BRPI9912974 B8 BR PI9912974B8 BR PI9912974 A BRPI9912974 A BR PI9912974A BR 9912974 A BR9912974 A BR 9912974A BR PI9912974 B8 BRPI9912974 B8 BR PI9912974B8
- Authority
- BR
- Brazil
- Prior art keywords
- peg
- urate oxidase
- urate
- conjugates
- poly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13039298A | 1998-08-06 | 1998-08-06 | |
PCT/US1999/017514 WO2000007629A2 (en) | 1998-08-06 | 1999-08-02 | Peg-urate oxidase conjugates and use thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
BR9912974A BR9912974A (pt) | 2001-05-08 |
BRPI9912974B1 BRPI9912974B1 (pt) | 2015-08-25 |
BRPI9912974B8 true BRPI9912974B8 (pt) | 2021-05-25 |
Family
ID=22444494
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9917760A BRPI9917760B8 (pt) | 1998-08-06 | 1999-08-02 | método para isolar uma forma tetramérica de uricase a partir de uma solução de uricase purificada |
BRPI9912974A BRPI9912974B8 (pt) | 1998-08-06 | 1999-08-02 | conjugados de peg-urato oxidase e seu uso |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9917760A BRPI9917760B8 (pt) | 1998-08-06 | 1999-08-02 | método para isolar uma forma tetramérica de uricase a partir de uma solução de uricase purificada |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1100542B1 (pt) |
JP (3) | JP5183836B2 (pt) |
KR (2) | KR100614212B1 (pt) |
AU (1) | AU770014B2 (pt) |
BR (2) | BRPI9917760B8 (pt) |
CZ (1) | CZ303751B6 (pt) |
HU (2) | HU228916B1 (pt) |
IL (3) | IL141220A0 (pt) |
NZ (1) | NZ509595A (pt) |
PL (2) | PL220873B1 (pt) |
RU (3) | RU2278680C2 (pt) |
TW (1) | TW570981B (pt) |
WO (1) | WO2000007629A2 (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
CA2728907C (en) | 1998-08-06 | 2015-11-24 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
ES2352451T3 (es) | 1998-08-06 | 2011-02-18 | Duke University | Urato oxidasa. |
WO2000007629A2 (en) * | 1998-08-06 | 2000-02-17 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
AU2006203252B8 (en) * | 2000-02-10 | 2009-06-18 | Duke University | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
CA2404737C (en) | 2000-04-03 | 2010-06-29 | Santen Pharmaceutical Co., Ltd. | Drug delivering substance containing polyalkylene glycol and phospholipid covalently bonded to drug |
DE60137635D1 (de) * | 2000-06-28 | 2009-03-26 | Merck & Co Inc | Verwendung von allopurinol zur behandlung von bluthochdruck |
DK1421175T3 (da) | 2001-06-28 | 2009-03-23 | Mountain View Pharmaceuticals | Polymerstabiliserede proteinaser |
US6913915B2 (en) * | 2001-08-02 | 2005-07-05 | Phoenix Pharmacologics, Inc. | PEG-modified uricase |
US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
BRPI0411172A (pt) | 2003-05-12 | 2006-07-18 | Affymax Inc | peptìdeo, dìmero de peptìdeo, seu uso e composição farmacêutica |
US7919118B2 (en) | 2003-05-12 | 2011-04-05 | Affymax, Inc. | Spacer moiety for poly (ethylene glycol) modified peptide based compounds |
JP2008505119A (ja) * | 2004-06-30 | 2008-02-21 | ネクター セラピューティクス アラバマ,コーポレイション | 高分子−第ix因子部分の抱合体 |
US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
HU229626B1 (hu) | 2005-04-11 | 2014-03-28 | Savient Pharmaceuticals | Urát oxidáz változat és alkalmazása |
HU229068B1 (en) | 2005-04-11 | 2013-07-29 | Savient Pharmaceuticals | Variant forms of urate oxidase and use thereof |
US8841333B2 (en) | 2005-05-09 | 2014-09-23 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for treating nephrolithiasis |
US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
KR101288027B1 (ko) | 2006-04-12 | 2013-07-22 | 새비언트 파마수티컬즈 인크. | 양이온 계면활성제를 이용한 단백질 정제 방법 |
JP4890132B2 (ja) * | 2006-07-20 | 2012-03-07 | 東洋紡績株式会社 | ウリカーゼの比活性を向上させる方法、および比活性の向上した改変型ウリカーゼ |
RU2535038C2 (ru) | 2009-06-25 | 2014-12-10 | Криэлта Фармасьютикалз ЭлЭлСи | Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови |
HUE030959T2 (en) * | 2010-03-02 | 2017-06-28 | Protalix Ltd | Stabilized alpha-galactosidase and its uses |
RU2013109380A (ru) | 2010-09-10 | 2014-10-20 | Такеда Фармасьютикалс Ю.С.А.,Инк. | Способ сопутствующей терапии с применением теофиллина и фебуксостата |
CN102634492B (zh) | 2011-02-14 | 2015-06-10 | 重庆富进生物医药有限公司 | 聚乙二醇化犬源尿酸氧化酶类似物及其制备方法和应用 |
WO2013151638A1 (en) | 2012-04-06 | 2013-10-10 | Indus Pharmaceuticals, Inc. | Novel compositions of combinations of non-covalent dna binding agents and anti-cancer and/or anti-inflammatory agents and their use in disease treatment |
CA2984926A1 (en) * | 2015-05-15 | 2016-11-24 | Medimmune, Llc | Improved uricase sequences and methods of treatment |
CN105412942B (zh) * | 2015-12-23 | 2019-02-26 | 沈阳三生制药有限责任公司 | 聚乙二醇化的重组产朊假丝酵母尿酸氧化酶冻干注射剂 |
CN112980808A (zh) * | 2019-12-12 | 2021-06-18 | 深圳迈瑞生物医疗电子股份有限公司 | 尿酸酶、及其制备方法和用途 |
EP4240423A1 (en) | 2020-11-03 | 2023-09-13 | Protalix Ltd. | Modified uricase and uses thereof |
WO2022172343A1 (ja) | 2021-02-10 | 2022-08-18 | オリエンタル酵母工業株式会社 | ウリカーゼ活性化剤及び尿酸測定試薬 |
CN114181917B (zh) * | 2022-02-14 | 2022-06-03 | 潍坊华卓生物科技有限公司 | 一种改造尿酸酶、基因序列、制备方法及应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55135590A (en) * | 1979-04-05 | 1980-10-22 | Mihama Hisaharu | Modified asparaginase and uricase and their preparation |
JPS57192435A (en) * | 1981-05-20 | 1982-11-26 | Toyobo Co Ltd | Modified polypeptide |
JPS6255079A (ja) * | 1986-04-23 | 1987-03-10 | Mihama Hisaharu | 修飾ウリカ−ゼ |
US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
WO2000007629A2 (en) * | 1998-08-06 | 2000-02-17 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
ES2352451T3 (es) * | 1998-08-06 | 2011-02-18 | Duke University | Urato oxidasa. |
-
1999
- 1999-08-02 WO PCT/US1999/017514 patent/WO2000007629A2/en active Application Filing
- 1999-08-02 RU RU2004104953/15A patent/RU2278680C2/ru not_active IP Right Cessation
- 1999-08-02 IL IL14122099A patent/IL141220A0/xx active IP Right Grant
- 1999-08-02 HU HU0800112A patent/HU228916B1/hu not_active IP Right Cessation
- 1999-08-02 BR BRPI9917760A patent/BRPI9917760B8/pt not_active IP Right Cessation
- 1999-08-02 PL PL383331A patent/PL220873B1/pl unknown
- 1999-08-02 KR KR1020047014428A patent/KR100614212B1/ko not_active IP Right Cessation
- 1999-08-02 CZ CZ20010317A patent/CZ303751B6/cs unknown
- 1999-08-02 JP JP2000563311A patent/JP5183836B2/ja not_active Expired - Fee Related
- 1999-08-02 EP EP99937745A patent/EP1100542B1/en not_active Expired - Lifetime
- 1999-08-02 KR KR10-2001-7001569A patent/KR100488848B1/ko not_active IP Right Cessation
- 1999-08-02 HU HU0103003A patent/HU226294B1/hu not_active IP Right Cessation
- 1999-08-02 BR BRPI9912974A patent/BRPI9912974B8/pt not_active IP Right Cessation
- 1999-08-02 NZ NZ509595A patent/NZ509595A/xx not_active IP Right Cessation
- 1999-08-02 RU RU2001103144/15A patent/RU2246318C2/ru not_active IP Right Cessation
- 1999-08-02 PL PL380583A patent/PL202799B1/pl unknown
- 1999-08-02 AU AU52515/99A patent/AU770014B2/en not_active Ceased
- 1999-08-05 TW TW088113406A patent/TW570981B/zh not_active IP Right Cessation
-
2001
- 2001-02-01 IL IL141220A patent/IL141220A/en not_active IP Right Cessation
-
2006
- 2006-03-09 RU RU2006107111/15A patent/RU2349341C2/ru not_active IP Right Cessation
-
2007
- 2007-06-14 IL IL183948A patent/IL183948A/en not_active IP Right Cessation
-
2009
- 2009-07-24 JP JP2009173148A patent/JP5290901B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-12 JP JP2012248770A patent/JP5291235B2/ja not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 25/08/2015, OBSERVADAS AS CONDICOES LEGAIS. |
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B15K | Others concerning applications: alteration of classification |
Free format text: PROCEDIMENTO AUTOMATICO DE RECLASSIFICACAO. AS CLASSIFICACOES IPC ANTERIORES ERAM: A61K 47/48; A61K 38/44; C12N 9/06. Ipc: C12N 9/06 (2006.01), A61K 47/60 (2017.01), A61K 38 Ipc: C12N 9/06 (2006.01), A61K 47/60 (2017.01), A61K 38 |
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B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/08/1999 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 02/08/2019 |