BR9909129A - Conjugados de proteases - Google Patents
Conjugados de proteasesInfo
- Publication number
- BR9909129A BR9909129A BR9909129-1A BR9909129A BR9909129A BR 9909129 A BR9909129 A BR 9909129A BR 9909129 A BR9909129 A BR 9909129A BR 9909129 A BR9909129 A BR 9909129A
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- protease
- acid sequence
- conjugates
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Detergent Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
Abstract
"CONJUGADOS DE PROTEASES". A presente invenção refere-se a conjugados das proteases subtilisinas, compreendendo um agrupamento protease e um ou mais grupos de adição, em que o grupamento protease tem uma seq³ência de amonoácidos modificada de uma seq³ência de aminoácidos parental, sendo que a seq³ência de aminoácidos parental compreende uma primeira região de epítopo, uma segunda região de epítopo, e uma terceira região de epítopo, em que a seq³ência de aminoácidos modificada compreende uma substituição com um aminoácido substituinte em uma ou mais posições das regiões de epítopos, e onde cada grupamento de adição está ligado de modo covalente a um dos grupamentos substituintes. A presente invenção refere-se ainda a composições de limpeza e de higiene pessoal, que compreendem esses conjugados de proteases.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4817498A | 1998-03-26 | 1998-03-26 | |
US09/088,912 US6495136B1 (en) | 1998-03-26 | 1998-06-02 | Proteases having modified amino acid sequences conjugated to addition moieties |
PCT/IB1999/000511 WO1999048918A1 (en) | 1998-03-26 | 1999-03-25 | Protease conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909129A true BR9909129A (pt) | 2000-12-19 |
Family
ID=26725868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909129-1A BR9909129A (pt) | 1998-03-26 | 1999-03-25 | Conjugados de proteases |
Country Status (9)
Country | Link |
---|---|
US (1) | US6495136B1 (pt) |
EP (1) | EP1068228A1 (pt) |
JP (1) | JP3642735B2 (pt) |
KR (1) | KR20010034685A (pt) |
CN (1) | CN1163507C (pt) |
AU (1) | AU2742399A (pt) |
BR (1) | BR9909129A (pt) |
CA (1) | CA2324506A1 (pt) |
WO (1) | WO1999048918A1 (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69839076T2 (de) * | 1997-08-29 | 2009-01-22 | Novozymes A/S | Proteasevarianten und zusammensetzungen |
US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
BR9909130A (pt) | 1998-03-26 | 2000-12-19 | Procter & Gamble | Variantes de protease de serina tendo substituições de amino-ácido |
US6495136B1 (en) | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
US6936249B1 (en) * | 1998-04-15 | 2005-08-30 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
US6838269B1 (en) * | 1998-04-15 | 2005-01-04 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
EP1210415A2 (en) | 1999-07-22 | 2002-06-05 | The Procter & Gamble Company | Subtilisin protease variants having amino acid substitutions in defined epitope regions |
CN1372593A (zh) * | 1999-07-22 | 2002-10-02 | 宝洁公司 | 具有空间保护的表位区域的蛋白酶缀合物 |
BR0012693A (pt) | 1999-07-22 | 2002-04-09 | Procter & Gamble | Variante, de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal |
KR20020021395A (ko) | 1999-07-22 | 2002-03-20 | 데이비드 엠 모이어 | 입체적으로 보호된 clip 부위를 갖는 프로테아제콘쥬게이트 |
US20030170846A1 (en) * | 2000-04-24 | 2003-09-11 | Weisgerber David John | Enzyme variants having one or more D-amino acid substitutions |
US20030206896A1 (en) * | 2000-09-13 | 2003-11-06 | O'prey Conor James | Cosmetic method |
WO2003002716A2 (en) * | 2001-06-28 | 2003-01-09 | Mountain View Pharmaceuticals, Inc. | Polymer stabilized proteinases |
EP2314712B1 (en) * | 2001-11-07 | 2014-01-08 | Mannkind Corporation | Expression vectors encoding epitopes of antigens and methods for their design |
WO2003041667A2 (en) * | 2001-11-13 | 2003-05-22 | The Procter & Gamble Company | Compositions containing enzymes stabilized with certain osmo-protectants and methods for using such compositions in personal care |
AU2003213580A1 (en) * | 2002-02-26 | 2003-09-09 | Genencor International, Inc. | Subtilisin carlsberg proteins with reduced immunogenicity |
EP1578842B1 (en) | 2002-12-31 | 2009-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
EP1581582B2 (en) * | 2003-01-06 | 2017-06-07 | Nektar Therapeutics | Thiol-selective water-soluble polmer derivatives |
US20050118058A1 (en) * | 2003-12-01 | 2005-06-02 | Erning Xia | Gentle preservative compositions for self-preserving solutions |
US20050118129A1 (en) * | 2003-12-01 | 2005-06-02 | Erning Xia | Gentle and enhanced preservative systems |
AU2005300860B2 (en) * | 2004-11-08 | 2008-12-11 | Unilever Plc | Liquid detergent composition |
CN101275363B (zh) * | 2008-05-08 | 2010-09-08 | 江南大学 | 一种用复配酶制剂对棉织物进行同浴煮练和漂白的方法 |
EP2213715A1 (en) * | 2009-02-02 | 2010-08-04 | The Procter & Gamble Company | Liquid hand dishwashing detergent composition |
EP2216391A1 (en) * | 2009-02-02 | 2010-08-11 | The Procter & Gamble Company | Liquid hand dishwashing detergent composition |
EP2216392B1 (en) * | 2009-02-02 | 2013-11-13 | The Procter and Gamble Company | Liquid hand dishwashing detergent composition |
JP5662349B2 (ja) * | 2009-02-02 | 2015-01-28 | ザ プロクター アンド ギャンブルカンパニー | 食器手洗い用液体洗剤組成物 |
EP2213713B1 (en) * | 2009-02-02 | 2014-03-12 | The Procter and Gamble Company | Liquid hand dishwashing detergent composition |
EP2216390B1 (en) * | 2009-02-02 | 2013-11-27 | The Procter and Gamble Company | Hand dishwashing method |
ES2488117T3 (es) * | 2009-02-02 | 2014-08-26 | The Procter & Gamble Company | Composición detergente líquida para lavado de vajillas a mano |
CA2825861A1 (en) * | 2010-01-26 | 2011-08-04 | Robert S. Hodges | Conjugates utilizing platform technology for stimulating immune response |
JP5819684B2 (ja) * | 2010-11-24 | 2015-11-24 | 花王株式会社 | 硬質表面用液体洗浄剤組成物 |
JP5819685B2 (ja) * | 2010-11-24 | 2015-11-24 | 花王株式会社 | 硬質表面用液体洗浄剤組成物 |
JP7282739B2 (ja) * | 2017-08-25 | 2023-05-29 | ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ | 抗微生物組成物 |
EP4065078A1 (en) | 2019-11-27 | 2022-10-05 | L'oreal | Hair treatment compositions, kits, and methods of use |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
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BE795238A (fr) | 1972-02-09 | 1973-08-09 | Schering Ag | Derives d'insuline reticules de maniere intramoleculaire, leur procede de preparation et leur utilisation |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
DE2631656C2 (de) | 1976-07-14 | 1983-02-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung eines Hydroxysuccinimidoester-Derivats zur Bindung von biologisch aktiven Proteinen aneinander und/oder an flüssige oder feste Trägerstoffe |
SE447661C (sv) | 1978-07-04 | 1997-04-14 | Novo Industri As | Subtilisinhaltig proteasprodukt med reducerad allergenicitet herledd ur bacillus licheniformis, forfarande for dess framstellning, tvettmedelskomposition innehallande densamma samt b. licheniformisstam nrrl b-11301, b-1 |
US4556554A (en) | 1981-06-01 | 1985-12-03 | Germaine Monteil Cosmetiques Corp. | Immobilized enzymes |
US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
US4732863A (en) | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
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ATE116365T1 (de) | 1986-04-30 | 1995-01-15 | Genencor Int | Mutante einer nicht menschlichen carbonyl- hydrolase, für diese kodierende dns-sequenzen und vektoren und durch diese vektoren transformierte wirte. |
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US5543302A (en) | 1988-05-27 | 1996-08-06 | Solvay Enzymes, Inc. | Proteases of altered stability to autolytic degradation |
JPH02219571A (ja) | 1989-02-20 | 1990-09-03 | Kanebo Ltd | 修飾プロテアーゼ及びその製造法 |
US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
BR9006827A (pt) | 1989-06-26 | 1991-08-06 | Unilever Nv | Composicoes detergentes enzimaticas |
US5658871A (en) | 1989-07-07 | 1997-08-19 | Lever Brothers Company, Division Of Conopco, Inc. | Microbial lipase muteins and detergent compositions comprising same |
DK97190D0 (da) | 1990-04-19 | 1990-04-19 | Novo Nordisk As | Oxidationsstabile detergentenzymer |
US5230891A (en) | 1990-08-20 | 1993-07-27 | Kanebo Limited | Modified protease, method of producing the same and cosmetic products containing the modified protease |
US5133968A (en) | 1990-08-20 | 1992-07-28 | Kanebo, Ltd. | Modified protease, method of producing the same and cosmetic products containing the modified protease |
DE69130113T2 (de) | 1990-12-05 | 1999-05-12 | Novo Nordisk A/S, Bagsvaerd | Proteine mit geänderten epitopen und verfahren zur deren herstellung |
ES2090481T3 (es) | 1991-05-01 | 1996-10-16 | Unilever Nv | Composiciones detergentes que contienen enzimas estabilizadas. |
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IT1260468B (it) | 1992-01-29 | 1996-04-09 | Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole | |
GB9207280D0 (en) | 1992-04-02 | 1992-05-13 | Unilever Plc | Skin care method and composition |
GB9207288D0 (en) | 1992-04-02 | 1992-05-13 | Unilever Plc | Cosmetic composition |
WO1994004193A1 (en) | 1992-08-21 | 1994-03-03 | Enzon, Inc. | Novel attachment of polyalkylene oxides to bio-effecting substances |
CA2101361A1 (en) | 1992-08-27 | 1994-02-28 | Robert A. Snow | Low diol polyalkylene oxide biologically active proteinaceous substances |
US5567601A (en) | 1993-06-01 | 1996-10-22 | University Of Maryland | Subtilisin mutants lacking a primary calcium binding site |
US6436690B1 (en) | 1993-09-15 | 2002-08-20 | The Procter & Gamble Company | BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted |
MA23346A1 (fr) | 1993-10-14 | 1995-04-01 | Genencor Int | Variantes de la subtilisine |
US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
ZA952220B (en) | 1994-05-02 | 1995-12-14 | Procter & Gamble | Bpn' variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted |
US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
EP0793726A1 (en) | 1994-11-24 | 1997-09-10 | Novo Nordisk A/S | A process for producing polypeptides with reduced allergenicity |
MX9704137A (es) | 1994-12-07 | 1997-09-30 | Novo Nordisk As | Polipeptidos de alergenicidad reducida. |
JP4067058B2 (ja) | 1995-03-10 | 2008-03-26 | 中村 敏一 | Peg化hgf |
WO1996040792A1 (en) | 1995-06-07 | 1996-12-19 | Novo Nordisk A/S | Modification of polypeptides |
WO1996040791A1 (en) | 1995-06-07 | 1996-12-19 | Novo Nordisk A/S | Modification of polypeptides |
DE19530816A1 (de) | 1995-08-23 | 1997-02-27 | Cognis Bio Umwelt | Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten |
AU4690796A (en) | 1995-12-29 | 1997-07-28 | Procter & Gamble Company, The | Detergent compositions comprising immobilized enzymes |
JPH11502256A (ja) | 1995-12-29 | 1999-02-23 | ザ、プロクター、エンド、ギャンブル、カンパニー | 固定化酵素を含有する洗剤組成物 |
CA2242488A1 (en) | 1996-02-15 | 1997-08-21 | Novo Nordisk A/S | Conjugation of polypeptides |
US6946280B1 (en) | 1996-03-29 | 2005-09-20 | Genencor International, Inc. | Enzyme multimer and process of producing same |
DK0942962T3 (da) | 1996-11-26 | 2007-05-07 | Genencor Int | Kemisk modificerede enzymer |
AU736806B2 (en) | 1997-01-10 | 2001-08-02 | Novozymes A/S | A modified enzyme for skin care |
AU740207B2 (en) | 1997-02-06 | 2001-11-01 | Novozymes A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
AU751880B2 (en) | 1997-06-25 | 2002-08-29 | Novozymes A/S | A modified polypeptide |
US6284246B1 (en) * | 1997-07-30 | 2001-09-04 | The Procter & Gamble Co. | Modified polypeptides with high activity and reduced allergenicity |
JP2002500874A (ja) | 1998-01-23 | 2002-01-15 | ジェネンコア インターナショナル インコーポレーテッド | ペプチド合成のための修飾された酵素およびその使用方法 |
BR9909130A (pt) | 1998-03-26 | 2000-12-19 | Procter & Gamble | Variantes de protease de serina tendo substituições de amino-ácido |
US6495136B1 (en) | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
AU772427B2 (en) | 1998-11-10 | 2004-04-29 | Genencor International, Inc. | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity |
ATE438724T1 (de) | 1998-12-21 | 2009-08-15 | Genencor Int | Chemisch modifizierte enzymen mit mehrfachgeladenen varianten |
-
1998
- 1998-06-02 US US09/088,912 patent/US6495136B1/en not_active Expired - Fee Related
-
1999
- 1999-03-25 JP JP2000537900A patent/JP3642735B2/ja not_active Expired - Fee Related
- 1999-03-25 CN CNB998061816A patent/CN1163507C/zh not_active Expired - Fee Related
- 1999-03-25 BR BR9909129-1A patent/BR9909129A/pt not_active IP Right Cessation
- 1999-03-25 WO PCT/IB1999/000511 patent/WO1999048918A1/en not_active Application Discontinuation
- 1999-03-25 CA CA002324506A patent/CA2324506A1/en not_active Abandoned
- 1999-03-25 AU AU27423/99A patent/AU2742399A/en not_active Abandoned
- 1999-03-25 EP EP99907800A patent/EP1068228A1/en not_active Withdrawn
- 1999-03-25 KR KR1020007010656A patent/KR20010034685A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1163507C (zh) | 2004-08-25 |
US6495136B1 (en) | 2002-12-17 |
AU2742399A (en) | 1999-10-18 |
WO1999048918A1 (en) | 1999-09-30 |
JP2002507626A (ja) | 2002-03-12 |
CA2324506A1 (en) | 1999-09-30 |
CN1301270A (zh) | 2001-06-27 |
KR20010034685A (ko) | 2001-04-25 |
EP1068228A1 (en) | 2001-01-17 |
JP3642735B2 (ja) | 2005-04-27 |
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