ATE308617T1 - Rantes mutanten und deren therapeutischen anwendungen - Google Patents

Rantes mutanten und deren therapeutischen anwendungen

Info

Publication number
ATE308617T1
ATE308617T1 AT03027936T AT03027936T ATE308617T1 AT E308617 T1 ATE308617 T1 AT E308617T1 AT 03027936 T AT03027936 T AT 03027936T AT 03027936 T AT03027936 T AT 03027936T AT E308617 T1 ATE308617 T1 AT E308617T1
Authority
AT
Austria
Prior art keywords
rantes
therapeutic applications
rantes mutants
mutants
wild
Prior art date
Application number
AT03027936T
Other languages
English (en)
Inventor
Paolo Lusso
Simona Polo
Original Assignee
San Raffaele Centro Fond
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI972865 external-priority patent/IT1297015B1/it
Priority claimed from IT98MI001866 external-priority patent/IT1302012B1/it
Application filed by San Raffaele Centro Fond filed Critical San Raffaele Centro Fond
Application granted granted Critical
Publication of ATE308617T1 publication Critical patent/ATE308617T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT03027936T 1997-12-23 1998-12-21 Rantes mutanten und deren therapeutischen anwendungen ATE308617T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI972865 IT1297015B1 (it) 1997-12-23 1997-12-23 Mutanti di rantes e loro applicazioni terapeutiche
IT98MI001866 IT1302012B1 (it) 1998-08-07 1998-08-07 Derivati di rantes e loro applicazioni terapeutiche.

Publications (1)

Publication Number Publication Date
ATE308617T1 true ATE308617T1 (de) 2005-11-15

Family

ID=26331556

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98966650T ATE308616T1 (de) 1997-12-23 1998-12-21 Rantes mutanten und deren therapeutische verwendungen
AT03027936T ATE308617T1 (de) 1997-12-23 1998-12-21 Rantes mutanten und deren therapeutischen anwendungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT98966650T ATE308616T1 (de) 1997-12-23 1998-12-21 Rantes mutanten und deren therapeutische verwendungen

Country Status (10)

Country Link
US (2) US6608177B1 (de)
EP (2) EP1040191B1 (de)
JP (1) JP4323094B2 (de)
AT (2) ATE308616T1 (de)
AU (1) AU2415599A (de)
CA (1) CA2316447C (de)
DE (2) DE69832216T2 (de)
DK (2) DK1431391T3 (de)
ES (2) ES2247738T3 (de)
WO (1) WO1999033989A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
UA77950C2 (en) 2000-10-04 2007-02-15 Applied Research Systems Use of mutants of cc chemokines for treatment of multiple sclerosis
JP2005525089A (ja) 2001-12-17 2005-08-25 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ ケモカイン・アンタゴニストとして作用するケモカイン突然変異体
SI1494703T1 (sl) * 2002-04-04 2006-06-30 Applied Research Systems Mutanti hemokinov z izboljsano oralno biorazpolozljivostjo
EP2360182A1 (de) * 2006-11-13 2011-08-24 Functional Genetics, Inc. Therapeutisches Targeting von Escort-Proteinen
EP2185719B1 (de) * 2007-08-02 2013-11-13 NovImmune SA Rantes-antikörper und verfahren zu ihrer verwendung
US20210205412A1 (en) 2018-05-28 2021-07-08 Université De Genève Methods of inhibiting cerebral inflammation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1087346C (zh) * 1994-12-08 2002-07-10 格拉克索公司 用于炎症治疗的rantfs肽和片段及包括它们的组合物
FR2748938B1 (fr) * 1996-05-22 1998-07-31 Pasteur Institut Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih
EP0972043A1 (de) * 1996-09-25 2000-01-19 British Biotech Pharmaceuticals Limited Mutanten von humanem rantes, die keine aggregate bilden können

Also Published As

Publication number Publication date
CA2316447A1 (en) 1999-07-08
JP2002507388A (ja) 2002-03-12
US6608177B1 (en) 2003-08-19
DE69832197D1 (de) 2005-12-08
JP4323094B2 (ja) 2009-09-02
EP1431391A3 (de) 2004-10-06
ES2247738T3 (es) 2006-03-01
US20030216549A1 (en) 2003-11-20
EP1040191B1 (de) 2005-11-02
DE69832216D1 (de) 2005-12-08
ES2247475T3 (es) 2006-03-01
DK1040191T3 (da) 2005-12-19
EP1431391B1 (de) 2005-11-02
ATE308616T1 (de) 2005-11-15
WO1999033989A2 (en) 1999-07-08
US7164000B2 (en) 2007-01-16
DE69832216T2 (de) 2006-05-24
DE69832197T2 (de) 2006-05-24
CA2316447C (en) 2009-07-28
EP1040191A2 (de) 2000-10-04
EP1431391A2 (de) 2004-06-23
WO1999033989A3 (en) 1999-08-26
AU2415599A (en) 1999-07-19
DK1431391T3 (da) 2005-12-19

Similar Documents

Publication Publication Date Title
ATE280826T1 (de) Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen
TR200002773T2 (tr) Alzheimer tedavisi için smilagenin ve anzurogenin-D ve bunların kullanımı.
NO911624L (no) Farmasoeytiske forbindelser.
DE69739665D1 (de) Isoliertes, dimerisches fibroblasten-aktivierendes protein alpha und anwendungen desselben
ATE476495T1 (de) Bazillus thuringiensis und dessen insektizide proteine
DE69324826D1 (de) Gegen Papillomaviren wirksame 2',5'-OLIGOADENYLAT-2',3'-CYCLOPHOSPHATE und 2',5'-OLIGOADENYLATE
DE60045681D1 (de) Vaskuläre adhesionsmoleküle und modulierung ihrer funktion
ATE218616T1 (de) Humanes zirkulierendes cytokin cc-1
ATE308617T1 (de) Rantes mutanten und deren therapeutischen anwendungen
BR9301641A (pt) Processo para produzir uma preparacao de fator viii,altamente purificada e uso
ES2080736T3 (es) Uso de 2,3,4,5-tetrahidro-1h-3-benzazepinas en el tratamiento de trastornos neurologicos.
ATE438658T1 (de) Neue polypeptide aus bienengift und dessen gebrauchsverfahren
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
BG103543A (en) The use of pramipexol in the treatment of the uneasy legs syndrome
DK0647654T3 (da) Anomere fluor-ribosylaminer
FR2710244B3 (fr) Composition diététique à base d'acides aminés essentiels.
ZA961897B (en) 6,7-substituted-2-aminotetralines and use thereof
SE8802323D0 (sv) 8alfa-acylaminoergoline, its preparation and pharmaceutical compositions containing it
Palani Professor Dr. N. Subbu Reddiar's contributions for the enrichment of Tamil
DE3689850T2 (de) Peptide und deren Verwendung in der Therapie.
ITRM920079A1 (it) Manufatto per l'allargamento di banchine stradali e procedimento di posa in opera.
TH8515EX (th) อุปกรณ์ปรับความดันของก๊าซแบบมีเครื่องตั้งเวลาและตำแหน่งปิด-เปิด
ITRM930343A0 (it) Proteine ricombinanti, vettori per l'espressione e loro usi.
ATE179714T1 (de) Gegen papillomaviren wirksame 2',5'-oligoadenylat-2',3'-cyclophosphate und 2',5'-oligoadenylate

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1431391

Country of ref document: EP