ES2080736T3 - Uso de 2,3,4,5-tetrahidro-1h-3-benzazepinas en el tratamiento de trastornos neurologicos. - Google Patents
Uso de 2,3,4,5-tetrahidro-1h-3-benzazepinas en el tratamiento de trastornos neurologicos.Info
- Publication number
- ES2080736T3 ES2080736T3 ES89112959T ES89112959T ES2080736T3 ES 2080736 T3 ES2080736 T3 ES 2080736T3 ES 89112959 T ES89112959 T ES 89112959T ES 89112959 T ES89112959 T ES 89112959T ES 2080736 T3 ES2080736 T3 ES 2080736T3
- Authority
- ES
- Spain
- Prior art keywords
- benzazepines
- tetrahydro
- treatment
- neurological disorders
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SON PRESENTADOS METODO Y COMPOSICIONES PARA EL TRATAMIENTO DE LA DEPENDENCIA DE DROGAS, DESORDEN DEL MOVIMIENTO Y COMPORTAMIENTO ESTEREOTIPO CON CIERTOS COMPUESTOS DE BENCIAZEPINAS FUSIONADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/223,739 US4973586A (en) | 1986-01-16 | 1988-07-18 | Fused benzazepines, compositions of, and medical use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2080736T3 true ES2080736T3 (es) | 1996-02-16 |
Family
ID=22837795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89112959T Expired - Lifetime ES2080736T3 (es) | 1988-07-18 | 1989-07-14 | Uso de 2,3,4,5-tetrahidro-1h-3-benzazepinas en el tratamiento de trastornos neurologicos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4973586A (es) |
EP (2) | EP0434695A1 (es) |
JP (1) | JPH0662420B2 (es) |
KR (1) | KR900701275A (es) |
AT (1) | ATE131056T1 (es) |
AU (1) | AU634973B2 (es) |
CA (1) | CA1336823C (es) |
DE (1) | DE68925004T2 (es) |
DK (1) | DK302190A (es) |
ES (1) | ES2080736T3 (es) |
IL (1) | IL90973A (es) |
WO (1) | WO1990000853A2 (es) |
ZA (1) | ZA895343B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5302716A (en) * | 1986-01-16 | 1994-04-12 | Schering Corporation | Fused benzazepines |
US5091526A (en) * | 1988-07-29 | 1992-02-25 | Schering Corporation | Process for the enantiospecific synthesis of intermediates for hexahydro-benzo[d]-naphtho[2,1-b]azepines |
CA2016465A1 (en) * | 1989-06-02 | 1990-12-02 | Zola Phillip Horovitz | Method for preventing or treating anxiety employing a calcium channel blocker |
JPH0613474B2 (ja) * | 1990-02-02 | 1994-02-23 | シェリング・コーポレーション | 4,5―シクロアルカノ―3―ベンズアゼピン―7―オール誘導体およびその使用 |
US5312819A (en) * | 1990-08-20 | 1994-05-17 | Sandoz Ltd. | Pharmaceutical compositions comprising clozapine and a radical scavenger |
US5461147A (en) * | 1993-09-27 | 1995-10-24 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
US5463051A (en) * | 1993-09-27 | 1995-10-31 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
US5461148A (en) * | 1993-09-27 | 1995-10-24 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
CA2304592A1 (en) * | 1997-09-24 | 1999-04-01 | The General Hospital Corporation | Inhibition of psychostimulant-induced and nicotine-induced craving |
US6410527B1 (en) | 1998-03-02 | 2002-06-25 | Schering Corporation | Method of treating obsessive compulsive disorders, somatoform disorders, dissociative disorders, eating disorders, impulse control disorders, and autism |
US6875866B2 (en) * | 2002-02-21 | 2005-04-05 | Schering Corporation | Process for synthesis of D1 receptor antagonists |
DE60321354D1 (de) * | 2002-08-29 | 2008-07-10 | Schering Corp | Selektive d1/d5 rezeptorantagonisten zur behandlung von fettleibigkeit und von zns störungen |
EP1646623A2 (en) * | 2003-05-22 | 2006-04-19 | Schering Corporation | 5-h-benzo[d]naphth[2,1-b]azepine derivative as selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders |
EP2872145B8 (en) | 2012-07-12 | 2022-04-13 | Emalex Biosciences, Inc. | Fused benzazepines for treatment of tourette's syndrome |
RS60556B1 (sr) | 2013-10-18 | 2020-08-31 | Emalex Biosciences Inc | Kondenzovani benzazepini za lečenje mucanja |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
CH481110A (de) * | 1967-02-17 | 1969-11-15 | Geigy Ag J R | Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen |
GB1118688A (en) * | 1967-02-17 | 1968-07-03 | Scherico Ltd | Novel benzazepines and process for making same |
US3609138A (en) * | 1967-12-22 | 1971-09-28 | Ciba Geigy Corp | 1-aryl-3-benzazepines |
FR2137627A1 (es) * | 1971-05-10 | 1972-12-29 | Hoffmann La Roche | |
US3983234A (en) * | 1974-07-04 | 1976-09-28 | Sandoz Ltd. | Treatment of dyskinesias |
US3939165A (en) * | 1974-11-14 | 1976-02-17 | Morton-Norwich Products, Inc. | 5,6,6A,6B,7,8-Hexahydrobenz[a]phenanthridine hydrochloride |
US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
US4284555A (en) * | 1979-04-27 | 1981-08-18 | Schering Corporation | 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
US4315926A (en) * | 1979-12-26 | 1982-02-16 | Ciba-Geigy Corporation | Dibenz[c,e]azepines |
US4477378A (en) * | 1980-02-05 | 1984-10-16 | Schering Corp. | Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
DE3007710C2 (de) * | 1980-02-29 | 1982-04-15 | Gödecke AG, 1000 Berlin | 5,6;8,9-Tetrahydro-7H-dibenz(d,f)azonin-derivate, Verfahren zu deren Herstellung und Arzneimittel |
AU588080B2 (en) * | 1986-01-16 | 1989-09-07 | Schering Corporation | Fused benzazepines |
HU203537B (en) * | 1987-07-15 | 1991-08-28 | Schering Corp | Process for producing condensed benzazepine derivatives and pharmaceutical compositions containing them |
-
1988
- 1988-07-18 US US07/223,739 patent/US4973586A/en not_active Expired - Lifetime
-
1989
- 1989-07-13 ZA ZA895343A patent/ZA895343B/xx unknown
- 1989-07-14 ES ES89112959T patent/ES2080736T3/es not_active Expired - Lifetime
- 1989-07-14 EP EP89908786A patent/EP0434695A1/en active Pending
- 1989-07-14 AU AU39884/89A patent/AU634973B2/en not_active Ceased
- 1989-07-14 CA CA000605690A patent/CA1336823C/en not_active Expired - Fee Related
- 1989-07-14 IL IL9097389A patent/IL90973A/en not_active IP Right Cessation
- 1989-07-14 WO PCT/US1989/002997 patent/WO1990000853A2/en active Search and Examination
- 1989-07-14 JP JP1508220A patent/JPH0662420B2/ja not_active Expired - Fee Related
- 1989-07-14 EP EP89112959A patent/EP0351733B1/en not_active Expired - Lifetime
- 1989-07-14 AT AT89112959T patent/ATE131056T1/de not_active IP Right Cessation
- 1989-07-14 DE DE68925004T patent/DE68925004T2/de not_active Expired - Fee Related
-
1990
- 1990-03-16 KR KR1019900700564A patent/KR900701275A/ko not_active Application Discontinuation
- 1990-12-20 DK DK302190A patent/DK302190A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1990000853A8 (en) | 2005-06-16 |
IL90973A (en) | 1994-04-12 |
AU634973B2 (en) | 1993-03-11 |
CA1336823C (en) | 1995-08-29 |
AU3988489A (en) | 1990-02-19 |
WO1990000853A2 (en) | 1990-02-08 |
EP0434695A1 (en) | 1991-07-03 |
ATE131056T1 (de) | 1995-12-15 |
DE68925004D1 (de) | 1996-01-18 |
EP0351733A1 (en) | 1990-01-24 |
EP0351733B1 (en) | 1995-12-06 |
ZA895343B (en) | 1991-03-27 |
JPH0662420B2 (ja) | 1994-08-17 |
JPH03502100A (ja) | 1991-05-16 |
US4973586A (en) | 1990-11-27 |
DK302190A (da) | 1991-01-11 |
DE68925004T2 (de) | 1996-05-15 |
KR900701275A (ko) | 1990-12-01 |
DK302190D0 (da) | 1990-12-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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