ATE131056T1 - Verwendung von 2,3,4,5-tetrahydro-1h-3- benzazepinen bei der behandlung von neurologischen störungen. - Google Patents
Verwendung von 2,3,4,5-tetrahydro-1h-3- benzazepinen bei der behandlung von neurologischen störungen.Info
- Publication number
- ATE131056T1 ATE131056T1 AT89112959T AT89112959T ATE131056T1 AT E131056 T1 ATE131056 T1 AT E131056T1 AT 89112959 T AT89112959 T AT 89112959T AT 89112959 T AT89112959 T AT 89112959T AT E131056 T1 ATE131056 T1 AT E131056T1
- Authority
- AT
- Austria
- Prior art keywords
- benzazepines
- tetrahydro
- treatment
- neurological disorders
- chem
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/223,739 US4973586A (en) | 1986-01-16 | 1988-07-18 | Fused benzazepines, compositions of, and medical use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE131056T1 true ATE131056T1 (de) | 1995-12-15 |
Family
ID=22837795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89112959T ATE131056T1 (de) | 1988-07-18 | 1989-07-14 | Verwendung von 2,3,4,5-tetrahydro-1h-3- benzazepinen bei der behandlung von neurologischen störungen. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4973586A (de) |
EP (2) | EP0351733B1 (de) |
JP (1) | JPH0662420B2 (de) |
KR (1) | KR900701275A (de) |
AT (1) | ATE131056T1 (de) |
AU (1) | AU634973B2 (de) |
CA (1) | CA1336823C (de) |
DE (1) | DE68925004T2 (de) |
DK (1) | DK302190A (de) |
ES (1) | ES2080736T3 (de) |
IL (1) | IL90973A (de) |
WO (1) | WO1990000853A2 (de) |
ZA (1) | ZA895343B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5302716A (en) * | 1986-01-16 | 1994-04-12 | Schering Corporation | Fused benzazepines |
US5091526A (en) * | 1988-07-29 | 1992-02-25 | Schering Corporation | Process for the enantiospecific synthesis of intermediates for hexahydro-benzo[d]-naphtho[2,1-b]azepines |
CA2016465A1 (en) * | 1989-06-02 | 1990-12-02 | Zola Phillip Horovitz | Method for preventing or treating anxiety employing a calcium channel blocker |
WO1991011437A1 (en) * | 1990-02-02 | 1991-08-08 | Schering Corporation | 4,5-cycloalkano-3-benzazepin-7-ol-derivatives and their use |
US5312819A (en) * | 1990-08-20 | 1994-05-17 | Sandoz Ltd. | Pharmaceutical compositions comprising clozapine and a radical scavenger |
US5461147A (en) * | 1993-09-27 | 1995-10-24 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
US5463051A (en) * | 1993-09-27 | 1995-10-31 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
US5461148A (en) * | 1993-09-27 | 1995-10-24 | Schering Corporation | Process for preparing benzazepine intermediates for the synthesis of D1 antagonists |
US6517812B1 (en) * | 1997-09-24 | 2003-02-11 | The General Hospital Corporation | Inhibition of psychostimulant-induced and nicotine-induced craving |
US6410527B1 (en) | 1998-03-02 | 2002-06-25 | Schering Corporation | Method of treating obsessive compulsive disorders, somatoform disorders, dissociative disorders, eating disorders, impulse control disorders, and autism |
US6875866B2 (en) * | 2002-02-21 | 2005-04-05 | Schering Corporation | Process for synthesis of D1 receptor antagonists |
ES2308016T3 (es) * | 2002-08-29 | 2008-12-01 | Schering Corporation | Anatagonistas selectivos de los receptores d1/d5 para el tratamiento de la obesidad y trastornos del snc. |
EP1646623A2 (de) * | 2003-05-22 | 2006-04-19 | Schering Corporation | 5-h-benzo[d]naphth[2,1-b]azepinderivate als selektive d1/d5-rezeptorantagonisten zur behandlung von obesitas und zns-erkrankungen |
HUE058696T2 (hu) | 2012-07-12 | 2022-09-28 | Emalex Biosciences Inc | Fúzionált benzazepinek a turett-szindróma terápiájában |
PL3057595T3 (pl) | 2013-10-18 | 2021-03-08 | Emalex Biosciences, Inc. | Skondensowane benzazepiny do leczenia jąkania |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
GB1118688A (en) * | 1967-02-17 | 1968-07-03 | Scherico Ltd | Novel benzazepines and process for making same |
CH481110A (de) * | 1967-02-17 | 1969-11-15 | Geigy Ag J R | Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen |
US3609138A (en) * | 1967-12-22 | 1971-09-28 | Ciba Geigy Corp | 1-aryl-3-benzazepines |
IL39381A0 (en) * | 1971-05-10 | 1972-07-26 | Sparamedica Ag | Rheadan-type alkaloids,their preparation and pharmaceutical compositions containing them |
US3983234A (en) * | 1974-07-04 | 1976-09-28 | Sandoz Ltd. | Treatment of dyskinesias |
US3939165A (en) * | 1974-11-14 | 1976-02-17 | Morton-Norwich Products, Inc. | 5,6,6A,6B,7,8-Hexahydrobenz[a]phenanthridine hydrochloride |
US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
US4284555A (en) * | 1979-04-27 | 1981-08-18 | Schering Corporation | 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
US4315926A (en) * | 1979-12-26 | 1982-02-16 | Ciba-Geigy Corporation | Dibenz[c,e]azepines |
US4477378A (en) * | 1980-02-05 | 1984-10-16 | Schering Corp. | Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
DE3007710C2 (de) * | 1980-02-29 | 1982-04-15 | Gödecke AG, 1000 Berlin | 5,6;8,9-Tetrahydro-7H-dibenz(d,f)azonin-derivate, Verfahren zu deren Herstellung und Arzneimittel |
EP0254737B1 (de) * | 1986-01-16 | 1990-07-25 | Schering Corporation | Kondensierte benzazepine |
DE3780649T2 (de) * | 1987-07-15 | 1992-12-10 | Schering Corp | Kondensierte benzazepine. |
-
1988
- 1988-07-18 US US07/223,739 patent/US4973586A/en not_active Expired - Lifetime
-
1989
- 1989-07-13 ZA ZA895343A patent/ZA895343B/xx unknown
- 1989-07-14 EP EP89112959A patent/EP0351733B1/de not_active Expired - Lifetime
- 1989-07-14 EP EP89908786A patent/EP0434695A1/de active Pending
- 1989-07-14 AT AT89112959T patent/ATE131056T1/de not_active IP Right Cessation
- 1989-07-14 CA CA000605690A patent/CA1336823C/en not_active Expired - Fee Related
- 1989-07-14 AU AU39884/89A patent/AU634973B2/en not_active Ceased
- 1989-07-14 IL IL9097389A patent/IL90973A/en not_active IP Right Cessation
- 1989-07-14 JP JP1508220A patent/JPH0662420B2/ja not_active Expired - Fee Related
- 1989-07-14 DE DE68925004T patent/DE68925004T2/de not_active Expired - Fee Related
- 1989-07-14 WO PCT/US1989/002997 patent/WO1990000853A2/en active Search and Examination
- 1989-07-14 ES ES89112959T patent/ES2080736T3/es not_active Expired - Lifetime
-
1990
- 1990-03-16 KR KR1019900700564A patent/KR900701275A/ko not_active Application Discontinuation
- 1990-12-20 DK DK302190A patent/DK302190A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0351733A1 (de) | 1990-01-24 |
ZA895343B (en) | 1991-03-27 |
DK302190D0 (da) | 1990-12-20 |
KR900701275A (ko) | 1990-12-01 |
AU634973B2 (en) | 1993-03-11 |
DE68925004D1 (de) | 1996-01-18 |
ES2080736T3 (es) | 1996-02-16 |
CA1336823C (en) | 1995-08-29 |
DE68925004T2 (de) | 1996-05-15 |
US4973586A (en) | 1990-11-27 |
JPH0662420B2 (ja) | 1994-08-17 |
EP0351733B1 (de) | 1995-12-06 |
DK302190A (da) | 1991-01-11 |
WO1990000853A8 (en) | 2005-06-16 |
WO1990000853A2 (en) | 1990-02-08 |
EP0434695A1 (de) | 1991-07-03 |
IL90973A (en) | 1994-04-12 |
AU3988489A (en) | 1990-02-19 |
JPH03502100A (ja) | 1991-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |