HRP990130B1 - HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A - Google Patents

HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A

Info

Publication number
HRP990130B1
HRP990130B1 HR990130A HRP990130A HRP990130B1 HR P990130 B1 HRP990130 B1 HR P990130B1 HR 990130 A HR990130 A HR 990130A HR P990130 A HRP990130 A HR P990130A HR P990130 B1 HRP990130 B1 HR P990130B1
Authority
HR
Croatia
Prior art keywords
meaning
arylthiocarbamoyl
homoerythromycin
deoxo
arylcarbamoyl
Prior art date
Application number
HR990130A
Other languages
English (en)
Inventor
Maruueic-Iuetuk Zorica
Kujundžic Nedjeljko
Kobrehel Gabrijela
Mutak Stjepan
Marueic Natauea
Original Assignee
Pliva D D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva D D filed Critical Pliva D D
Priority to HR990130A priority Critical patent/HRP990130B1/xx
Priority to UA2001118221A priority patent/UA71962C2/uk
Priority to EA200101170A priority patent/EA005214B1/ru
Priority to AT00920940T priority patent/ATE244258T1/de
Priority to DK00920940T priority patent/DK1175429T3/da
Priority to NZ515278A priority patent/NZ515278A/xx
Priority to IL14598600A priority patent/IL145986A0/xx
Priority to MXPA01011038A priority patent/MXPA01011038A/es
Priority to BR0010231-8A priority patent/BR0010231A/pt
Priority to PT00920940T priority patent/PT1175429E/pt
Priority to EEP200100582A priority patent/EE05007B1/xx
Priority to EP00920940A priority patent/EP1175429B1/en
Priority to GEAP20006227A priority patent/GEP20032928B/en
Priority to ES00920940T priority patent/ES2202107T3/es
Priority to TR2001/03143T priority patent/TR200103143T2/xx
Priority to DE60003671T priority patent/DE60003671T2/de
Priority to KR1020017014046A priority patent/KR100714740B1/ko
Priority to CA002372977A priority patent/CA2372977A1/en
Priority to JP2000615632A priority patent/JP2002543213A/ja
Priority to CZ20013913A priority patent/CZ20013913A3/cs
Priority to CNB008071500A priority patent/CN1140535C/zh
Priority to SI200030188T priority patent/SI1175429T1/xx
Priority to SK1570-2001A priority patent/SK284513B6/sk
Priority to AU41350/00A priority patent/AU767681B2/en
Priority to PCT/HR2000/000013 priority patent/WO2000066603A1/en
Priority to US09/959,662 priority patent/US6872707B1/en
Priority to HU0201146A priority patent/HUP0201146A3/hu
Priority to PL00351402A priority patent/PL351402A1/xx
Priority to ZA200108484A priority patent/ZA200108484B/xx
Priority to IL145986A priority patent/IL145986A/en
Priority to IS6115A priority patent/IS6115A/is
Publication of HRP990130A2 publication Critical patent/HRP990130A2/hr
Priority to NO20015346A priority patent/NO320138B1/no
Priority to BG106173A priority patent/BG106173A/bg
Priority to HK02107027.0A priority patent/HK1045522B/zh
Publication of HRP990130B1 publication Critical patent/HRP990130B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR990130A 1999-05-03 1999-05-03 HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A HRP990130B1 (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
HR990130A HRP990130B1 (en) 1999-05-03 1999-05-03 HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
UA2001118221A UA71962C2 (en) 1999-05-03 2000-02-05 Halo derivatives of 9-deoxo-9a-aza-9a-homoerythromycin a, a method for the preparation thereof and a pharmaceutical composition
CA002372977A CA2372977A1 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin a
CZ20013913A CZ20013913A3 (cs) 1999-05-03 2000-05-02 Halogenderiváty 9a-N-(N´-arylkarbamoyl)-a 9a-N-(N´-arylthiokarbamoyl)-9-deoxo-9a-aza-9a-homoerythromycinu A
DK00920940T DK1175429T3 (da) 1999-05-03 2000-05-02 Halogenderivater af 9-deoxo-9a-aza-9a-homoerythromycin A
NZ515278A NZ515278A (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a- homerythromycin A their salts and preparation process
JP2000615632A JP2002543213A (ja) 1999-05-03 2000-05-02 ９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシンＡのハロ誘導体
MXPA01011038A MXPA01011038A (es) 1999-05-03 2000-05-02 Derivados halo de 9-desoxo-9a-aza-9a-homoeritromicina a.
BR0010231-8A BR0010231A (pt) 1999-05-03 2000-05-02 Derivados de halo de 9a-n-(n'-larilcarbamoil)- e 9a-n-(n'l- ariltiocarbamoil)-9-desoxo-9a-aza-9a-homoeritromici na a
AT00920940T ATE244258T1 (de) 1999-05-03 2000-05-02 Halo-derivate von 9-deoxo-9a-aza-9a- homerythromycin a
EEP200100582A EE05007B1 (et) 1999-05-03 2000-05-02 9a-N-(N'-arlkarbamol)- ja 9a-N-(N'-arltiokarbamol)-9-desokso-9a-asa-9a-homoertromtsiini Ahalogeenderivaadid, nende valmistamismeetod, farmatseutiline kompositsioon ja kasutamine
CNB008071500A CN1140535C (zh) 1999-05-03 2000-05-02 9-脱氧-9a-氮杂-9a-高红霉素A的卤代衍生物
GEAP20006227A GEP20032928B (en) 1999-05-03 2000-05-02 Halo Derivatives of 9-Deoxo-9a-Aza-9a-Homerythromycin A, Method for its Production, Pharmaceutical Compositions Containing the Same and Their Use for Treatment or Prevention of Bacterial Infections
ES00920940T ES2202107T3 (es) 1999-05-03 2000-05-02 Derivados halo de 9-desoxi-9a-aza-9a-homoeritromicina a.
TR2001/03143T TR200103143T2 (tr) 1999-05-03 2000-05-02 9-Deokso-9A-AZA-9A-Homeritromisin 9A'nın Halo Türevleri.
DE60003671T DE60003671T2 (de) 1999-05-03 2000-05-02 Halo-derivate von 9-deoxo-9a-aza-9a-homerythromycin a
KR1020017014046A KR100714740B1 (ko) 1999-05-03 2000-05-02 9-데옥소-9ａ-아자-9ａ-호모에리스로마이신 ａ의 할로 유도체들
EA200101170A EA005214B1 (ru) 1999-05-03 2000-05-02 ГАЛОИДПРОИЗВОДНЫЕ 9-ДЕОКСО-9a-АЗА-9a-ГОМОЭРИТРОМИЦИНА А
IL14598600A IL145986A0 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin a
PT00920940T PT1175429E (pt) 1999-05-03 2000-05-02 Derivados halo de 9-desoxo-9a-aza-9a-homoeritromicina a
EP00920940A EP1175429B1 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin a
SI200030188T SI1175429T1 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin a
SK1570-2001A SK284513B6 (sk) 1999-05-03 2000-05-02 Halogénderiváty 9a-N-(N´-arylkarbamoyl)- a 9a-N-(N´-aryltiokarbamoyl)-9-deoxo-9a-aza-9a-homoerytromycínu A, spôsob ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie
AU41350/00A AU767681B2 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin A
PCT/HR2000/000013 WO2000066603A1 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin a
US09/959,662 US6872707B1 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-homerythromycin A
HU0201146A HUP0201146A3 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin a, process for their preparation and pharmaceutical compositions containing them
PL00351402A PL351402A1 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin a
ZA200108484A ZA200108484B (en) 1999-05-03 2001-10-16 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin A.
IL145986A IL145986A (en) 1999-05-03 2001-10-17 History of a9 - deoxo - 9a - aza 9a - (Aril (Thio) Karbmobil) - 9a - Humarithromycin A Preparation, and pharmaceutical preparations containing them
IS6115A IS6115A (is) 1999-05-03 2001-10-19 Haló afleiður af 9-deoxó-9a-aza-9a-hómerýþrómýsíni A
NO20015346A NO320138B1 (no) 1999-05-03 2001-11-01 Haloderivater av 9-deoksy-9a-aza-9a-homoerytromycin A, fremgangsmate for fremstilling derav, farmasoytiske preparater omfattende dem, samt anvendelse derav.
BG106173A BG106173A (bg) 1999-05-03 2001-12-03 Халогенови производни на 9-дезоксо-9а-аза-9а-хомеритромицин а
HK02107027.0A HK1045522B (zh) 1999-05-03 2002-09-26 9-脫氧-9a-氮雜-9a-高紅霉素a的鹵代衍生物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR990130A HRP990130B1 (en) 1999-05-03 1999-05-03 HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A

Publications (2)

Publication Number Publication Date
HRP990130A2 HRP990130A2 (en) 2001-10-31
HRP990130B1 true HRP990130B1 (en) 2004-06-30

Family

ID=10946916

Family Applications (1)

Application Number Title Priority Date Filing Date
HR990130A HRP990130B1 (en) 1999-05-03 1999-05-03 HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A

Country Status (33)

Country Link
US (1) US6872707B1 (is)
EP (1) EP1175429B1 (is)
JP (1) JP2002543213A (is)
KR (1) KR100714740B1 (is)
CN (1) CN1140535C (is)
AT (1) ATE244258T1 (is)
AU (1) AU767681B2 (is)
BG (1) BG106173A (is)
BR (1) BR0010231A (is)
CA (1) CA2372977A1 (is)
CZ (1) CZ20013913A3 (is)
DE (1) DE60003671T2 (is)
DK (1) DK1175429T3 (is)
EA (1) EA005214B1 (is)
EE (1) EE05007B1 (is)
ES (1) ES2202107T3 (is)
GE (1) GEP20032928B (is)
HK (1) HK1045522B (is)
HR (1) HRP990130B1 (is)
HU (1) HUP0201146A3 (is)
IL (2) IL145986A0 (is)
IS (1) IS6115A (is)
MX (1) MXPA01011038A (is)
NO (1) NO320138B1 (is)
NZ (1) NZ515278A (is)
PL (1) PL351402A1 (is)
PT (1) PT1175429E (is)
SI (1) SI1175429T1 (is)
SK (1) SK284513B6 (is)
TR (1) TR200103143T2 (is)
UA (1) UA71962C2 (is)
WO (1) WO2000066603A1 (is)
ZA (1) ZA200108484B (is)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20010146B1 (en) * 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020886A2 (en) * 2002-11-11 2005-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. SUBSTITUTED 9a-N-[N'-(BENZENSULFONYL)CARBAMOYL-γ-AMINOPROPYL) AND 9a-N(N' -(?-CYANOETHIL)-N' -(b
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
HRP20030381B1 (en) * 2003-05-14 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
JP2008526948A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗マラリア活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
WO2009039177A1 (en) * 2007-09-17 2009-03-26 Enanta Pharmaceuticals, Inc. 6, 11-bicycloides: bridged biaryl macrolide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
KR930702369A (ko) * 1990-10-15 1993-09-08 우에노 아키라 에리쓰로마이신 또는 그의 유도체의 2'위치 수식 화합물
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A

Also Published As

Publication number Publication date
ZA200108484B (en) 2003-03-26
NO320138B1 (no) 2005-10-31
SI1175429T1 (en) 2003-12-31
EA005214B1 (ru) 2004-12-30
PL351402A1 (en) 2003-04-07
PT1175429E (pt) 2003-11-28
HRP990130A2 (en) 2001-10-31
CN1140535C (zh) 2004-03-03
HK1045522B (zh) 2004-08-20
MXPA01011038A (es) 2002-07-22
IL145986A (en) 2006-10-31
DE60003671T2 (de) 2004-06-17
US6872707B1 (en) 2005-03-29
EE05007B1 (et) 2008-04-15
UA71962C2 (en) 2005-01-17
NO20015346L (no) 2001-11-01
EP1175429B1 (en) 2003-07-02
GEP20032928B (en) 2003-03-25
HUP0201146A2 (hu) 2002-07-29
HUP0201146A3 (en) 2003-03-28
CA2372977A1 (en) 2000-11-09
NO20015346D0 (no) 2001-11-01
BR0010231A (pt) 2002-02-19
KR20020007397A (ko) 2002-01-26
DK1175429T3 (da) 2003-10-20
HK1045522A1 (en) 2002-11-29
KR100714740B1 (ko) 2007-05-07
ATE244258T1 (de) 2003-07-15
SK15702001A3 (sk) 2002-04-04
SK284513B6 (sk) 2005-05-05
DE60003671D1 (de) 2003-08-07
IL145986A0 (en) 2002-07-25
EA200101170A1 (ru) 2002-04-25
JP2002543213A (ja) 2002-12-17
EE200100582A (et) 2003-02-17
CZ20013913A3 (cs) 2002-04-17
TR200103143T2 (tr) 2002-04-22
ES2202107T3 (es) 2004-04-01
NZ515278A (en) 2003-06-30
CN1351606A (zh) 2002-05-29
WO2000066603A1 (en) 2000-11-09
AU4135000A (en) 2000-11-17
IS6115A (is) 2001-10-19
EP1175429A1 (en) 2002-01-30
AU767681B2 (en) 2003-11-20
BG106173A (bg) 2002-07-31

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