TR200103143T2 - 9-Deokso-9A-AZA-9A-Homeritromisin 9A'nın Halo Türevleri. - Google Patents

9-Deokso-9A-AZA-9A-Homeritromisin 9A'nın Halo Türevleri.

Info

Publication number
TR200103143T2
TR200103143T2 TR2001/03143T TR200103143T TR200103143T2 TR 200103143 T2 TR200103143 T2 TR 200103143T2 TR 2001/03143 T TR2001/03143 T TR 2001/03143T TR 200103143 T TR200103143 T TR 200103143T TR 200103143 T2 TR200103143 T2 TR 200103143T2
Authority
TR
Turkey
Prior art keywords
halo
aza
formula
group
homerythromycin
Prior art date
Application number
TR2001/03143T
Other languages
English (en)
Inventor
Marusic-Istuk Zorica
Kujundzic Nedjeljko
Kobrehel Gabrijela
Mutak Stjepan
Marsic Natasa
Original Assignee
Pliva Farmaceutska Industrija, Dionicko Drustuo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutska Industrija, Dionicko Drustuo filed Critical Pliva Farmaceutska Industrija, Dionicko Drustuo
Publication of TR200103143T2 publication Critical patent/TR200103143T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Bulus, genel formülün (I) 9a-N-(N'arilkarbamoil)-ve 9a-N-(N'-ariltiokarbamoil) -9-de-okso-9a-aza-9a-homoeritromisin A'nin halo türevlerine dairdir, ki burada R, formülün (II) bir muadil hale getirilmis aril grubu anlamina gelir, ki burada muadil a,b,c,d ve e ayni veya farklidir ve en az bunlardan biri halo, bir (C1-C6)haloalkil veya bir (C1-C6) haloalkoksi grubu anlamina gelir, öte yandan kalanlar hidrojen, halo, bir (C1-C6) haloalkil veya bir (C1-C6)haloalkoksi, grubu anlamina gelir ve X oksijen veya sülfür anlamina gelir, ve bunlarin organik veya inorganik asitlerle birlikte farmasotik olarak kabul edilebilir ekleme tuzlarina, bunlari kapsayan farmasotik kompozisyonlarin hazirlanmasina yönelik bir usüle ve bu farmasotik kompozisyonlarin bakteriyel enfeksiyonlarin tedavi veya önlenmesi için kullanimina dairdir (FORMÜL VAR).
TR2001/03143T 1999-05-03 2000-05-02 9-Deokso-9A-AZA-9A-Homeritromisin 9A'nın Halo Türevleri. TR200103143T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR990130A HRP990130B1 (en) 1999-05-03 1999-05-03 HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A

Publications (1)

Publication Number Publication Date
TR200103143T2 true TR200103143T2 (tr) 2002-04-22

Family

ID=10946916

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03143T TR200103143T2 (tr) 1999-05-03 2000-05-02 9-Deokso-9A-AZA-9A-Homeritromisin 9A'nın Halo Türevleri.

Country Status (33)

Country Link
US (1) US6872707B1 (tr)
EP (1) EP1175429B1 (tr)
JP (1) JP2002543213A (tr)
KR (1) KR100714740B1 (tr)
CN (1) CN1140535C (tr)
AT (1) ATE244258T1 (tr)
AU (1) AU767681B2 (tr)
BG (1) BG106173A (tr)
BR (1) BR0010231A (tr)
CA (1) CA2372977A1 (tr)
CZ (1) CZ20013913A3 (tr)
DE (1) DE60003671T2 (tr)
DK (1) DK1175429T3 (tr)
EA (1) EA005214B1 (tr)
EE (1) EE05007B1 (tr)
ES (1) ES2202107T3 (tr)
GE (1) GEP20032928B (tr)
HK (1) HK1045522B (tr)
HR (1) HRP990130B1 (tr)
HU (1) HUP0201146A3 (tr)
IL (2) IL145986A0 (tr)
IS (1) IS6115A (tr)
MX (1) MXPA01011038A (tr)
NO (1) NO320138B1 (tr)
NZ (1) NZ515278A (tr)
PL (1) PL351402A1 (tr)
PT (1) PT1175429E (tr)
SI (1) SI1175429T1 (tr)
SK (1) SK284513B6 (tr)
TR (1) TR200103143T2 (tr)
UA (1) UA71962C2 (tr)
WO (1) WO2000066603A1 (tr)
ZA (1) ZA200108484B (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20010146B1 (en) * 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
HRP20020886A2 (en) * 2002-11-11 2005-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. SUBSTITUTED 9a-N-[N'-(BENZENSULFONYL)CARBAMOYL-γ-AMINOPROPYL) AND 9a-N(N' -(?-CYANOETHIL)-N' -(b
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
HRP20030381B1 (en) * 2003-05-14 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
US20080227730A1 (en) * 2005-01-14 2008-09-18 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9A-Carbamoyl and Thiocarbamoyl Azalides With Antimalarial Activity
WO2009075923A2 (en) * 2007-09-17 2009-06-18 Enanta Pharmaceuticals, Inc. 6, 11-bridged biaryl macrolides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
CA2094060A1 (en) * 1990-10-15 1992-04-16 Toshifumi Asaka 2'-position modified compound of erythromycin or its derivative
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A

Also Published As

Publication number Publication date
PL351402A1 (en) 2003-04-07
HRP990130A2 (en) 2001-10-31
BR0010231A (pt) 2002-02-19
SK15702001A3 (sk) 2002-04-04
EA005214B1 (ru) 2004-12-30
HUP0201146A3 (en) 2003-03-28
UA71962C2 (en) 2005-01-17
KR100714740B1 (ko) 2007-05-07
JP2002543213A (ja) 2002-12-17
SK284513B6 (sk) 2005-05-05
ATE244258T1 (de) 2003-07-15
CN1140535C (zh) 2004-03-03
HRP990130B1 (en) 2004-06-30
AU767681B2 (en) 2003-11-20
KR20020007397A (ko) 2002-01-26
MXPA01011038A (es) 2002-07-22
EP1175429A1 (en) 2002-01-30
EE05007B1 (et) 2008-04-15
GEP20032928B (en) 2003-03-25
IL145986A (en) 2006-10-31
IS6115A (is) 2001-10-19
EE200100582A (et) 2003-02-17
DK1175429T3 (da) 2003-10-20
IL145986A0 (en) 2002-07-25
EA200101170A1 (ru) 2002-04-25
DE60003671T2 (de) 2004-06-17
ZA200108484B (en) 2003-03-26
DE60003671D1 (de) 2003-08-07
NO320138B1 (no) 2005-10-31
NO20015346D0 (no) 2001-11-01
CA2372977A1 (en) 2000-11-09
NO20015346L (no) 2001-11-01
NZ515278A (en) 2003-06-30
BG106173A (bg) 2002-07-31
CZ20013913A3 (cs) 2002-04-17
HK1045522B (zh) 2004-08-20
CN1351606A (zh) 2002-05-29
AU4135000A (en) 2000-11-17
PT1175429E (pt) 2003-11-28
WO2000066603A1 (en) 2000-11-09
SI1175429T1 (en) 2003-12-31
HK1045522A1 (en) 2002-11-29
EP1175429B1 (en) 2003-07-02
US6872707B1 (en) 2005-03-29
ES2202107T3 (es) 2004-04-01
HUP0201146A2 (hu) 2002-07-29

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