HK1045522B - 9-脫氧-9a-氮雜-9a-高紅霉素a的鹵代衍生物 - Google Patents

9-脫氧-9a-氮雜-9a-高紅霉素a的鹵代衍生物

Info

Publication number
HK1045522B
HK1045522B HK02107027.0A HK02107027A HK1045522B HK 1045522 B HK1045522 B HK 1045522B HK 02107027 A HK02107027 A HK 02107027A HK 1045522 B HK1045522 B HK 1045522B
Authority
HK
Hong Kong
Prior art keywords
meaning
halo
deoxo
aza
homerythromycin
Prior art date
Application number
HK02107027.0A
Other languages
English (en)
Other versions
HK1045522A1 (en
Inventor
Z‧馬魯西克-艾斯圖克
N‧庫君德兹克
G‧科伯裡赫爾
S‧穆塔克
N‧馬西克
Original Assignee
普利瓦藥物工業公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 普利瓦藥物工業公司 filed Critical 普利瓦藥物工業公司
Publication of HK1045522A1 publication Critical patent/HK1045522A1/xx
Publication of HK1045522B publication Critical patent/HK1045522B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK02107027.0A 1999-05-03 2002-09-26 9-脫氧-9a-氮雜-9a-高紅霉素a的鹵代衍生物 HK1045522B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR990130A HRP990130B1 (en) 1999-05-03 1999-05-03 HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
PCT/HR2000/000013 WO2000066603A1 (en) 1999-05-03 2000-05-02 Halo derivatives of 9-deoxo-9a-aza-9a-homerythromycin a

Publications (2)

Publication Number Publication Date
HK1045522A1 HK1045522A1 (en) 2002-11-29
HK1045522B true HK1045522B (zh) 2004-08-20

Family

ID=10946916

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02107027.0A HK1045522B (zh) 1999-05-03 2002-09-26 9-脫氧-9a-氮雜-9a-高紅霉素a的鹵代衍生物

Country Status (33)

Country Link
US (1) US6872707B1 (zh)
EP (1) EP1175429B1 (zh)
JP (1) JP2002543213A (zh)
KR (1) KR100714740B1 (zh)
CN (1) CN1140535C (zh)
AT (1) ATE244258T1 (zh)
AU (1) AU767681B2 (zh)
BG (1) BG106173A (zh)
BR (1) BR0010231A (zh)
CA (1) CA2372977A1 (zh)
CZ (1) CZ20013913A3 (zh)
DE (1) DE60003671T2 (zh)
DK (1) DK1175429T3 (zh)
EA (1) EA005214B1 (zh)
EE (1) EE05007B1 (zh)
ES (1) ES2202107T3 (zh)
GE (1) GEP20032928B (zh)
HK (1) HK1045522B (zh)
HR (1) HRP990130B1 (zh)
HU (1) HUP0201146A3 (zh)
IL (2) IL145986A0 (zh)
IS (1) IS6115A (zh)
MX (1) MXPA01011038A (zh)
NO (1) NO320138B1 (zh)
NZ (1) NZ515278A (zh)
PL (1) PL351402A1 (zh)
PT (1) PT1175429E (zh)
SI (1) SI1175429T1 (zh)
SK (1) SK284513B6 (zh)
TR (1) TR200103143T2 (zh)
UA (1) UA71962C2 (zh)
WO (1) WO2000066603A1 (zh)
ZA (1) ZA200108484B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20010146B1 (en) * 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020886A2 (en) * 2002-11-11 2005-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. SUBSTITUTED 9a-N-[N'-(BENZENSULFONYL)CARBAMOYL-γ-AMINOPROPYL) AND 9a-N(N' -(?-CYANOETHIL)-N' -(b
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
HRP20030381B1 (en) * 2003-05-14 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
JP2008526948A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗マラリア活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
WO2009039177A1 (en) * 2007-09-17 2009-03-26 Enanta Pharmaceuticals, Inc. 6, 11-bicycloides: bridged biaryl macrolide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
KR930702369A (ko) * 1990-10-15 1993-09-08 우에노 아키라 에리쓰로마이신 또는 그의 유도체의 2'위치 수식 화합물
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A

Also Published As

Publication number Publication date
ZA200108484B (en) 2003-03-26
NO320138B1 (no) 2005-10-31
SI1175429T1 (en) 2003-12-31
EA005214B1 (ru) 2004-12-30
PL351402A1 (en) 2003-04-07
PT1175429E (pt) 2003-11-28
HRP990130A2 (en) 2001-10-31
CN1140535C (zh) 2004-03-03
MXPA01011038A (es) 2002-07-22
IL145986A (en) 2006-10-31
DE60003671T2 (de) 2004-06-17
US6872707B1 (en) 2005-03-29
EE05007B1 (et) 2008-04-15
UA71962C2 (en) 2005-01-17
NO20015346L (no) 2001-11-01
EP1175429B1 (en) 2003-07-02
GEP20032928B (en) 2003-03-25
HUP0201146A2 (hu) 2002-07-29
HUP0201146A3 (en) 2003-03-28
CA2372977A1 (en) 2000-11-09
NO20015346D0 (no) 2001-11-01
BR0010231A (pt) 2002-02-19
KR20020007397A (ko) 2002-01-26
DK1175429T3 (da) 2003-10-20
HK1045522A1 (en) 2002-11-29
KR100714740B1 (ko) 2007-05-07
ATE244258T1 (de) 2003-07-15
SK15702001A3 (sk) 2002-04-04
SK284513B6 (sk) 2005-05-05
DE60003671D1 (de) 2003-08-07
IL145986A0 (en) 2002-07-25
EA200101170A1 (ru) 2002-04-25
JP2002543213A (ja) 2002-12-17
EE200100582A (et) 2003-02-17
CZ20013913A3 (cs) 2002-04-17
TR200103143T2 (tr) 2002-04-22
ES2202107T3 (es) 2004-04-01
NZ515278A (en) 2003-06-30
CN1351606A (zh) 2002-05-29
WO2000066603A1 (en) 2000-11-09
AU4135000A (en) 2000-11-17
IS6115A (is) 2001-10-19
HRP990130B1 (en) 2004-06-30
EP1175429A1 (en) 2002-01-30
AU767681B2 (en) 2003-11-20
BG106173A (bg) 2002-07-31

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090502