HRP940753A2 - Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion - Google Patents

Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion Download PDF

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Publication number
HRP940753A2
HRP940753A2 HRP-325/92A HRP940753A HRP940753A2 HR P940753 A2 HRP940753 A2 HR P940753A2 HR P940753 A HRP940753 A HR P940753A HR P940753 A2 HRP940753 A2 HR P940753A2
Authority
HR
Croatia
Prior art keywords
piperidinyl
dihydro
acetyl
benzodiazepine
pyrido
Prior art date
Application number
HRP-325/92A
Other languages
English (en)
Croatian (hr)
Inventor
Wolfgang Eberlein
Gerhard Mihm
Wolfhard Engel
Klaus Rudolf
Henri Doods
Harald Ziegler
Michael Entzeroth
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of HRP940753A2 publication Critical patent/HRP940753A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HRP-325/92A 1991-04-12 1994-10-25 Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion HRP940753A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4112014A DE4112014A1 (de) 1991-04-12 1991-04-12 Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung
YU32592A YU48645B (sh) 1991-04-12 1992-03-30 Kondenzovani diazepinoni i postupci za njihovo dobijanje

Publications (1)

Publication Number Publication Date
HRP940753A2 true HRP940753A2 (en) 1997-08-31

Family

ID=6429483

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-325/92A HRP940753A2 (en) 1991-04-12 1994-10-25 Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion

Country Status (28)

Country Link
US (1) US5641772A (cs)
EP (1) EP0508370B1 (cs)
JP (1) JPH0597845A (cs)
KR (1) KR100196969B1 (cs)
AT (1) ATE140004T1 (cs)
AU (1) AU653802B2 (cs)
CA (1) CA2065800A1 (cs)
CZ (1) CZ283399B6 (cs)
DE (2) DE4112014A1 (cs)
DK (1) DK0508370T3 (cs)
ES (1) ES2090396T3 (cs)
FI (1) FI97470C (cs)
GR (1) GR3020860T3 (cs)
HR (1) HRP940753A2 (cs)
HU (2) HUT61301A (cs)
IE (1) IE921147A1 (cs)
IL (1) IL101560A (cs)
MX (1) MX9201675A (cs)
NO (1) NO180303C (cs)
NZ (1) NZ242305A (cs)
PL (1) PL169745B1 (cs)
RU (1) RU2081870C1 (cs)
SG (1) SG48793A1 (cs)
SI (1) SI9210325A (cs)
SK (1) SK279466B6 (cs)
TW (1) TW205551B (cs)
YU (1) YU48645B (cs)
ZA (1) ZA922617B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332168A1 (de) * 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DK0693070T3 (da) * 1993-04-05 2002-11-11 Pharmaceutical Discovery Corp Pyrido[2,3-b][1,4]benzodiazepinoner som M2-receptorligand til behandling af neurologiske lidelser
WO1996013488A1 (fr) * 1994-10-31 1996-05-09 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive de benzodiazepinone et composition medicinale constituee de celui-ci
US5573780A (en) * 1995-08-04 1996-11-12 Apotex Usa Inc. Stable solid formulation of enalapril salt and process for preparation thereof
RU2194707C2 (ru) * 2000-04-04 2002-12-20 Научно-исследовательский институт фармакологии РАМН 2-(2'-ГИДРОКСИ-2'-ЗАМЕЩЕННЫЕ)ЭТИЛ-1,2,3,4-ТЕТРАГИДРОПИРРОЛО[1,2-a]ПИРАЗИНЫ ИЛИ ИХ ФУМАРАТЫ, ОБЛАДАЮЩИЕ АНТИАРИТМИЧЕСКОЙ И ПРОТИВОИШЕМИЧЕСКОЙ АКТИВНОСТЬЮ
WO2007056388A2 (en) * 2005-11-07 2007-05-18 The General Hospital Corporation Compositions and methods for modulating poly (adp-ribose) polymerase activity
BRPI0812849A2 (pt) * 2007-07-02 2014-12-09 Ac Immune Sa Composto ou uma composição farmacêutica, e, métodos para usar um composto, para reduzir a carga de placa b-amilóide e/ou inibir a formação das placas b-amilóides e/ou retardar o aumento da carga amilóide no cérebro de um animal, para tratar uma condição, e, para reter ou aumentar a capacidade de memória cognitiva em um animal
KR102478480B1 (ko) 2021-11-17 2022-12-19 주식회사 지농 통신 데이터 사용량을 최소화한 스마트팜 제어 및 동작확인 장치
KR102774905B1 (ko) 2023-01-04 2025-03-05 (주)다온정보기술 스마트기기를 이용한 스마트팜 제어시스템

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409237A1 (de) * 1984-03-14 1985-09-19 Dr. Karl Thomae Gmbh, 7950 Biberach Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3735895A1 (de) * 1987-10-23 1989-05-03 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3919076A1 (de) * 1989-06-10 1990-12-13 Thomae Gmbh Dr K Mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung

Also Published As

Publication number Publication date
NO921447D0 (no) 1992-04-10
EP0508370B1 (de) 1996-07-03
KR920019792A (ko) 1992-11-20
IE921147A1 (en) 1992-10-21
NO180303C (no) 1997-03-26
TW205551B (cs) 1993-05-11
SK279466B6 (sk) 1998-11-04
ZA922617B (en) 1993-10-11
SG48793A1 (en) 1998-05-18
CZ111192A3 (en) 1993-04-14
DE59206679D1 (de) 1996-08-08
FI921589A0 (fi) 1992-04-10
NZ242305A (en) 1994-09-27
ES2090396T3 (es) 1996-10-16
AU653802B2 (en) 1994-10-13
HU9201247D0 (en) 1992-07-28
IL101560A (en) 1996-03-31
GR3020860T3 (en) 1996-11-30
FI921589A7 (fi) 1992-10-13
HUT61301A (en) 1992-12-28
JPH0597845A (ja) 1993-04-20
AU1481492A (en) 1992-10-15
EP0508370A1 (de) 1992-10-14
NO180303B (no) 1996-12-16
YU48645B (sh) 1999-06-15
FI97470B (fi) 1996-09-13
MX9201675A (es) 1992-10-01
CA2065800A1 (en) 1992-10-13
YU32592A (sh) 1998-09-18
DE4112014A1 (de) 1992-10-15
RU2081870C1 (ru) 1997-06-20
SK111192A3 (en) 1995-04-12
PL169745B1 (pl) 1996-08-30
NO921447L (no) 1992-10-13
HU211156A9 (en) 1995-10-30
ATE140004T1 (de) 1996-07-15
PL294184A1 (en) 1993-05-04
FI97470C (fi) 1996-12-27
IL101560A0 (en) 1992-12-30
US5641772A (en) 1997-06-24
CZ283399B6 (cs) 1998-04-15
SI9210325A (en) 1995-04-30
DK0508370T3 (da) 1996-11-04
KR100196969B1 (ko) 1999-06-15

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A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODBC Application rejected