ES2090396T3 - Diazepinonas condensadas, procedimiento para su preparacion y agentes que contienen estos compuestos para el tratamiento de enfermedades del sistema nervioso central y para fomentar la circulacion sanguinea cerebral. - Google Patents

Diazepinonas condensadas, procedimiento para su preparacion y agentes que contienen estos compuestos para el tratamiento de enfermedades del sistema nervioso central y para fomentar la circulacion sanguinea cerebral.

Info

Publication number
ES2090396T3
ES2090396T3 ES92105989T ES92105989T ES2090396T3 ES 2090396 T3 ES2090396 T3 ES 2090396T3 ES 92105989 T ES92105989 T ES 92105989T ES 92105989 T ES92105989 T ES 92105989T ES 2090396 T3 ES2090396 T3 ES 2090396T3
Authority
ES
Spain
Prior art keywords
diseases
nervous system
central nervous
compounds
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92105989T
Other languages
English (en)
Inventor
Wolfgang Dr Eberlein
Gerhard Dr Mihm
Wolfhard Dr Engel
Klaus Dr Rudolf
Henri Dr Doods
Harald Dr Ziegler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Application granted granted Critical
Publication of ES2090396T3 publication Critical patent/ES2090396T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

DIAZOPINONA CONDENSADA, PROCEDIMIENTO PARA SU OBTENCION Y MEDIOS QUE CONTIENEN ESTOS COMPUESTOS PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL Y PARA AUMENTAR EL RIEGO SANGUINEO CEREBRAL. LA INVENCION TRATA DE UNA NUEVA DIAZOPINONA CONDENSADA DE LA FORMULA GENERAL (I) EN LA QUE B REPRESENTA UNO DE LOS RESTOS BIVALENTES Y X, L, M, N Y R1 HASTA R7 ESTAN DEFINIDOS COMO EN LA SOLICITUD 1, ADEMAS SUS SALES CON ACIDOS ORGANICOS O INORGANICOS Y EL PROCEDIMIENTO PARA SU OBTENCION. LAS SUSTANCIAS SIRVEN PARA MEJORAR O NORMALIZAR LOS TRASTORNOS CAUSADOS POR ARTERIOSCLEROSIS EN EL RIEGO SANGUINEO DEL CEREBRO, PARA LA TERAPIA DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL, ESPECIALMENTE LA ENFERMEDAD DE ALZHEIMER Y LA DE PARKINSON, Y COMO MARCAPASOS DEL SISTEMA VAGO, PARA EL TRATAMIENTO DE BRADICARDIAS Y BRADIARRITMIAS Y, ADEMAS, PARA EL FORTALECIMIENTO DEL RENDIMIENTO DE LA MEMORIA.
ES92105989T 1991-04-12 1992-04-07 Diazepinonas condensadas, procedimiento para su preparacion y agentes que contienen estos compuestos para el tratamiento de enfermedades del sistema nervioso central y para fomentar la circulacion sanguinea cerebral. Expired - Lifetime ES2090396T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4112014A DE4112014A1 (de) 1991-04-12 1991-04-12 Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung

Publications (1)

Publication Number Publication Date
ES2090396T3 true ES2090396T3 (es) 1996-10-16

Family

ID=6429483

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92105989T Expired - Lifetime ES2090396T3 (es) 1991-04-12 1992-04-07 Diazepinonas condensadas, procedimiento para su preparacion y agentes que contienen estos compuestos para el tratamiento de enfermedades del sistema nervioso central y para fomentar la circulacion sanguinea cerebral.

Country Status (28)

Country Link
US (1) US5641772A (es)
EP (1) EP0508370B1 (es)
JP (1) JPH0597845A (es)
KR (1) KR100196969B1 (es)
AT (1) ATE140004T1 (es)
AU (1) AU653802B2 (es)
CA (1) CA2065800A1 (es)
CZ (1) CZ283399B6 (es)
DE (2) DE4112014A1 (es)
DK (1) DK0508370T3 (es)
ES (1) ES2090396T3 (es)
FI (1) FI97470C (es)
GR (1) GR3020860T3 (es)
HR (1) HRP940753A2 (es)
HU (2) HUT61301A (es)
IE (1) IE921147A1 (es)
IL (1) IL101560A (es)
MX (1) MX9201675A (es)
NO (1) NO180303C (es)
NZ (1) NZ242305A (es)
PL (1) PL169745B1 (es)
RU (1) RU2081870C1 (es)
SG (1) SG48793A1 (es)
SI (1) SI9210325A (es)
SK (1) SK279466B6 (es)
TW (1) TW205551B (es)
YU (1) YU48645B (es)
ZA (1) ZA922617B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332168A1 (de) * 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DK0693070T3 (da) * 1993-04-05 2002-11-11 Pharmaceutical Discovery Corp Pyrido[2,3-b][1,4]benzodiazepinoner som M2-receptorligand til behandling af neurologiske lidelser
WO1996013488A1 (fr) * 1994-10-31 1996-05-09 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive de benzodiazepinone et composition medicinale constituee de celui-ci
US20070105835A1 (en) * 2005-11-07 2007-05-10 Kazantsev Aleksey G Compositions and methods for modulating poly(ADP-ribose) polymerase activity
EP2173355A2 (en) * 2007-07-02 2010-04-14 AC Immune S.A. Pirenzepine and derivatives thereof as anti-amyloid agents
KR102478480B1 (ko) 2021-11-17 2022-12-19 주식회사 지농 통신 데이터 사용량을 최소화한 스마트팜 제어 및 동작확인 장치

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409237A1 (de) * 1984-03-14 1985-09-19 Dr. Karl Thomae Gmbh, 7950 Biberach Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3735895A1 (de) * 1987-10-23 1989-05-03 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3919076A1 (de) * 1989-06-10 1990-12-13 Thomae Gmbh Dr K Mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung

Also Published As

Publication number Publication date
IE921147A1 (en) 1992-10-21
HU9201247D0 (en) 1992-07-28
DK0508370T3 (da) 1996-11-04
KR100196969B1 (ko) 1999-06-15
EP0508370A1 (de) 1992-10-14
AU1481492A (en) 1992-10-15
CZ283399B6 (cs) 1998-04-15
NO180303B (no) 1996-12-16
PL294184A1 (en) 1993-05-04
DE59206679D1 (de) 1996-08-08
IL101560A (en) 1996-03-31
HUT61301A (en) 1992-12-28
CZ111192A3 (en) 1993-04-14
ATE140004T1 (de) 1996-07-15
GR3020860T3 (en) 1996-11-30
IL101560A0 (en) 1992-12-30
RU2081870C1 (ru) 1997-06-20
CA2065800A1 (en) 1992-10-13
HRP940753A2 (en) 1997-08-31
DE4112014A1 (de) 1992-10-15
AU653802B2 (en) 1994-10-13
SK111192A3 (en) 1995-04-12
NO180303C (no) 1997-03-26
YU48645B (sh) 1999-06-15
JPH0597845A (ja) 1993-04-20
HU211156A9 (en) 1995-10-30
FI921589A (fi) 1992-10-13
US5641772A (en) 1997-06-24
TW205551B (es) 1993-05-11
KR920019792A (ko) 1992-11-20
NO921447L (no) 1992-10-13
YU32592A (sh) 1998-09-18
FI97470B (fi) 1996-09-13
FI921589A0 (fi) 1992-04-10
FI97470C (fi) 1996-12-27
EP0508370B1 (de) 1996-07-03
SK279466B6 (sk) 1998-11-04
NZ242305A (en) 1994-09-27
SI9210325A (en) 1995-04-30
ZA922617B (en) 1993-10-11
SG48793A1 (en) 1998-05-18
PL169745B1 (pl) 1996-08-30
MX9201675A (es) 1992-10-01
NO921447D0 (no) 1992-04-10

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