ES2180575T3 - Pirido(2,3-b)(1,4)benzodiazepinonas como ligando de receptor m2 para el tratamiento de trastornos neurologicos. - Google Patents
Pirido(2,3-b)(1,4)benzodiazepinonas como ligando de receptor m2 para el tratamiento de trastornos neurologicos.Info
- Publication number
- ES2180575T3 ES2180575T3 ES94914039T ES94914039T ES2180575T3 ES 2180575 T3 ES2180575 T3 ES 2180575T3 ES 94914039 T ES94914039 T ES 94914039T ES 94914039 T ES94914039 T ES 94914039T ES 2180575 T3 ES2180575 T3 ES 2180575T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- neurological disorders
- receptor
- benzodiazepinones
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
Abstract
SE DESCRIBEN LIGANTES DEL RECEPTOR M2 MUSCARINICO QUE SON ADECUADOS PARA EL TRATAMIENTO DE ENFERMEDADES NEUROLOGICAS, QUE PUEDEN ADMINISTRARSE CON EFECTOS COLATERALES MINIMOS. TAMBIEN SE DESCRIBE UN METODO DE SINTESIS DE LOS COMPUESTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4287293A | 1993-04-05 | 1993-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2180575T3 true ES2180575T3 (es) | 2003-02-16 |
Family
ID=21924192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94914039T Expired - Lifetime ES2180575T3 (es) | 1993-04-05 | 1994-04-05 | Pirido(2,3-b)(1,4)benzodiazepinonas como ligando de receptor m2 para el tratamiento de trastornos neurologicos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5712269A (es) |
EP (2) | EP0693070B1 (es) |
JP (1) | JP3638950B2 (es) |
AT (1) | ATE221067T1 (es) |
AU (1) | AU688318B2 (es) |
CA (1) | CA2159815A1 (es) |
DE (1) | DE69431050T2 (es) |
DK (1) | DK0693070T3 (es) |
ES (1) | ES2180575T3 (es) |
PT (1) | PT693070E (es) |
WO (1) | WO1994022861A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
ITMI991452A1 (it) * | 1999-07-01 | 2001-01-01 | Mediolanum Farmaceutici Srl | Antagonisti selettivi per i recettori m2 con struttura 5h-dibenzo b,fazepinica |
AR025884A1 (es) * | 1999-10-01 | 2002-12-18 | Takeda Pharmaceutical | Compuestos de amina ciclica, su produccion y su uso |
WO2003089004A1 (fr) * | 2002-04-19 | 2003-10-30 | Takeda Pharmaceutical Company Limited | Agents prophylactiques utilises pour prevenir l'infection par vih |
AU2005263577C1 (en) | 2004-07-16 | 2010-08-26 | Proteosys Ag | Muscarinic antagonists with PARP and SiR modulating activity as cytoprotective agents |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
KR20230085223A (ko) * | 2008-12-04 | 2023-06-13 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
EP2379080A1 (en) | 2009-01-13 | 2011-10-26 | ProteoSys AG | Pirenzepine as otoprotective agent |
GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH438343A (de) * | 1962-11-08 | 1967-06-30 | Thomae Gmbh Dr K | Verfahren zur Herstellung von 5,6-Dihydro-6-oxo-11H-pyrido (2,3-b) (1,4)-benzodiazepinen |
DE3735895A1 (de) * | 1987-10-23 | 1989-05-03 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE3818299A1 (de) * | 1988-05-30 | 1989-12-07 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
GB9000302D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Muscarinic receptor antagonists |
DE4112014A1 (de) * | 1991-04-12 | 1992-10-15 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung |
-
1994
- 1994-04-05 DK DK94914039T patent/DK0693070T3/da active
- 1994-04-05 JP JP52246994A patent/JP3638950B2/ja not_active Expired - Fee Related
- 1994-04-05 AU AU66261/94A patent/AU688318B2/en not_active Ceased
- 1994-04-05 DE DE69431050T patent/DE69431050T2/de not_active Expired - Fee Related
- 1994-04-05 EP EP94914039A patent/EP0693070B1/en not_active Expired - Lifetime
- 1994-04-05 CA CA002159815A patent/CA2159815A1/en not_active Abandoned
- 1994-04-05 AT AT94914039T patent/ATE221067T1/de not_active IP Right Cessation
- 1994-04-05 PT PT94914039T patent/PT693070E/pt unknown
- 1994-04-05 EP EP01200454A patent/EP1120416A1/en not_active Withdrawn
- 1994-04-05 WO PCT/US1994/003720 patent/WO1994022861A1/en active IP Right Grant
- 1994-04-05 ES ES94914039T patent/ES2180575T3/es not_active Expired - Lifetime
-
1995
- 1995-01-24 US US08/377,667 patent/US5712269A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0693070A1 (en) | 1996-01-24 |
EP1120416A1 (en) | 2001-08-01 |
EP0693070B1 (en) | 2002-07-24 |
JPH08510999A (ja) | 1996-11-19 |
CA2159815A1 (en) | 1994-10-13 |
ATE221067T1 (de) | 2002-08-15 |
DE69431050T2 (de) | 2003-03-13 |
DK0693070T3 (da) | 2002-11-11 |
US5712269A (en) | 1998-01-27 |
AU688318B2 (en) | 1998-03-12 |
PT693070E (pt) | 2002-12-31 |
AU6626194A (en) | 1994-10-24 |
DE69431050D1 (de) | 2002-08-29 |
WO1994022861A1 (en) | 1994-10-13 |
JP3638950B2 (ja) | 2005-04-13 |
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